Anton Cozijnsen

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  NATURE COMMUNICATIONS

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Development of Plasmodium-specific liver-resident memory CD8( ) T cells after heat-killed sporozoite immunization in mice

Sonia Ghilas, Matthias H Enders, Rose May, Lauren E Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A Cockburn, Geoffrey McFadden, William R Heath, Lynette Beattie

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Malaria remains a major cause of mortality in the world and an efficient vaccine is the best chance of reducing the disease burden..

Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species

Matthias H Enders, Ganchimeg Bayarsaikhan, Sonia Ghilas, Yu Cheng Chua, Rose May, Maria N de Menezes, Zhengyu Ge, Peck Szee Tan, Anton Cozijnsen, Vanessa Mollard, Katsuyuki Yui, Geoffrey I McFadden, Mireille H Lahoud, Irina Caminschi, Anthony W Purcell, Ralf B Schittenhelm, Lynette Beattie, William R Heath, Daniel Fernandez-Ruiz

Journal article  |  2021  |  Current Research in Immunology

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

Glycolipid-peptide vaccination induces liver-resident memory CD8 T cells that protect against malaria

Lauren Holz, Yu Cheng Chua, Regan Anderson, Sarah Draper, Benjamin Compton, Susanna Chan, Juby Mathew, Maria de Menezes, Anton Cozijnsen, Vanessa Mollard, Geoffrey McFadden, Gavin Painter, William R Heath

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Alternative splicing is required for stage differentiation in malaria parasites

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Emma McHugh, V Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2019  |  GENOME BIOLOGY

BACKGROUND: In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protis..

CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  CELL REPORTS

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoi..

Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  JOURNAL OF IMMUNOLOGY

We describe an MHC class II (I-Ab)-restricted TCR transgenic mouse line that produces CD4+ T cells specific for Plasmodium species..

Development of a Novel CD4 TCR Transgenic Line that Reveals a Dominant Role for CD8 DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen Jones, Wei Yi Ng, Gayle Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Ganchimeg Bayarsaikhan, Sanne Hendriks, Kylie James, Anton Cozijnsen, Vanessa Mollard, Tania de Koning-Ward, Paul Gilson, Tsuneyasu Kaisho, Ashraful Haque, Brendan Crabb, Francis Carbone, et al.

Journal article  |  2017

Abstract We describe an MHC II (IA b )-restricted T cell receptor (TCR) transgenic mouse line that produces CD4 + T cells specific..