Lachlan Whitehead

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Journal article  |  2023  |  ELIFE

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly an..

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.

Kunlun Li, Lizeth G Meza Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S Alexander, Nadia J Kershaw, Jeffrey J Babon, Karen Doggett, Sandra E Nicholson

Journal article  |  2022  |  Biosci Rep

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice ..

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.

Ashleigh R Poh, Megan O'Brien, David Chisanga, Hong He, David Baloyan, Jasmin Traichel, Christine Dijkstra, Michaël Chopin, Stephen Nutt, Lachlan Whitehead, Louis Boon, Ashleigh Parkin, Clifford Lowell, Marina Pajic, Wei Shi, Mehrdad Nikfarjam, Matthias Ernst

Journal article  |  2022  |  Cell Rep

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a low 5-year survival rate and is associated with poor respo..

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Isabella Y Kong, Stephanie Trezise, Amanda Light, Izabela Todorovski, Gisela Mir Arnau, Sreeja Gadipally, David Yoannidis, Kaylene J Simpson, Xueyi Dong, Lachlan Whitehead, Jessica C Tempany, Anthony J Farchione, Amania A Sheikh, Joanna R Groom, Kelly L Rogers, Marco J Herold, Vanessa L Bryant, Matthew E Ritchie, Simon N Willis, Ricky W Johnstone, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell fu..

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

Ashleigh R Poh, Christopher G Love, David Chisanga, James H Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G Ellies, Christophe Macri, Justine D Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L Chand, Clifford A Lowell, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be la..

Langerhans cells are an essential cellular intermediary in chronic dermatitis

Holly Anderton, Michael Chopin, Caleb A Dawson, Stephen L Nutt, Lachlan Whitehead, Natasha Silke, Najoua Lalaloui, John Silke

Journal article  |  2022  |  CELL REPORTS

SHARPIN regulates signaling from the tumor necrosis factor (TNF) superfamily and pattern-recognition receptors. An inactivating Sh..

DaXi-high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy.

Bin Yang, Merlin Lange, Alfred Millett-Sikking, Xiang Zhao, Jordão Bragantini, Shruthi VijayKumar, Mason Kamb, Rafael Gómez-Sjöberg, Ahmet Can Solak, Wanpeng Wang, Hirofumi Kobayashi, Matthew N McCarroll, Lachlan W Whitehead, Reto P Fiolka, Thomas B Kornberg, Andrew G York, Loic A Royer

Journal article  |  2022  |  Nat Methods

The promise of single-objective light-sheet microscopy is to combine the convenience of standard single-objective microscopes with..

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Andrew Keniry, Natasha Jansz, Linden J Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M Nefzger, Peter F Hickey, Quentin Gouil, Joy Liu, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A Kinkel, Phillippa C Taberlay, Tracy Willson, Miha Pakusch, Matthew E Ritchie, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishab..

Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death

Simona Seizova, Ushma Ruparel, Alexandra L Garnham, Stefanie M Bader, Alessandro D Uboldi, Michael J Coffey, Lachlan W Whitehead, Kelly L Rogers, Christopher J Tonkin

Journal article  |  2022  |  CELL HOST & MICROBE

Toxoplasma gondii develops a latent infection in the muscle and central nervous system that acts as a reservoir for acute-stage re..

Analyzing Vessel Regression and Endothelial Apoptosis as a Component of Angiogenic Vessel Remodeling.

Lachlan Whitehead, Emma C Watson, Zoe L Grant

Book Chapter  |  2022  |  Methods in Molecular Biology

Angiogenic vessel remodeling is a critical step in establishing a hierarchical vessel network. Vessel networks rapidly expand thro..