Anton Cozijnsen

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  Science Immunology

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  Cell Reports

Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  The Journal of Immunology

LIVER-RESIDENT MEMORY T CELLS CAN BE HARNESSED FOR UNPRECEDENTED PROTECTION AGAINST MALARIA

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren Holz, Anton Cozijnsen, Vanessa Mollard, Roghieh Skandari, Jonathan H Manton, Szun Szun Tay, David G Bowen, Friedrich Koch-Nolte, Bjorn Rissiek, Francis R Carbone, Brendan S Crabb, Scott N Mueller, Patrick Bertolino, Geoffrey I McFadden, Irina Caminschi, William R Heath

Conference Proceedings  |  2017  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2016  |  Immunity

Liver resident memory T cells express CXCR6 and patrol in the sinusoids

L Holz, D Fernandez-Ruiz, A Zaid, WY Ng, YC Wong, V Mollard, A Cozijnsen, G Davey, D Bowen, SS Tay, M Lahoud, P Bertolino, S Mueller, G McFadden, I Caminschi, W Heath

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Liver-resident memory T cells can be harnessed for sterile protection against malaria

D Fernandez-Ruiz, WY Ng, L Holz, J Ma, A Zaid, Chun Y Wong, LS Lau, V Mollard, A Cozijnsen, N Collins, J Li, G Davey, SS Tay, PS Tan, D Bowen, F Koch-Nolte, B Rissiek, F Carbone, B Crabb, M Lahoud, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Using a "prime-and-trap" vaccine strategy to generate liver TRM and protect mice form malaria liver-stage infection

WY Ng, D Fernandez-Ruiz, J Ma, A Zaid, YC Wong, LS Lau, V Mollard, A Cozijnsen, N Collins, J Li, GM Davey, L Holz, SS Tay, PS Tan, DG Bowen, F Koch-Nolte, R Bjoern, FR Carbone, BS Crabb, M Lahoud, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

Christopher D Goodman, Josephine E Siregar, Vanessa Mollard, Joel Vega-Rodriguez, Din Syafruddin, Hiroyuki Matsuoka, Motomichi Matsuzaki, Tomoko Toyama, Angelika Sturm, Anton Cozijnsen, Marcelo Jacobs-Lorena, Kiyoshi Kita, Sangkot Marzuki, Geoffrey I McFadden

Journal article  |  2016  |  Science

PRE-CLINICAL EVALUATION OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) AS A POTENTIAL MULTI-STAGE, PAN SPECIES MALARIA VACCINE

Qiao Ye Tan, Ramin Mazhari-Tabrizi, Julia C Cutts, Vanessa Mollard, Anton Cozijnsen, Geoff I McFadden, Stewart Campbell, Krystal Evans, Jetsumon Sattabongkot, Louis Schofield

Conference Proceedings  |  2015  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

Angelika Sturm, Vanessa Mollard, Anton Cozijnsen, Christopher D Goodman, Geoffrey I McFadden

Journal article  |  2015  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility

Andrey Kan, Yan-Hong Tan, Fiona Angrisano, Eric Hanssen, Kelly L Rogers, Lachlan Whitehead, Vanessa P Mollard, Anton Cozijnsen, Michael J Delves, Simon Crawford, Robert E Sinden, Geoffrey I McFadden, Christopher Leckie, James Bailey, Jake Baum

Journal article  |  2014  |  CELLULAR MICROBIOLOGY

CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden, et al.

Journal article  |  2014  |  PLOS PATHOGENS

Identifying resistance genes to Leptosphaeria maculans in Australian Brassica napus cultivars based on reactions to isolates with known avirulence genotypes

Steve J Marcroft, Vicki L Elliott, Anton J Cozijnsen, Phillip A Salisbury, Barbara J Howlett, Angela P Van de Wouw

Journal article  |  2012  |  Crop and Pasture Science

Idenitfying resistance genes to Leptosphaeria maculans in Australian Brassica napus cultivars based on reactions to isolates with known avirulence genotypes

SJ Marcroft, VL Elliott, AJ Cozijnsen, P Salisbury, BJ Howlett, AP Van De Wouw

Journal article  |  2012  |  Crop and Pasture Science

Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Thierry Rouxel, Jonathan Grandaubert, James K Hane, Claire Hoede, Angela P van de Wouw, Arnaud Couloux, Victoria Dominguez, Veronique Anthouard, Pascal Bally, Salim Bourras, Anton J Cozijnsen, Lynda M Ciuffetti, Alexandre Degrave, Azita Dilmaghani, Laurent Duret, Isabelle Fudal, Stephen B Goodwin, Lilian Gout, Nicolas Glaser, Juliette Linglin, et al.

Journal article  |  2011  |  Nature Communications

Evolution of Linked Avirulence Effectors in Leptosphaeria maculans Is Affected by Genomic Environment and Exposure to Resistance Genes in Host Plants

Angela P Van de Wouw, Anton J Cozijnsen, James K Hane, Patrick C Brunner, Bruce A McDonald, Richard P Oliver, Barbara J Howlett

Journal article  |  2010  |  PLoS Pathogens

The Secondary Metabolite Toxin, Sirodesmin PL, and Its Role in Virulence of the Blackleg Fungus

Barbara J Howlett, Ellen M Fox, Anton J Cozijnsen, Angela P Van de Wouw, Candace E Elliott

Book Chapter  |  2010

Cloning, purification and characterisation of brassinin glucosyltransferase, a phytoalexin-detoxifying enzyme from the plant pathogen Sclerotinia sclerotiorum

Adrienne C Sexton, Zoran Minic, Anton J Cozijnsen, M Soledade C Pedras, Barbara J Howlett

Journal article  |  2009  |  Fungal Genetics and Biology

Identification of Leptosphaeria biglobosa 'canadensis' on Brassica juncea stubble from northern New South Wales, Australia

A VAN DE WOUW, V THOMAS, A COZIJNSEN, SJ Marcroft, P SALISBURY, B HOWLETT

Journal article  |  2008  |  Australasian Plant Disease Notes

Identification of Leptosphaeria biglobosa 'canadensis' on Brassica juncea stubble from northern New South Wales, Australia

AP Van De Wouw, VL Elliott, AJ Cozijnsen, SM Marcroft, P Salisbury, BJ Howlett

Journal article  |  2008  |  Australasian Plant Disease Notes

Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus

Candace E Elliott, Donald M Gardiner, Georgina Thomas, Anton Cozijnsen, Angela Van De Wouw, Barbara J Howlett

Journal article  |  2007  |  Molecular Plant Pathology

Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes

Nicola J Patron, Ross F Waller, Anton J Cozijnsen, David C Straney, Donald M Gardiner, William C Nierman, Barbara J Howlett

Journal article  |  2007  |  BMC EVOLUTIONARY BIOLOGY

Microsatellite and minisatellite analysis of Leptosphaeria maculans in Australia reveals regional genetic differentiation

Helen L Hayden, Anton J Cozijnsen, Barbara J Howlett

Journal article  |  2007  |  Phytopathology

Comparison of transcription of multiple genes at three developmental stages of the plant pathogen Sclerotinia sclerotiorum

AC Sexton, AJ Cozijnsen, A Keniry, E Jewell, CG Love, J Batley, D Edwards, BJ Howlett

Journal article  |  2006  |  FEMS MICROBIOLOGY LETTERS

Sequence analysis of two genomic regions of Leptosphaeria maculans, the fungus that causes blackleg disease (phoma stem canker) of Brassica napus

BJ Howlett, DM Gardiner, AJ Cozijnsen, LM Wilson, L Cattolico, M Soledade, C Pedras, T Rouxel, A Attard, L Gout, F Parlange, S Ross, MH Balesdent

Conference Proceedings  |  2006  |  Proceedings of the joint meeting of the XIVth Crucifer Genetics Workshop and IVth ISHS Symposium of Brassicas

Phylogenetic relationships between members of the crucifer pathogenic Leptosphaeria maculans species complex as shown by mating type (MAT1-2), actin, and beta-tubulin sequences

K Voigt, AJ Cozijnsen, R Kroymann, S Poggeler, BJ Howlett

Journal article  |  2005  |  Molecular Phylogenetics and Evolution

Characterization and cross-species amplification of microsatellite loci in the plant pathogenic fungus Leptosphaeria maculans

HL Hayden, LM Wilson, AJ Cozijnsen, BJ Howlett

Journal article  |  2004  |  Molecular Ecology Notes

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans

DM Gardiner, AJ Cozijnsen, LM Wilson, MSC Pedras, BJ Howlett

Journal article  |  2004  |  Molecular Microbiology

Characterisation of the mating-type locus of the plant pathogenic ascomycete Leptosphaeria maculans

AJ Cozijnsen, BJ Howlett

Journal article  |  2003  |  Current Genetics

Pathogenic and genetic variation in Leptosphaeria maculans in Australia

HL HAYDEN, AJ COZIJNSEN, SJ MARCROFT, BJ HOWLETT

Conference Proceedings  |  2003  |  Thirteenth Biennial Australian Research Assembly on Brassicas - Conference Proceedings

Genetic diversity of isolates of the Leptosphaeria maculans species complex from Australia, Europe and North America using amplified fragment length polymorphism analysis

A Purwantara, JM Barrins, AJ Cozijnsen, PK Ades, BJ Howle

Journal article  |  2000  |  Mycological Research

Genetic analysis of the blackleg fungus Leptosphaeria maculans

BJ Howlett, AJ Cozijnsen, K Popa, A Idnurm, AC Sexton, A Purwantara

Conference Proceedings  |  2000  |  Acta Horticulturae

Genome analysis of the plant pathogenic ascomycete Leptosphaeria maculans; mapping mating type and host specificity loci

AJ Cozijnsen, KM Popa, A Purwantara, BD Rolls, BJ Howlett

Journal article  |  2000  |  Molecular Plant Pathology

Organisation of ribosomal DNA in the ascomycete Leptosphaeria maculans.

BJ Howlett, BD Rolls, AJ Cozijnsen

Journal article  |  1997  |  Microbiological Research

In the ascomycete Leptosphaeria maculans tandem repeats of ribosomal DNA (rDNA) are restricted to one or two particular chromosome..

Nitrogen limitation induces expression of the avirulence gene avr9 in the tomato pathogen Cladosporium fulvum.

GF Van den Ackerveken, RM Dunn, AJ Cozijnsen, JP Vossen, HW Van den Broek, PJ De Wit

Journal article  |  1994  |  Molecular and General Genetics MGG

The avirulence gene avr9 of the fungal tomato pathogen Cladosporium fulvum encodes a race-specific peptide elicitor that induces t..

A fungal tomato pathogen circumvents host plant resistance by a single base pair change in an avirulence gene

A Cozijnsen, M Joosten, P De Wit

Journal article  |  1994  |  Nature