Una Greferath

Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium

Jessica YW Ma, Ursula Greferath, Josephine HC Wong, Linda J Fothergill, Andrew I Jobling, Kirstan A Vessey, Erica L Fletcher

Journal article  |  2023  |  Neurobiology of Aging

KCTD1 and Scalp-Ear-Nipple ('Finlay-Marks') syndrome may be associated with myopia and Thin basement membrane nephropathy through an effect on the collagen IV alpha 3 and alpha 4 chains

Dongmao Wang, Paul Trevillian, Stephen May, Peter Diakumis, Yanyan Wang, Deb Colville, Melanie Bahlo, Una Greferath, Erica Fletcher, Barbara Young, Heather G Mack, Judy Savige

Journal article  |  2022  |  OPHTHALMIC GENETICS

INTRODUCTION: Scalp-Ear-Nipple syndrome is caused by pathogenic KCTD1 variants and characterised by a scalp defect, prominent ears..

Reticular pseudodrusen: A critical phenotype in age-related macular degeneration

Zhichao Wu, Erica L Fletcher, Himeesh Kumar, Ursula Greferath, Robyn H Guymer

Journal article  |  2022  |  PROGRESS IN RETINAL AND EYE RESEARCH

Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct lesions that occur in the subretinal space..

Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)

Kirstan A Vessey, Andrew Jobling, Mai X Tran, Anna Y Wang, Ursula Greferath, Erica L Fletcher

Journal article  |  2022  |  AUTOPHAGY

Age-related macular degeneration (AMD) is a leading cause of vision loss with recent evidence indicating an important role for mac..

Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system.

Josephine HC Wong, Jessica YW Ma, Andrew I Jobling, Alice Brandli, Ursula Greferath, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2022  |  Front Neurosci

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the older population. Classical hallmarks..

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

Samuel A Mills, Andrew Jobling, Michael A Dixon, Bang Bui, Kirstan A Vessey, Joanna A Phipps, Ursula Greferath, Gene Venables, Vickie HY Wong, Connie HY Wong, Zheng He, Flora Hui, James C Young, Josh Tonc, Elena Ivanova, Botir T Sagdullaev, Erica L Fletcher

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local blood flow control within the central nervous system (CNS) is critical to proper function and is dependent on coordination b..

The Contribution of Microglia to the Development and Maturation of the Visual System

Michael A Dixon, Ursula Greferath, Erica L Fletcher, Andrew I Jobling

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Microglia, the resident immune cells of the central nervous system (CNS), were once considered quiescent cells that sat in readine..

Dorsal-Ventral Differences in Retinal Structure in the Pigmented Royal College of Surgeons Model of Retinal Degeneration

Una Greferath, Mario Huynh, Andrew Ian Jobling, Kirstan Anne Vessey, Gene Venables, Denver Surrao, Helen Christine O'Neill, Ioannis J Limnios, Erica Lucy Fletcher

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Retinitis pigmentosa is a family of inherited retinal degenerations associated with gradual loss of photoreceptors, that ultimatel..

Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat str..

Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma

Anna YM Wang, Pei Ying Lee, Bang Bui, Andrew Jobling, Ursula Greferath, Alice Brandli, Michael A Dixon, Quan Findlay, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2020  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neuro..