Elizabeth Hinde

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control.

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  The Journal of Lipid Research

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Jieqiong Lou, David G Priest, Ashleigh Solano, Adele Kerjouan, Elizabeth Hinde

Journal article  |  2020  |  Nature Communications

Tumor suppressor p53-binding protein 1 (53BP1) is a DNA repair protein essential for the detection, assessment, and resolution of ..

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters

Journal article  |  2020  |  PLoS One

Mutations that cause Huntington's Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntin..

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Tze Cin Owyong, Pramod Subedi, Jieru Deng, Elizabeth Hinde, Jason J Paxman, Jonathan M White, Weisan Chen, Begona Heras, Wallace WH Wong, Yuning Hong

Journal article  |  2020  |  Angewandte Chemie International Edition

Environmental polarity is an important factor that drives biomolecular interactions to regulate cell function. Herein, a general m..

Quantifying nuclear wide chromatin compaction by phasor analysis of histone Forster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data

Zhen Liang, Jieqiong Lou, Lorenzo Scipioni, Enrico Gratton, Elizabeth Hinde

Journal article  |  2020  |  Data in Brief

Mapping the Diffusive Route of Oligomeric Transcription Factors during DNA Target Search

Elizabeth Hinde

Conference Proceedings  |  2020  |  BIOPHYSICAL JOURNAL

Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics

Sunyuan Zhang, Elizabeth Hinde, Molly Parkyn Schneider, David A Jans, Marie A Bogoyevitch

Journal article  |  2020  |  Scientific Reports

A mutant form of the ataxin-1 protein with an expanded polyglutamine (polyQ) tract is the underlying cause of the inherited neurod..

Cell Scientist to Watch - Elizabeth Hinde

Elizabeth Hinde

Journal article  |  2019  |  Journal of Cell Science

Fluorescence fluctuation spectroscopy: an invaluable microscopy tool for uncovering the biophysical rules for navigating the nuclear landscape

David G Priest, Ashleigh Solana, Jieqiong Lou, Elizabeth Hinde

Journal article  |  2019  |  Biochemical Society Transactions

Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response

Jieqiong Lou, Lorenzo Scipioni, Belinda K Wright, Tara K Bartolec, Jessie Zhang, V Pragathi Masamsetti, Katharina Gaus, Enrico Gratton, Anthony J Cesare, Elizabeth Hinde

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA