Tracy Nero

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  NATURE METABOLISM

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments

Marcos Perini, Rhynelle S Dmello, Tracy L Nero, Ashwini L Chand

Journal article  |  2020  |  PHARMACOLOGY & THERAPEUTICS

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cellular membrane receptors identified and character..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  CELL HOST & MICROBE

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is compose..

Abstract 4962: Repurposingbazedoxifeneto suppress gastrointestinal cancer growth

Pathum Thilakasiri, Tracy Nero, Michael W Parker, Matthias Ernst, Ashwini L Chand

Conference Proceedings  |  2019  |  Immunology

Repurposing bazedoxifene to suppress gastrointestinal cancer growth

Pathum Thilakasiri, Tracy Nero, Michael W Parker, Matthias Ernst, Ashwini L Chand

Conference Proceedings  |  2019  |  CANCER RESEARCH

EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018)

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2019  |  SCIENTIFIC REPORTS

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been..

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

Journal article  |  2019  |  EMBO Molecular Medicine

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

Protein structure and computational drug discovery

Tracy L Nero, Michael W Parker, Craig J Morton

Journal article  |  2018  |  BIOCHEMICAL SOCIETY TRANSACTIONS

The first protein structures revealed a complex web of weak interactions stabilising the three-dimensional shape of the molecule. ..

EPO does not promote interaction between the erythropoietin and beta-common receptors

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2018  |  SCIENTIFIC REPORTS

A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) ..