Nigel Jones

NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour

Matthew R Hudson, Elysia Sokolenko, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  Neurobiology of Disease

BACKGROUND: NMDAr antagonists induce disturbances to gamma frequency oscillations, including increasing ongoing gamma activity and..

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

Peravina Therajaran, John A Hamilton, Terence J O'Brien, Nigel C Jones, Idrish Ali

Journal article  |  2020  |  Epilepsia

Owing to the complexity of the pathophysiological mechanisms driving epileptogenesis following traumatic brain injury (TBI), effec..

Raloxifene recovers effects of prenatal immune activation on cognitive task-induced gamma power

Anna Schroeder, Jay P Nakamura, Matthew Hudson, Nigel C Jones, Xin Du, Suresh Sundram, Rachel A Hill

Journal article  |  2019  |  Psychoneuroendocrinology

There is currently no treatment available for the cognitive symptoms of schizophrenia, but evidence suggests that selective estrog..

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches

Yam Nath Paudel, Bridgette D Semple, Nigel C Jones, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2019  |  Journal of Neurochemistry

Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% o..

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy.

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  Progress in Neurobiology

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies

Naomi Dvir, Muhammad S Javaid, Nigel C Jones, Kim L Powell, Patrick Kwan, Terence J O'Brien, Ana Antonic-Baker

Journal article  |  2019  |  Systematic Reviews

BACKGROUND: Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It af..

Imaging biomarkers of posttraumatic epileptogenesis

Rachael Garner, Marianna La Rocca, Paul Vespa, Nigel Jones, Martin M Monti, Arthur W Toga, Dominique Duncan

Journal article  |  2019  |  Epilepsia

Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer's Disease

Yam Nath Paudel, Efthalia Angelopoulou, Nigel C Jones, Terence J O'Brien, Patrick Kwan, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2019  |  ACS Chemical Neuroscience

Emerging findings point toward an important interconnection between epilepsy and Alzheimer's disease (AD) pathogenesis. Patients w..

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Cesar Santana-Gomez, Pedro Andrade, Matthew R Hudson, Tomi Paananen, Robert Ciszek, Gregory Smith, Idrish Ali, Brian K Rundle, Xavier Ekolle Ndode-Ekane, Pablo M Casillas-Espinosa, Riikka Immonen, Noora Puhakka, Nigel Jones, Rhys D Brady, Piero Perucca, Sandy R Shultz, Asia Pitkanen, Terence J O'Brien, Richard Staba

Journal article  |  2019  |  Epilepsy Research

Studies of chronic epilepsy show pathological high frequency oscillations (HFOs) are associated with brain areas capable of genera..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Pablo M Casillas-Espinosa, Pedro Andrade, Cesar Santana-Gomez, Tomi Paananen, Gregory Smith, Idrish Ali, Robert Ciszek, Xavier Ekolle Ndode-Ekane, Rhys D Brady, Jussi Tohka, Matthew R Hudson, Piero Perucca, Emma L Braine, Riikka Immonen, Noora Puhakka, Sandy R Shultz, Nigel C Jones, Richard J Staba, Asia Pitkanen, Terence J O'Brien

Journal article  |  2019  |  Epilepsy Research

RATIONALE: The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded mult..

The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia

Jay P Nakamura, Anna Schroeder, Matthew Hudson, Nigel Jones, Brendan Gillespie, Xin Du, Michael Notaras, Vaidy Swaminathan, William R Reay, Joshua R Atkins, Melissa J Green, Vaughan J Carr, Murray J Cairns, Suresh Sundram, Rachel A Hill

Journal article  |  2019  |  Brain, Behavior, and Immunity

A hallmark feature of schizophrenia is altered high frequency neural oscillations, including reduced auditory-evoked gamma oscilla..

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz

Journal article  |  2019  |  Brain Injury

Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools

Simone Carron, Gabi Dersi, Ezgi Ozturk, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2019  |  EPILEPSIA

OBJECTIVE: Cognitive deficits are commonly observed in people with epilepsy, but the biologic causation of these is challenging to..

Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury - A population based cohort study

Jakob Christensen, Henrik Schou Pedersen, Morten Fenger-Gron, Jesse R Fann, Nigel C Jones, Mogens Vestergaard

Journal article  |  2019  |  PLOS ONE

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk

Journal article  |  2019  |  Journal of Neurotrauma

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Rodney Luwor, Andrew P Morokoff, Stephanie Amiridis, Giovanna D'Abaco, Lucia Paradiso, Stanley S Stylli, Hong PT Nguyen, Mark Tarleton, Kelly A Young, Terence J O'Brien, Phillip J Robinson, Megan Chircop, Adam McCluskey, Nigel C Jones

Journal article  |  2019  |  Cancer Investigation

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Bridgette D Semple, Akram Zamani, Genevieve Rayner, Sandy R Shultz, Nigel C Jones

Journal article  |  2019  |  Neurobiology of Disease

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J Bell, Thomas P Bleck, Manuel Buitrago Blanco, Jan Claassen, Ramon Diaz-Arrastia, Dominique Duncan, Ben Ellingson, Brandon Foreman, Emily J Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien, et al.

Journal article  |  2019  |  Neurobiology of Disease

High-Frequency Neuronal Oscillatory Abnormalities in the Phospholipase C-beta 1 Knockout Mouse Model of Schizophrenia

Matthew R Hudson, Anthony J Hannan, Terence J O'Brien, Nigel C Jones

Journal article  |  2019  |  International Journal of Neuropsychopharmacology

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Meral A Tubiv, Evan Lutkenhof, Manuel Buitrago Blanco, David McArthur, Pablo Villablanca, Benjamin Ellingson, Ramon Diaz-Arrastia, Paul Van Ness, Courtney Real, Vikesh Shrestha, Jerome Engel, Paul M Vespa, Denes Agoston, Alicia Au, Michael J Bell, Tom Bleck, Craig Branch, Manuel Buitrago Blanco, Ross Bullock, Brian T Burrows, et al.

Journal article  |  2019  |  Neurobiology of Disease

Targeting neurodegeneration to prevent post-traumatic epilepsy

Idrish Ali, Juliana C Silva, Shijie Liu, Sandy R Shultz, Patrick Kwan, Nigel C Jones, Terence J O'Brien

Journal article  |  2019  |  Neurobiology of Disease

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring

Shobi Sivathamboo, Sarah Farrand, Zhibin Chen, Elise J White, Andrew Andreas Pattichis, Callum Hollis, John Carino, Caitlin J Roberts, Thomas Minogue, Nigel C Jones, Raju Yerra, Christopher French, Piero Perucca, Patrick Kwan, Dennis Velakoulis, Terence J O'Brien, Jeremy Goldin

Journal article  |  2019  |  Neurology

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Alaa Kamnaksh, Noora Puhakka, Idrish Ali, Gregory Smith, Roxanne Aniceto, Jesse McCullough, Shalini Das Gupta, Xavier Ekolle Ndode-Ekane, Rhys Brady, Pablo Casillas-Espinosa, Matt Hudson, Cesar Santana-Gomez, Riikka Immonen, Pedro Andrade de Abreu, Nigel Jones, Sandy Shultz, Richard J Staba, Terence J O'Brien, Denes Agoston, Asia Pitkanen

Journal article  |  2019  |  Epilepsy Research

The mGluR(2/3) agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice

Elysia Sokolenko, Matthew R Hudson, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2019  |  Journal of Psychopharmacology

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

A Mazarati, NC Jones, AS Galanopoulou, LC Harte-Hargrove, LE Kalynchuk, PP Lenck-Santini, JS Medel-Matus, A Nehlig, LM de la Prida, K Sarkisova, J Veliskova

Journal article  |  2018  |  Epilepsia Open

Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice

Nigel C Jones, Matthew Hudson, Joshua Foreman, Gil Rind, Rachel Hill, Elizabeth E Manning, Maarten van den Buuse

Journal article  |  2018  |  European Journal of Neuroscience

Thinking above the genome: Epigenetic manipulation as a disease-modifying strategy in epilepsy

NC Jones

Journal article  |  2018  |  Epilepsy Currents

Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors

Crystal Li, Juliana Silva, Ezgi Ozturk, Gabriella Dezsi, Terence J O'Brien, Thibault Renoir, Nigel C Jones

Journal article  |  2018  |  Epilepsia

Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome

Michael S Hildebrand, A Simon Harvey, Stephen Malone, John A Damiano, Hongdo Do, Zimeng Ye, Lara McQuillan, Wirginia Maixner, Renate Kalnins, Bernadette Nolan, Martin Wood, Ezgi Ozturk, Nigel C Jones, Greta Gillies, Kate Pope, Paul J Lockhart, Alexander Dobrovic, Richard J Leventer, Ingrid E Scheffer, Samuel F Berkovic

Journal article  |  2018  |  Neurology Genetics

Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment

Shobi Sivathamboo, Piero Perucca, Dennis Velakoulis, Nigel C Jones, Jeremy Goldin, Patrick Kwan, Terence J O'Brien

Journal article  |  2018  |  Sleep

The influence of immunological stressors on traumatic brain injury

Mujun Sun, Stuart J McDonald, Rhys D Brady, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Brain, Behavior, and Immunity

Disease-Modification in Epilepsy by Nonpharmacological Methods

Nigel C Jones

Journal article  |  2018  |  Epilepsy Currents

Sensitive quantitative detection of somatic mosaic mutation in "double cortex" syndrome

John A Damiano, Hongdo Do, Ezgi Ozturk, Rosemary Burgess, Renate Kalnins, Nigel C Jones, Alexander Dobrovic, Samuel F Berkovic, Michael S Hildebrand

Journal article  |  2017  |  Epileptic Disorders

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun, Rhys D Brady, David K Wright, Hyun Ah Kim, Shenpeng R Zhang, Christopher G Sobey, Maddison R Johnstone, Terence J O'Brien, Bridgette D Semple, Stuart J McDonald, Sandy R Shultz

Journal article  |  2017  |  Brain, Behavior, and Immunity

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Shijie Liu, Yu Shen, Sandy R Shultz, Nguyen Anne, Christopher Hovens, Paul A Adlard, Ashley I Bush, Jianxiong Chan, Patrick Kwan, Terence J O'Brien, Nigel C Jones

Journal article  |  2017  |  Epilepsia

Extensive phenotyping of two ARX polyalanine expansion mutation mouse models that span clinical spectrum of intellectual disability and epilepsy

Matilda R Jackson, Kristie Lee, Tessa Mattiske, Emily J Jaehne, Ezgi Ozturk, Bernhard T Baune, Terence J O'Brien, Nigel Jones, Cheryl Shoubridge

Journal article  |  2017  |  Neurobiology of Disease

LOCAL NMDA RECEPTOR HYPOFUNCTION EVOKES GENERALIZED EFFECTS ON GAMMA AND HIGH-FREQUENCY OSCILLATIONS AND BEHAVIOR

Jaime Lee, Matthew R Hudson, Terence J O'Brien, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2017  |  NEUROSCIENCE

Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain

Pablo M Casillas-Espinosa, Kim L Powell, Mingfu Zhu, C Ryan Campbell, Jessica M Maia, Zhong Ren, Nigel C Jones, Terence J O'Brien, Slave Petrovski

Journal article  |  2017  |  PLOS ONE

Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy

Gabi Dezsi, Frank Sieg, Mark Thomas, Terence J O'Brien, Marieke van der Hart, Nigel C Jones

Journal article  |  2017  |  Neurochemical Research

The N-Methyl D-Aspartate Glutamate Receptor Antagonist Ketamine Disrupts the Functional State of the Corticothalamic Pathway

Paul M Anderson, Nigel C Jones, Terence J O'Brien, Didier Pinault

Journal article  |  2017  |  Cerebral Cortex

INHIBITION OF MICROGLIAL ACTIVATION WITH MINOCYCLINE AT THE INTRATHECAL LEVEL ATTENUATES SYMPATHOEXCITATORY AND PROARRHYTHMOGENIC CHANGES IN RATS WITH CHRONIC TEMPORAL LOBE EPILEPSY

Amol M Bhandare, Komal Kapoor, Kim L Powell, Emma Braine, Pablo Casillas-Espinosa, Terence J O'Brien, Melissa MJ Farnham, Paul M Pilowsky

Journal article  |  2017  |  Neuroscience

The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies

Sandy R Shultz, Stuart J McDonald, Cole Vonder Haar, Alicia Meconi, Robert Vink, Paul van Donkelaar, Chand Taneja, Grant L Iverson, Brian R Christie

Journal article  |  2017  |  Neuroscience & Biobehavioral Reviews

Estradiol and raloxifene modulate hippocampal gamma oscillations during a spatial memory task

Anna Schroeder, Matthew Hudson, Xin Du, Yee Wen Candace Wu, Jay Nakamura, Maarten van den Buuse, Nigel C Jones, Rachel A Hill

Journal article  |  2017  |  Psychoneuroendocrinology

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states

Guy Barry, James A Briggs, Do Won Hwang, Sam P Nayler, Patrick RJ Fortuna, Nicky Jonkhout, Fabien Dachet, Jesper LV Maag, Pieter Mestdagh, Erin M Singh, Lotta Avesson, Dominik C Kaczorowski, Ezgi Ozturk, Nigel C Jones, Irina Vetter, Luis Arriola-Martinez, Jianfei Hu, Gloria R Franco, Victoria M Warn, Andrew Gong, et al.

Journal article  |  2017  |  Scientific Reports

The pathophysiology of cardiac dysfunction in epilepsy

Krishnan Ravindran, Kim L Powell, Marian Todaro, Terence J O'Brien

Journal article  |  2016  |  Epilepsy Research

Early childhood trauma and hippocampal volumes in patients with epileptic and psychogenic seizures

Benjamin Johnstone, Dennis Velakoulis, Cheng Yi Yuan, Anthony Ang, Chris Steward, Patricia Desmond, Terence J O'Brien

Journal article  |  2016  |  Epilepsy & Behavior

Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes

Xin L Tan, David K Wright, Shijie Liu, Christopher Hovens, Terence J O'Brien, Sandy R Shultz

Journal article  |  2016  |  Neuropharmacology

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones

Journal article  |  2016  |  Neurobiology of Disease

Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy

Michael S Hildebrand, Nicole G Griffin, John A Damiano, Elisa J Cops, Rosemary Burgess, Ezgi Ozturk, Nigel C Jones, Richard J Leventer, Jeremy L Freeman, A Simon Harvey, Lynette G Sadleir, Ingrid E Scheffer, Heather Major, Benjamin W Darbro, Andrew S Allen, David B Goldstein, John F Kerrigan, Samuel F Berkovic, Erin L Heinzen

Journal article  |  2016  |  The American Journal of Human Genetics

Deletion of the type-1 interferon receptor in APP(SWE)/PS1(Delta E9) mice preserves cognitive function and alters glial phenotype

Myles R Minter, Zachery Moore, Moses Zhang, Kate M Brody, Nigel C Jones, Sandy R Shultz, Juliet M Taylor, Peter J Crack

Journal article  |  2016  |  Acta Neuropathologica Communications

Potentiating the Strength of Extrasynaptic Currents by Neurosteroid Hormones

Nigel C Jones

Journal article  |  2016  |  Epilepsy Currents

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

Shi-jie Liu, Ping Zheng, David K Wright, Gabi Dezsi, Emma Braine, Nguyen Thanh, Niall M Corcoran, Leigh A Johnston, Christopher M Hovens, Jamie N Mayo, Matthew Hudson, Sandy R Shultz, Nigel C Jones, Terence J O'Brien

Journal article  |  2016  |  Brain

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

Ya Hui Hung, Mark Walterfang, Leonid Churilov, Lisa Bray, Laura H Jacobson, Kevin J Barnham, Nigel C Jones, Terence J O'Brien, Dennis Velakoulis, Ashley I Bush

Journal article  |  2016  |  Neurotherapeutics

Social dysfunction after pediatric traumatic brain injury: A translational perspective

Nicholas P Ryan, Cathy Catroppa, Celia Godfrey, Linda J Noble-Haeusslein, Sandy R Shultz, Terence J O'Brien, Vicki Anderson, Bridgette D Semple

Journal article  |  2016  |  Neuroscience & Biobehavioral Reviews

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

Stuart J McDonald, Mujun Sun, Denes V Agoston, Sandy R Shultz

Journal article  |  2016  |  Journal of Neuroinflammation

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O'Brien, NC Jones

Journal article  |  2016  |  Translational Psychiatry

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones

Journal article  |  2016  |  Epilepsia

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Kyria M Webster, David K Wright, Mujun Sun, Bridgette D Semple, Ezgi Ozturk, Donald G Stein, Terence J O'Brien, Sandy R Shultz

Journal article  |  2015  |  Journal of Neuroinflammation

In response: LQT, HCN, and epilepsy model

Kim L Powell, Terence J O'Brien

Journal article  |  2015  |  Epilepsia

Neuregulin 1 Expression and Electrophysiological Abnormalities in the Neuregulin 1 Transmembrane Domain Heterozygous Mutant Mouse

Leonora E Long, Paul Anderson, Elisabeth Frank, Alex Shaw, Shijie Liu, Xu-Feng Huang, Didier Pinault, Tim Karl, Terence J O'Brien, Cynthia Shannon Weickert, Nigel C Jones

Journal article  |  2015  |  PLOS ONE

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Sandy R Shultz, David K Wright, Ping Zheng, Ryan Stuchbery, Shi-Jie Liu, Maithili Sashindranath, Robert L Medcalf, Leigh A Johnston, Christopher M Hovens, Nigel C Jones, Terence J O'Brien

Journal article  |  2015  |  Brain

Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats

Sandy R Shultz, Noor AB Aziz, Li Yang, Mujun Sun, Derrick F MacFabe, Terence J O'Brien

Journal article  |  2015  |  Behavioural Brain Research

A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death

AI BUSH, J Chan, NC Jones, TJ O'Brien, P Kwan

Journal article  |  2015  |  Epilepsia

Memory Impairment in Rats after Desflurane Anesthesia is Age and Dose Dependent

Jennifer K Callaway, Nigel C Jones, Alistair G Royse, Colin F Royse

Journal article  |  2015  |  Journal of Alzheimer’s disease: JAD

Validation of a multigenic model to predict seizure control in newly treated epilepsy

Kanvel Shazadi, Slave Petrovski, Annie Roten, Hugh Miller, Richard M Huggins, Martin J Brodie, Munir Pirmohamed, Michael R Johnson, Anthony G Marson, Terence J O'Brien, Graeme J Sills

Journal article  |  2014  |  Epilepsy Research

Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg

Kim L Powell, Howard Tang, Caroline Ng, Isabelle Guillemain, Gabriel Dieuset, Gabi Dezsi, Nihan Carcak, Filiz Onat, Benoit Martin, Terence J O'Brien, Antoine Depaulis, Nigel C Jones

Journal article  |  2014  |  Epilepsia

Interaction between sex and early-life stress: Influence on epileptogenesis and epilepsy comorbidities

Nigel C Jones, Terence J O'Brien, Lionel Carmant

Journal article  |  2014  |  Neurobiology of Disease

Chronic administration of antipsychotics attenuates ongoing and ketamine-induced increases in cortical gamma oscillations

Paul M Anderson, Didier Pinault, Terence J O'Brien, Nigel C Jones

Journal article  |  2014  |  The International Journal of Neuropsychopharmacology

Effects of aberrant gamma frequency oscillations on prepulse inhibition

Nigel C Jones, Paul Anderson, Gil Rind, Caley Sullivan, Maarten van den Buuse, Terence J O'Brien

Journal article  |  2014  |  International Journal of Neuropsychopharmacology

Hyperphosphorylated Tau is Implicated in Acquired Epilepsy and Neuropsychiatric Comorbidities

Ping Zheng, Sandy R Shultz, Chris M Hovens, Dennis Velakoulis, Nigel C Jones, Terence J O'Brien

Journal article  |  2014  |  Molecular Neurobiology: a review journal

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Sandy R Shultz, Xin L Tan, David K Wright, Shijie J Liu, Bridgette D Semple, Leigh Johnston, Nigel C Jones, Andrew D Cook, John A Hamilton, Terence J O'Brien

Journal article  |  2014  |  Journal of Neurotrauma

The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien

Journal article  |  2014  |  Epilepsia

Neuroimaging the Epileptogenic Process

Sandy R Shultz, Terence J O'Brien, Maria Stefanidou, Ruben I Kuzniecky

Journal article  |  2014  |  Neurotherapeutics

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Kim L Powell, Nigel C Jones, Jeremy T Kennard, Caroline Ng, Vijay Urmaliya, Shannen Lau, Adora Tran, Thomas Zheng, Ezgi Ozturk, Gabi Dezsi, Ika Megatia, Lea M Delbridge, Didier Pinault, Christopher A Reid, Paul J White, Terence J O'Brien

Journal article  |  2014  |  Epilepsia

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones

Journal article  |  2014  |  Psychoneuroendocrinology

Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones

Journal article  |  2014  |  Neurobiology of Disease

DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

Ziv M Machnes, Tony CT Huang, Philip KY Chang, Raminder Gill, Nicholas Reist, Gabriella Dezsi, Ezgi Ozturk, Francois Charron, Terence J O'Brien, Nigel C Jones, R Anne McKinney, Moshe Szyf

Journal article  |  2013  |  PLoS One

Time-frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures

Jade Bayly, John Carino, Slave Petrovski, Michelle Smit, Dilini A Fernando, Anita Vinton, Bernard Yan, Jayavardhana R Gubbi, Marimuthu S Palaniswami, Terence J O'Brien

Journal article  |  2013  |  Epilepsia

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy

Rosemary C Harty, Tae Hwan Kim, Evan A Thomas, Lisa Cardamone, Nigel C Jones, Steven Petrou, Verena C Wimmer

Journal article  |  2013  |  Epilepsy Research

Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?

Sandy R Shultz, Lisa Cardamone, Ying R Liu, R Edward Hogan, Luigi Maccotta, David K Wright, Ping Zheng, Amelia Koe, Marie-Claude Gregoire, John P Williams, Rodney J Hicks, Nigel C Jones, Damian E Myers, Terence J O'Brien, Viviane Bouilleret

Journal article  |  2013  |  Epilepsia

Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy

Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien

Journal article  |  2013  |  PLoS One

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

Gabi Dezsi, Ezgi Ozturk, Davor Stanic, Kim L Powell, Hal Blumenfeld, Terence J O'Brien, Nigel C Jones

Journal article  |  2013  |  Epilepsia

Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?

L Cardamone, MR Salzberg, TJ O'Brien, NC Jones

Journal article  |  2013  |  British Journal of Pharmacology

Stress, epilepsy, and psychiatric comorbidity: How can animal models inform the clinic?

Nigel C Jones, Terence J O'Brien

Journal article  |  2013  |  Epilepsy and Behavior

Repeatedly stressed rats have enhanced vulnerability to amygdala kindling epileptogenesis

Nigel C Jones, Han Ee Lee, Meng Yang, Sandra M Rees, Margaret J Morris, Terence J O'Brien, Michael R Salzberg

Journal article  |  2013  |  Psychoneuroendocrinology

Reply to: Isoflurane is not necessarily the only cause of cognitive deficits

Jennifer K Callaway, Nigel C Jones, Colin F Royse

Journal article  |  2013  |  European Journal of Anaesthesiology

Antidepressant therapy in epilepsy: can treating the comorbidities affect the underlying disorder?

L CARDAMONE, MR Salzberg, TJ O'Brien, NC Jones

Journal article  |  2013  |  British Journal of Pharmacology

Sevoflurane Anesthesia Does Not Impair Acquisition Learning or Memory in the Morris Water Maze in Young Adult and Aged Rats

Jennifer K Callaway, Nigel C Jones, Alistair G Royse, Colin F Royse

Journal article  |  2012  |  Anesthesiology

Tissue plasminogen activator does not alter development of acquired epilepsy

Mei-Lyn Tan, Ashley Ng, Puneet S Pandher, Maithili Sashindranath, John A Hamilton, Stephen M Davis, Terence J O'Brien, Robert L Medcalf, Bernard Yan, Nigel C Jones

Journal article  |  2012  |  Epilepsia

THE PRESENCE OF THE CAV3.2 R1584P MUTATION IS ASSOCIATED WITH RESISTANCE TO KINDLING INDUCED CHANGE IN THE TRN NEURON FIRING PATTERN

N Carcak, T Zheng, NC Jones, L Van Raay, K Powell, F Onat, TJ O'Brien

Conference Proceedings  |  2012  |  EPILEPSIA

Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE

Bianca Jupp, John Williams, David Binns, Rodney J Hicks, Lisa Cardamone, Nigel Jones, Sandra Rees, Terence J O'Brien

Journal article  |  2012  |  Epilepsia

Acute administration of typical and atypical antipsychotics reduces EEG gamma power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in gamma power

Nigel C Jones, Maya Reddy, Paul Anderson, Michael R Salzberg, Terence J O'Brien, Didier Pinault

Journal article  |  2012  |  International Journal of Neuropsychopharmacology

Isoflurane induces cognitive deficits in the Morris water maze task in rats

Jennifer K Callaway, Nigel C Jones, Colin F Royse

Journal article  |  2012  |  European Journal of Anaesthesiology

Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments

Sandy R Shultz, Derrick F MacFabe, Kelly A Foley, Roy Taylor, Donald P Cain

Journal article  |  2012  |  Behavioural Brain Research

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

Nigel C Jones, Nguyen Thanh, Niall M Corcoran, Dennis Velakoulis, Tracy Chen, Robert Grundy, Terence J O'Brien, Christopher M Hovens

Journal article  |  2012  |  Neurobiology of Disease

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

Elizabeth Tringham, Kim L Powell, Stuart M Cain, Kristy Kuplast, Janette Mezeyova, Manjula Weerapura, Cyrus Eduljee, Xinpo Jiang, Paula Smith, Jerrie-Lynn Morrison, Nigel C Jones, Emma Braine, Gil Rind, Molly Fee-Maki, David Parker, Hassan Pajouhesh, Manjeet Parmar, Terence J O'Brien, Terrance P Snutch

Journal article  |  2012  |  Science Translational Medicine

Repeated Mild Lateral Fluid Percussion Brain Injury in the Rat Causes Cumulative Long-Term Behavioral Impairments, Neuroinflammation, and Cortical Loss in an Animal Model of Repeated Concussion

Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald Peter Cain

Journal article  |  2012  |  Journal of Neurotrauma

A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: Support for an animal model of concussion

Sandy R Shultz, Derrick F MacFabe, Kelly A Foley, Roy Taylor, Donald P Cain

Journal article  |  2011  |  Behavioural Brain Research

Confounding Neurodegenerative Effects of Manganese for In Vivo MR Imaging in Rat Models of Brain Insults

Viviane Bouilleret, Lisa Cardamone, Cyril Liu, Amelia S Koe, Ke Fang, John P Williams, Damian E Myers, Terence J O'Brien, Nigel C Jones

Journal article  |  2011  |  Journal of Magnetic Resonance Imaging

Early Life Stress Enhancement of Limbic Epileptogenesis in Adult Rats: Mechanistic Insights

Gaurav Kumar, Nigel C Jones, Margaret J Morris, Sandra Rees, Terence J O'Brien, Michael R Salzberg

Journal article  |  2011  |  PLoS One

Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells

Megan Chircop, Swetha Perera, Anna Mariana, Hui Lau, Maggie PC Ma, Jayne Gilbert, Nigel C Jones, Christopher P Gordon, Kelly A Young, Andrew Morokoff, Jennette Sakoff, Terence J O'Brien, Adam McCluskey, Phillip J Robinson

Journal article  |  2011  |  Molecular Cancer Therapeutics

THE ENDURING EFFECTS OF EARLY-LIFE STRESS ON LIMBIC EPILEPTOGENESIS ARE MEDIATED BY HPA AXIS HYPERREACTIVITY

M Salzberg, A Koe, TJ O'Brien, MJ Morris, NC Jones

Conference Proceedings  |  2011  |  EPILEPSIA

Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia

Michael R Barnes, Julie Huxley-Jones, Peter R Maycox, Mark Lennon, Amy Thornber, Fiona Kelly, Stewart Bates, Adam Taylor, Juliet Reid, Neil Jones, Joern Schroeder, Carol A Scorer, Ceri Davies, Jim J Hagan, James NC Kew, Claire Angelinetta, Tariq Akbar, Steven Hirsch, Ann M Mortimer, Thomas RE Barnes, et al.

Journal article  |  2011  |  Journal of Neuroscience Research

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Maithili Sashindranath, Andre Laval Samson, Catherine Eliza Downes, Peter John Crack, Andrew John Lawrence, Qiao-Xin Li, Ashley Quan Ping Ng, Nigel Charles Jones, Jessica Jade Farrugia, Eman Abdella, Jean-Dominique Vassalli, Rime Madani, Robert Lindsay Medcalf

Journal article  |  2011  |  Laboratory Investigation

Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures

Nigel C Jones, Terence J O'Brien, Kim L Powell

Journal article  |  2011  |  Neuroscience Letters

Electrophysiological insights into the enduring effects of early life stress on the brain

Idrish Ali, Michael R Salzberg, Chris French, Nigel C Jones

Journal article  |  2011  |  Psychopharmacology

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Ying R Liu, Lisa Cardamone, R Edward Hogan, Marie-Claude Gregoire, John P Williams, Rod J Hicks, David Binns, Amelia Koe, Nigel C Jones, Damian E Myers, Terence J O'Brien, Viviane Bouilleret

Journal article  |  2010  |  Journal of Nuclear Medicine

Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients

S Petrovski, CEI Szoeke, NC Jones, MR Salzberg, LJ Sheffield, RM Huggins, TJ O'Brien

Journal article  |  2010  |  Neurology

A genetic epilepsy rat model displays endophenotypes of psychosis

Nigel C Jones, Sally Martin, Ika Megatia, Tahir Hakami, Michael R Salzberg, Didier Pinault, Margaret J Morris, Terence J O'Brien, Maarten van den Buuse

Journal article  |  2010  |  Neurobiology of Disease

Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes

Bernard Zinman, Steven M Haffner, William H Herman, Rury R Holman, John M Lachin, Barbara G Kravitz, Gitanjali Paul, Nigel P Jones, R Paul Aftring, Giancarlo Viberti, Steven E Kahn

Journal article  |  2010  |  The Journal of Clinical Endocrinology & Metabolism

REPEATED RESTRAINT STRESS ACCELERATES ELECTRICAL AMYGDALA KINDLING IN RATS

NC Jones, HE Lee, G Kumar, MJ Morris, SM Rees, TJ O'Brien, MR Salzberg

Conference Proceedings  |  2009  |  EPILEPSIA

ACCELERATED LIMBIC EPILEPTOGENESIS FOLLOWING EARLY LIFE STRESS IS ASSOCIATED WITH ENHANCED CORTICOSTERONE RESPONSE, HIPPOCAMPAL CELL LOSS AND NEUROGENESIS

Gaurav Kumar, NC Jones, SM Rees, MJ Morris, TJ O'Brien, MJ Salzberg

Conference Proceedings  |  2009  |  EPILEPSIA

In-vivo imaging with small animal FDG-PET: A tool to unlock the secrets of epileptogenesis?

Terence J O'Brien, Bianca Jupp

Journal article  |  2009  |  Experimental Neurology

A PRE-TREATMENT NEUROCOGNITIVE QUESTIONNAIRE PROVIDES PREDICTIVE VALUE FOR SEIZURE RECURRENCE IN NEWLY TREATED EPILEPSY

Slave Petrovski, CE Szoeke, NC Jones, MR Salzberg, RJ Panelli, RM Huggins, TJ O'Brien

Conference Proceedings  |  2009  |  EPILEPSIA

ACCELERATED LIMBIC EPILEPTOGENESIS FOLLOWING EARLY LIFE STRESS IS ASSOCIATED WITH ENHANCED CORTICOSTERONE RESPONSE, HIPPOCAMPAL CELL LOSS AND NEUROGENESIS

Gaurav Kumar, NC Jones, SM Rees, MJ Morris, TJ O'Brien, MJ Salzberg

Conference Proceedings  |  2009  |  EPILEPSIA

ENVIRONMENTAL ENRICHMENT DELAYS THE ONSET OF LIMBIC EPILEPSY AND IMPROVES ANXIETY-LIKE AND NEUROCOGNITIVE BEHAVIOURS

Meng Yang, MR Salzberg, SM Rees, TJ O'Brien, NC Jones

Conference Proceedings  |  2009  |  EPILEPSIA

Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats

Nigel C Jones, Gaurav Kumar, Terence J O'Brien, Margaret J Morris, Sandra M Rees, Michael R Salzberg

Journal article  |  2009  |  Behavioural Brain Research

A regulatory role for protease-activated receptor-2 in motivational learning in rats

Rink-Jan Lohman, Nigel C Jones, Terence J O'Brien, Thomas M Cocks

Journal article  |  2009  |  Neurobiology of Learning and Memory

RESTRAINT STRESS ACCELERATES AMYGDALA KINDLING EPILEPTOGENESIS IN RATS

M Salzberg, HE Lee, G Kumar, M Morris, S Rees, T O'Brien, N Jones

Conference Proceedings  |  2009  |  EPILEPSIA

NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant gamma Oscillations Independent of Hyperlocomotion and the State of Consciousness

Tahir Hakami, Nigel C Jones, Elena A Tolmacheva, Julien Gaudias, Joseph Chaumont, Michael Salzberg, Terence J O'Brien, Didier Pinault

Journal article  |  2009  |  PLoS One

Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?

Viviane Bouilleret, R Edward Hogan, Dennis Velakoulis, Michael R Salzberg, Lei Wang, Gary F Egan, Terence J O'Brien, Nigel C Jones

Journal article  |  2009  |  Neuroimage

Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Amelia S Koe, Nigel C Jones, Michael R Salzberg

Journal article  |  2009  |  Frontiers in Behavioral Neuroscience

Experimental Traumatic Brain Injury Induces a Pervasive Hyperanxious Phenotype in Rats

Nigel C Jones, Lisa Cardamone, John P Williams, Michael R Salzberg, Damian Myers, Terence J O'Brien

Journal article  |  2008  |  Journal of Neurotrauma

The cost-effective use of F-18-FDG PET in the presurgical evaluation of medically refractory focal epilepsy

Terence J O'Brien, Ken Miles, Robert Ware, Mark J Cook, David S Binns, Rodney J Hicks

Journal article  |  2008  |  Journal of Nuclear Medicine

MATERNAL SEPARATION STRESS-INDUCED ENHANCEMENT OF KINDLING EPILEPTOGENESIS IS ASSOCIATED WITH HEIGHTENED CORTICOSTERONE RESPONSES AND CA3C HIPPOCAMPAL CELL LOSS

Gaurav Kumar, NC Jones, Gaurav Kumar, MJ Morris, SM Ress, Terence J O'Brien, MR Salzberg

Conference Proceedings  |  2008  |  EPILEPSIA

Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation

Nigel C Jones, Michael R Salzberg, Gaurav Kumar, Abble Couper, Margaret J Morris, Terence J O'Brien

Journal article  |  2008  |  Experimental Neurology

BRAIN AND HEART LINKS: ALTERATIONS IN CARDIAC FUNCTION AND HCN CHANNEL EXPRESSION IN GENETIC ABSENCE EPILEPSY RATS FROM STRASBOURG

Ika Megatia, NC Jones, Didier Pinault, Terence J O'Brien, Kim L Powell

Conference Proceedings  |  2008  |  EPILEPSIA

Early postnatal stress confers enduring vulnerability to limbic epileptogenesis

Michael Salzberg, Gaurav Kumar, Laureen Supit, Nigel C Jones, Margaret J Morris, Sandra Rees, Terence J O'Brien

Journal article  |  2007  |  Epilepsia

Psychosis-like behavior in a genetic rat model of absence epilepsy

Nigel C Jones, TJ O'Brien, MR Salzberg, MJ Morris, M Van den Buuse

Conference Proceedings  |  2007  |  EPILEPSIA

The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors

Gaurav Kumar, Abble Couper, Terence J O'Brien, Michael R Salzberg, Nigel C Jones, Sandra M Rees, Margaret J Morris

Journal article  |  2007  |  Psychoneuroendocrinology

Early postnatal separation stress enhances vulnerability to later limbic epileptogenesis in young adult female but not male rats

G Kumar, N Jones, M Morris, T O'Brien, M Salzberg

Conference Proceedings  |  2007  |  EPILEPSIA

Evidence for co-morbid psychotic-like behaviour in a genetic rat model of absence epilepsy

N Jones, M van den Buuse, M Salzberg, M Morris, T O'Brien

Conference Proceedings  |  2007  |  EPILEPSIA

Early postnatal separation stress enhances vulnerability to later limbic epileptogenesis in young adult rats

Gaurav Kumar, Laureen Supit, Nigel C Jones, Margaret J Morris, Abbie J Coupar, Sandra M Rees, Terence J O'Brien, Michael R Salzberg

Conference Proceedings  |  2006  |  EPILEPSIA

The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors

Gaurav Kumar, Nigel C Jones, Michael R Salzberg, Sandra M Rees, Abbie J Coupar, Terence J O'Brien, Margaret J Morris

Conference Proceedings  |  2006  |  EPILEPSIA

Increased depressive and anxiety-like behaviors are seen in the GAERS rat model of genetic absence epilepsy

Nigel C Jones, Gaurav Kumar, Michael R Salzberg, Margaret J Morris, Sandra M Rees, Terence J O'Brien

Conference Proceedings  |  2006  |  EPILEPSIA

G-CSF suppresses edema formation and reduces interleukin-1 beta expression after cerebral ischemia in mice

CL Gibson, NC Jones, MJW Prior, PMW Bath, SP Murphy

Journal article  |  2005  |  Journal of Neuropathology and Experimental Neurology

Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes

NC Jones, MJW Prior, E Burden-Teh, CA Marsden, PG Morris, S Murphy

Journal article  |  2005  |  European Journal of Neuroscience

The neuroprotective effect of progesterone after traumatic brain injury in male mice is independent of both the inflammatory response and growth factor expression

NC Jones, D Constantin, MJW Prior, PG Morris, CA Marsden, S Murphy

Journal article  |  2005  |  European Journal of Neuroscience

A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury

NC Jones, D Constantin, CL Gibson, MJW Prior, PG Morris, CA Marsden, S Murphy

Journal article  |  2004  |  Journal of Neuropathology and Experimental Neurology