Nigel Jones

Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy

Kim L Powell, Zining Liu, Claire L Curl, Antonia JA Raaijmakers, Pragati Sharma, Emma L Braine, Flavia M Gomes, Shobi Sivathamboo, Vaughan G Macefield, Pablo M Casillas-Espinosa, Nigel C Jones, Lea M Delbridge, Terence J O'Brien

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

OBJECTIVE: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilept..

Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy

Juliana C Silva, Lucy Vivash, Charles B Malpas, Yong Hao, Catriona McLean, Zhibin Chen, Terence J O'Brien, Nigel C Jones, Patrick Kwan

Journal article  |  2021  |  EPILEPSIA

OBJECTIVE: Cognitive impairment is common in patients with chronic drug-resistant temporal lobe epilepsy (TLE). Hyperphosphorylate..

Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease

Hattapark Dejakaisaya, Patrick Kwan, Nigel C Jones

Journal article  |  2021  |  EPILEPSIA

Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10-fold compared to healthy age-matched controls. However, the..

Altered metabolic pathways in a transgenic mouse model suggest mechanistic role of amyloid precursor protein overexpression in Alzheimer's disease

Hattapark Dejakaisaya, Anna Harutyunyan, Patrick Kwan, Nigel C Jones

Journal article  |  2021  |  METABOLOMICS

INTRODUCTION: The mechanistic role of amyloid precursor protein (APP) in Alzheimer's disease (AD) remains unclear. OBJECTIVES: Her..

Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer

Matthew Drill, Nigel C Jones, Martin Hunn, Terence J O'Brien, Mastura Monif

Journal article  |  2021  |  PURINERGIC SIGNALLING

The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular func..

Microglial Cells in Epilepsy: Not That Bad After All?

Nigel C Jones

Journal article  |  2020  |  EPILEPSY CURRENTS

Microglial Depletion Aggravates the Severity of Acute and Chronic Seizures in Mice Wu W, Li Y, Wei Y, et al. Brain Behav Immun. 20..

Cardiorespiratory and autonomic function in epileptic seizures: A video-EEG monitoring study

Shobi Sivathamboo, Thomas N Constantino, Zhibin Chen, Paul B Sparks, Jeremy Goldin, Dennis Velakoulis, Nigel C Jones, Patrick Kwan, Vaughan G Macefield, Terence J O'Brien, Piero Perucca

Journal article  |  2020  |  EPILEPSY & BEHAVIOR

PURPOSE: Seizure-induced cardiorespiratory and autonomic dysfunction has long been recognized, and growing evidence points to its ..

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  SCIENTIFIC REPORTS

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7..

Acute NMDA Receptor Antagonism Impairs Working Memory Performance but Not Attention in Rats-Implications for the NMDAr Hypofunction Theory of Schizophrenia

Jaime Lee, Maarten van den Buuse, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2020  |  BEHAVIORAL NEUROSCIENCE

Cognitive deficits in schizophrenia, which include impairments in working memory and attention, represent some of the most disabli..

MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV plus interneurons or forebrain pyramidal cells

Elysia Sokolenko, Jess Nithianantharajah, Nigel C Jones

Journal article  |  2020  |  NEUROPHARMACOLOGY

NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: ..