Lachlan Whitehead

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.

Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  Cancer Cell

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Ranja Salvamoser, Kerstin Brinkmann, Lorraine A O'Reilly, Lachlan Whitehead, Andreas Strasser, Marco J Herold

Journal article  |  2019  |  Cell Death & Differentiation

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article  |  2019  |  Cancer Cell

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Cyril Seillet, Elysa Carr, Derek Lacey, Michael D Stutz, Marc Pellegrini, Lachlan Whitehead, Joel Rimes, Edwin D Hawkins, Ben Roediger, Gabrielle T Belz, Philippe Bouillet

Journal article  |  2019  |  Immunology and Cell Biology

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Brandon J Aubrey, Ana Janic, Yunshun Chen, Catherine Chang, Elizabeth C Lieschke, Sarah T Diepstraten, Andrew J Kueh, Jonathan P Bernardini, Grant Dewson, Lorraine A O'Reilly, Lachlan Whitehead, Anne K Voss, Gordon K Smyth, Andreas Strasser, Gemma L Kelly

Journal article  |  2018  |  Genes & Development

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Stephanie Grabow, Andrew J Kueh, Francine Ke, Hannah K Vanyai, Bilal N Sheikh, Michael A Dengler, William Chiang, Samantha Eccles, Ian M Smyth, Lynelle K Jones, Frederic J de Sauvage, Mark Scott, Lachlan Whitehead, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell Reports

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  Cancer Discovery

Quantification of Extracellular Double-stranded RNA Uptake and Subcellular Localization Using Flow Cytometry and Confocal Microscopy

Tan A Nguyen, Lachlan Whitehead, Ken C Pang

Journal article  |  2018  |  BIO-PROTOCOL

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Francine FS Ke, Hannah K Vanyai, Angus D Cowan, Alex RD Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell

Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway

Simon M Chatfield, Kathrin Grebe, Lachlan W Whitehead, Kelly L Rogers, Thomas Nebl, James M Murphy, Ian P Wicks

Journal article  |  2018  |  The Journal of Immunology

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, et al.

Journal article  |  2018  |  Science

Detection and Quantification of MAVS Aggregation via Confocal Microscopy.

Tan A Nguyen, Lachlan Whitehead, Ken C Pang

Book Chapter  |  2018  |  Methods in Molecular Biology

During infection, the cytosolic detection of viral double-stranded RNA (dsRNA) leads to the oligomerization and activation of mito..

Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes

K Pham, A Kan, L Whitehead, RJ Hennessy, K Rogers, PD Hodgkin

Journal article  |  2018  |  Cell Cycle

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Tan A Nguyen, Blake RC Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang

Journal article  |  2017  |  Immunity

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

Sash Lopaticki, Annie SP Yang, Alan John, Nichollas E Scott, James P Lingford, Matthew T O'Neill, Sara M Erickson, Nicole C McKenzie, Charlie Jennison, Lachlan W Whitehead, Donna N Douglas, Norman M Kneteman, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2017  |  Nature Communications

The reinvention of twentieth century microscopy for three-dimensional imaging

Lachlan W Whitehead, Kate McArthur, Niall D Geoghegan, Kelly L Rogers

Journal article  |  2017  |  Immunology & Cell Biology

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Ashleigh R Poh, Christopher G Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L Putoczki, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2017  |  Cancer Cell

Analysis of Ca2 mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Rebecca J Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E Sleebs, Guillaume Lessene, Malcolm J McConville, Kelly L Rogers, Christopher J Tonkin

Journal article  |  2017  |  Cellular Microbiology

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

Xavier Sisquella, Thomas Nebr, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, Niraj H Tolia, Andrea Fleig, Joseph O'Neill, Wai-Hong Timm, F David Horgen, Alan F Cowman

Journal article  |  2017  |  eLife

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

X Sisquella, T Nebl, JK Thompson, L Whitehead, BM Malpede, ND Salinas, K Rogers, NH Tolia, A Fleig, J O’Neill, WH Tham, FD Horgen, AF Cowman

Journal article  |  2017  |  eLife

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Nunez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux, Kate E Lawlor, Lisa M Lindqvist, James E Vince

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers

GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader

Conference Proceedings  |  2017  |  General Session Abstracts

Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis

Emma C Watson, Monica N Koenig, Zoe L Grant, Lachlan Whitehead, Evelyn Trounson, Grant Dewson, Leigh Coultas

Journal article  |  2016  |  Development

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2016  |  Nature Medicine

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1

EC Watson, L Whitehead, RH Adams, G Dewson, L Coultas

Journal article  |  2016  |  Cell Death & Differentiation

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

Jennifer C Volz, Alan Yap, Xavier Sisquella, Jenn K Thompson, Nicholas TY Lim, Lachlan W Whitehead, Lin Chen, Marko Lampe, Wai-Hong Tham, Danny Wilson, Thomas Nebl, Danushka Marapana, Tony Triglia, Wilson Wong, Kelly L Rogers, Alan F Cowman

Journal article  |  2016  |  Cell Host & Microbe

Essential role for a novel population of binucleated mammary epithelial cells in lactation

Anne C Rios, Nai Yang Fu, Paul R Jamieson, Bhupinder Pal, Lachlan Whitehead, Kevin R Nicholas, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Nature Communications

Phosphorylation of SNAP is Required for Secretory Organelle Biogenesis in Toxoplasma gondii

Rebecca J Stewart, David JP Ferguson, Lachlan Whitehead, Clare H Bradin, Hong J Wu, Christopher J Tonkin

Journal article  |  2016  |  Traffic

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

Andrew J Murphy, Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Man KS Lee, Kate E Lawlor, John M Wentworth, Ajithkumar Vasanthakumar, Motti Gerlic, Lachlan W Whitehead, Ladina DiRago, Louise Cengia, Rachael M Lane, Donald Metcalf, James E Vince, Leonard C Harrison, Axel Kallies, Benjamin T Kile, Ben A Croker, Mark A Febbraio, et al.

Journal article  |  2016  |  Cell Metabolism

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion

David T Riglar, Lachlan Whitehead, Alan F Cowman, Kelly L Rogers, Jake Baum

Journal article  |  2016  |  Journal of Cell Science

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Kathryn S Potts, Tobias J Sargeant, John F Markham, Wei Shi, Christine Biben, Emma C Josefsson, Lachlan W Whitehead, Kelly L Rogers, Anna Liakhovitskaia, Gordon K Smyth, Benjamin T Kile, Alexander Medvinsky, Warren S Alexander, Douglas J Hilton, Samir Taoudi

Journal article  |  2014  |  Blood

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Guenther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article  |  2014  |  PLoS Biology

Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility

Andrey Kan, Yan-Hong Tan, Fiona Angrisano, Eric Hanssen, Kelly L Rogers, Lachlan Whitehead, Vanessa P Mollard, Anton Cozijnsen, Michael J Delves, Simon Crawford, Robert E Sinden, Geoffrey I McFadden, Christopher Leckie, James Bailey, Jake Baum

Journal article  |  2014  |  Cellular Microbiology