James Ryall

A Metabolic Roadmap for Somatic Stem Cell Fate.

C Hai Ly, Gordon S Lynch, James G Ryall

Journal article  |  2020  |  Cell Metabolism

While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, rece..

The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

John H Nguyen, Jin D Chung, Gordon S Lynch, James G Ryall

Journal article  |  2019  |  Frontiers in Cell and Developmental Biology

Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle ..

Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress

Savant S Thakur, Janine L James, Nicola J Cranna, Victoria L Chhen, Kristy Swiderski, James G Ryall, Gordon S Lynch

Journal article  |  2019  |  Cell Stress and Chaperones

Ketogenic diets and tumour hypoxia - kulturkampf and 'the insurgency'

George Grimble, James Ryall

Journal article  |  2019  |  Current Opinion in Clinical Nutrition & Metabolic Care

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Yea Seul Shin, James G Ryall, Joanne M Britto, Chew L Lau, Rodney J Devenish, Phillip Nagley, Philip M Beart

Journal article  |  2019  |  Journal of Neurochemistry

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  Stem Cells International

The molecular signature of muscle stem cells is driven by nutrient availability and innate cell metabolism

James G Ryall, Gordon S Lynch

Journal article  |  2018  |  Current Opinion in Clinical Nutrition and Metabolic Care

Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch

Journal article  |  2018  |  Philosophical Transactions of the Royal Society B: Biological Sciences

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Richard J Mills, Drew M Titmarsh, Xaver Koenig, Benjamin L Parker, James G Ryall, Gregory A Quaife-Ryan, Holly K Voges, Mark P Hodson, Charles Ferguson, Lauren Drowley, Alleyn T Plowright, Elise J Needham, Qing-Dong Wang, Paul Gregorevic, Mei Xin, Walter G Thomas, Robert G Parton, Lars K Nielsen, Bradley S Launikonis, David E James, et al.

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

Sung-Jun Park, Faiyaz Ahmad, Jee-Hyun Um, Alexandra L Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James Ryall, Andrew Philp, Simon Schenk, Myung K Kim, Vittorio Sartorelli, Jay H Chung

Journal article  |  2017  |  EBioMedicine

Simultaneous Measurement of Mitochondrial and Glycolytic Activity in Quiescent Muscle Stem Cells.

James G Ryall

Book Chapter  |  2017  |  Methods in Molecular Biology

Cellular metabolism has recently been identified as an important regulator of cell identity, with several adult stem cell populati..

Measuring Mitochondrial Substrate Utilization in Skeletal Muscle Stem Cells

C Hai Ly, James G Ryall

Book Chapter  |  2017  |  Methods in Molecular Biology

Skeletal Muscle Development Preface

James G Ryall

Book Chapter  |  2017  |  Methods in Molecular Biology

The A(2b) adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

Christina Molck, James Ryall, Laura M Failla, Janine L Coates, Jean-Marc Pascussi, Joan K Heath, Gregory Stewart, Frederic Hollande

Journal article  |  2016  |  Cancer Letters

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells

Julie Giraud, Laura M Failla, Jean-Marc Pascussi, Ebba L Lagerqvist, Jeremy Ollier, Pascal Finetti, Francois Bertucci, Chu Ya, Imene Gasmi, Jean-Francois Bourgaux, Michel Prudhomme, Thibault Mazard, Imade Ait-Arsa, Leila Houhou, Daniel Birnbaum, Andre Pelegrin, Charles Vincent, James G Ryall, Dominique Joubert, Julie Pannequin, et al.

Journal article  |  2016  |  Cancer Research

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

Jonathan R Davey, Kevin I Watt, Benjamin L Parker, Rima Chaudhuri, James G Ryall, Louise Cunningham, Hongwei Qian, Vittorio Sartorelli, Marco Sandri, Jeffrey Chamberlain, David E James, Paul Gregorevic

Journal article  |  2016  |  JCI Insight

Epigenetic Regulation Shapes the Stem Cells State

G Caretti, L Berghella, A Juan, L Latella, J RYALL

Journal article  |  2016  |  Stem Cells International

DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

Rhianna C Laker, James G Ryall

Journal article  |  2016  |  Stem Cells International

Metabolic Reprogramming of Stem Cell Epigenetics

James G Ryall, Tim Cliff, Stephen Dalton, Vittorio Sartorelli

Journal article  |  2015  |  Cell Stem Cell

Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism

Benjamin D Rowlands, Chew Ling Lau, James G Ryall, Donald S Thomas, Matthias Klugmann, Philip M Beart, Caroline D Rae

Journal article  |  2015  |  Journal of Neuroscience Research

The NAD( )-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

James G Ryall, Stefania Dell'Orso, Assia Derfoul, Aster Juan, Hossein Zare, Xuesong Feng, Daphney Clermont, Miroslav Koulnis, Gustavo Gutierrez-Cruz, Marcella Fulco, Vittorio Sartorelli

Journal article  |  2015  |  Cell Stem Cell

Functional beta-Adrenoceptors Are Important for Early Muscle Regeneration in Mice through Effects on Myoblast Proliferation and Differentiation

Jarrod E Church, Jennifer Trieu, Radhika Sheorey, Annabel Y-M Chee, Timur Naim, Dale M Baum, James G Ryall, Paul Gregorevic, Gordon S Lynch

Journal article  |  2014  |  PLoS ONE

A metabolic link to skeletal muscle wasting and regeneration

Rene Koopman, C Hai Ly, James G Ryall

Journal article  |  2014  |  Frontiers in Physiology

Metabolic reprogramming as a novel regulator of skeletal muscle development and regeneration

James G Ryall

Journal article  |  2013  |  FEBS Journal

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

Valentina Proserpio, Raffaella Fittipaldi, James G Ryall, Vittorio Sartorelli, Giuseppina Caretti

Journal article  |  2013  |  Genes & Development

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

Alessia Peserico, Fulvio Chiacchiera, Valentina Grossi, Antonio Matrone, Dominga Latorre, Marta Simonatto, Aurora Fusella, James G Ryall, Lydia WS Finley, Marcia C Haigis, Gaetano Villani, Pier Lorenzo Puri, Vittorio Sartorelli, Cristiano Simone

Journal article  |  2013  |  Cellular and Molecular Life Sciences

The role of sirtuins in the regulation of metabolic homeostasis in skeletal muscle

James G Ryall

Journal article  |  2012  |  Current Opinion in Clinical Nutrition and Metabolic Care

Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury

Chris van der Poel, Luc E Gosselin, Jonathan D Schertzer, James G Ryall, Kristy Swiderski, Meron Wondemaghen, Gordon S Lynch

Journal article  |  2011  |  Journal of Inflammation

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

Aster H Juan, Assia Derfoul, Xuesong Feng, James G Ryall, Stefania Dell'Orso, Alessandra Pasut, Hossein Zare, James M Simone, Michael A Rudnicki, Vittorio Sartorelli

Journal article  |  2011  |  Genes & Development

Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice

Kate T Murphy, Vera Cobani, James G Ryall, Chikwendu Ibebunjo, Gordon S Lynch

Journal article  |  2011  |  Journal of Applied Physiology

Role of beta-Adrenergic Signalling in Skeletal Muscle Wasting: Implications for Sarcopenia

James G Ryall, Gordon S Lynch

Book Chapter  |  2011

Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

Kate T Murphy, James G Ryall, Sarah M Snell, Lawrence Nair, Rene Koopman, Philip A Krasney, Chikwendu Ibebunjo, Kathryn S Holden, Paula M Loria, Christopher T Salatto, Gordon S Lynch

Journal article  |  2010  |  American Journal of Pathology

Novel role for beta-adrenergic signalling in skeletal muscle growth, development and regeneration

James G Ryall, Jarrod E Church, Gordon S Lynch

Journal article  |  2010  |  Clinical and Experimental Pharmacology and Physiology

The role of beta-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders

Rene Koopman, James G Ryall, Jarrod E Church, Gordon S Lynch

Journal article  |  2009  |  Current Opinion in Clinical Nutrition and Metabolic Care

Expression profiling of skeletal muscle following acute and chronic beta(2)-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm

Michael A Pearen, James G Ryall, Gordon S Lynch, George EO Muscat

Journal article  |  2009  |  BMC Genomics

Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice

SM Turpin, JG Ryall, R Southgate, I Darby, AL Hevener, MA Febbraio, BE Kemp, GS Lynch, MJ Watt

Journal article  |  2009  |  Journal of Physiology

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  Journal of Physiology

The potential and the pitfalls of beta-adrenoceptor agonists for the management of skeletal muscle wasting

James G Ryall, Gordon S Lynch

Journal article  |  2008  |  Pharmacology and Therapeutics

Insulin-like growth factor-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage

Stefan M Gehrig, James G Ryall, Jonathan D Schertzer, Gordon S Lynch

Journal article  |  2008  |  Experimental Physiology

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

James G Ryall, Jonathan D Schertzer, Gordon S Lynch

Journal article  |  2008  |  Biogerontology

Intramuscular beta(2)-agonist administration enhances early regeneration and functional repair in rat skeletal muscle after myotoxic injury

James G Ryall, Jonathan D Schertzer, Tammy M Alabakis, Stefan M Gehrig, David R Plant, Gordon S Lynch

Journal article  |  2008  |  Journal of Applied Physiology

Anabolic agents for improving muscle regeneration and function after injury

Gordon S Lynch, Jonathan D Schertzer, James G Ryall

Journal article  |  2008  |  Clinical and Experimental Pharmacology and Physiology

The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle

Michael A Pearen, Stephen A Myers, Suryaprakash Raichur, James G Ryall, Gordon S Lynch, George EO Muscat

Journal article  |  2008  |  Endocrinology

Chronic beta(2)-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2 -ATPase protein and activity

James G Ryall, Jonathan D Schertzer, Kate T Murphy, Andrew M Allen, Gordon S Lynch

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

Transcriptional suppression of lipid-induced apoptosis in skeletal muscle in vivo

Sarah Maggie Turpin, JG Ryall, RJ Southgate, I Darby, MA Febbraio, BE Kemp, GS Lynch, MJ Watt

Journal article  |  2008  |  FASEB JOURNAL

Role of beta-adrenoceptor signaling in skeletal muscle: Implications for muscle wasting and disease

Gordon S Lynch, James G Ryall

Journal article  |  2008  |  Physiological Reviews

Modulation of insulin-like growth factor (IGF)-I and IGF-Binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice

Jonathan D Schertzer, Stefan M Gehrig, James G Ryall, Gordon S Lynch

Journal article  |  2007  |  American Journal of Pathology

NNOS is necessary for normal increases in glucose uptake during contraction of skeletal muscle

GK McConetl, KC Linden, JG Ryall, C Van der Poel, JD Schertzer, GS Lynch

Conference Proceedings  |  2007  |  DIABETOLOGIA

Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: Therapeutic implications for sarcopenia

James G Ryall, Jonathan D Schertzer, Gordon S Lynch

Journal article  |  2007  |  The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Disruption of IGF-I/IGFBP interactions decreases contractioninduced injury in dystrophic skeletal muscle

Gordon S Lynch, Stefan M Gehrig, Jonathan D Schertzer, James G Ryall

Conference Proceedings  |  2007  |  FASEB JOURNAL

The membrane sealant poloxa,mer reduces membrane permeability in tibialis anterior muscles from dystrophic mdx mice

James G Ryall, Chris van der Poel, Jonathan D Schertzer, David R Plant, Gordon S Lynch

Conference Proceedings  |  2007  |  FASEB JOURNAL

Therapeutic approaches for muscle wasting disorders

Gordon S Lynch, Jonathan D Schertzer, James G Ryall

Journal article  |  2007  |  Pharmacology and Therapeutics

Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue

Leah J Harcourt, Jonathan D Schertzer, James G Ryall, Gordon S Lynch

Journal article  |  2007  |  Neuromuscular Disorders

The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle

Michael A Pearen, James G Ryall, Megan A Maxwell, Naganari Ohkura, Gordon S Lynch, George EO Muscat

Journal article  |  2006  |  Endocrinology

Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice

Jonathan D Schertzer, James G Ryall, Gordon S Lynch

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Intramuscular injection of the beta-agonist formoterol enhances early functional repair after myotoxic injury in rat skeletal muscles

GS Lynch, TM Alabakis, JG Ryall, JD Schertzer, F Beitzel, DR Plant

Conference Proceedings  |  2006  |  FASEB JOURNAL

Systemic administration of beta(2)-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses

JG Ryall, MN Sillence, GS Lynch

Journal article  |  2006  |  British Journal of Pharmacology

Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density

P Gregorevic, JG Ryall, DR Plant, MN Sillence, GS Lynch

Journal article  |  2005  |  American Journal of Physiology - Heart and Circulatory Physiology

beta(2)-agonist administration increases sarcoplasmic reticulum Ca2 -ATPase activity in aged rat skeletal muscle

JD Schertzer, DR Plant, JG Ryall, F Beitzel, N Stupka, GS Lynch

Journal article  |  2005  |  American Journal of Physiology - Endocrinology and Metabolism

beta(2)-Adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury

F Beitzel, P Gregorevic, JG Ryall, DR Plant, MN Sillence, GS Lynch

Journal article  |  2004  |  Journal of Applied Physiology

Treatment with the beta(2)-agonist fenoterol attenuates age-related alterations in skeletal muscle sarcoplasmic reticulum Ca2 -ATPase function

JD Schertzer, JG Ryall, DR Plant, SB Harrap, GS Lynch

Conference Proceedings  |  2004  |  FASEB JOURNAL

The beta(2)-agonist formoterol produces greater muscle hypertrophy in rats than fenoterol

JG Ryall, DR Plant, GS Lynch

Conference Proceedings  |  2004  |  FASEB JOURNAL

beta(2)-agonist administration reverses muscle wasting and improves muscle function in aged rats

JG Ryall, DR Plant, P Gregorevic, MN Sillence, GS Lynch

Journal article  |  2004  |  Journal of Physiology

Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.

James G Ryall, David R Plant, Paul Gregorevic, Martin N Sillence, Gordon S Lynch

Journal article  |  2004  |  The Journal of Physiology

The beta2-adrenoceptor agonist (beta2-agonist) fenoterol has potent anabolic effects on rat skeletal muscle. We conducted an exten..

beta(2)-Agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol

JG Ryall, P Gregorevic, DR Plant, MN Sillence, GS Lynch

Journal article  |  2002  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

β2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol

JG Ryall, P Gregorevic, DR Plant, MN Sillence, GS Lynch

Journal article  |  2002  |  American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA-MB-231 cell line variants

Yan Tu, Cameron N Johnstone, James G Ryall, Guillermo H López-Campos, Christine R Keenan, Alastair G Stewart

Journal article  |  Journal of Cancer Metastasis and Treatment