Tracy Nero

Cytokine Receptors and Their Ligands

Karen SCT Shing, Winnie L Kan, Tracy L Nero, Timothy R Hercus, Denis Tvorogov, Riley D Metcalfe, Michael DW Griffin, Nicole A De Weerd, Mark A Guthridge, Paul J Hertzog, Angel F Lopez, Michael W Parker

Book Chapter  |  2023

A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein

Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balazs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, et al.

Journal article  |  2022  |  EMBO MOLECULAR MEDICINE

C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We re..

C-reactive protein, immunothrombosis and venous thromboembolism

Caroline Dix, Johannes Zeller, Hannah Stevens, Steffen U Eisenhardt, Karen S Cheung Tung Shing, Tracy L Nero, Craig J Morton, Michael W Parker, Karlheinz Peter, James D McFadyen

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical pract..

Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

Marisa R Morrow, Battsetseg Batchuluun, Jianhan Wu, Elham Ahmadi, Julie M Leroux, Pedrum Mohammadi-Shemirani, Eric M Desjardins, Zhichao Wang, Evangelia E Tsakiridis, Declan CT Lavoie, Amir Reihani, Brennan K Smith, Jacek M Kwiecien, James S Lally, Tracy L Nero, Michael W Parker, Kjetil Ask, John W Scott, Lei Jiang, Guillaume Pare, et al.

Journal article  |  2022  |  CELL METABOLISM

Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and can be inhibited by targeting acetyl-Co..

Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases

J Zeller, B Bogner, JD McFadyen, J Kiefer, D Braig, G Pietersz, G Krippner, TL Nero, CJ Morton, KS Cheung Tung Shing, MW Parker, K Peter, SU Eisenhardt

Journal article  |  2022  |  PHARMACOLOGY & THERAPEUTICS

C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of in..

Structural biology of cell surface receptors implicated in Alzheimer's disease.

Stefan J Hermans, Tracy L Nero, Craig J Morton, Jonathan H Gooi, Gabriela AN Crespi, Nancy C Hancock, Chen Gao, Kenta Ishii, Jasmina Markulić, Michael W Parker

Journal article  |  2022  |  Biophys Rev

Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics..

Messing with beta c: A unique receptor with many goals

Winnie L Kan, Karen S Cheung Tung Shing, Tracy L Nero, Timothy R Hercus, Denis Tvorogov, Michael W Parker, Angel F Lopez

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Our understanding of the biological role of the βc family of cytokines has evolved enormously since their initial identification a..

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  NATURE METABOLISM

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments

Marcos Perini, Rhynelle S Dmello, Tracy L Nero, Ashwini L Chand

Journal article  |  2020  |  PHARMACOLOGY & THERAPEUTICS

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cellular membrane receptors identified and character..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..