Ken Snibson

Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis

Udari Eshani Perera, Louise Organ, Simon G Royce, Chrishan S Samuel, Habtamu B Derseh, Sasika NV Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J Snibson

Journal article  |  2023  |  CANADIAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the inte..

Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms

Simon G Royce, Paul V Licciardi, Raymond C Beh, Jane E Bourke, Chantal Donovan, Andrew Hung, Ishant Khurana, Julia J Liang, Scott Maxwell, Nadia Mazarakis, Eleni Pitsillou, Ya Yun Siow, Kenneth J Snibson, Mark J Tobin, Katherine Ververis, Jitraporn Vongsvivut, Mark Ziemann, Chrishan S Samuel, Mimi LK Tang, Assam El-Osta, et al.

Journal article  |  2022  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic ..

The Efficacy and Safety of Pinocembrin in a Sheep Model of Bleomycin-Induced Pulmonary Fibrosis

HB Derseh, JQD Goodger, J-PY Scheerlinck, SS Chrishan, IE Woodrow, E Palombo, R Bischof, A Cumming, K Snibson

Conference Proceedings  |  2022  |  C70. NEW STUDIES OF LUNG FIBROSIS

The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Jason QD Goodger, Jean-Pierre Y Scheerlinck, Chrishan S Samuel, Ian E Woodrow, Enzo A Palombo, Alistair Cumming, Ken Snibson

Journal article  |  2021  |  PLOS ONE

The primary flavonoid, pinocembrin, is thought to have a variety of medical uses which relate to its reported anti-oxidant, anti-i..

The effects of the dietary compound L-sulforaphane against respiratory pathogens

Nadia Mazarakis, Rachel A Higgins, Jeremy Anderson, Zheng Quan Toh, Rodney B Luwor, Kenneth J Snibson, Tom C Karagiannis, Lien Anh Ha Do, Paul Licciardi

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

L-sulforaphane (LSF) is an isothiocyanate derived from cruciferous vegetables that has long been known for its anticarcinogenic, a..

Evaluation of microRNA expression in a sheep model for lung fibrosis

Udari Eshani Perera, Habtamu B Derseh, Sasika N Dewage, Andrew Stent, Rukmali Wijayarathna, Kenneth J Snibson

Journal article  |  2021  |  BMC GENOMICS

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibroproliferative disorder that has one of the poorest p..

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis

Habtamu B Derseh, Kopiyawaththage UE Perera, Sasika N Vithana Dewage, Andrew Stent, Emmanuel Koumoundouros, Louise Organ, Charles N Pagel, Ken J Snibson

Journal article  |  2021  |  FRONTIERS IN PHARMACOLOGY

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by excessive extracellular matrix (ECM) de..

Increased Levels of ER Stress and Apoptosis in a Sheep Model for Pulmonary Fibrosis Are Alleviated by In Vivo Blockade of the KCa3.1 Ion Channel

Udari E Perera, Louise Organ, Sasika NV Dewage, Habtamu B Derseh, Andrew Stent, Kenneth J Snibson

Journal article  |  2021  |  CANADIAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease, characterized by progressive damage to the lung tissues...

Examination of Novel Immunomodulatory Effects of L-Sulforaphane

Nadia Mazarakis, Jeremy Anderson, Zheng Quan Toh, Rachel A Higgins, Lien Anh Ha Do, Rodney B Luwor, Kenneth J Snibson, Tom C Karagiannis, Paul Licciardi

Journal article  |  2021  |  NUTRIENTS

The dietary isothiocyanate L-sulforaphane (LSF), derived from cruciferous vegetables, is reported to have several beneficial biolo..

Small airway remodeling in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Udari E Perera, Emmanuel Koumoundouros, Charles N Pagel, Louise Organ, Ken J Snibson

Journal article  |  2020  |  EXPERIMENTAL LUNG RESEARCH

BACKGROUND: Although IPF is described traditionally as a disease affecting lung parenchyma, there is renewed interest in the alter..