Elizabeth Hinde

Super-resolution microscopy reveals the arrangement of inner membrane protein complexes in mammalian mitochondria

Catherine S Palmer, Jieqiong Lou, Betty Kouskousis, Elvis Pandzic, Alexander J Anderson, Yilin Kang, Elizabeth Hinde, Diana Stojanovski

Journal article  |  2021  |  JOURNAL OF CELL SCIENCE

The mitochondrial inner membrane is a protein-rich environment containing large multimeric complexes, including complexes of the m..

Live cell dynamics of the NF-Y transcription factor

David G Priest, Andrea Bernardini, Jieqiong Lou, Roberto Mantovani, Elizabeth Hinde

Journal article  |  2021  |  SCIENTIFIC REPORTS

Transcription factors (TFs) are core players in the control of gene expression, evolutionarily selected to recognise a subset of s..

Nanophotonics enhanced coverslip for phase imaging in biology

Lukas Wesemann, Jon Rickett, Jingchao Song, Jieqiong Lou, Elizabeth Hinde, Timothy J Davis, Ann Roberts

Journal article  |  2021  |  LIGHT-SCIENCE & APPLICATIONS

The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experime..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF LIPID RESEARCH

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Jieqiong Lou, David G Priest, Ashleigh Solano, Adele Kerjouan, Elizabeth Hinde

Journal article  |  2020  |  Nature Communications

Tumor suppressor p53-binding protein 1 (53BP1) is a DNA repair protein essential for the detection, assessment, and resolution of ..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters

Journal article  |  2020  |  PLOS ONE

Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begoña Heras, Wallace WH Wong, Yuning Hong

Journal article  |  2020  |  Angewandte Chemie

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begona Heras, Wallace WH Wong, Yuning Hong

Journal article  |  2020  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general m..

Quantifying nuclear wide chromatin compaction by phasor analysis of histone Forster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data

Zhen Liang, Jieqiong Lou, Lorenzo Scipioni, Enrico Gratton, Elizabeth Hinde

Journal article  |  2020  |  DATA IN BRIEF

The nanometer spacing between nucleosomes throughout global chromatin organisation modulates local DNA template access, and throug..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control

Angelique Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny Hatters

Journal article  |  2020

Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..