Ken Snibson

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Scientific Reports

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

Nadia Mazarakis, Kenneth Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Clinical Nutrition

According to the World Health Organisation, 70% of all deaths globally can be attributed to chronic inflammatory diseases such as ..

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis.

Sasika NV Dewage, Louise Organ, Emmanuel Koumoundouros, Habtamu B Derseh, Kopiyawaththage UE Perera, Chrishan S Samuel, Andrew W Stent, Ken J Snibson

Journal article  |  2020  |  Experimental Lung Research

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with unknown cause. While the drugs nintedanib ..

K(Ca)3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Kopiyawaththage UE Perera, Charles N Pagel, Emmanuel Koumoundouros, Louise Organ, Ken J Snibson

Journal article  |  2019  |  Scientific Reports

In vivo blockade of KCa3.1 ion channel alleviates ER stress in type II alveolar epithelial cells and macrophages in pulmonary fibrosis

K Udari Eshani Perera, Sasika Nimanthi Vithana Dewage, Habtamu B Derseh, Paul John Benham, Andrew Stent, Louise Organ, Ken Snibson

Conference Proceedings  |  2019  |  Idiopathic interstitial pneumonias

Optical coherence tomography angiography findings in a case of adult-onset vitelliform dystrophy

Joe Wang, Jessie Tan, Kent Snibson, Kwang Meng Cham

Journal article  |  2019  |  Clinical and Experimental Optometry

Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Large Animal Model

HB Derseh, KUE Perera, VDS Nimanthi, E Koumoundouros, A Stent, CN Pagel, L Organ, K Snibson

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of in vivo blockade of the KCa3.1 ion channel on type II alveolar epithelial cell turnover in pulmonary fibrosis

K Udari Eshani Perera, Louise Organ, Habtamu Biyazen Derseh, Sasika Nimanthi Dewage, Andrew Stent, Ken Snibson

Conference Proceedings  |  2018  |  Idiopathic interstitial pneumonias

Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling

Junfei Wang, Alen Faiz, Qi Ge, Cornelis J Vermeulen, Joanne Van der Velden, Kenneth J Snibson, Rob van de Velde, Sonia Sawant, Dikaia Xenaki, Brian Oliver, Wim Timens, Nick ten Hacken, Maarten van den Berge, Alan James, John G Elliot, Liang Dong, Janette K Burgess, Anthony W Ashton

Journal article  |  2018  |  Journal of Cellular and Molecular Medicine

Unique Mechanisms of Connective Tissue Growth Factor Regulation in Airway Smooth Muscle in Asthma: Relationship with Airway Remodelling

JK Burgess, J Wang, A Faiz, Q Ge, CJ Vermeulen, K Snibson, BGG Oliver, W Timens, NH Hacken, M Van den Berge, AL James, J Elliot, L Dong, AW Ashton

Conference Proceedings  |  2018  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparative Study Between Murine and Sheep Models of Bleomycin-Induced Pulmonary Fibrosis

UE Perera, L Organ, S Royce, E Koumoundouros, HB Derseh, V Nimanthi, A Stent, K Snibson

Conference Proceedings  |  2018  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synchrotron-Fourier transform infrared maps of ovalbumin-induced murine chronic allergic airways disease: Correlation with conventional histology.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Kenneth J Snibson, Simon G Royce, Tom C Karagiannis

Journal article  |  2017  |  Hellenic journal of nuclear medicine

Asthma is a chronic respiratory disease characterised by airway inflammation, remodeling and hyperresponsiveness. The ability to r..

Inhibition of the K(Ca)3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model

Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Wayne G Kimpton, Chrishan S Samuel, Cameron J Nowell, Peter Bradding, Katy M Roach, Glen Westall, Jade Jaffar, Ken J Snibson

Journal article  |  2017  |  American Journal of Respiratory Cell and Molecular Biology

The Effects of Tumstatin on Vascularity, Airway Inflammation and Lung Function in an Experimental Sheep Model of Chronic Asthma

Joanne Van der Velden, Louise M Harkness, Donna M Barker, Garry J Barcham, Cathryn L Ugalde, Emmanuel Koumoundouros, Heidi Bao, Louise A Organ, Ana Tokanovic, Janette K Burgess, Kenneth J Snibson

Journal article  |  2016  |  Scientific Reports

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Garry Barcham, Marjorie Milne, Wayne Kimpton, Chrishan Samuel, Ken Snibson

Journal article  |  2015  |  BMC Pulmonary Medicine

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Garry Barcham, Wayne Kimpton, Cameron J Nowell, Chrishan Samuel, Ken Snibson

Journal article  |  2015  |  Experimental Lung Research

ISCOMATRIX (TM) adjuvant reduces mucosal tolerance for effective pulmonary vaccination against influenza

Andrea A Timothy, Ana Tokanovic, Kenneth J Snibson, Stirling J Edwards, Martin J Pearse, Jean-Pierre Y Scheerlinck, Philip Sutton

Journal article  |  2015  |  Human Vaccines & Immunotherapeutics

Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma

Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis HY Green, Ken J Snibson

Journal article  |  2014  |  Respiratory Research

K(Ca)3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma

Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson

Journal article  |  2013  |  PLoS One

Tracking adaptive controller gains to examine the effects of mechanical disturbances to the airway tone in sheep that have asthma-like responses

E Koumoundouros, KJ Snibson, G Barcham, IMY Mareels

Conference Proceedings  |  2013  |  IFMBE Proceedings

Increased vascular density is a persistent feature of airway remodeling in a sheep model of chronic asthma

Joanne Van der Velden, Donna Barker, Garry Barcham, Emmanuel Koumoundouros, Kenneth Snibson

Journal article  |  2012  |  Experimental Lung Research

Mucosal vaccination: Lung versus nose

Ana Vujanic, Philip Sutton, Kenneth J Snibson, Hung-Hsun Yen, Jean-Pierre Y Scheerlinck

Journal article  |  2012  |  Veterinary Immunology and Immunopathology

Increased Mast Cell Density and Airway Responses to Allergic and Non-Allergic Stimuli in a Sheep Model of Chronic Asthma

Joanne Van der Velden, Donna Barker, Garry Barcham, Emmanuel Koumoundouros, Kenneth Snibson

Journal article  |  2012  |  PLoS One

Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer

Katrin Friedbichler, Madeleine Themanns, Kristina M Mueller, Michaela Schlederer, Jan-Wilhelm Kornfeld, Luigi M Terracciano, Andrey V Kozlov, Susanne Haindl, Lukas Kenner, Thomas Kolbe, Mathias Mueller, Kenneth J Snibson, Markus H Heim, Richard Moriggl

Journal article  |  2012  |  Hepatology

Long-Term Antibody and Immune Memory Response Induced by Pulmonary Delivery of the Influenza Iscomatrix Vaccine

Ana Vujanic, Kenneth J Snibson, Janet LK Wee, Stirling J Edwards, Martin J Pearse, Jean-Pierre Y Scheerlinck, Philip Sutton

Journal article  |  2012  |  Clinical and Vaccine Immunology

Assessment of Peripheral Airway Function following Chronic Allergen Challenge in a Sheep Model of Asthma

Joanne Van der Velden, Donna Barker, Garry Barcham, Emmanuel Koumoundouros, Kenneth Snibson

Journal article  |  2011  |  PLoS One

Adaptive control of airway tone in sheep that have asthma-like responses

E Koumoundouros, KJ Snibson, IM Mareels

Conference Proceedings  |  2011  |  Proceedings of Australian Control Conference

Airway disease: The use of large animal models for drug discovery

Joanne Van der Velden, Kenneth J Snibson

Journal article  |  2011  |  Pulmonary Pharmacology and Therapeutics

Immune cell kinetics in the ovine abomasal mucosa following hyperimmunization and challenge with Haemonchus contortus

Nicholas Robinson, David Piedrafita, Kenneth Snibson, Paul Harrison, Els N Meeusen

Journal article  |  2010  |  Veterinary Research

Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIX (TM) adjuvanted recombinant antigens

Ana Vujanic, Janet LK Wee, Kenneth J Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Moloney, Shirley Taylor, Jean-Pierre Y Scheerlinck, Philip Sutton

Journal article  |  2010  |  Vaccine

Increased baseline airway resistance and smooth muscle content in sheep exposed to repeated challenges of house dust mite

E Koumoundouros, JL Van Der Velden, RJ Bischof, IMY Mareels, KJ Snibson

Conference Proceedings  |  2010  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Measurement and impact of remodeling in the lung: airway neovascularization in asthma.

Robert J Bischof, Jane E Bourke, Stuart J Hirst, Els NT Meeusen, Kenneth J Snibson, Joanne Van Der Velden

Journal article  |  2009  |  Proceedings of the American Thoracic Society

Expansion of the airway wall vascular compartment has recently been established as a feature of asthma involving both enlargement ..

Sheep as a model species for the study and treatment of human asthma and other respiratory diseases

EN Meeusen, KJ Snibson, SJ Hirst, RJ Bischof

Journal article  |  2009  |  Drug Discovery Today

Persistent bronchiolar remodeling following brief ventilation of the very immature ovine lung

Megan O'Reilly, Stuart B Hooper, Beth J Allison, Sharon J Flecknoe, Ken Snibson, Richard Harding, Foula Sozo

Journal article  |  2009  |  American Journal of Physiology - Lung Cellular and Molecular Physiology

Lung function in developing lambs: is it affected by preterm birth?

Robert De Matteo, Ken Snibson, Bruce Thompson, Emmanuel Koumoundouros, Richard Harding

Journal article  |  2009  |  Journal of Applied Physiology

Thoracic duct cannulation without thoracotomy in sheep: A method for accessing efferent lymph from the lung

Hung-Hsun Yen, Janet L-K Wee, Kenneth J Snibson, Jean-Pierre Y Scheerlinck

Journal article  |  2009  |  Veterinary Immunology and Immunopathology

The effects of Stat5 deficiency on liver pathogenesis in an inflammatory liver cancer mouse model

Katrin Friedbichler, Jan-Wilhelm Kornfeld, Susanne Haindl, Tricia Behling, Lukas Kenner, Ken Snibson, Andrey Kozlov, Richard Moriggl

Conference Proceedings  |  2009  |  CANCER RESEARCH

Pulmonary delivery of ISCOMATRIX influenza vaccine induces both systemic and mucosal immunity with antigen dose sparing (vol 1, pg 489, 2008)

JLJ Wee, J-PY Scheerlinck, KJ Snibson, S Edwards, M Pearse, C Quinn, P Sutton

Journal article  |  2009  |  Mucosal Immunology

Early environmental influences on lung development: Implications for lung function and respiratory health throughout life

K SNIBSON, J Harding, undefined O Reilly, undefined Maritz

Book Chapter  |  2009

Early Environmental Influences on Lung Development: Implications for Lung Function and Respiratory Health throughout Life

Richard Harding, Ken Snibson, Megan O'Reilly, Gert Maritz

Book Chapter  |  2009

Pulmonary delivery of ISCOMATRIX influenza vaccine induces both systemic and mucosal immunity with antigen dose sparing

JLK Wee, J-PY Scheerlinck, KJ Snibson, S Edwards, M Pearse, C Quinn, P Sutton

Journal article  |  2008  |  Mucosal Immunology

Immune response to allergens in sheep sensitized to house dust mite

Robert J Bischof, Ken J Snibson, Joanne Van Der Velden, Els NT Meeusen

Journal article  |  2008  |  Journal of Inflammation

Biomedical applications of sheep models: from asthma to vaccines

Jean-Pierre Y Scheerlinck, Kenneth J Snibson, Vernon M Bowles, Philip Sutton

Journal article  |  2008  |  Trends in Biotechnology

Lung parenchyma at maturity is influenced by postnatal growth but not by moderate preterm birth in sheep

Gert Maritz, Megan Probyn, Robert De Matteo, Ken Snibson, Richard Harding

Journal article  |  2008  |  Neonatology: foetal and neonatal research

Oesophageal techniques for deriving the lung dynamics of quietly breathing sheep

E Koumoundouros, K Snibson, IMY Mareels

Conference Proceedings  |  2008  |  Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: 'Personalized Healthcare through Technology'

Postnatal growth rate, but not mild preterm birth, influences airway structure in adult sheep challenged with house dust mite

Ken Snibson, Richard Harding

Journal article  |  2008  |  Experimental Lung Research

Claims of current inhaled corticosteroid patents for treating asthma.

Shari Lofthouse, Ken Snibson

Journal article  |  2007  |  Recent Patents on Inflammation & Allergy Drug Discovery

The advent and evolution of corticosteroid treatment strategies over the preceding decades means that asthma is now at least contr..

Chronic airway disease: Deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite

Emmanuel Koumoundouros, Robert J Bischof, Els N Meeusen, Iven MY Mareels, Kenneth J Snibson

Journal article  |  2006  |  Experimental Lung Research

Altered airway responsiveness in adult sheep born prematurely: Effects of allergen exposure

Kenneth J Snibson, Robert J Bischof, Emmanuel Koumoundouros, Lachlan S McMurtrie, Megan Cock, Richard Harding

Journal article  |  2006  |  Experimental Lung Research

Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite

KJ Snibson, RJ Bischof, RF Slocombe, EN Meeusen

Journal article  |  2005  |  Clinical and Experimental Allergy

Effects of implantation and early pregnancy on the expression of cytokines and vascular surface molecules in the sheep endometrium

ANMA Rahman, KJ Snibson, CS Lee, ENT Meeusen

Journal article  |  2004  |  Journal of Reproductive Immunology

Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite

RJ Bischof, K Snibson, R Shaw, ENT Meeusen

Journal article  |  2003  |  Clinical and Experimental Allergy

Hepatocellular kinetics and the expression of growth hormone (GH) in the livers and liver tumours of GH-transgenic mice

KJ Snibson

Journal article  |  2002  |  Tissue and Cell

Animal model for allergy

K SNIBSON, NT Meeusen, J Bischof

Patent  |  2002

Overexpressed growth hormone (GH) synergistically promotes carcinogen initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH transgenic mice

KJ Snibson, PS Bhathal, TE Adams

Journal article  |  2001  |  Liver

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice

KJ Snibson, PS Bhathal, CL Hardy, MR Brandon, TE Adams

Journal article  |  1999  |  Liver International

Allelic variation of ovine MHC class II DQA1 and DQA2 genes

KJ Snibson, JF Maddox, SA Fabb, MR Brandon

Journal article  |  1998  |  Animal Genetics

Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer

CL Hardy, PS Bhathal, KJ Snibson, TE Adams

Journal article  |  1997  |  Immunology

METHYLATION AND EXPRESSION OF A METALLOTHIONEIN PROMOTER OVINE GROWTH-HORMONE FUSION GENE (MTOGH1) IN TRANSGENIC MICE

KJ SNIBSON, D WOODCOCK, JM ORIAN, MR BRANDON, TE ADAMS

Journal article  |  1995  |  Transgenic Research

ELEVATION OF GROWTH-HORMONE (GH) AND PROLACTIN RECEPTORS IN TRANSGENIC MICE EXPRESSING OVINE GH

JM ORIAN, K SNIBSON, JL STEVENSON, MR BRANDON, AC HERINGTON

Journal article  |  1991  |  Endocrinology

Ultrastructural localization and gradient of activity of alkaline phosphatase activity during rodent odontogenesis.

HJ Orams, KJ Snibson

Journal article  |  1982  |  Calcified Tissue International

The ultrastructural localization and gradient of activity of alkaline phosphatase were studied with respect to cell differentiatio..