Bradley Turner

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS.

Taide Wang, Nirma D Perera, Mathew DF Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, André L Samson, Wayne Cawthorne, Eric N Valor, James M Murphy, Bradley J Turner

Journal article  |  2019  |  Cell Death & Differentiation

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regu..

Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Victoria M McLeod, Chew L Lau, Mathew DF Chiam, Thusitha W Rupasinghe, Ute Roessner, Elvan Djouma, Wah C Boon, Bradley J Turner

Journal article  |  2019  |  British Journal of Pharmacology

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

Samantha K Barton, Jenna M Gregory, Siddharthan Chandran, Bradley J Turner

Journal article  |  2019  |  Frontiers in Molecular Neuroscience

Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

Nitin A Patil, John A Karas, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2019  |  Bioconjugate Chemistry

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Xin Lin Tan, Mujun Sun, Rhys D Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David K Wright, Pablo M Casillas-Espinosa, Maithili Sashindranath, Terence J O'Brien, Stuart J McDonald, Bradley J Turner, Sandy R Shultz

Journal article  |  2019  |  Journal of Neurotrauma

SYT1-associated neurodevelopmental disorder: a case series

Kate Baker, Sarah L Gordon, Holly Melland, Fabian Bumbak, Daniel J Scott, Tess J Jiang, David Owen, Bradley J Turner, Stewart G Boyd, Mari Rossi, Mohammed Al-Raqad, Orly Elpeleg, Dawn Peck, Grazia MS Mancini, Martina Wilke, Marcella Zollino, Giuseppe Marangi, Heike Weigand, Ingo Borggraefe, Tobias Haack, et al.

Journal article  |  2018  |  Brain

GAL3 receptor knockout mice exhibit an alcohol-preferring phenotype.

Shannyn G Genders, Karlene J Scheller, Emily J Jaehne, Bradley J Turner, Andrew J Lawrence, Susanne M Brunner, Barbara Kofler, Maarten van den Buuse, Elvan Djouma

Journal article  |  2018  |  Addiction Biology

Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL1-3 ). Administration of a GAL3 ant..

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis A Study of Humans and a Transgenic Mouse Model

Rebecca K Sheean, Fiona C McKay, Erika Cretney, Christopher R Bye, Nirma D Perera, Doris Tomas, Richard A Weston, Karlene J Scheller, Elvan Djouma, Parvathi Menon, Stephen D Schibeci, Najwa Marmash, Justin J Yerbury, Stephen L Nutt, David R Booth, Graeme J Stewart, Mathew C Kiernan, Steve Vucic, Bradley J Turner

Journal article  |  2018  |  JAMA Neurology

The Assembly of Fluorescently Labeled Peptide-Oligonucleotide Conjugates via Orthogonal Ligation Strategies

John Karas, Bradley J Turner, Fazel Shabanpoor

Book Chapter  |  2018  |  Methods in Molecular Biology

Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells

Tong Chen, Bradley J Turner, Philip M Beart, Lucy Sheehan-Hennessy, Chinasom Elekwachi, Hakan Muyderman

Journal article  |  2018  |  Neurochemistry International

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Nirma D Perera, Rebecca K Sheean, Chew L Lau, Yea Seul Shin, Philip M Beart, Malcolm K Horne, Bradley J Turner

Journal article  |  2018  |  Autophagy

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts

Anna Farrelly-Rosch, Chew Ling Lau, Nitin Patil, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2017  |  Neurochemistry International

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies

Emily E Handley, Kimberley A Pitman, Edgar Dawkins, Kaylene M Young, Rosemary M Clark, Tongcui C Jiang, Bradley J Turner, Tracey C Dickson, Catherine A Blizzard

Journal article  |  2017  |  Cerebral Cortex

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Diane Moujalled, Alexandra Grubman, Karla Acevedo, Shu Yang, Yazi D Ke, Donia M Moujalled, Clare Duncan, Aphrodite Caragounis, Nirma D Perera, Bradley J Turner, Mercedes Prudencio, Leonard Petrucelli, Ian Blair, Lars M Ittner, Peter J Crouch, Jeffrey R Liddell, Anthony R White

Journal article  |  2017  |  Human Molecular Genetics

Emerging Therapies and Challenges in Spinal Muscular Atrophy

Michelle A Farrar, Susanna B Park, Steve Vucic, Kate A Carey, Bradley J Turner, Thomas H Gillingwater, Kathryn J Swoboda, Matthew C Kiernan

Journal article  |  2017  |  Annals of Neurology

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Nirma D Perera, Rebecca K Sheean, Peter J Crouch, Anthony R White, Malcolm K Horne, Bradley J Turner

Journal article  |  2016  |  Human Molecular Genetics

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways

Judith M Silverman, Sarah M Fernando, Leslie I Grad, Andrew F Hill, Bradley J Turner, Justin J Yerbury, Neil R Cashman

Journal article  |  2016  |  Cellular and Molecular Neurobiology

AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis

Nirma D Perera, Bradley J Turner

Journal article  |  2016  |  Neurochemical Research

Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

Dusan Matusica, Fabienne Alfonsi, Bradley J Turner, Tim J Butler, Stephanie R Shepheard, Mary-Louise Rogers, Sune Skeldal, Clare K Underwood, Marie Mangelsdorf, Elizabeth J Coulson

Journal article  |  2016  |  Journal of Cell Science

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Rafaa Zeineddine, Jay F Pundavela, Lisa Corcoran, Elise M Stewart, Dzung Do-Ha, Monique Bax, Gilles Guillemin, Kara L Vine, Danny M Hatters, Heath Ecroyd, Christopher M Dobson, Bradley J Turner, Lezanne Ooi, Mark R Wilson, Neil R Cashman, Justin J Yerbury

Journal article  |  2015  |  Molecular Neurodegeneration

Effect of thymic stimulation of CD4 T cell expansion on disease onset and progression in mutant SOD1 mice

Rebecca K Sheean, Richard H Weston, Nirma D Perera, Angela D'Amico, Stephen L Nutt, Bradley J Turner

Journal article  |  2015  |  Journal of Neuroinflammation

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

KI Watt, BJ Turner, A Hagg, X Zhang, JR Davey, H Qian, C Beyer, CE Winbanks, KF Harvey, P Gregorevic

Journal article  |  2015  |  Nature Communications

Characterisation of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: Implications for stem cell biology and tissue repair

TY Wang, KAF Bruggeman, RK Sheean, DR Nisbet, CL Parish

Conference Proceedings  |  2015  |  IFMBE Proceedings

© Springer International Publishing Switzerland 2015. In the context of biological applications, the timely delivery of molecules ..

Diverse Roles for Wnt7a in Ventral Midbrain Neurogenesis and Dopaminergic Axon Morphogenesis

Chathurini V Fernando, Julianna Kele, Christopher R Bye, Jonathan C Niclis, Walaa Alsanie, Brette D Blakely, Jan Stenman, Brad J Turner, Clare L Parish

Journal article  |  2014  |  Stem Cells and Development

Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.

Journal article  |  2014  |  Journal of Neuroscience

Characterization of the Stability and Bio-functionality of Tethered Proteins on Bioengineered Scaffolds IMPLICATIONS FOR STEM CELL BIOLOGY AND TISSUE REPAIR

Ting-Yi Wang, Kiara AF Bruggeman, Rebecca K Sheean, Bradley J Turner, David R Nisbet, Clare L Parish

Journal article  |  2014  |  Journal of Biological Chemistry

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

Bradley J Turner, Neza Alfazema, Rebecca K Sheean, James N Sleigh, Kay E Davies, Malcolm K Horne, Kevin Talbot

Journal article  |  2014  |  Neurobiology of Aging

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

Julie D Atkin, Manal A Farg, Kai Ying Soo, Adam K Walker, Mark Halloran, Bradley J Turner, Phillip Nagley, Malcolm K Horne

Journal article  |  2014  |  Journal of Neurochemistry

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

Saskia Polling, Yee-Foong Mok, Yasmin M Ramdzan, Bradley J Turner, Justin J Yerbury, Andrew F Hill, Danny M Hatters

Journal article  |  2014  |  Journal of Biological Chemistry

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Leslie I Grad, Justin J Yerbury, Bradley J Turner, William C Guest, Edward Pokrishevsky, Megan A O'Neill, Anat Yanai, Judith M Silverman, Rafaa Zeineddine, Lisa Corcoran, Janet R Kumita, Leila M Luheshi, Masoud Yousefi, Bradley M Coleman, Andrew F Hill, Steven S Plotkin, Ian R Mackenzie, Neil R Cashman

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

ND Perera, RK Sheean, JW Scott, BE Kemp, MK Horne, BJ Turner

Journal article  |  2014  |  PLoS ONE

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

Adam K Walker, Kai Y Soo, Vinod Sundaramoorthy, Sonam Parakh, Yi Ma, Manal A Farg, Robyn H Wallace, Peter J Crouch, Bradley J Turner, Malcolm K Horne, Julie D Atkin

Journal article  |  2013  |  PLoS One

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Catherine E Winbanks, Justin L Chen, Hongwei Qian, Yingying Liu, Bianca C Bernardo, Claudia Beyer, Kevin I Watt, Rachel E Thomson, Timothy Connor, Bradley J Turner, Julie R McMullen, Lars Larsson, Sean L McGee, Craig A Harrison, Paul Gregorevic

Journal article  |  2013  |  Journal of Cell Biology

Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis

John D Lee, Nur A Kamaruzaman, Jenny NT Fung, Stephen M Taylor, Bradley J Turner, Julie D Atkin, Trent M Woodruff, Peter G Noakes

Journal article  |  2013  |  Journal of neuroinflammation

Genetics of motor neuron disorders: From gene diversity to common cellular conspirators in selective neuronal killing

RK Sheean, BJ Turner

Book Chapter  |  2013

CO-REGULATION OF SURVIVAL OF MOTOR NEURON AND BCL-XL EXPRESSION: IMPLICATIONS FOR NEUROPROTECTION IN SPINAL MUSCULAR ATROPHY

RS Anderton, LL Price, BJ Turner, BP Meloni, C Mitrpant, FL Mastaglia, C Goh, SD Wilton, S Boulos

Journal article  |  2012  |  Neuroscience

Membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS

BJ Turner, undefined Atkin

Book Chapter  |  2012

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.

Journal article  |  2011  |  Journal of Biological Chemistry

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Cynthia PW Soon, Peter J Crouch, Bradley J Turner, Catriona A McLean, Katrina M Laughton, Julie D Atkin, Colin L Masters, Anthony R White, Qiao-Xin Li

Journal article  |  2010  |  Neuromuscular Disorders

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

Bradley J Turner, Steven Ackerley, Kay E Davies, Kevin Talbot

Journal article  |  2010  |  Human Molecular Genetics

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

Bradley J Turner, Dirk Baumer, Nicholas J Parkinson, Jakub Scaber, Olaf Ansorge, Kevin Talbot

Journal article  |  2008  |  BMC Neuroscience

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

Bradley J Turner, Kevin Talbot

Journal article  |  2008  |  Progress in Neurobiology

Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1

BJ Turner, QX Li, KM Laughton, CL Masters, EC Lopes, JD Atkin, SS Cheema

Journal article  |  2004  |  Neurochemical Research

Chemotherapy delays progression of motor neuron disease in the SOD1 G93A transgenic mouse

KM Bruce, K Narayan, HC Kong, I Larmour, EC Lopes, BJ Turner, JF Bertram, SS Cheema

Journal article  |  2004  |  Chemotherapy

Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice

BJ Turner, A Rembach, R Spark, EC Lopes, SS Cheema

Journal article  |  2003  |  Journal of Neuroscience Research

Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice

BJ Turner, IK Cheah, KJ Macfarlane, EC Lopes, S Petratos, SJ Langford, SS Cheema

Journal article  |  2003  |  Journal of Neurochemistry

Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis

BJ Turner, EC Lopes, SS Cheema

Journal article  |  2003  |  Neuroscience Letters