Doctor James Ryall was awarded his PhD in the field of skeletal muscle physiology in 2006 at The University of Melbourne. In 2008 he was awarded a CJ Martin Overseas Biomedical Research Fellowship (NH&MRC) and from 2008-2013 he worked with Dr Vittorio Sartorelli at the National Institutes of Health in Bethesda, MD (USA) on trying to understand the links between intrinsic cell metabolism and the process of myogenic lineage commitment in skeletal muscle stem cells.
This work was the first to provide the whole transcriptome of quiescent and actively proliferating muscle stem cells, and defined a process of metabolic programming. In 2013 Dr Ryall returned to Australia and The University of Melbourne, where he is now a leading scientist within the Centre for Muscle Research (CMR). Dr Ryall’s current research lies in better understanding the link between skeletal muscle stem cells and their metabolic environment as they transition from quiescence to proliferating myogenic progenitor. A better understanding of the link between metabolism and cell identity will lead to improvements in stem cell transplantation and regenerative medicine, nuclear reprogramming, transdifferentiation, and stable ex vivo expansion of stem cells.
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James Ryall's selected work
The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferat..
Expression and localization of heat-shock proteins during skeletal muscle cell proliferati..
Displaying the 5 most recent projects by James Ryall.
Internal Research Grant
Displaying the 67 most recent scholarly works by James Ryall.
The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
John H Nguyen, Jin D Chung, Gordon S Lynch, James G Ryall
Journal article | 2019 | Frontiers in Cell and Developmental Biology
Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle ..
Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress
Savant S Thakur, Janine L James, Nicola J Cranna, Victoria L Chhen, Kristy Swiderski, James G Ryall, Gordon S Lynch
Journal article | 2019 | Cell Stress and Chaperones
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
Richard J Mills, Drew M Titmarsh, Xaver Koenig, Benjamin L Parker, James G Ryall, Gregory A Quaife-Ryan, Holly K Voges, Mark P Hodson, Charles Ferguson, Lauren Drowley, Alleyn T Plowright, Elise J Needham, Qing-Dong Wang, Paul Gregorevic, Mei Xin, Walter G Thomas, Robert G Parton, Lars K Nielsen, Bradley S Launikonis, David E James, et al.
Journal article | 2017 | Proceedings of the National Academy of Sciences
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK
Sung-Jun Park, Faiyaz Ahmad, Jee-Hyun Um, Alexandra L Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James Ryall, Andrew Philp, Simon Schenk, Myung K Kim, Vittorio Sartorelli, Jay H Chung
Journal article | 2017 | EBioMedicine
The A(2b) adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism
Christina Molck, James Ryall, Laura M Failla, Janine L Coates, Jean-Marc Pascussi, Joan K Heath, Gregory Stewart, Frederic Hollande
Journal article | 2016 | Cancer Letters
Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells
Julie Giraud, Laura M Failla, Jean-Marc Pascussi, Ebba L Lagerqvist, Jeremy Ollier, Pascal Finetti, Francois Bertucci, Chu Ya, Imene Gasmi, Jean-Francois Bourgaux, Michel Prudhomme, Thibault Mazard, Imade Ait-Arsa, Leila Houhou, Daniel Birnbaum, Andre Pelegrin, Charles Vincent, James G Ryall, Dominique Joubert, Julie Pannequin, et al.
Journal article | 2016 | Cancer Research
Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass
Jonathan R Davey, Kevin I Watt, Benjamin L Parker, Rima Chaudhuri, James G Ryall, Louise Cunningham, Hongwei Qian, Vittorio Sartorelli, Marco Sandri, Jeffrey Chamberlain, David E James, Paul Gregorevic
Journal article | 2016 | JCI Insight
Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism
Benjamin D Rowlands, Chew Ling Lau, James G Ryall, Donald S Thomas, Matthias Klugmann, Philip M Beart, Caroline D Rae
Journal article | 2015 | Journal of Neuroscience Research
The NAD( )-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
James G Ryall, Stefania Dell'Orso, Assia Derfoul, Aster Juan, Hossein Zare, Xuesong Feng, Daphney Clermont, Miroslav Koulnis, Gustavo Gutierrez-Cruz, Marcella Fulco, Vittorio Sartorelli
Journal article | 2015 | Cell Stem Cell
Functional beta-Adrenoceptors Are Important for Early Muscle Regeneration in Mice through Effects on Myoblast Proliferation and Differentiation
Jarrod E Church, Jennifer Trieu, Radhika Sheorey, Annabel Y-M Chee, Timur Naim, Dale M Baum, James G Ryall, Paul Gregorevic, Gordon S Lynch
Journal article | 2014 | PLoS ONE
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels
Alessia Peserico, Fulvio Chiacchiera, Valentina Grossi, Antonio Matrone, Dominga Latorre, Marta Simonatto, Aurora Fusella, James G Ryall, Lydia WS Finley, Marcia C Haigis, Gaetano Villani, Pier Lorenzo Puri, Vittorio Sartorelli, Cristiano Simone
Journal article | 2013 | Cellular and Molecular Life Sciences
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells
Aster H Juan, Assia Derfoul, Xuesong Feng, James G Ryall, Stefania Dell'Orso, Alessandra Pasut, Hossein Zare, James M Simone, Michael A Rudnicki, Vittorio Sartorelli
Journal article | 2011 | Genes & Development
Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice
Kate T Murphy, James G Ryall, Sarah M Snell, Lawrence Nair, Rene Koopman, Philip A Krasney, Chikwendu Ibebunjo, Kathryn S Holden, Paula M Loria, Christopher T Salatto, Gordon S Lynch
Journal article | 2010 | American Journal of Pathology
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg
Journal article | 2008 | Journal of Physiology
Modulation of insulin-like growth factor (IGF)-I and IGF-Binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice
Jonathan D Schertzer, Stefan M Gehrig, James G Ryall, Gordon S Lynch
Journal article | 2007 | American Journal of Pathology
Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.
James G Ryall, David R Plant, Paul Gregorevic, Martin N Sillence, Gordon S Lynch
Journal article | 2004 | The Journal of Physiology
The beta2-adrenoceptor agonist (beta2-agonist) fenoterol has potent anabolic effects on rat skeletal muscle. We conducted an exten..
Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA-MB-231 cell line variants
Yan Tu, Cameron N Johnstone, James G Ryall, Guillermo H López-Campos, Christine R Keenan, Alastair G Stewart
Journal article | Journal of Cancer Metastasis and Treatment
Honours, Awards and Fellowships
RM Gibson Research Award
Postgraduate student prize for best publication
Caroline tum Suden/Frances A. Hellebrandt professional opportunity award
CEPP prize for best student oral presentation
CEPP prize for best student oral presentation
Australian Association of Gerontology
Australian Physiological Society
Doctor of Philosophy - Medicine, Dentistry and Health Sciences
University of Melbourne
Bachelor of Science (Honours)
University of Melbourne