Scott Williams

Event-Free Survival, a Prostate-Specific Antigen-Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation.

Wanling Xie, Meredith M Regan, Marc Buyse, Susan Halabi, Philip W Kantoff, Oliver Sartor, Howard Soule, Donald Berry, Noel Clarke, Laurence Collette, Anthony D'Amico, Richard De Abreu Lourenco, James Dignam, Mario Eisenberger, Nicholas James, Karim Fizazi, Silke Gillessen, Yohann Loriot, Nicolas Mottet, Wendy Parulekar, et al.

Journal article  |  2020  |  Journal of Clinical Oncology

PURPOSE: Recently, we have shown that metastasis-free survival is a strong surrogate for overall survival (OS) in men with interme..

Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of Lu-177-PSMA-617 Theranostics in Metastatic Castration-Resistant Prostate Cancer

John Violet, Shahneen Sandhu, Amir Iravani, Justin Ferdinandus, Thang Sue-Ping, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, David Pattison, Alexis Beaulieu, Jennifer Mooi, Ben Tran, Christina Guo, Victor Kalff, Declan G Murphy, Price Jackson, Peter Eu, Mark Scalzo, Scott G Williams, Rod J Hicks, et al.

Journal article  |  2020  |  Journal of Nuclear Medicine

177Lu-PSMA-617 is a radioligand with high affinity for prostate-specific membrane antigen (PSMA), enabling targeted β-irradiation ..

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.

Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson

Journal article  |  2020  |  Journal for ImmunoTherapy of Cancer

BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few inf..

Standard versus hypofractionated intensity-modulated radiotherapy for prostate cancer: assessing the impact on dose modulation and normal tissue effects when using patient-specific cancer biology.

Emily Jungmin Her, Martin Andrew Ebert, Angel M Kennedy, Hayley M Reynolds, Yu Sun, Scott Williams, Annette Haworth

Journal article  |  2020  |  Physics in Medicine & Biology

Hypofractionation of prostate cancer radiotherapy achieves tumour control at lower total radiation doses, however, increased recta..

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  International Journal of Molecular Sciences

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study

Michael S Hofman, Nathan Lawrentschuk, Roslyn J Francis, Colin Tang, Ian Vela, Paul Thomas, Natalie Rutherford, Jarad M Martin, Mark Frydenberg, Ramdave Shakher, Lih-Ming Wong, Kim Taubman, Sze Ting Lee, Edward Hsiao, Paul Roach, Michelle Nottage, Ian Kirkwood, Dickon Hayne, Emma Link, Petra Marusic, et al.

Journal article  |  2020  |  The Lancet

BACKGROUND: Conventional imaging using CT and bone scan has insufficient sensitivity when staging men with high-risk localised pro..

Prognostic biomarkers in men with metastatic castration-resistant prostate cancer receiving [177Lu]-PSMA-617.

Justin Ferdinandus, John Violet, Shahneen Sandhu, Rodney J Hicks, Aravind S Ravi Kumar, Amir Iravani, Grace Kong, Tim Akhurst, Sue Ping Thang, Declan G Murphy, Scott Williams, Michael S Hofman

Journal article  |  2020  |  European Journal of Nuclear Medicine and Molecular Imaging

PURPOSE: We analysed quantitative biomarkers derived from both baseline whole-body imaging and blood serum to identify prognostic ..

Is adjuvant radiotherapy now history? Implications of the RAVES and RADICALS trial on current practice

M Pearse, A Kneebone, C Fraser-Browne, G Duchesne, A Herschtal, M Frydenberg, S Williams, D Fisher, J Tierney, C Vale, C Adrian, C Parker, M Parmar, M Sydes, S Chabaud, P Richaud, P Sargos

Conference Proceedings  |  2020  |  BJU INTERNATIONAL

DASL-HiCAP (ANZUP1801): The impact of darolutamide on standard therapy for localized very high-risk cancer of the prostate-A randomized phase III double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high-risk, clinically localized prostate cancer

Tamim Niazi, Scott Williams, Ian D Davis, Martin R Stockler, Andrew James Martin, Wendy Hague, Karen Bracken, Margot Gorzeman, Felicia Roncolato, Sonia Yip, Lisa Horvath, Shomik Sengupta, Simon Hughes, Raymond S McDermott, James WF Catto, Neha Vapiwala, Wendy R Parulekar, Christopher Sweeney

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Adjuvant docetaxel for high-risk localized prostate cancer: Update of NRG Oncology/RTOG 0521

Howard M Sandler, Theodore Karrison, A Oliver Sartor, Leonard G Gomella, Mahul B Amin, James Purdy, Jeff M Michalski, Mark Garzotto, Nadeem Pervez, Alexander G Balogh, George Rodrigues, Luis Souhami, M Neil Reaume, Scott Williams, Raquibul Hannan, Christopher U Jones, Eric M Horwitz, Joseph P Rodgers, Felix Y Feng, Seth A Rosenthal

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Molecular Imaging of Newly Diagnosed Prostate Cancer

Scott Williams

Journal article  |  2020  |  The Cancer Journal

Positron emission tomography (PET) is a valuable imaging in evaluating many malignancies. There are various molecular imaging trac..

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A Takano, Clelia Timpone, Arjelle D Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G Horvath, Stephen B Fox, Scott G Williams, Andrea Russo, Enzo Gallo, Piotr J Paul, Catherine Mitchell, Shahneen Sandhu, Simon P Keam, et al.

Journal article  |  2019  |  iScience

Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6A..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Ga-68-prostate-specific membrane antigen (PSMA) PET/CT as a clinical decision-making tool in biochemically recurrent prostate cancer after definitive treatment: An Australian prospective study

Amy Davies, Edmond M Kwan, John Kourambas, Nicholas Redgrave, Scott Donnellan, Sree Appu, Scott Williams, Andrew Coleman, Marcus Foo, Shakher Ramdave, Arun Azad

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Poor Outcomes for Patients with Metastatic Castration-resistant Prostate Cancer with Low Prostate-specific Membrane Antigen (PSMA) Expression Deemed Ineligible for 177Lu-labelled PSMA Radioligand Therapy

Sue Ping Thang, John Violet, Shahneen Sandhu, Amir Iravani, Tim Akhurst, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Scott G Williams, Rodney J Hicks, Michael S Hofman

Journal article  |  2019  |  European Urology Oncology

BACKGROUND: Prostate-specific membrane antigen (PSMA) is overexpressed in metastatic castration-resistant prostate cancer (mCRPC) ..

TheraP: a randomized phase 2 trial of Lu-177-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603)

Michael S Hofman, Louise Emmett, John Violet, Alison Y Zhang, Nicola J Lawrence, Martin Stockler, Roslyn J Francis, Amir Iravani, Scott Williams, Arun Azad, Andrew Martin, Margaret McJannett, Ian D Davis

Journal article  |  2019  |  BJU International

OBJECTIVE: To assess the activity and safety of cabazitaxel chemotherapy vs that of treatment with 177 Lu-PSMA-617, a novel radiol..

A Phase III Multi-Centre Randomised Trial comparing adjuvant versus early salvage Radiotherapy following a Radical Prostatectomy: Results of the TROG 08.03 and ANZUP "RAVES" Trial

A Kneebone, C Fraser-Browne, W Delprado, G Duchesne, R Fisher, M Frydenberg, A Haworth, A Herschtal, DJ Joseph, TS Lim, JM Martin, JL Millar, M Sidhom, N Spry, CI Tang, S Turner, SG Williams, KL Wiltshire, H Woo, M Pearse

Conference Proceedings  |  2019  |  International Journal of Radiation Oncology*Biology*Physics

Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer

Ian D Davis, Andrew J Martin, Martin R Stockler, Stephen Begbie, Kim N Chi, Simon Chowdhury, Xanthi Coskinas, Mark Frydenberg, Wendy E Hague, Lisa G Horvath, Anthony M Joshua, Nicola J Lawrence, Gavin Marx, John McCaffrey, Ray McDermott, Margaret McJannett, Scott A North, Francis Parnis, Wendy Parulekar, David W Pook, et al.

Journal article  |  2019  |  New England Journal of Medicine

Immune Profiling of Primary Prostate Cancer Arising in Men with and Without Germline DNA Repair Defects

Shahneen Sandhu, Anna Trigos, Anu Pasam, Patricia Banks, Simon Keam, Heather Thorn, Catherine Mitchell, David Clouston, Declan Murphy, Damien Bolton, Phil Darcy, Ygal Haupt, Scot Williams, David Goode, Paul Neeson

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Molecular Imaging of Recurrent and Metastatic Prostate Cancer

Robert E Ware, Scott Williams, Rodney J Hicks

Journal article  |  2019  |  Seminars in Nuclear Medicine

Voxel-wise correlation of positron emission tomography/computed tomography with multiparametric magnetic resonance imaging and histology of the prostate using a sophisticated registration framework

Hayley M Reynolds, Scott Williams, Price Jackson, Catherine Mitchell, Michael S Hofman, Rodney J Hicks, Declan G Murphy, Annette Haworth

Journal article  |  2019  |  BJU International

Effect of Chemotherapy With Docetaxel With Androgen Suppression and Radiotherapy for Localized High-Risk Prostate Cancer: The Randomized Phase III NRG Oncology RTOG 0521 Trial

Seth A Rosenthal, Chen Hu, Oliver Sartor, Leonard G Gomella, Mahul B Amin, James Purdy, Jeff M Michalski, Mark G Garzotto, Nadeem Pervez, Alexander G Balogh, George B Rodrigues, Luis Souhami, M Neil Reaume, Scott G Williams, Raquibul Hannan, Eric M Horwitz, Adam Raben, Christopher A Peters, Felix Y Feng, William U Shipley, et al.

Journal article  |  2019  |  Journal of Clinical Oncology

Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer

Weranja KB Ranasinghe, Scott Williams, Joseph Ischia, David Wetherell, Graham Baldwin, Arthur Shulkes, Shomik Sengupta, Damien Bolton, Oneel Patel

Conference Proceedings  |  2019  |  BJU International

Automatic stratification of prostate tumour aggressiveness using multiparametric MRI: a horizontal comparison of texture features

Yu Sun, Hayley M Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Annette Haworth

Journal article  |  2019  |  Acta Oncologica

Dosimetry of Lu-177-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer: Correlations Between Pretherapeutic Imaging and Whole-Body Tumor Dosimetry with Treatment Outcomes

John Violet, Price Jackson, Justin Ferdinandus, Shahneen Sandhu, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Sue Ping Thang, Peter Eu, Mark Scalzo, Declan Murphy, Scott Williams, Rodney J Hicks, Michael S Hofman

Journal article  |  2019  |  Journal of Nuclear Medicine

Strategies for Evaluation of Novel Imaging in Prostate Cancer: Putting the Horse Back Before the Cart

Neha Vapiwala, Michael S Hofman, Declan G Murphy, Scott Williams, Christopher Sweeney

Journal article  |  2019  |  Journal of Clinical Oncology

Use of contemporary prostate brachytherapy approaches in clinical trials

A Haworth, Y Sun, M Ebert, H Reynolds, J Betts, D Wraith, C Mitchell, D Murphy, B Parameswaran, S Williams

Conference Proceedings  |  2019  |  Journal of Physics: Conference Series

TheraP: A randomized phase II trial of [Lu-177]-PSMA-617 theranostic versus cabazitaxel in progressive metastatic castration-resistant prostate cancer

Michael Hofman, Louise Emmett, John A Violet, Nicola Jane Lawrence, Scott Williams, Martin R Stockler, Roslyn J Francis, Amir Iravani, Alison Yan Zhang, Andrew James Martin, Arun Azad, Sonia Yip, Ailsa Langford, Margaret Mary McJannett, Ian D Davis

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.

Scott Williams, Simon Keam, Heloise Halse, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phil Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

A randomized trial comparing fluorocholine-PET/CT with conventional imaging in prostate cancer.

Scott Williams, Jean-Mathieu Beauregard, Peter Roselt, Kate Moody, Richard Fisher, Elizabeth Drummond, Rodney J Hicks

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Results of a 50 patient single-center phase II prospective trial of Lutetium-177 PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

Michael Hofman, John A Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Timothy J Akhurst, Jennifer Mooi, Christina Guo, Ben Tran, Price Jackson, Mark Scalzo, Peter Eu, Scott Williams, Shahneen Kaur Sandhu

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Health Technology Assessment and Health Care Utilisation in the Management of Early Prostate Cancer

Richard De Abreu Lourenco, Scott Williams

Journal article  |  2019  |  European Urology Focus

Health technology assessment (HTA) is a key tool used to allocate health care funding. A critical aspect of HTA is the performance..

The "ProPSMA Study" clinical trial protocol: A prospective randomized multi-center study of the impact of Ga-68 PSMA PET/CT imaging for staging high-risk prostate cancer prior to curative-intent surgery or radiotherapy.

Michael Hofman, Declan G Murphy, Scott Williams, Tatenda Nzenza, Alan Herschtal, Anetta Matera, Petra Marusic, Richard De Abreu Lourenco, Dale L Bailey, Amir Iravani, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Multiparametric MRI and radiomics in prostate cancer: a review

Yu Sun, Hayley M Reynolds, Bimal Parameswaran, Darren Wraith, Mary E Finnegan, Scott Williams, Annette Haworth

Journal article  |  2019  |  Australasian Physical & Engineering Sciences in Medicine

Association analysis between quantitative MRI features and hypoxia-related genetic profiles in prostate cancer: a pilot study

Yu Sun, Scott Williams, David Byrne, Simon Keam, Hayley M Reynolds, Catherine Mitchell, Darren Wraith, Declan Murphy, Annette Haworth

Journal article  |  2019  |  The British Journal of Radiology

OBJECTIVE: To investigate the association between multiparametric MRI (mpMRI) imaging features and hypoxia-related genetic profile..

Management of patients with advanced prostate cancer in the Asia Pacific region: "real-world' consideration of results from the Advanced Prostate Cancer Consensus Conference (APCCC) 2017

Edmund Chiong, Declan G Murphy, Hideyuki Akaza, Nicholas C Buchan, Byung Ha Chung, Ravindran Kanesvaran, Makarand Khochikar, Jason Letran, Bannakij Lojanapiwat, Chi-fai Ng, Teng Ong, Yeong-Shiau Pu, Marniza Saad, Kathryn Schubach, Levent Turkeri, Rainy Umbas, Le Chuyen Vu, Scott Williams, Ding-Wei Ye, Ian D Davis

Journal article  |  2019  |  BJU International

A First-in-Human Study of Ga-68-Nanocolloid PET/CT Sentinel Lymph Node Imaging in Prostate Cancer Demonstrates Aberrant Lymphatic Drainage Pathways

Jacki A Doughton, Michael S Hofman, Peter Eu, Rodney J Hicks, Scott Williams

Journal article  |  2018  |  Journal of Nuclear Medicine

Building an Understanding of the Value of Docetaxel Plus Hormone Therapy in Prostate Cancer: An Ever-growing Evidence Base

Richard De Abreu Lourenco, Scott G Williams

Journal article  |  2018  |  European Urology Oncology

Voxel-wise prostate cell density prediction using multiparametric magnetic resonance imaging and machine learning

Yu Sun, Hayley M Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Annette Haworth

Journal article  |  2018  |  Acta Oncologica

A prospective randomized multicentre study of the impact of gallium-68 prostate-specific membrane antigen (PSMA) PET/CT imaging for staging high-risk prostate cancer prior to curative-intent surgery or radiotherapy (proPSMA study): clinical trial protocol

Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk

Journal article  |  2018  |  BJU International

GDPR-not just an EU regulation?

Scott Williams

Journal article  |  2018  |  The Lancet Oncology

Meeting report from the Prostate Cancer Foundation PSMA-directed radionuclide scientific working group

Andrea K Miyahira, Kenneth J Pienta, Michael J Morris, Neil H Bander, Richard P Baum, Wolfgang P Fendler, William Goeckeler, Michael A Gorin, Hartwig Hennekes, Martin G Pomper, Oliver Sartor, Scott T Tagawa, Scott Williams, Howard R Soule

Journal article  |  2018  |  The Prostate

Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study

Geoffrey D Coughlin, John W Yaxley, Suzanne K Chambers, Stefano Occhipinti, Hema Samaratunga, Leah Zajdlewicz, Patrick Teloken, Nigel Dunglison, Scott Williams, Martin F Lavin, Robert A Gardiner

Journal article  |  2018  |  The Lancet Oncology

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Gisela Mir Arnau, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Scott G Williams, Ygal Haupt

Journal article  |  2018  |  Radiation and Environmental Biophysics

Radiobiological parameters in a tumour control probability model for prostate cancer LDR brachytherapy

EJ Her, HM Reynolds, C Mears, S Williams, C Moorehouse, JL Millar, MA Ebert, A Haworth

Journal article  |  2018  |  Physics in Medicine & Biology

Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry

Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Ygal Haupt, Scott G Williams

Journal article  |  2018  |  The Prostate

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells

Twishi Gulati, Cheng Huang, Franco Caramia, Dinesh Raghu, Piotr J Paul, Robert JA Goode, Simon P Keam, Scott G Williams, Sue Haupt, Oded Kleifeld, Ralf B Schittenhelm, Cristina Gamell, Ygal Haupt

Journal article  |  2018  |  Molecular & Cellular Proteomics

Surrogate endpoints in early prostate cancer research

Scott Williams

Journal article  |  2018  |  Translational Andrology and Urology

[Lu-177]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study

Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu

Journal article  |  2018  |  The Lancet Oncology

Lutetium-177 PSMA617 theranostics in metastatic castrate-resistant prostate cancer (mCRPC): Interim results of a phase II trial.

Shahneen Kaur Sandhu, John A Violet, Justin Ferdinandus, Sue-Ping Thang, Amir Iravani, Christina Guo, Grace Kong, Aravind Ravi Kumar, Timothy J Akhurst, Alexis Beaulieu, Declan G Murphy, Jennifer Mooi, Ben Tran, Guy C Toner, Scott Williams, Rodney J Hicks, Michael Hofman

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

The poor outcome of patients with mCRPC whom were deemed ineligible for PSMA theranostics based on molecular imaging characteristics.

Sue Ping Thang, John A Violet, Shahneen Kaur Sandhu, Amir Iravani, Timothy J Akhurst, Aravind Ravi Kumar, Grace Kong, Scott Williams, Rodney J Hicks, Michael Hofman, Michael Hofman

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

High activity, pain reduction and low toxicity with Lutetium-177 PSMA617 theranostics in metastatic castrate-resistant prostate cancer (mCRPC): results of a phase II prospective trial

Michael Hofman, John Violet, Shahneen Sandhu, Justin Ferdinandus, Sue Ping Thang, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, Price Jackson, Mark Scalzo, Scott Williams, Rodney Hicks

Conference Proceedings  |  2018  |  JOURNAL OF NUCLEAR MEDICINE

The BiRT project - linking radiomics to advanced approaches for treatment of prostate cancer

A Haworth, Y Sun, H Reynolds, D Wraith, C Mitchell, D Murphy, B Parameswaran, M DiFranco, M Ebert, S Williams

Conference Proceedings  |  2018  |  Radiotherapy and Oncology

Randomised phase 3 trial of enzalutamide in androgen deprivation therapy (ADT) with radiation therapy for high risk, clinically localized prostate cancer: ENZARAD (ANZUP 1303).

Scott Williams, Ian D Davis, Christopher Sweeney, Martin R Stockler, Andrew James Martin, Wendy Hague, Xanthi Coskinas, Sonia Yip, Emily Tu, Nicola Jane Lawrence, Namrata Nayar, Ray McDermott, Paul Kelly, Olwyn Deignan, Simon Hughes, Valerie Fonteyne, Bertrand F Tombal, Paul L Nguyen

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Prostate cancer-specific PET radiotracers: A review on the clinical utility in recurrent disease

Jaden D Evans, Krishan R Jethwa, Piet Ost, Scott Williams, Eugene D Kwon, Val J Lowe, Brian J Davis

Journal article  |  2018  |  Practical Radiation Oncology

The Transcriptional Landscape of Radiation-Treated Human Prostate Cancer: Analysis of a Prospective Tissue Cohort

Simon P Keam, Franco Caramia, Cristina Gamell, Piotr J Paul, Gisela Mir Arnau, Paul J Neeson, Scott G Williams, Ygal Haupt

Journal article  |  2018  |  International Journal of Radiation Oncology*Biology*Physics

Ga-68 PSMA-11 PET with CT urography protocol in the initial staging and biochemical relapse of prostate cancer

Amir Iravani, Michael S Hofman, Tony Mulcahy, Scott Williams, Declan Murphy, Bimal K Parameswaran, Rodney J Hicks

Journal article  |  2017  |  Cancer Imaging

Seduction by Sensitivity: Reality, Illusion, or Delusion? The Challenge of Assessing Outcomes after PSMA Imaging Selection of Patients for Treatment

Rodney J Hicks, Declan G Murphy, Scott G Williams

Journal article  |  2017  |  Journal of Nuclear Medicine

Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer

Wanling Xie, Meredith M Regan, Marc Buyse, Susan Halabi, Philip W Kantoff, Oliver Sartor, Howard Soule, Noel W Clarke, Laurence Collette, James J Dignam, Karim Fizazi, Wendy R Paruleker, Howard M Sandler, Matthew R Sydes, Bertrand Tombal, Scott G Williams, Christopher J Sweeney

Journal article  |  2017  |  Journal of Clinical Oncology

Threat of Sexual Disqualification: The Consequences of Erectile Dysfunction and Other Sexual Changes for Gay and Bisexual Men With Prostate Cancer

Jane M Ussher, Janette Perz, Duncan Rose, Gary W Dowsett, Suzanne Chambers, Scott Williams, Ian Davis, David Latini

Journal article  |  2017  |  Archives of Sexual Behavior

Focal therapy for prostate cancer: the technical challenges

Annette Haworth, Scott Williams

Journal article  |  2017  |  Journal of Contemporary Brachytherapy

E6AP promotes prostate cancer by reducing p27 expression

Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt

Journal article  |  2017  |  Oncotarget

Randomised phase III trial of enzalutamide in androgen deprivation therapy (ADT) with radiation therapy for clinically localised, high risk, or node-positive prostate cancer: ENZARAD (ANZUP 1303).

Scott Williams, Ian D Davis, Christopher Sweeney, Martin R Stockier, Andrew James Martin, Wendy Hague, Xanthi Coskinas, Sonia Yip, Emily Tu, Nicola Jane Lawrence, Ray McDermott, Paul J Kelly, Olwyn Deignan, Simon Hughes, Valerie Fonteyne, Bertrand F Tombal, Paul L Nguyen

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer

M Diana van Die, Scott G Williams, Jon Emery, Kerry M Bone, Jeremy MG Taylor, Elizabeth Lusk, Marie V Pirotta

Journal article  |  2017  |  The Prostate

Support for the use of objective comorbidity indices in the assessment of noncancer death risk in prostate cancer patients

Sweet Ping Ng, Gillian Duchesne, Keen-Hun Tai, Farshad Foroudi, Gargi Kothari, Scott Williams

Journal article  |  2017  |  Prostate International

Predicting prostate tumour location from multiparametric MRI using Gaussian kernel support vector machines: a preliminary study

Yu Sun, Hayley Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Martin A Ebert, Annette Haworth

Journal article  |  2017  |  Australasian Physical & Engineering Sciences in Medicine

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

Journal article  |  2016  |  ONCOGENE

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study

John W Yaxley, Geoffrey D Coughlin, Suzanne K Chambers, Stefano Occhipinti, Hema Samaratunga, Leah Zajdlewicz, Nigel Dunglison, Rob Carter, Scott Williams, Diane J Payton, Joanna Perry-Keene, Martin F Lavin, Robert A Gardiner

Journal article  |  2016  |  The Lancet

Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials

Margaret Diana van Die, Kerry M Bone, Jon Emery, Scott G Williams, Marie V Pirotta, Channing J Paller

Journal article  |  2016  |  BJU International

Health-Related Quality of Life, Psychological Distress, and Sexual Changes Following Prostate Cancer: A Comparison of Gay and Bisexual Men With Heterosexual Men

Jane M Ussher, Janette Perz, Andrew Kellett, Suzanne Chambers, David Latini, Ian D Davis, Duncan Rose, Gary W Dowsett, Scott Williams

Journal article  |  2016  |  The Journal of Sexual Medicine

A radiobiology-based inverse treatment planning method for optimisation of permanent l-125 prostate implants in focal brachytherapy

Annette Haworth, Christopher Mears, John M Betts, Hayley M Reynolds, Guido Tack, Kevin Leo, Scott Williams, Martin A Ebert

Journal article  |  2016  |  Physics in Medicine and Biology

A randomised control trial of salvage radiotherapy and androgen deprivation therapy following prostatectomy: Commentary on five year follow-up findings

S Williams, JW Yaxley, GD Coughlin, RA Gardiner

Journal article  |  2016  |  Translational Andrology and Urology

Development of a registration framework to validate MRI with histology for prostate focal therapy

HM Reynolds, S Williams, A Zhang, R Chakravorty, D Rawlinson, CS Ong, M Esteva, C Mitchell, B Parameswaran, M Finnegan, G Liney, A Haworth

Journal article  |  2015  |  Medical Physics

ADVANCES IN THE IMAGING OF THE PROSTATE IN THE SETTING OF ELEVATED PSA LEVELS

Rodney J Hicks, Bimal K Parameswaran, Michael S Hofman, Declan G Murphy, Nathan Lawrentschuk, Scott G Williams

Journal article  |  2015  |  Cancer Forum

CHANGING STATUS OF INVESTIGATIONS FOR PROSTATE CANCER DETECTION

Lachlan AN Gordon, John Yaxley, Mark Frydenberg, Scott G Williams, Robert A Gardiner

Journal article  |  2015  |  Cancer Forum

Long-term Survival Outcomes for Men Who Provided Ejaculate Specimens for Prostate Cancer Research: Implications for Patient Management

Darius Ashrafi, Peter Baade, John Yaxley, Matthew J Roberts, Scott Williams, Robert A Gardiner

Journal article  |  2015  |  European Urology Focus

BACKGROUND: Determining whether men diagnosed with early prostate cancer (PCa) will live long enough to benefit from interventions..

The Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group - a new co-operative cancer trials group in genitourinary oncology

Shomik Sengupta, Peter Grimison, Dickon Hayne, Scott Williams, Suzanne Chambers, Paul DeSouza, Martin Stockler, Margaret McJannett, Guy Toner, Ian D Davis

Journal article  |  2015  |  BJU International

Ensemble prostate tumor classification in H&E whole slide imaging via stain normalization and cell density estimation

M Weingant, HM Reynolds, A Haworth, C Mitchell, S Williams, MD DiFranco

Journal article  |  2015  |  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Performance assessment of automated tissue characterization for prostate H&E stained histopathology

Matthew D Di Franco, Hay Ley M Reynolds, Catherine Mitchell, Scott Williams, Prue Allan, Annette Haworth

Journal article  |  2015  |  Medical Imaging 2015: Digital Pathology

Efficacy of High-dose Palliative Radiotherapy for Localised, Castration-resistant Prostate Cancer

R White, R Khor, M Bressel, G Duchesne, S Williams, P Bowden, K Tai, F Foroudi

Journal article  |  2015  |  Clinical Oncology

'What is this active surveillance thing?' Men's and partners' reactions to treatment decision making for prostate cancer when active surveillance is the recommended treatment option

Clare O'Callaghan, Tracey Dryden, Amelia Hyatt, Joanne Brooker, Sue Burney, Addie C Wootten, Alan White, Mark Frydenberg, Declan Murphy, Scott Williams, Penelope Schofield

Journal article  |  2014  |  Psycho-Oncology

Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials

M Diana van Die, Kerry M Bone, Scott G Williams, Marie V Pirotta

Journal article  |  2014  |  BJU International

The effects of nonspecific HIF1 alpha inhibitors on development of castrate resistance and metastases in prostate cancer

Weranja KB Ranasinghe, Shomik Sengupta, Scott Williams, Mike Chang, Arthur Shulkes, Damien M Bolton, Graham Baldwin, Oneel Patel

Journal article  |  2014  |  CANCER MEDICINE

A Progress Report on a Prospective Randomised Trial of Open and Robotic Prostatectomy

Robert A Gardiner, Geoffrey D Coughlin, John W Yaxley, Nigel T Dunglison, Stefano Occhipinti, Sandra J Younie, Rob C Carter, Scott G Williams, Robyn J Medcraft, Hema M Samaratunga, Joanna L Perry-Keene, Diane J Payton, Martin F Lavin, Suzanne K Chambers

Journal article  |  2014  |  European Urology

A Phase III trial to investigate the timing of radiotherapy for prostate cancer with high-risk features: background and rationale of the Radiotherapy - Adjuvant Versus Early Salvage (RAVES) trial

Maria Pearse, Carol Fraser-Browne, Ian D Davis, Gillian M Duchesne, Richard Fisher, Mark Frydenberg, Annette Haworth, Chakiath Jose, David J Joseph, Tee S Lim, John Matthews, Jeremy Millar, Mark Sidhom, Nigel A Spry, Colin I Tang, Sandra Turner, Scott G Williams, Kirsty Wiltshire, Henry H Woo, Andrew Kneebone

Journal article  |  2014  |  BJU International

Cell density in prostate histopathology images as a measure of tumour distribution

Hayley M Reynolds, Scott Williams, Alan M Zhang, Cheng Soon Ong, David Rawlinson, Rajib Chakravorty, Catherine Mitchell, Annette Haworth

Conference Proceedings  |  2014  |  Medical Imaging 2014: Digital Pathology

Contemporary Issues in Radiotherapy for Clinically Localized Prostate Cancer

Richard Khor, Scott Williams

Journal article  |  2013  |  Hematology / Oncology Clinics of North America

Validation of a radiobiological model for low-dose-rate prostate boost focal therapy treatment planning

Annette Haworth, Scott Williams, Hayley Reynolds, David Waterhouse, Gillian M Duchesne, Joseph Bucci, David Joseph, Sean Bydder, Martin Ebert

Journal article  |  2013  |  Brachytherapy

Management of prostate cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013

Scott Williams, Edmund Chiong, Bannakij Lojanapiwat, Rainy Umbas, Hideyuki Akaza

Journal article  |  2013  |  Lancet Oncology

Real-Time Individual Predictions of Prostate Cancer Recurrence Using Joint Models

Jeremy MG Taylor, Yongseok Park, Donna P Ankerst, Cecile Proust-Lima, Scott Williams, Larry Kestin, Kyoungwha Bae, Tom Pickles, Howard Sandler

Journal article  |  2013  |  Biometrics

Direct 2-Arm Comparison Shows Benefit of High-Dose-Rate Brachytherapy Boost vs External Beam Radiation Therapy Alone for Prostate Cancer

Richard Khor, Gillian Duchesne, Keen-Hun Tai, Farshad Foroudi, Sarat Chander, Sylvia Van Dyk, Margaret Garth, Scott Williams

Journal article  |  2013  |  International Journal of Radiation: Oncology - Biology - Physics

New types of radiotherapy improve cancer outcome but at what cost?

Declan G Murphy, Scott Williams, Matthew R Cooperberg

Journal article  |  2012  |  Nature Reviews Urology

Percentage of Positive Biopsy Cores: A Better Risk Stratification Model for Prostate Cancer?

Jiayi Huang, Frank A Vicini, Scott G Williams, Hong Ye, Samuel McGrath, Mihai Ghilezan, Daniel Krauss, Alvaro A Martinez, Larry L Kestin

Journal article  |  2012  |  International Journal of Radiation Oncology*Biology*Physics

A randomised trial of robotic and open prostatectomy in men with localised prostate cancer

Robert A Gardiner, John Yaxley, Geoff Coughlin, Nigel Dunglison, Stefano Occhipinti, Sandra Younie, Rob Carter, Scott Williams, Robyn J Medcraft, Nigel Bennett, Martin F Lavin, Suzanne Kathleen Chambers

Journal article  |  2012  |  BMC Cancer

Validating the Interval to Biochemical Failure for the Identification of Potentially Lethal Prostate Cancer

Mark K Buyyounouski, Tom Pickles, Larry L Kestin, Roger Allison, Scott G Williams

Journal article  |  2012  |  Journal of Clinical Oncology

HIGH-DOSE-RATE BRACHYTHERAPY AS A MONOTHERAPY FOR FAVORABLE-RISK PROSTATE CANCER: A PHASE II TRIAL

Maroie Barkati, Scott G Williams, Farshad Foroudi, Keen Hun Tai, Sarat Chander, Sylvia van Dyk, Andrew See, Gillian M Duchesne

Journal article  |  2012  |  International Journal of Radiation: Oncology - Biology - Physics

Value of PET scan in patients with retroperitoneal sarcoma treated with preoperative radiotherapy

Simone Alford, Peter Choong, Sarat Chander, Michael Henderson, Julie Chu, Gerard Powell, Scott Williams, Samuel Ngan

Journal article  |  2012  |  European Journal of Surgical Oncology

Electronic portal imaging vs kilovoltage imaging in fiducial marker image-guided radiotherapy for prostate cancer: an analysis of set-up uncertainties

S Gill, J Thomas, C Fox, T Kron, A Thompson, S Chander, S Williams, KH Tai, G Duchesne, F Foroudi

Journal article  |  2012  |  British Journal of Radiology

Interfraction patient motion and implant displacement in prostate high dose rate brachytherapy

CD Fox, T Kron, M Leahy, G Duchesne, S Williams, KH Tai, A Haworth, A Herschtal, F Foroudi

Journal article  |  2011  |  Medical Physics

ONLINE ADAPTIVE RADIOTHERAPY FOR MUSCLE-INVASIVE BLADDER CANCER: RESULTS OF A PILOT STUDY

Farshad Foroudi, Jacky Wong, Tomas Kron, Aldo Rolfo, Annetre Haworth, Paul Roxby, Jessica Thomas, A Herschtal, Daniel Pham, Scott Williams, Keen Hun Tai, Gillian Duchesne

Journal article  |  2011  |  International Journal of Radiation: Oncology - Biology - Physics

Acute toxicity in prostate cancer patients treated with and without image-guided radiotherapy

Suki Gill, Jessica Thomas, Chris Fox, Tomas Kron, Aldo Rolfo, Mary Leahy, Sarat Chander, Scott Williams, Keen Hun Tai, Gillian M Duchesne, Farshad Foroudi

Journal article  |  2011  |  Radiation Oncology

A NEW METHOD FOR SYNTHESIZING RADIATION DOSE-RESPONSE DATA FROM MULTIPLE TRIALS APPLIED TO PROSTATE CANCER: IN REGARD TO DIEZ P, ET AL. (INT J RADIAT ONCOL BIOL PHYS 2010;77:1066-1071)

Scott G Williams

Journal article  |  2011  |  International Journal of Radiation Oncology*Biology*Physics

PREDICTORS OF ANDROGEN DEPRIVATION THERAPY EFFICACY COMBINED WITH PROSTATIC IRRADIATION: THE CENTRAL ROLE OF TUMOR STAGE AND RADIATION DOSE

Scott Williams, Mark Buyyounouski, Larry Kestin, Gillian Duchesne, Tom Pickles

Journal article  |  2011  |  International Journal of Radiation: Oncology - Biology - Physics

CONFIRMATION OF A LOW alpha/beta RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS

Cecile Proust-Lima, Jeremy MG Taylor, Solene Secher, Howard Sandler, Larry Kestin, Tom Pickles, Kyoungwha Bae, Roger Allison, Scott Williams

Journal article  |  2011  |  International Journal of Radiation Oncology*Biology*Physics

Pilot comparison of F-18-fluorocholine and F-18-fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer

J-M Beauregard, SG Williams, TR DeGrado, P Roselt, RJ Hicks

Journal article  |  2010  |  Journal of Medical Imaging and Radiation Oncology

Prospective development of an individualised predictive model for treatment coverage using offline cone beam computed tomography surrogate measures in post-prostatectomy radiotherapy

PK Tran, A Haworth, F Foroudi, A Paneghel, AG Herschtal, KH Tai, SG Williams, S Soteriou, M Laferlita, GM Duchesne

Journal article  |  2009  |  Journal of Medical Imaging and Radiation Oncology

Urethral stricture following high dose rate brachytherapy for prostate cancer

Lisa Sullivan, Scott G Williams, Keen Hun Tai, Farshad Foroudi, L Cleeve, Gillian M Duchesne

Journal article  |  2009  |  Radiotherapy and Oncology

Determining if pretreatment PSA doubling time predicts PSA trajectories after radiation therapy for localized prostate cancer

Daniel E Soto, Rebecca R Andridge, Charlie C Pan, Scott G Williams, Jeremy MG Taylor, Howard M Sandler

Journal article  |  2009  |  Radiotherapy and Oncology

In patients experiencing biochemical failure after radiotherapy, pretreatment risk group and PSA velocity predict differences in overall survival and biochemical failure-free interval

Daniel E Soto, Rebecca R Andridge, Charlie C Pan, Scott G Williams, Jeremy MG Taylor, Howard M Sandler

Journal article  |  2008  |  International Journal of Radiation: Oncology - Biology - Physics

Percentage of biopsy cores positive for malignancy and biochemical failure following prostate cancer radiotherapy in 3,264 men: Statistical significance without predictive performance

SG Williams, MK Buyyounouski, T Pickles, L Kestin, A Martinez, AL Hanlon, GM Duchesne

Journal article  |  2008  |  International Journal of Radiation: Oncology - Biology - Physics

An international multicenter study evaluating the impact of an alternative biochemical failure definition on the judgment of prostate cancer risk

SG Williams, GM Duchesne, NK Gogna, JL Millar, T Pickles, GR Pratt, S Turner

Journal article  |  2006  |  International Journal of Radiation: Oncology - Biology - Physics

A prospective dose escalation trial of high-dose-rate brachytherapy boost for prostate cancer

JI tang, S WILLIAMS, KH tai, J dean, G DUCHESNE

Journal article  |  2006  |  Brachytherapy