Daniel Poole

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.

Quynh N Mai, Priyank Shenoy, Tim Quach, Jeffri S Retamal, Arisbel B Gondin, Holly R Yeatman, Luigi Aurelio, Joshua W Conner, Daniel P Poole, Meritxell Canals, Cameron J Nowell, Bim Graham, Thomas P Davis, Stephen J Briddon, Stephen J Hill, Christopher JH Porter, Nigel W Bunnett, Michelle L Halls, Nicholas A Veldhuis

Journal article  |  2021  |  Journal of Biological Chemistry

G protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from en..

New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

Joshua W Conner, Daniel P Poole, Manuela Jorg, Nicholas A Veldhuis

Journal article  |  2020  |  Future Medicinal Chemistry

G protein-coupled receptors (GPCRs) are essential signaling proteins and tractable therapeutic targets. To develop new drug candid..

Transcriptional Memory-Like Imprints and Enhanced Functional Activity in gamma delta T Cells Following Resolution of Malaria Infection

Rasika Kumarasingha, Lisa J Ioannidis, Waruni Abeysekera, Stephanie Studniberg, Dinidu Wijesurendra, Ramin Mazhari, Daniel P Poole, Ivo Mueller, Louis Schofield, Diana S Hansen, Emily M Eriksson

Journal article  |  2020  |  Frontiers in Immunology

Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation

Vladimir Grubisic, Jonathon L McClain, David E Fried, Iveta Grants, Pradeep Rajasekhar, Eva Csizmadia, Olujimi A Ajijola, Ralph E Watson, Daniel P Poole, Simon C Robson, Fievos L Christofi, Brian D Gulbransen

Journal article  |  2020  |  Cell Reports

Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the gastrointestinal tract, but the signaling ..

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Nestor N Jimenez-Vargas, Jing Gong, Matthew J Wisdom, Dane D Jensen, Rocco Latorre, Alan Hegron, Shavonne Teng, Jesse J DiCello, Pradeep Rajasekhar, Nicholas A Veldhuis, Simona E Carbone, Yang Yu, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Meritxell Canals, David E Reed, Alan E Lomax, Brian L Schmidt, Kam W Leong, Stephen J Vanner, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of the United States of America

Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic ta..

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Scott Peng, Megan S Grace, Arisbel B Gondin, Jeffri S Retamal, Larissa Dill, William Darby, Nigel W Bunnett, Fe C Abogadie, Simona E Carbone, Tara Tigani, Thomas P Davis, Daniel P Poole, Nicholas A Veldhuis, Peter McIntyre

Journal article  |  2020  |  Laboratory Investigation

Endothelial barrier disruption is a hallmark of tissue injury, edema, and inflammation. Vascular endothelial cells express the G p..

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon

Journal article  |  2020  |  Journal of Neuroscience

The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent yea..

Inflammation without pain: Immune-derived opioids hold the key

Simona E Carbone, Daniel P Poole

Journal article  |  2020  |  Neurogastroenterology & Motility

Visceral pain is commonly associated with acute or remitting inflammatory bowel disease (IBD). In marked contrast, chronic IBD is ..

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

Jesse J DiCello, Simona E Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P Poole

Journal article  |  2020  |  Cellular and Molecular Gastroenterology and Hepatology

BACKGROUND & AIMS: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potent..

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Paulina D Ramirez-Garcia, Jeffri S Retamal, Priyank Shenoy, Wendy Imlach, Matthew Sykes, Nghia Truong, Luis Constandil, Teresa Pelissier, Cameron J Nowell, Song Y Khor, Louis M Layani, Chris Lumb, Daniel P Poole, TinaMarie Lieu, Gregory D Stewart, Quynh N Mai, Dane D Jensen, Rocco Latorre, Nicole N Scheff, Brian L Schmidt, et al.

Journal article  |  2019  |  Nature Nanotechnology

Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanism..