Ken Snibson

Increased Levels of ER Stress and Apoptosis in a Sheep Model for Pulmonary Fibrosis Are Alleviated by In Vivo Blockade of the KCa3.1 Ion Channel

Udari E Perera, Louise Organ, Sasika NV Dewage, Habtamu B Derseh, Andrew Stent, Kenneth J Snibson

Journal article  |  2021  |  CANADIAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease, characterized by progressive damage to the lung tissues...

Examination of Novel Immunomodulatory Effects of L-Sulforaphane

Nadia Mazarakis, Jeremy Anderson, Zheng Quan Toh, Rachel A Higgins, Lien Anh Ha Do, Rodney B Luwor, Kenneth J Snibson, Tom C Karagiannis, Paul Licciardi

Journal article  |  2021  |  NUTRIENTS

The dietary isothiocyanate L-sulforaphane (LSF), derived from cruciferous vegetables, is reported to have several beneficial biolo..

Small airway remodeling in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Udari E Perera, Emmanuel Koumoundouros, Charles N Pagel, Louise Organ, Ken J Snibson

Journal article  |  2020  |  EXPERIMENTAL LUNG RESEARCH

BACKGROUND: Although IPF is described traditionally as a disease affecting lung parenchyma, there is renewed interest in the alter..

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  SCIENTIFIC REPORTS

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

Nadia Mazarakis, Kenneth Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  CLINICAL NUTRITION

According to the World Health Organisation, 70% of all deaths globally can be attributed to chronic inflammatory diseases such as ..

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis.

Sasika NV Dewage, Louise Organ, Emmanuel Koumoundouros, Habtamu B Derseh, Kopiyawaththage UE Perera, Chrishan S Samuel, Andrew W Stent, Ken J Snibson

Journal article  |  2020  |  Experimental Lung Research

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with unknown cause. While the drugs nintedanib ..

K(Ca)3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Kopiyawaththage UE Perera, Charles N Pagel, Emmanuel Koumoundouros, Louise Organ, Ken J Snibson

Journal article  |  2019  |  SCIENTIFIC REPORTS

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited therapeutic options and poor prognosis. IPF..

In vivo blockade of KCa3.1 ion channel alleviates ER stress in type II alveolar epithelial cells and macrophages in pulmonary fibrosis

K Udari Eshani Perera, Sasika Nimanthi Vithana Dewage, Habtamu B Derseh, Paul John Benham, Andrew Stent, Louise Organ, Ken Snibson

Conference Proceedings  |  2019  |  EUROPEAN RESPIRATORY JOURNAL

Optical coherence tomography angiography findings in a case of adult-onset vitelliform dystrophy

Joe Wang, Jessie Tan, Kent Snibson, Kwang Meng Cham

Journal article  |  2019  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Large Animal Model

HB Derseh, KUE Perera, VDS Nimanthi, E Koumoundouros, A Stent, CN Pagel, L Organ, K Snibson

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE