Stuart Dashper is the Professor of Oral Microbiology and Director of Research in the Melbourne Dental School. Most of his current research fits under the umbrella of determining the causes of microbiome-mediated oral diseases, particularly periodontal diseases and dental caries.
This research has involved the development of systems biology approaches to investigate chronic human disease. In particular the development of novel methodologies for the culture on polymicrobial biofilms and the determination the molecular interactions that underpin the symbiotic relationships of oral pathobionts. Stuart has applied microbiomic approaches to determine predictive biomarkers of disease in children. The long-term aim of all of these studies is to develop novel strategies for the prevention and treatment of oral diseases. He is an author on over 100 research publications and a named inventor on eight patents. His research is funded by the NHMRC and he has received NIH (USA) research grants in addition to the International Association for Dental Research (IADR)-GSK Innovation in Oral Care Award. Stuart is an Associate Editor of Molecular Oral Microbiology and on the on the Editorial Boards of the Journal of Oral Microbiology and the Journal of Oral Biosciences. He is a recipient of The Alan Docking IADR Science Award for outstanding scientific achievement in the field of dental research. He was a Project Leader in the Oral Health Cooperative Research Centre (2003-2018) where he was involved in the translation of basic research into commercial products. He has supervised 17 PhD, 6 Doctor of Clinical Dentistry and 18 BSc(Hons) students to completion. He has had a role in curriculum development and teaching in the Melbourne Dental School for over 25 years.
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Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by..
To Characterise The Interactome Of The Type Ix Secretion System Protein Components In Porp..
Displaying the 31 most recent projects by Stuart Dashper.
Internal Research Grant
Displaying the 114 most recent scholarly works by Stuart Dashper.
The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis
Engku Anis Fariha Enguku Nasrullah Satiman, Hasna Ahmad, Ahmad Bazli Ramzi, Ridhwan Abdul Wahab, Mohd Arifin Kaderi, Wan Himratul Aznita Wan Harun, Stuart Dashper, Michael McCullough, Mohd Hafiz Arzmi
Journal article | 2020 | Journal of Oral Pathology & Medicine
Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral h..
A methodological study to assess the measurement properties (reliability and validity) of a caries risk assessment tool for children
Bradley Christian, Hanny Calache, Geoff Adams, Martin Hall, Stuart Dashper, Lisa Gibbs, Mark Gussy
Journal article | 2020 | Journal of Dentistry
OBJECTIVES: To assess the CAMBRA caries risk assessment tool (CRAT) in terms of its measurement properties: reliability, validity ..
Identifying predictors of early childhood caries among Australian children using sequential modelling: Findings from the VicGen birth cohort study
Mark Gussy, George Mnatzaganian, Stuart Dashper, Lauren Carpenter, Hanny Calache, Helen Mitchell, Eric Reynolds, Lisa Gibbs, Shalika Hegde, Geoff Adams, Shae Johnson, Emily Amezdroz, Bradley Christian
Journal article | 2020 | Journal of Dentistry
OBJECTIVES: The aim of this birth cohort study was to identify concurrent associations between early childhood caries and putative..
Temporal development of the oral microbiome and prediction of early childhood caries
SG Dashper, HL Mitchell, K-A Le Cao, L Carpenter, MG Gussy, H Calache, SL Gladman, DM Bulach, B Hoffmann, D Catmull, S Pruilh, S Johnson, L Gibbs, E Amezdroz, U Bhatnagar, T Seemann, G Mnatzaganian, DJ Manton, EC Reynolds
Journal article | 2019 | Scientific Reports
Human microbiomes are predicted to assemble in a reproducible and ordered manner yet there is limited knowledge on the development..
The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis
Hong Min Ng, Nada Slakeski, Catherine A Butler, Paul D Veith, Yu-Yen Chen, Sze Wei Liu, Brigitte Hoffmann, Stuart G Dashper, Eric C Reynolds
Journal article | 2019 | Frontiers in Cellular and Infection Microbiology
The prebiotic effect of CPP-ACP sugar-free chewing gum
James R Fernando, Catherine A Butler, Geoffrey G Adams, Helen L Mitchell, Stuart G Dashper, Karen Escobar, Brigitte Hoffmann, Peiyan Shen, Glenn D Walker, Yi Yuan, Coralie Reynolds, Eric C Reynolds
Journal article | 2019 | Journal of Dentistry
OBJECTIVES: To determine if chewing gum containing casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) promoted..
Polymicrobial interactions of Candida albicans and its role in oral carcinogenesis
Mohd Hafiz Arzmi, Stuart Dashper, Michael McCullough
Journal article | 2019 | Journal of Oral Pathology & Medicine
The oral microbiome is composed of microorganisms residing in the oral cavity, which are critical components of health and disease..
Genomic, morphological and functional characterisation of novel bacteriophage FNU1 capable of disrupting Fusobacterium nucleatum biofilms
Mwila Kabwe, Teagan L Brown, Stuart Dashper, Lachlan Speirs, Heng Ku, Steve Petrovski, Hiu Tat Chan, Peter Lock, Joseph Tucci
Journal article | 2019 | SCIENTIFIC REPORTS
Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles
Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton
Journal article | 2017 | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Bacterial membrane vesicles transport their DNA cargo into host cells
Natalie J Bitto, Ross Chapman, Sacha Pidot, Adam Costin, Camden Lo, Jasmine Choi, Tanya D'Cruze, Eric C Reynolds, Stuart G Dashper, Lynne Turnbull, Cynthia B Whitchurch, Timothy P Stinear, Katryn J Stacey, Richard L Ferrero
Journal article | 2017 | SCIENTIFIC REPORTS
Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors
Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds
Journal article | 2017 | FRONTIERS IN MICROBIOLOGY
PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System
Jacqueline E Heath, Christine A Seers, Paul D Veith, Catherine A Butler, Nor A Nor Muhammad, Yu-Yen Chen, Nada Slakeski, Benjamin Peng, Lianyi Zhang, Stuart G Dashper, Keith J Cross, Steven M Cleal, Caroline Moore, Eric C Reynolds
Journal article | 2016 | PLOS ONE
Casein Phosphopeptide-Amorphous Calcium Phosphate Reduces Streptococcus mutans Biofilm Development on Glass Ionomer Cement and Disrupts Established Biofilms
Stuart G Dashper, Deanne V Catmull, Sze-Wei Liu, Helen Myroforidis, Ilya Zalizniak, Joseph EA Palamara, N Laila Huq, Eric C Reynolds
Journal article | 2016 | PLOS ONE
Natural history of dental caries in very young Australian children
Mark Gussy, Rosie Ashbolt, Lauren Carpenter, Monica Virgo-Milton, Hanny Calache, Stuart Dashper, Pamela Leong, Andrea de Silva, Alysha de Livera, Julie Simpson, Elizabeth Waters
Journal article | 2016 | International Journal of Paediatric Dentistry
The Porphyromonas gingivalis Ferric Uptake Regulator Orthologue Binds Hemin and Regulates Hemin-Responsive Biofilm Development
Catherine A Butler, Stuart G Dashper, Lianyi Zhang, Christine A Seers, Helen L Mitchell, Deanne V Catmull, Michelle D Glew, Jacqueline E Heath, Yan Tan, Hasnah SG Khan, Eric C Reynolds
Journal article | 2014 | PLOS ONE
Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis
Neville Gully, Richard Bright, Victor Marino, Ceilidh Marchant, Melissa Cantley, David Haynes, Catherine Butler, Stuart Dashper, Eric Reynolds, Mark Bartold
Journal article | 2014 | PLoS One
Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses
Kheng H Tan, Christine A Seers, Stuart G Dashper, Helen L Mitchell, James S Pyke, Vincent Meuric, Nada Slakeski, Steven M Cleal, Jenny L Chambers, Malcolm J McConville, Eric C Reynolds
Journal article | 2014 | PLOS PATHOGENS
Oxantel Disrupts Polymicrobial Biofilm Development of Periodontal Pathogens
Stuart Dashper, Neil O'Brien-Simpson, Sze Wei Liu, Rita Paolini, Helen Mitchell, Katrina Walsh, Tanya D'Cruze, Brigitte Hoffmann, Deanne Catmull, Ying Zhu, Eric Reynolds
Journal article | 2014 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Protein Substrates of a Novel Secretion System Are Numerous in the Bacteroidetes Phylum and Have in Common a Cleavable C-Terminal Secretion Signal, Extensive Post-Translational Modification, and Cell-Surface Attachment
Paul D Veith, Nor A Nor Muhammad, Stuart G Dashper, Vladimir A Likic, Dhana G Gorasia, Dina Chen, Samantha J Byrne, Deanne V Catmull, Eric C Reynolds
Journal article | 2013 | JOURNAL OF PROTEOME RESEARCH
The outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis
Yu-Yen Chen, Benjamin Peng, Qiaohui Yang, Michelle D Glew, Paul D Veith, Keith J Cross, Kenneth N Goldie, Dina Chen, Neil O'Brien-Simpson, Stuart G Dashper, Eric C Reynolds
Journal article | 2011 | Molecular Microbiology
Porphyromonas gingivalis Cysteine Proteinase Inhibition by kappa-Casein Peptides
Elena CY Toh, Stuart G Dashper, N Laila Huq, Troy J Attard, Neil M O'Brien-Simpson, Yu-Yen Chen, Keith J Cross, David P Stanton, Rita A Paolini, Eric C Reynolds
Journal article | 2011 | Antimicrobial Agents and Chemotherapy
Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation
Sacha J Pidot, Jessica L Porter, Nicholas J Tobias, Jeffrey Anderson, Deanne Catmull, Torsten Seemann, Stephen Kidd, John K Davies, Eric Reynolds, Stuart Dashper, Timothy P Stinear
Journal article | 2010 | Molecular Microbiology
FimR and FimS: Biofilm Formation and Gene Expression in Porphyromonas gingivalis
Alvin Lo, Christine Seers, Stuart Dashper, Catherine Butler, Glenn Walker, Katrina Walsh, Deanne Catmull, Brigitte Hoffmann, Steven Cleal, Patricia Lissel, John Boyce, Eric Reynolds
Journal article | 2010 | Journal of Bacteriology
The VicGeneration study - a birth cohort to examine the environmental, behavioural and biological predictors of early childhood caries: background, aims and methods
Andrea M de Silva-Sanigorski, Hanny Calache, Mark Gussy, Stuart Dashper, Jane Gibson, Elizabeth Waters
Journal article | 2010 | BMC Public Health
Response of Porphyromonas gingivalis to Heme Limitation in Continuous Culture
Stuart G Dashper, Ching-Seng Ang, Paul D Veith, Helen L Mitchell, Alvin WH Lo, Christine A Seers, Katrina A Walsh, Nada Slakeski, Dina Chen, J Patricia Lissel, Catherine A Butler, Neil M O'Brien-Simpson, Ian G Barr, Eric C Reynolds
Journal article | 2009 | Journal of Bacteriology
The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis
Christine A Seers, Nada Slakeski, Paul D Veith, Todd Nikolof, Yu-Yen Chen, Stuart G Dashper, Eric C Reynolds
Journal article | 2006 | Journal of Bacteriology
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.
Paul D Veith, Gert H Talbo, Nada Slakeski, Stuart G Dashper, Caroline Moore, Rita A Paolini, Eric C Reynolds
Journal article | 2002 | Biochemical Journal
Porphyromonas gingivalis is an anaerobic, asaccharolytic Gram-negative rod associated with chronic periodontitis. We have undertak..
Chemical synthesis, characterization and activity of RK-1, a novel alpha-defensin-related peptide.
NF Dawson, DJ Craik, AM McManus, SG Dashper, EC Reynolds, GW Tregear, L Otvos, JD Wade
Journal article | 2000 | Journal of Peptide Science
The 32-residue peptide, RK-1, a novel kidney-derived three disulfide-bonded member of the antimicrobial alpha-defensin family, was..
Displaying the 4 most recent news articles by Stuart Dashper.
Honours, Awards and Fellowships
Alan Docking Award
Awarded for role in implementation of new BDSc curriculum
Based on published research
Based on published research
Best publication in Journal of Dental Research in 1992
Melbourne Dental School
Australian Society for Microbiology
International Association for Dental Research
Doctor of Philosophy
University of Melbourne
Bachelor of Science (honours)
La Trobe University