Laura Vella

The function and composition of brain tissue derived exosomes in human Alzheimer’s disease

Laura J Vella, Huaqi Su, Tiana Koukoulis, Lesley Cheng, Adityas Purnianto, Leah Beauchamp, Catriona McLean, Ashley I Bush, Colin L Masters, Gavin Reid, Andrew F Hill, Kevin J Barnham

Journal article  |  2020  |  Alzheimer's & Dementia

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

Lesley Cheng, Laura J Vella, Kevin J Barnham, Catriona McLean, Colin L Masters, Andrew F Hill

Journal article  |  2020  |  JOURNAL OF EXTRACELLULAR VESICLES

Alzheimer's disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinica..

Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders

T Yap, C Seers, K Koo, L Cheng, LJ Vella, AF Hill, E Reynolds, A Nastri, N Cirillo, M McCullough

Journal article  |  2019  |  ORAL ONCOLOGY

INTRODUCTION: We have previously shown that oral swirls are a robust source of microRNA protected by extracellular vesicles, poten..

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated ..

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K Atkin-Smith, D Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N Bauer, Amy A Baxter, Mary Bebawy, Carla Beckham, et al.

Journal article  |  2019  |  JOURNAL OF EXTRACELLULAR VESICLES

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological funct..

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough

Journal article  |  2018  |  CANCER PREVENTION RESEARCH

Oral swirls are a noninvasive, rapidly collected source of salivary microRNA (miRNA) potentially useful in the early detection of ..

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnham

Journal article  |  2018  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Parkinson's disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic ..

Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle-Associated PDGFR beta

Laura J Vella, Andreas Behren, Bradley Coleman, David W Greening, Andrew F Hill, Jonathan Cebon

Journal article  |  2017  |  NEOPLASIA

Treatment of BRAF mutant melanoma with kinase inhibitors has been associated with rapid tumor regression; however, this clinical b..

A rigorous method to enrich for exosomes from brain tissue

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill

Journal article  |  2017  |  JOURNAL OF EXTRACELLULAR VESICLES

Extracellular vesicles, including exosomes, are released by all cells, including those of the nervous system. Capable of deliverin..

Generation of Infectious Prions and Detection with the Prion-Infected Cell Assay

Laura J Vella, Bradley Coleman, Andrew F Hill

Journal article  |  2017  |  PRIONS: METHODS AND PROTOCOLS

Cell lines propagating prions are an efficient and useful means for studying the cellular and molecular mechanisms implicated in p..