Michael Dagley

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality (vol 11, 2857, 2020)

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked prolifera..

High Spare Respiratory Capacity is a Canonical Feature of Virtual Memory, but not Conventional Memory CD8 T Cells, and is Driven by IL-15 Signalling

Nicole L La Gruta, Kylie M Quinn, Felix Kraus, Luke Formosa, Michael Dagley, Eleanor Saunders, Tabinda Hussain, Lisa Assmus, Adam Costin, Joan Clark, Georg Ramm, Kim Good-Jacobson, Malcolm McConville, Michael Ryan

Journal article  |  2019  |  The Journal of Immunology

Abstract Virtual memory T (TVM) cells are antigen-naïve CD8 T cell cells that exist in a semi-differentiated state...

DExSI: a new tool for the rapid quantitation of C-13-labelled metabolites detected by GC-MS

Michael J Dagley, Malcolm J McConville

Journal article  |  2018  |  BIOINFORMATICS

SUMMARY: Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and anima..

Using metabolomics to dissect host-parasite interactions

J Kloehn, M Blume, SA Cobbold, EC Saunders, MJ Dagley, MJ McConville

Journal article  |  2016  |  CURRENT OPINION IN MICROBIOLOGY

Protozoan parasites have evolved diverse growth and metabolic strategies for surviving and proliferating within different extracel..

Drug resistance in Giardia duodenalis

Brendan RE Ansell, Malcolm J McConville, Showgy Y Ma'ayeh, Michael J Dagley, Robin B Gasser, Staffan G Svard, Aaron R Jex

Journal article  |  2015  |  BIOTECHNOLOGY ADVANCES

Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a major contributor to diarrheal and post..

Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans.

Jiyoti Verma-Gaur, Yue Qu, Paul F Harrison, Tricia L Lo, Tara Quenault, Michael J Dagley, Matthew Bellousoff, David R Powell, Traude H Beilharz, Ana Traven

Journal article  |  2015  |  PLoS Genet

The yeast Candida albicans is a human commensal and opportunistic pathogen. Although both commensalism and pathogenesis depend on ..

High-Content Assay for Measuring Intracellular Growth of Leishmania in Human Macrophages

Michael J Dagley, Eleanor C Saunders, Kaylene J Simpson, Malcolm J McConville

Journal article  |  2015  |  ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Leishmania species are sandfly-transmitted protozoan parasites that cause a spectrum of diseases, ranging from localized skin lesi..

Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling

Joachim Kloehn, Eleanor C Saunders, Sean O'Callaghan, Michael J Dagley, Malcolm J McConville

Journal article  |  2015  |  PLOS PATHOGENS

Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflectin..

Leishmania carbon metabolism in the macrophage phagolysosome- feast or famine?

Malcolm J McConville, Eleanor C Saunders, Joachim Kloehn, Michael J Dagley

Journal article  |  2015  |  F1000Res

A number of medically important microbial pathogens target and proliferate within macrophages and other phagocytic cells in their ..