Graham Brown

The significance and expectations of HIV cure research among people living with HIV in Australia

Jennifer Power, Gary W Dowsett, Andrew Westle, Joseph D Tucker, Sophie Hill, Jeremy Sugarman, Sharon R Lewin, Graham Brown, Jayne Lucke

Journal article  |  2020  |  PLOS ONE

Most people living with HIV (PLHIV) with reliable access to antiretroviral treatment (ART) have a life expectancy similar to uninf..

The &ITPlasmodium falciparum &ITtranscriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding &ITvar &ITgenes

Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy

Journal article  |  2018  |  PLOS BIOLOGY

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment..

Sources of information-seeking on sexually transmitted infections and safer sex by older heterosexual Australian men and women

Anthony Lyons, Gosia Mikolajczak, Wendy Heywood, B Fileborn, Victor Minichiello, Sharon Hinchliff, Sue Malta, Briony Dow, Catherine Barrett, Graham Brown

Journal article  |  2018  |  Educational Gerontology

Sexually transmitted infections (STIs) have risen among older people in Australia and other countries. To guide future initiatives..

Safer Sex in Later Life: Qualitative Interviews With Older Australians on Their Understandings and Practices of Safer Sex

Bianca Fileborn, Graham Brown, Anthony Lyons, Sharron Hinchliff, Wendy Heywood, Victor Minichiello, Sue Malta, Catherine Barrett, Pauline Crameri

Journal article  |  2018  |  JOURNAL OF SEX RESEARCH

Rates of sexually transmitted infections (STIs) are increasing in older cohorts in Western countries such as Australia, the United..

Activation and clustering of a Plasmodium falciparum var gene are affected by subtelomeric sequences

Michael F Duffy, Jingyi Tang, Fransisca Sumardy, Hanh HT Nguyen, Shamista A Selvarajah, Gabrielle A Josling, Karen P Day, Michaela Petter, Graham V Brown

Journal article  |  2017  |  FEBS JOURNAL

The Plasmodium falciparum var multigene family encodes the cytoadhesive, variant antigen PfEMP1. P. falciparum antigenic variation..

Functional Antibodies and Protection against Blood-Stage Malaria

Andrew Teo, Gaoqian Feng, Graham V Brown, James G Beeson, Stephen J Rogerson

Journal article  |  2016  |  TRENDS IN PARASITOLOGY

Numerous efforts to understand the functional roles of antibodies demonstrated that they can protect against malaria. However, it ..

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Michael F Duffy, Rintis Noviyanti, Takafumi Tsuboi, Zhi-Ping Feng, Leily Trianty, Boni F Sebayang, Eizo Takashima, Fransisca Sumardy, Daniel A Lampah, Louise Turner, Thomas Lavstsen, Freya JI Fowkes, Peter Siba, Stephen J Rogerson, Thor G Theander, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Graham V Brown, Anthony T Papenfuss

Journal article  |  2016  |  MALARIA JOURNAL

BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic..

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

Gabrielle A Josling, Michaela Petter, Sophie C Oehring, Archna P Gupta, Olivier Dietz, Danny W Wilson, Thomas Schubert, Gernot Laengst, Paul R Gilson, Brendan S Crabb, Suzette Moes, Paul Jenoe, Shu Wei Lim, Graham V Brown, Zbynek Bozdech, Till S Voss, Michael F Duffy

Journal article  |  2015  |  CELL HOST & MICROBE

During red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes repeated rounds of replication, egress, and..

Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Andrew Teo, Wina Hasang, Louise M Randall, Holger W Unger, Peter M Siba, Ivo Mueller, Graham V Brown, Stephen J Rogerson

Journal article  |  2015  |  MALARIA JOURNAL

BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic..

High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancy

Caroline Lin Lin Chua, Leanne J Robinson, Francesca Baiwog, Danielle I Stanisic, John A Hamilton, Graham V Brown, Stephen J Rogerson, Philippe Boeuf

Journal article  |  2015  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

During gestational malaria, Plasmodium falciparum-infected erythrocytes can sequester within the placenta, contributing to poor pr..