Nigel Jones

Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer

Matthew Drill, Nigel C Jones, Martin Hunn, Terence J O'Brien, Mastura Monif

Journal article  |  2021  |  Purinergic Signalling

Microglial Cells in Epilepsy: Not That Bad After All?

Nigel C Jones

Journal article  |  2020  |  Epilepsy Currents

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Cardiorespiratory and autonomic function in epileptic seizures: A video-EEG monitoring study

Shobi Sivathamboo, Thomas N Constantino, Zhibin Chen, Paul B Sparks, Jeremy Goldin, Dennis Velakoulis, Nigel C Jones, Patrick Kwan, Vaughan G Macefield, Terence J O'Brien, Piero Perucca

Journal article  |  2020  |  Epilepsy & Behavior

PURPOSE: Seizure-induced cardiorespiratory and autonomic dysfunction has long been recognized, and growing evidence points to its ..

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  Scientific Reports

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12-15 months. The P2X receptor 7 (P2X7..

Acute NMDA Receptor Antagonism Impairs Working Memory Performance but Not Attention in Rats-Implications for the NMDAr Hypofunction Theory of Schizophrenia

Jaime Lee, Maarten van den Buuse, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2020  |  Behavioral Neuroscience

Cognitive deficits in schizophrenia, which include impairments in working memory and attention, represent some of the most disabli..

MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV plus interneurons or forebrain pyramidal cells

Elysia Sokolenko, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2020  |  Neuropharmacology

NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: ..

A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

Dana Jazayeri, Emma Braine, Stuart McDonald, Sebastian Dworkin, Kim L Powell, Karen Griggs, Frank JE Vajda, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  Epilepsia

Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer's Disease-Related Epileptic Seizures

Runxuan Lin, Nigel Charles Jones, Patrick Kwan

Journal article  |  2020  |  International Journal of Molecular Sciences

Alzheimer's disease (AD) is the most common form of dementia. An increasing body of evidence describes an elevated incidence of ep..

NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour

Matthew R Hudson, Elysia Sokolenko, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  Neurobiology of Disease

BACKGROUND: NMDAr antagonists induce disturbances to gamma frequency oscillations, including increasing ongoing gamma activity and..

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

Peravina Therajaran, John A Hamilton, Terence J O'Brien, Nigel C Jones, Idrish Ali

Journal article  |  2020  |  Epilepsia

Owing to the complexity of the pathophysiological mechanisms driving epileptogenesis following traumatic brain injury (TBI), effec..