James Ryall

Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia

Kate T Murphy, Kristy Swiderski, James G Ryall, Jonathan R Davey, Hongwei Qian, Séverine Lamon, Victoria C Foletta, Jennifer Trieu, Annabel Chee, Suzannah J Read, Timur Naim, Paul Gregorevic, Gordon S Lynch

Journal article  |  2022  |  JCSM Rapid Communications

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

Luyi Tian, Jafar S Jabbari, Rachel Thijssen, Quentin Gouil, Shanika L Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei RM Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W Law, Alexis Lucattini, Yair David Joseph Prawer, Coralina Collar-Fernandez, Jin D Chung, Timur Naim, Audrey Chan, Chi Hai Ly, et al.

Journal article  |  2021  |  GENOME BIOLOGY

A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing toget..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Savant S Thakur, Kristy Swiderski, Victoria L Chhen, Janine L James, Nicki J Cranna, AM Taufiqual Islam, James G Ryall, Gordon S Lynch

Journal article  |  2020  |  BIOLOGY OPEN

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..

A Metabolic Roadmap for Somatic Stem Cell Fate

C Hai Ly, Gordon S Lynch, James G Ryall

Journal article  |  2020  |  CELL METABOLISM

While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, rece..

The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

John H Nguyen, Jin D Chung, Gordon S Lynch, James G Ryall

Journal article  |  2019  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle ..

Ketogenic diets and tumour hypoxia - kulturkampf and 'the insurgency'

George Grimble, James Ryall

Journal article  |  2019  |  CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress

Savant S Thakur, Janine L James, Nicola J Cranna, Victoria L Chhen, Kristy Swiderski, James G Ryall, Gordon S Lynch

Journal article  |  2019  |  CELL STRESS & CHAPERONES

Skeletal myogenesis is a coordinated sequence of events associated with dramatic changes in cell morphology, motility, and metabol..

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Yea Seul Shin, James G Ryall, Joanne M Britto, Chew L Lau, Rodney J Devenish, Phillip Nagley, Philip M Beart

Journal article  |  2019  |  JOURNAL OF NEUROCHEMISTRY

Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuro..

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Jarmon G Lees, Timothy S Cliff, Amanda Gammilonghi, James G Ryall, Stephen Dalton, David K Gardner, Alexandra J Harvey

Journal article  |  2019  |  STEM CELLS INTERNATIONAL

Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, current understanding is almost excl..