Prithvipall Bhathal

STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis.

Ruby E Dawson, Virginie Deswaerte, Alison C West, Ke Tang, Alice J West, Jesse J Balic, Linden J Gearing, Mohamed I Saad, Liang Yu, Yonghui Wu, Prithi S Bhathal, Beena Kumar, Jayati T Chakrabarti, Yana Zavros, Hiroko Oshima, Dennis M Klinman, Masanobu Oshima, Patrick Tan, Brendan J Jenkins

Journal article  |  2022  |  Gut

OBJECTIVE: The absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of auto..

Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology.

Ansgar W Lohse, Marcial Sebode, Prithi S Bhathal, Andrew D Clouston, Hans P Dienes, Dhanpat Jain, Annette SH Gouw, Maha Guindi, Sanjay Kakar, David E Kleiner, Till Krech, Carolin Lackner, Thomas Longerich, Romil Saxena, Luigi Terracciano, Kay Washington, Sören Weidemann, Stefan G Hübscher, Dina Tiniakos

Journal article  |  2022  |  Liver Int

BACKGROUND & AIMS: Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously p..

An unusual cause of colonic ulceration

Melissa Chew, Julien Dion Schulberg, Prithi Bhathal, Tom R Sutherland, Mayur Garg

Journal article  |  2022  |  GUT

Collagen and elastic fibres in acute and chronic liver injury

Andrew Hall, Corina Cotoi, Tu Vinh Luong, Jennifer Watkins, Prithi Bhathal, Alberto Quaglia

Journal article  |  2021  |  SCIENTIFIC REPORTS

The histological distinction between acute and chronic liver injury is a challenging aspect of liver histopathology. It is traditi..

Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue

Michelle Chonwerawong, Jonathan Ferrand, Hassan Mohammad Chaudhry, Chloe Higgins, Le Son Tran, San Sui Lim, Marjorie M Walker, Prithi S Bhathal, Anouk Dev, Gregory T Moore, William Sievert, Brendan J Jenkins, Mario M D'Elios, Dana J Philpott, Thomas A Kufer, Richard L Ferrero

Journal article  |  2020  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Helicobacter pylori induces strong inflammatory responses that are directed at clearing the infection, but if n..

Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease.

Jesse J Balic, Mohamed I Saad, Ruby Dawson, Alice J West, Louise McLeod, Alison C West, Kimberley D'Costa, Virginie Deswaerte, Anouk Dev, William Sievert, Daniel J Gough, Prithi S Bhathal, Richard L Ferrero, Brendan J Jenkins

Journal article  |  2020  |  Am J Pathol

Gastric cancer is associated with chronic inflammation (gastritis) triggered by persistent Helicobacter pylori (H. pylori) infecti..

Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity.

Jesse J Balic, Daniel J Garama, Mohamed I Saad, Liang Yu, Alison C West, Alice J West, Thaleia Livis, Prithi S Bhathal, Daniel J Gough, Brendan J Jenkins

Journal article  |  2019  |  Cancer Res

Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric..

971 – The Innate Immune Molecule Nlrc5 Protects Against Gastric B Cell Lymphoid Formation in Response to Chronic Helicobacter Infection

Michelle Chonwerawong, Jonathan Ferrand, Hassan Chaudhry, Chloe Higgins, Le Son Tran, Marjorie M Walker, Prithi Bhathal, Anouk Dev, Gregory T Moore, William Sievert, Veit Hornung, Brendan Jenkins, Mario D'Elios, Dana Philpott, Thoma Kufer, Richard L Ferrero

Journal article  |  2019  |  Gastroenterology

Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model

Sarah Walker, Miriam Wankell, Vikki Ho, Rose White, Nikita Deo, Carol Devine, Brittany Dewdney, Prithi Bhathal, Olivier Govaere, Tania Roskams, Liang Qiao, Jacob George, Lionel Hebbard

Journal article  |  2019  |  PLOS ONE

Liver cancer is a poor prognosis cancer with limited treatment options. To develop a new therapeutic approach, we derived HCC cell..

Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.

David G Hill, Liang Yu, Hugh Gao, Jesse J Balic, Alison West, Hiroko Oshima, Louise McLeod, Masanobu Oshima, Awen Gallimore, Kimberley D'Costa, Prithi S Bhathal, William Sievert, Richard L Ferrero, Brendan J Jenkins, Gareth W Jones

Journal article  |  2018  |  Int J Cancer

Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often deve..