Michael McKinley

Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-α responses to endotoxaemia.

Michael J McKinley, Davide Martelli, Pedro Trevizan-Baú, Robin M McAllen

Journal article  |  2022  |  J Physiol

The efferent branches of the splanchnic sympathetic nerves that enhance interleukin-10 (IL-10) and suppress tumour necrosis factor..

Reflex regulation of systemic inflammation by the autonomic nervous system.

Robin M McAllen, Michael J McKinley, Davide Martelli

Journal article  |  2022  |  Auton Neurosci

This short review focusses on the inflammatory reflex, which acts in negative feedback manner to moderate the inflammatory consequ..

The autonomic inflammatory reflex

RM McAllen, MJ McKinley, D Martelli

Book Chapter  |  2022

Immune challenges are detected by the CNS, which then activates a sympathetic nerve pathway whose function is to dampen down the s..

The endogenous inflammatory reflex inhibits the inflammatory response to different immune challenges in mice

Alessandra Occhinegro, Chinn Yi Wong, Brendon Y Chua, David C Jackson, Michael J McKinley, Robin M McAllen, Davide Martelli

Journal article  |  2021  |  BRAIN BEHAVIOR AND IMMUNITY

The splanchnic anti-inflammatory pathway, the efferent arm of the endogenous inflammatory reflex, has been shown to suppress the a..

Hyperdipsia in sheep bearing lesions in the medial septal nucleus

A Smardencas, DA Denton, MJ McKinley

Journal article  |  2021  |  BRAIN RESEARCH

Previous experiments in rodents showed that ablation of the septal brain region caused hyperdipsia. We investigated which part of ..

The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis.

Michael J McKinley, Glenn L Pennington, Philip J Ryan

Journal article  |  2021  |  Handb Clin Neurol

Located in the midline lamina terminalis of the anterior wall of the third ventricle, the median preoptic nucleus is a thin elonga..

Sympathetic nerves control bacterial clearance

Yugeesh R Lankadeva, Clive N May, Michael J McKinley, Melanie R Neeland, Shuai Ma, Dianna M Hocking, Roy Robins-Browne, Sammy Bedoui, David GS Farmer, Simon R Bailey, Davide Martelli, Robin M McAllen

Journal article  |  2020  |  SCIENTIFIC REPORTS

A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but it..

Regional brain responses associated with using imagination to evoke and satiate thirst

Pascal Saker, Steve Carey, Marcus Grohmann, Michael J Farrell, Philip J Ryan, Gary F Egan, Michael J McKinley, Derek A Denton

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In response to dehydration, humans experience thirst. This subjective state is fundamental to survival as it motivates drinking, w..

Prior Ablation of the Splanchnic Sympathetic Nerves Increases Plasma Inflammatory Cytokine Levels and Suppresses Bacteremia in Response to Systemically Administered E. coli in Sheep

Michael McKinley, Kaylani Almeida, Sammy Bedoui, David Farmer, Dianna Hocking, Yugeesh Lankadeva, Davide Martelli, Clive May, Roy Robins-Browne, Robin McAllen

Conference Proceedings  |  2020  |  FASEB JOURNAL

The splanchnic anti-inflammatory pathway requires the brain stem but not the hypothalamus

A Occhinegro, DGS Farmer, MJ McKinley, RM McAllen, D Martellia

Conference Proceedings  |  2019  |  ACTA PHYSIOLOGICA