James Ryall

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Savant S Thakur, Kristy Swiderski, Victoria L Chhen, Janine L James, Nicki J Cranna, AM Taufiqual Islam, James G Ryall, Gordon S Lynch

Journal article  |  2020  |  BIOLOGY OPEN

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..

A Metabolic Roadmap for Somatic Stem Cell Fate

C Hai Ly, Gordon S Lynch, James G Ryall

Journal article  |  2020  |  CELL METABOLISM

While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, rece..

The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

John H Nguyen, Jin D Chung, Gordon S Lynch, James G Ryall

Journal article  |  2019  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle ..

Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress

Savant S Thakur, Janine L James, Nicola J Cranna, Victoria L Chhen, Kristy Swiderski, James G Ryall, Gordon S Lynch

Journal article  |  2019  |  CELL STRESS & CHAPERONES

Skeletal myogenesis is a coordinated sequence of events associated with dramatic changes in cell morphology, motility, and metabol..

Ketogenic diets and tumour hypoxia - kulturkampf and 'the insurgency'

George Grimble, James Ryall

Journal article  |  2019  |  CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Yea Seul Shin, James G Ryall, Joanne M Britto, Chew L Lau, Rodney J Devenish, Phillip Nagley, Philip M Beart

Journal article  |  2019  |  JOURNAL OF NEUROCHEMISTRY

Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuro..

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  STEM CELLS INTERNATIONAL

Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, current understanding is almost excl..

The molecular signature of muscle stem cells is driven by nutrient availability and innate cell metabolism

James G Ryall, Gordon S Lynch

Journal article  |  2018  |  CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

PURPOSE OF REVIEW: To discuss how innate muscle stem-cell metabolism and nutrient availability can provide temporal regulation of ..

Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch

Journal article  |  2018  |  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by d..