Kesha Rana

Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann

Journal article  |  2017  |  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice

Rachel A Davey, Michele V Clarke, Patricia K Russell, Kesha Rana, Jane Seto, Kelly N Roeszler, Jackie MY How, Ling Yeong Chia, Kathryn North, Jeffrey D Zajac

Journal article  |  2017  |  ENDOCRINOLOGY

Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data fr..

Muscle-specific androgen receptor deletion shows limited actions in myoblasts but not in myofibers in different muscles in vivo

Kesha Rana, Maria WS Chiu, Patricia K Russell, Jarrod P Skinner, Nicole KL Lee, Barbara C Fam, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2016  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

The aim of this study was to investigate the direct muscle cell-mediated actions of androgens by comparing two different mouse lin..

Expression of androgen receptor target genes in skeletal muscle

Kesha Rana, Nicole KL Lee, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2014  |  ASIAN JOURNAL OF ANDROLOGY

We aimed to determine the mechanisms of the anabolic actions of androgens in skeletal muscle by investigating potential androgen r..

Human androgen deficiency: insights gained from androgen receptor knockout mouse models

Kesha Rana, Rachel A Davey, Jeffrey D Zajac

Journal article  |  2014  |  ASIAN JOURNAL OF ANDROLOGY

The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens..

Normal phenotype in conditional androgen receptor (AR) exon 3-floxed neomycin-negative male mice

Kesha Rana, Michele V Clarke, Jeffrey D Zajac, Rachel A Davey, Helen E MacLean

Journal article  |  2014  |  ENDOCRINE RESEARCH

Androgens (testosterone and dihydrotestosterone) acting via the androgen receptor (AR) are required for male sexual differentiatio..

Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii)

Damian G D'Souza, Kesha Rana, Kristi M Milley, Helen E MacLean, Jeffrey D Zajac, Justin Bell, Sydney Brenner, Byrappa Venkatesh, Samantha J Richardson, Janine A Danks

Journal article  |  2013  |  GENERAL AND COMPARATIVE ENDOCRINOLOGY

Jawed vertebrates (Gnasthostomes) are broadly separated into cartilaginous fishes (Chondricthyes) and bony vertebrates (Osteichthy..

Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance

Kesha Rana, Barbara C Fam, Michele V Clarke, Tammy PS Pang, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2011  |  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In men, as testosterone levels decrease, fat mass increases and muscle mass decreases. Increased fat mass in men, in particular ce..

DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females

Helen E MacLean, Alison J Moore, Stephen A Sastra, Howard A Morris, Ali Ghasem-Zadeh, Kesha Rana, Anna-Maree Axell, Amanda J Notini, David J Handelsman, Ego Seeman, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2010  |  JOURNAL OF ENDOCRINOLOGY

We used our genomic androgen receptor (AR) knockout (ARKO) mouse model, in which the AR is unable to bind DNA to: 1) document gend..

Increased Adiposity in Global Androgen Receptor Knockout (ARKO) Mice Indicates That Androgens Regulate Fat Mass Via the Androgen Receptor in Males

Kesha Rana, Barbara C Fam, Sofianos Andrikopoulos, Jeffrey D Zajac, Helen E Maclean

Conference Proceedings  |  2009  |  DIABETES