Bradley Turner

Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice

Nirma D Perera, Doris Tomas, Nayomi Wanniarachchillage, Brittany Cuic, Sophia J Luikinga, Valeria Rytova, Bradley J Turner

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

Autophagy, which mediates the delivery of cytoplasmic substrates to the lysosome for degradation, is essential for maintaining pro..

Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis

Doris Tomas, Victoria M McLeod, Mathew DF Chiam, Nayomi Wanniarachchillage, Wah C Boon, Bradley J Turner

Journal article  |  2021  |  SCIENTIFIC REPORTS

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is..

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Azin Amin, Nirma D Perera, Philip M Beart, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2020  |  CELLS

Over the past 20 years, there has been a drastically increased understanding of the genetic basis of Amyotrophic Lateral Sclerosis..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

Taide Wang, Nirma D Perera, Mathew DF Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, Andre L Samson, Wayne Cawthorne, Eric N Valor, James M Murphy, Bradley J Turner

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regu..

Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases

Mitsuto Sato, Hotake Takizawa, Akinori Nakamura, Bradley J Turner, Fazel Shabanpoor, Yoshitsugu Aoki

Journal article  |  2019  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

Neuromuscular and neurodegenerative diseases are mostly modeled using genetically modified animals such as mice. However, animal m..

GAL(3) receptor knockout mice exhibit an alcohol-preferring phenotype

Shannyn G Genders, Karlene J Scheller, Emily J Jaehne, Bradley J Turner, Andrew J Lawrence, Susanne M Brunner, Barbara Kofler, Maarten van den Buuse, Elvan Djouma

Journal article  |  2019  |  ADDICTION BIOLOGY

Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL1-3 ). Administration of a GAL3 ant..

Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Victoria M McLeod, Chew L Lau, Mathew DF Chiam, Thusitha W Rupasinghe, Ute Roessner, Elvan Djouma, Wah C Boon, Bradley J Turner

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, i..

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

Samantha K Barton, Jenna M Gregory, Siddharthan Chandran, Bradley J Turner

Journal article  |  2019  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

One of the key pathways implicated in amyotrophic lateral sclerosis (ALS) pathogenesis is abnormal RNA processing. Studies to date..

Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

Nitin A Patil, John A Karas, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2019  |  BIOCONJUGATE CHEMISTRY

Antisense oligonucleotide (ASO)-based drugs are emerging with great potential as therapeutic compounds for diseases with unmet med..