Suzanne Golub

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

SJ Gauci, SB Golub, L Tatarczuch, E Lee, D Chan, NC Walsh, CB Little, H Stanton, Z Lokmic, NA Sims, EJ Mackie, AJ Fosang

Journal article  |  2019  |  Matrix Biology

Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ..

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5

Fraser M Rogerson, Karena Last, Suzanne B Golub, Stephanie J Gauci, Heather Stanton, Katrina M Bell, Amanda J Fosang

Journal article  |  2019  |  International Journal of Molecular Sciences

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Rachel E Miller, Shingo Ishihara, Phuong B Tran, Suzanne B Golub, Karena Last, Richard J Miller, Amanda J Fosang, Anne-Marie Malfait

Journal article  |  2018  |  JCI Insight

A 32-MER FRAGMENT OF AGGRECAN PROMOTES KNEE HYPERALGESIA IN THE DMM MODEL OF OSTEOARTHRITIS THROUGH DIRECT NOCICEPTOR ACTIVATION VIA TLR2

RE Miller, RJ Miller, S Ishihara, A Belmadani, SB Golub, AJ Fosang, A-M Malfait

Conference Proceedings  |  2016  |  Osteoarthritis and Cartilage

Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation

Richard Wilson, Suzanne B Golub, Lynn Rowley, Constanza Angelucci, Yuliya V Karpievitch, John F Bateman, Amanda J Fosang

Journal article  |  2016  |  Journal of Proteome Research

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

Hansen J Kosasih, Karena Last, Fraser M Rogerson, Suzanne B Golub, Stephanie J Gauci, Vincenzo C Russo, Heather Stanton, Richard Wilson, Shireen R Lamande, Paul Holden, Amanda J Fosang

Journal article  |  2016  |  Journal of Biological Chemistry

A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons

Rachel E Miller, Richard J Miller, Abdelhak Belmadani, Suzanne Golub, Amanda J Fosang, Anne-Marie Malfait

Journal article  |  2015  |  ARTHRITIS & RHEUMATOLOGY

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

Sophie Lees, Suzanne B Golub, Karena Last, Weiguang Zeng, David C Jackson, Philip Sutton, Amanda J Fosang

Journal article  |  2015  |  Arthritis & Rheumatology

PPARDELTA PROMOTES THE PROGRESSION OF POST-TRAUMATIC OSTEOARTHRITIS

A Ratneswaran, I Welch, SB Golub, AJ Fosang, F Beier

Conference Proceedings  |  2015  |  Osteoarthritis and Cartilage

BIOACTIVITY IN AN AGGRECAN 32MER FRAGMENT IS MEDIATED VIA TOLL-LIKE RECEPTORS

AJ Fosang, SB Golub, K Last, S Lees, R Wilson, A Aspberg, CB Little, P Sutton

Conference Proceedings  |  2014  |  Osteoarthritis and Cartilage

Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2al-Cre; ROSA26R(Lacz) reporter mice

AJ Fosang, SB Golub, CJ East, FM Rogerson

Journal article  |  2013  |  Osteoarthritis and Cartilage

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

Edward R Bastow, Karena Last, Sue Golub, Jennifer L Stow, Amanda C Stanley, Amanda J Fosang

Journal article  |  2012  |  Biology Open

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage

Heather Stanton, Suzanne B Golub, Fraser M Rogerson, Karena Last, Christopher B Little, Amanda J Fosang

Journal article  |  2011  |  Nature Protocols

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

Amanda J Fosang, Karena Last, Heather Stanton, Suzanne B Golub, Christopher B Little, Lorena Brown, David C Jackson

Book Chapter  |  2010  |  Methods in Molecular Biology

Disturbed endochondral ossification in collagen II knockin mice resistant to collagenase cleavage

SJ Gauci, SB Golub, D Chan, AJ Fosang

Conference Proceedings  |  2009  |  INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair (Journal of Clinical Investigation (2008) 117, (1627-1636) DOI: 10.1172/JCI30765)

CB Little, CT Meeker, SB Golub, KE Lawlor, PJ Farmer, SM Smith, AJ Fosang

Journal article  |  2008  |  Journal of Clinical Investigation

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair (vol 117, pg 1627, 2007)

Christopher B Little, Clare T Meeker, Suzanne B Golub, Kate E Lawlor, Pamela J Farmer, Susan M Smith, Amanda J Fosang

Journal article  |  2008  |  Journal of Clinical Investigation

Evidence of a novel aggrecan-degrading activity in cartilage - Studies of mice deficient in both ADAMTS-4 and ADAMTS-5

Fraser M Rogerson, Heather Stanton, Charlotte J East, Suzanne B Golub, Leonie Tutolo, Pamela J Farmer, Amanda J Fosang

Journal article  |  2008  |  Arthritis and Rheumatism

Hyaluronan synthesis and degradation in cartilage and bone

ER Bastow, S Byers, SB Golub, CE Clarkin, AA Pitsillides, AJ Fosang

Journal article  |  2008  |  Cellular and Molecular Life Sciences

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage

SJ GAUCI, S GOLUB, L TUTOLO, CB LITTLE, N SIMS, ER LEE, E MACKIE, A FOSANG

Journal article  |  2008  |  The Journal of Musculoskeletal and Neuronal Interactions

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan

Charlotte J East, Heather Stanton, Suzanne B Golub, Fraser M Rogerson, Amanda J Fosang

Journal article  |  2007  |  Journal of Biological Chemistry

Aggrecan catabolism in mice lacking both ADAMTS-4 and ADAMTS-5 activities: evidence for another aggrecanase in cartilage

F ROGERSON, CJ East, S GOLUB, H STANTON, A FOSANG

Conference Proceedings  |  2007  |  Trans Orth Res Soc 2007

Lypsosomal exocytosis in hypertrophic chondrocytes

E BASTOW, R Wilson, S GOLUB, A FOSANG

Conference Proceedings  |  2007  |  Trans Orth Res Soc 2007

Characterisation of a knock-in mouse with type 11collagen resistant to collagenase

SJ Gauci, S GOLUB, LM Kurth, C LITTLE, A FOSANG

Conference Proceedings  |  2007  |  Trans. Orthp.Res. Soc.

Is ADAMTS-5 the only aggrecanase in mouse cartilage?

CJ East, H Stanton, FM Rogerson, SB Golub, AJ Fosang

Conference Proceedings  |  2006  |  European Cells and Materials

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

CB Little, CT Meeker, RM Hembry, NA Sims, KE Lawlor, SB Golub, K Last, AJ Fosang

Journal article  |  2005  |  Molecular and Cellular Biology

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

H Stanton, FM Rogerson, CJ East, SB Golub, KE Lawlor, CT Meeker, CB Little, K Last, PJ Farmer, IK Campbell, AM Fourie, AJ Fosang

Journal article  |  2005  |  Nature

ADAMTS-5 is the major aggrecanase in cartilage: In vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice

H STANTON, CJ East, S GOLUB, F ROGERSON, K LAWLOR, C LITTLE, A FOSANG

Conference Proceedings  |  2005  |  Trans Orth Res Soc 2005

Site-directed mutagenesis of human type X collagen - Expression of alpha 1(X) NC1, NC2, and helical mutations in vitro and in transfected cells

D Chan, YM Weng, AM Hocking, S Golub, DJ McQuillan, JF Bateman

Journal article  |  1996  |  Journal of Biological Chemistry

Type X collagen NC1 mutations produced by site-directed mutagenesis prevent in vitro assembly

D Chan, YM Weng, S Golub, JF Bateman

Conference Proceedings  |  1996  |  Annals of the New York Academy of Sciences

ENDOPLASMIC RETICULUM-MEDIATED QUALITY-CONTROL OF TYPE-I COLLAGEN PRODUCTION BY CELLS FROM OSTEOGENESIS IMPERFECTA PATIENTS WITH MUTATIONS IN THE PRO-ALPHA-1(I) CHAIN CARBOXYL-TERMINAL PROPEPTIDE WHICH IMPAIR SUBUNIT ASSEMBLY

SR LAMANDE, SD CHESSLER, SB GOLUB, PH BYERS, D CHAN, WG COLE, DO SILLENCE, JF BATEMAN

Journal article  |  1995  |  Journal of Biological Chemistry

DEPOSITION AND SELECTIVE DEGRADATION OF STRUCTURALLY-ABNORMAL TYPE-1 COLLAGEN IN A COLLAGEN MATRIX PRODUCED BY OSTEOGENESIS IMPERFECTA FIBROBLASTS IN-VITRO

JF BATEMAN, SB GOLUB

Journal article  |  1994  |  Matrix Biology

ASSESSMENT OF PROCOLLAGEN PROCESSING DEFECTS BY FIBROBLASTS CULTURED IN THE PRESENCE OF DEXTRAN SULFATE

JF BATEMAN, SB GOLUB

Journal article  |  1990  |  Biochemical Journal