Bradley Turner

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

Taide Wang, Nirma D Perera, Mathew DF Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, Andre L Samson, Wayne Cawthorne, Eric N Valor, James M Murphy, Bradley J Turner

Journal article  |  2020  |  Cell Death & Differentiation

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regu..

Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases

Mitsuto Sato, Hotake Takizawa, Akinori Nakamura, Bradley J Turner, Fazel Shabanpoor, Yoshitsugu Aoki

Journal article  |  2019  |  Frontiers in Molecular Neuroscience

GAL(3) receptor knockout mice exhibit an alcohol-preferring phenotype

Shannyn G Genders, Karlene J Scheller, Emily J Jaehne, Bradley J Turner, Andrew J Lawrence, Susanne M Brunner, Barbara Kofler, Maarten van den Buuse, Elvan Djouma

Journal article  |  2019  |  Addiction Biology

Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL1-3 ). Administration of a GAL3 ant..

Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Victoria M McLeod, Chew L Lau, Mathew DF Chiam, Thusitha W Rupasinghe, Ute Roessner, Elvan Djouma, Wah C Boon, Bradley J Turner

Journal article  |  2019  |  British Journal of Pharmacology

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

Samantha K Barton, Jenna M Gregory, Siddharthan Chandran, Bradley J Turner

Journal article  |  2019  |  Frontiers in Molecular Neuroscience

Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

Nitin A Patil, John A Karas, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2019  |  Bioconjugate Chemistry

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Xin Lin Tan, Mujun Sun, Rhys D Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David K Wright, Pablo M Casillas-Espinosa, Maithili Sashindranath, Terence J O'Brien, Stuart J McDonald, Bradley J Turner, Sandy R Shultz

Journal article  |  2019  |  Journal of Neurotrauma

SYT1-associated neurodevelopmental disorder: a case series

Kate Baker, Sarah L Gordon, Holly Melland, Fabian Bumbak, Daniel J Scott, Tess J Jiang, David Owen, Bradley J Turner, Stewart G Boyd, Mari Rossi, Mohammed Al-Raqad, Orly Elpeleg, Dawn Peck, Grazia MS Mancini, Martina Wilke, Marcella Zollino, Giuseppe Marangi, Heike Weigand, Ingo Borggraefe, Tobias Haack, et al.

Journal article  |  2018  |  Brain

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis A Study of Humans and a Transgenic Mouse Model

Rebecca K Sheean, Fiona C McKay, Erika Cretney, Christopher R Bye, Nirma D Perera, Doris Tomas, Richard A Weston, Karlene J Scheller, Elvan Djouma, Parvathi Menon, Stephen D Schibeci, Najwa Marmash, Justin J Yerbury, Stephen L Nutt, David R Booth, Graeme J Stewart, Mathew C Kiernan, Steve Vucic, Bradley J Turner

Journal article  |  2018  |  JAMA Neurology

The Assembly of Fluorescently Labeled Peptide-Oligonucleotide Conjugates via Orthogonal Ligation Strategies

John Karas, Bradley J Turner, Fazel Shabanpoor

Book Chapter  |  2018  |  Methods in Molecular Biology

Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells

Tong Chen, Bradley J Turner, Philip M Beart, Lucy Sheehan-Hennessy, Chinasom Elekwachi, Hakan Muyderman

Journal article  |  2018  |  Neurochemistry International

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Nirma D Perera, Rebecca K Sheean, Chew L Lau, Yea Seul Shin, Philip M Beart, Malcolm K Horne, Bradley J Turner

Journal article  |  2018  |  Autophagy

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts

Anna Farrelly-Rosch, Chew Ling Lau, Nitin Patil, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2017  |  Neurochemistry International

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies

Emily E Handley, Kimberley A Pitman, Edgar Dawkins, Kaylene M Young, Rosemary M Clark, Tongcui C Jiang, Bradley J Turner, Tracey C Dickson, Catherine A Blizzard

Journal article  |  2017  |  Cerebral Cortex

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Diane Moujalled, Alexandra Grubman, Karla Acevedo, Shu Yang, Yazi D Ke, Donia M Moujalled, Clare Duncan, Aphrodite Caragounis, Nirma D Perera, Bradley J Turner, Mercedes Prudencio, Leonard Petrucelli, Ian Blair, Lars M Ittner, Peter J Crouch, Jeffrey R Liddell, Anthony R White

Journal article  |  2017  |  Human Molecular Genetics

Emerging Therapies and Challenges in Spinal Muscular Atrophy

Michelle A Farrar, Susanna B Park, Steve Vucic, Kate A Carey, Bradley J Turner, Thomas H Gillingwater, Kathryn J Swoboda, Matthew C Kiernan

Journal article  |  2017  |  Annals of Neurology

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Nirma D Perera, Rebecca K Sheean, Peter J Crouch, Anthony R White, Malcolm K Horne, Bradley J Turner

Journal article  |  2016  |  Human Molecular Genetics

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways

Judith M Silverman, Sarah M Fernando, Leslie I Grad, Andrew F Hill, Bradley J Turner, Justin J Yerbury, Neil R Cashman

Journal article  |  2016  |  Cellular and Molecular Neurobiology

AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis

Nirma D Perera, Bradley J Turner

Journal article  |  2016  |  Neurochemical Research

Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

Dusan Matusica, Fabienne Alfonsi, Bradley J Turner, Tim J Butler, Stephanie R Shepheard, Mary-Louise Rogers, Sune Skeldal, Clare K Underwood, Marie Mangelsdorf, Elizabeth J Coulson

Journal article  |  2016  |  Journal of Cell Science

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Rafaa Zeineddine, Jay F Pundavela, Lisa Corcoran, Elise M Stewart, Dzung Do-Ha, Monique Bax, Gilles Guillemin, Kara L Vine, Danny M Hatters, Heath Ecroyd, Christopher M Dobson, Bradley J Turner, Lezanne Ooi, Mark R Wilson, Neil R Cashman, Justin J Yerbury

Journal article  |  2015  |  MOLECULAR NEURODEGENERATION

Effect of thymic stimulation of CD4 T cell expansion on disease onset and progression in mutant SOD1 mice

Rebecca K Sheean, Richard H Weston, Nirma D Perera, Angela D'Amico, Stephen L Nutt, Bradley J Turner

Journal article  |  2015  |  JOURNAL OF NEUROINFLAMMATION

Characterisation of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: Implications for stem cell biology and tissue repair

TY Wang, KAF Bruggeman, RK Sheean, DR Nisbet, CL Parish

Conference Proceedings  |  2015  |  IFMBE Proceedings

© Springer International Publishing Switzerland 2015. In the context of biological applications, the timely delivery of molecules ..

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

KI Watt, BJ Turner, A Hagg, X Zhang, JR Davey, H Qian, C Beyer, CE Winbanks, KF Harvey, P Gregorevic

Journal article  |  2015  |  Nature Communications

Diverse Roles for Wnt7a in Ventral Midbrain Neurogenesis and Dopaminergic Axon Morphogenesis

Chathurini V Fernando, Julianna Kele, Christopher R Bye, Jonathan C Niclis, Walaa Alsanie, Brette D Blakely, Jan Stenman, Brad J Turner, Clare L Parish

Journal article  |  2014  |  Stem Cells and Development

Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.

Journal article  |  2014  |  JOURNAL OF NEUROSCIENCE

Characterization of the Stability and Bio-functionality of Tethered Proteins on Bioengineered Scaffolds IMPLICATIONS FOR STEM CELL BIOLOGY AND TISSUE REPAIR

Ting-Yi Wang, Kiara AF Bruggeman, Rebecca K Sheean, Bradley J Turner, David R Nisbet, Clare L Parish

Journal article  |  2014  |  Journal of Biological Chemistry

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

Bradley J Turner, Neza Alfazema, Rebecca K Sheean, James N Sleigh, Kay E Davies, Malcolm K Horne, Kevin Talbot

Journal article  |  2014  |  NEUROBIOLOGY OF AGING

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

Julie D Atkin, Manal A Farg, Kai Ying Soo, Adam K Walker, Mark Halloran, Bradley J Turner, Phillip Nagley, Malcolm K Horne

Journal article  |  2014  |  JOURNAL OF NEUROCHEMISTRY

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

Saskia Polling, Yee-Foong Mok, Yasmin M Ramdzan, Bradley J Turner, Justin J Yerbury, Andrew F Hill, Danny M Hatters

Journal article  |  2014  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Leslie I Grad, Justin J Yerbury, Bradley J Turner, William C Guest, Edward Pokrishevsky, Megan A O'Neill, Anat Yanai, Judith M Silverman, Rafaa Zeineddine, Lisa Corcoran, Janet R Kumita, Leila M Luheshi, Masoud Yousefi, Bradley M Coleman, Andrew F Hill, Steven S Plotkin, Ian R Mackenzie, Neil R Cashman

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

ND Perera, RK Sheean, JW Scott, BE Kemp, MK Horne, BJ Turner

Journal article  |  2014  |  PLoS One

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

Adam K Walker, Kai Y Soo, Vinod Sundaramoorthy, Sonam Parakh, Yi Ma, Manal A Farg, Robyn H Wallace, Peter J Crouch, Bradley J Turner, Malcolm K Horne, Julie D Atkin

Journal article  |  2013  |  PLOS ONE

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic

Journal article  |  2013  |  JOURNAL OF CELL BIOLOGY

Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis

John D Lee, Nur A Kamaruzaman, Jenny NT Fung, Stephen M Taylor, Bradley J Turner, Julie D Atkin, Trent M Woodruff, Peter G Noakes

Journal article  |  2013  |  Journal of neuroinflammation

Genetics of motor neuron disorders: From gene diversity to common cellular conspirators in selective neuronal killing

RK Sheean, BJ Turner

Book Chapter  |  2013

CO-REGULATION OF SURVIVAL OF MOTOR NEURON AND BCL-XL EXPRESSION: IMPLICATIONS FOR NEUROPROTECTION IN SPINAL MUSCULAR ATROPHY

RS Anderton, LL Price, BJ Turner, BP Meloni, C Mitrpant, FL Mastaglia, C Goh, SD Wilton, S Boulos

Journal article  |  2012  |  Neuroscience

Membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS

BJ Turner, undefined Atkin

Book Chapter  |  2012

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.

Journal article  |  2011  |  Journal of Biological Chemistry

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Cynthia PW Soon, Peter J Crouch, Bradley J Turner, Catriona A McLean, Katrina M Laughton, Julie D Atkin, Colin L Masters, Anthony R White, Qiao-Xin Li

Journal article  |  2010  |  Neuromuscular Disorders

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

Bradley J Turner, Steven Ackerley, Kay E Davies, Kevin Talbot

Journal article  |  2010  |  Human Molecular Genetics

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

Bradley J Turner, Dirk Baumer, Nicholas J Parkinson, Jakub Scaber, Olaf Ansorge, Kevin Talbot

Journal article  |  2008  |  BMC Neuroscience

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

Bradley J Turner, Kevin Talbot

Journal article  |  2008  |  Progress in Neurobiology

Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

BJ Turner, QX Li, KM Laughton, CL Masters, EC Lopes, JD Atkin, SS Cheema

Journal article  |  2004  |  Neurochemical Research

Chemotherapy delays progression of motor neuron disease in the SOD1 G93A transgenic mouse

KM Bruce, K Narayan, HC Kong, I Larmour, EC Lopes, BJ Turner, JF Bertram, SS Cheema

Journal article  |  2004  |  Chemotherapy

Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice

BJ Turner, A Rembach, R Spark, EC Lopes, SS Cheema

Journal article  |  2003  |  Journal of Neuroscience Research

Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice

BJ Turner, IK Cheah, KJ Macfarlane, EC Lopes, S Petratos, SJ Langford, SS Cheema

Journal article  |  2003  |  Journal of Neurochemistry

Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis

BJ Turner, EC Lopes, SS Cheema

Journal article  |  2003  |  Neuroscience Letters