Laura Vella

ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism

Leah C Beauchamp, Xiang M Liu, Laura J Vella, Paul A Adlard, Ashley Bush, David Finkelstein, Kevin J Barnham

Journal article  |  2022  |  NEUROTHERAPEUTICS

Hyposmia is a prevalent prodromal feature of Parkinson's disease (PD), though the neuropathology that underlies this symptom is po..

Extracellular vesicular lipids as biomarkers for the diagnosis of Alzheimer’s disease

Huaqi Su, Yepy H Rustam, Colin L Masters, Enes Makalic, Catriona McLean, Andrew F Hill, Kevin J Barnham, Gavin E Reid, Laura J Vella

Journal article  |  2021  |  Alzheimer's & Dementia

An increasing number of studies have revealed that dysregulated lipid homeostasis is associated with the pathological processes th..

Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain

Rinie Bajracharya, Alayna C Caruso, Laura J Vella, Rebecca M Nisbet

Journal article  |  2021  |  PHARMACEUTICS

For the treatment of neurological diseases, achieving sufficient exposure to the brain parenchyma is a critical determinant of dru..

Quantitative proteomics of detergent insoluble tangles derived from Alzheimer's disease brains

S Mukherjee, C Dubois, K Perez, RM Nisbet, QX Li, S Varghese, LC Lago, S Klatt, I Birchall, L Jin, C McLean, V Streltsov, KJ Barnham, LJ Vella, CL Masters

Journal article  |  2021  |  Alzheimer's & dementia : the journal of the Alzheimer's Association

BACKGROUND: Ionic detergent N-laurly sarcosine (Sarkosyl) has been the general choice of extraction and enrichment of detergent-in..

Citrullination of Amyloid-beta Peptides in Alzheimer's Disease

Soumya Mukherjee, Keyla A Perez, Celine Dubois, Rebecca M Nisbet, Qiao-Xin Li, Shiji Varghese, Liang Jin, Ian Birchall, Victor A Streltsov, Laura J Vella, Catriona McLean, Kevin J Barham, Blaine R Roberts, Colin L Masters

Journal article  |  2021  |  ACS CHEMICAL NEUROSCIENCE

Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullinatio..

Characterization of brain-derived extracellular vesicle lipids in Alzheimer's disease

Huaqi Su, Yepy H Rustam, Colin L Masters, Enes Makalic, Catriona A McLean, Andrew F Hill, Kevin J Barnham, Gavin E Reid, Laura J Vella

Journal article  |  2021  |  JOURNAL OF EXTRACELLULAR VESICLES

Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been ..

The function and composition of brain tissue derived exosomes in human Alzheimer’s disease

Laura J Vella, Huaqi Su, Tiana Koukoulis, Lesley Cheng, Adityas Purnianto, Leah Beauchamp, Catriona McLean, Ashley I Bush, Colin L Masters, Gavin Reid, Andrew F Hill, Kevin J Barnham

Journal article  |  2020  |  Alzheimer's & Dementia

The role of dopamine mis-metabolism in preclinical Parkinson's disease olfactory deficits

L Beauchamp, L Vella, A Bush, K Barnham

Conference Proceedings  |  2020  |  MOVEMENT DISORDERS

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Natasha Vassileff, Laura J Vella, Harinda Rajapaksha, Mitch Shambrook, Amirmohammad Nasiri Kenari, Catriona McLean, Andrew F Hill, Lesley Cheng

Journal article  |  2020  |  CELLS

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the mo..

S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau

Leah C Beauchamp, Xiang M Liu, Amelia Sedjahtera, Mirjana Bogeski, Laura J Vella, Ashley Bush, Paul A Adlard, Kevin J Barnham

Journal article  |  2020  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: Alterations in the methionine cycle and abnormal tau phosphorylation are implicated in many neurodegenerative diseases..