Tracy Nero

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  Nature Metabolism

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments

Marcos Perini, Rhynelle S Dmello, Tracy L Nero, Ashwini L Chand

Journal article  |  2020  |  Pharmacology & Therapeutics

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cellular membrane receptors identified and character..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  Cell Host & Microbe

EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018)

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2019  |  Scientific Reports

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

Journal article  |  2019  |  EMBO Molecular Medicine

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

Protein structure and computational drug discovery

Tracy L Nero, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biochemical Society Transactions

EPO does not promote interaction between the erythropoietin and beta-common receptors

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2018  |  SCIENTIFIC REPORTS

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  NATURE COMMUNICATIONS

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment

U Flierl, TL Nero, B Lim, RK Andrews, MW Parker, EE Gardiner, K Peter

Journal article  |  2018  |  Journal of Thrombosis and Haemostasis

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Urmi Dhagat, Timothy R Hercus, Sophie E Broughton, Tracy L Nero, Karen S Cheung Tung Shing, Emma F Barry, Christy A Thomson, Steve Bryson, Emil F Pai, Barbara J McClure, John W Schrader, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  mAbs

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

David Braig, Tracy L Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R Thiele, Craig J Morton, Johannes Zeller, Jurij Kiefer, Lawrence A Potempa, Natalie A Mellett, Luke A Miles, Xiao-Jun Du, Peter J Meikle, Markus Huber-Lang, G Bjoern Stark, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

Journal article  |  2017  |  NATURE COMMUNICATIONS

Structural insights into the signaling of the human Interleukin-3 receptor

Michael William Parker, Urmi Dhagat, Tracy Nero, Sophie Broughton, Steffi K Cheung Tung, Tim Hercus, Angel Lopez

Conference Proceedings  |  2017  |  Acta Crystallographica Section A Foundations and Advances

The GM-CSF Receptor - mechanisms for affinity conversion and signalling

Sophie Elizabeth Broughton, Timothy Hercus, Tracy Nero, Mara Dottore, Barbara McClure, Urmi Dhagat, Houng Taing, Michael Gorman, Angel F Lopez, Michael W Parker

Conference Proceedings  |  2017  |  Acta Crystallographica Section A Foundations and Advances

Three-in-one bullets: Small molecule inhibitors of the beta-common receptor

Karen Steffi Cheung Tung Shing, Tracy Nero, Timothy Hercus, Sophie Broughton, Urmi Dhagat, Angel Lopez, Michael Parker

Conference Proceedings  |  2017  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Mara Dottore, Barbara J McClure, Urmi Dhagat, Houng Taing, Michael A Gorman, Jack King-Scott, Angel F Lopez, Michael W Parker

Journal article  |  2016  |  Structure

Cytokine Receptors and Their Ligands

U Dhagat, TL Nero, WL Kan, TR Hercus, SE Broughton, NA de Weerd, BJ Jenkins, A Mansell, MA Guthridge, PJ Hertzog, AF Lopez, MW Parker

Book Chapter  |  2016

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Louisa J Phillipson, David H Segal, Tracy L Nero, Michael W Parker, Soo San Wan, Melanie de Silva, Mark A Guthridge, Andrew H Wei, Christopher J Burns

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry

The beta c receptor family - Structural insights and their functional implications

Sophie E Broughton, Tracy L Nero, Urmi Dhagat, Winnie L Kan, Timothy R Hercus, Denis Tvorogov, Angel F Lopez, Michael W Parker

Journal article  |  2015  |  Cytokine

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Ulrike Flierl, Tracy L Nero, Bock Lim, Jane F Arthur, Yu Yao, Stephanie M Jung, Eelo Gitz, Alice Y Pollitt, Maria TK Zaldivia, Martine Jandrot-Perrus, Andreas Schaefer, Bernhard Nieswandt, Robert K Andrews, Michael W Parker, Elizabeth E Gardiner, Karlheinz Peter

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123

Tim R Hercus, Sophie E Broughton, Matthew P Hardy, Tracy L Nero, Barbara J McClure, Mara Dottore, Urmi Dhagat, Emma F Barry, Winnie L Kan, Samantha J Busfield, Andrew D Nash, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Conference Proceedings  |  2014  |  Cytokine

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Timothy R Hercus, Sophie E Broughton, Matthew P Hardy, Tracy L Nero, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Journal article  |  2014  |  Mol Cell Oncol

CSL362 is a humanized interleukin-3 (IL-3)-neutralizing monoclonal antibody with enhanced effector function that binds the α subun..

Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteolytic Activities

Harmeet Singh, Tracy L Nero, Yao Wang, Michael W Parker, Guiying Nie

Journal article  |  2014  |  PLOS ONE

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Sophie E Broughton, Timothy R Hercus, Matthew P Hardy, Barbara J McClure, Tracy L Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F Barry, Winnie L Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J Busfield, Catherine M Owczarek, Andrew D Nash, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Journal article  |  2014  |  Cell Reports

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

David B Ascher, Jerome Wielens, Tracy L Nero, Larissa Doughty, Craig J Morton, Michael W Parker

Journal article  |  2014  |  SCIENTIFIC REPORTS

Oncogenic protein interfaces: small molecules, big challenges

Tracy L Nero, Craig J Morton, Jessica K Holien, Jerome Wielens, Michael W Parker

Journal article  |  2014  |  Nature Reviews Cancer

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Urmi Dhagat, Catherine M Owczarek, Matthew P Hardy, Louis J Fabri, Pierre D Scotney, Andrew D Nash, Nicholas J Wilson, Angel F Lopez, Michael W Parker

Journal article  |  2014  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

The GM-CSF Receptor - mechanisms for affinity conversion and signalling

Sophie Elizabeth Broughton, Timothy Hercus, Tracy Nero, Mara Dottore, Barbara McClure, Urmi Dhagat, Houng Taing, Michael Gorman, Angel F Lopez, Michael W Parker

Conference Proceedings  |  2014  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Structural insights into the signaling of the human Interleukin-3 receptor

Michael William Parker, Urmi Dhagat, Tracy Nero, Sophie Broughton, Steffi K Cheung Tung, Tim Hercus, Angel Lopez

Conference Proceedings  |  2014  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Small Molecule Proprotein Convertase Inhibitors for Inhibition of Embryo Implantation

Huiting Ho, Harmeet Singh, Sophea Heng, Tracy L Nero, Sarah Paule, Michael W Parker, Alan T Johnson, Guan-Sheng Jiao, Guiying Nie

Journal article  |  2013  |  PLoS One

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A Powell, Francois Vergez, David H Segal, Nhu-Y N Nguyen, Adele Baker, Tse-Chieh Teh, Emma F Barry, Jean-Emmanuel Sarry, Erwin M Lee, Tracy L Nero, Anissa M Jabbour, Giovanna Pomilio, Benjamin D Green, Stephane Manenti, Stefan P Glaser, Michael W Parker, Angel F Lopez, Paul G Ekert, Richard B Lock, et al.

Journal article  |  2013  |  Blood

Signalling by the beta c family of cytokines

Timothy R Hercus, Urmi Dhagat, Winnie LT Kan, Sophie E Broughton, Tracy L Nero, Michelle Perugini, Jarrod J Sandow, Richard J D'Andrea, Paul G Ekert, Timothy Hughes, Michael W Parker, Angel F Lopez

Journal article  |  2013  |  Cytokine & Growth Factor Reviews

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF

Yanni Wang, Christy A Thomson, Lenka L Allan, Linda M Jackson, Melanie Olson, Timothy R Hercus, Tracy L Nero, Amanda Turner, Michael W Parker, Angel L Lopez, Thomas K Waddell, Gary P Anderson, John A Hamilton, John W Schrader

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: In vitro bioactivity, stability and in vivo pharmacokinetics

Huiting Ho, Tracy L Nero, Harmeet Singh, Michael W Parker, Guiying Nie

Journal article  |  2012  |  Peptides

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

Sophie E Broughton, Urmi Dhagat, Timothy R Hercus, Tracy L Nero, Michele A Grimbaldeston, Claudine S Bonder, Angel F Lopez, Michael W Parker

Journal article  |  2012  |  Immunological Reviews

Dimerisation and co-operativity of endoplasmic reticulum aminopeptidase 1 and 2: a process integral to antigen recognition

DB Ascher, G Polekhina, TL Nero, MW Parker

Conference Proceedings  |  2012  |  FEBS JOURNAL

Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8 alpha and C9

Stephanie E Wickham, Eileen M Hotze, Allison J Farrand, Galina Polekhina, Tracy L Nero, Stephen Tomlinson, Michael W Parker, Rodney K Tweten

Journal article  |  2011  |  Journal of Biological Chemistry

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)

Christopher J Burns, David G Bourke, Laura Andrau, Xianyong Bu, Susan A Charman, Andrew C Donohue, Emmanuelle Fantino, Michelle Farrugia, John T Feutrill, Max Joffe, Marcel R Kling, Margarita Kurek, Tracy L Nero, Thao Nguyen, James T Palmer, Ian Phillips, David M Shackleford, Harrison Sikanyika, Michelle Styles, Stephen Su, et al.

Journal article  |  2009  |  Bioorganic & Medicinal Chemistry Letters

Role of Tyr356(7.43) and Ser190(4.57) in antagonist binding in the rat β1-adrenergic receptor

LA Rezmann-Vitti, TL Nero, GP Jackman, CA Machida, BJ Duke, WJ Louis, SNS Louis

Journal article  |  2006  |  Journal of Medicinal Chemistry

Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta(1)-adrenergic receptor

Linda A Rezmann-Vitti, Tracy L Nero, Graham P Jackman, Curtis A Machida, Brian J Duke, William J Louis, Simon NS Louis

Journal article  |  2006  |  Journal of medicinal chemistry

Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43))

LA Rezmann-Vitti, SNS Louis, TL Nero, GP Jackman, D Iakovidis, CA Machida, WJ Louis

Journal article  |  2004  |  Biochemical Pharmacology

Site-directed mutagenesis of the rat beta(1)-adrenoceptor. Involvement of Tyr(356(7.43)) in ( /-)cyanopindolol but not ( /-)[(125)Iodo]cyanopindolol binding

LA Rezmann-Vitti, SNS Louis, TL Nero, GP Jackman, CA Machida, WJ Louis

Journal article  |  2004  |  European Journal of Medicinal Chemistry

A novel receptor, and compounds which bind thereto

WJ LOUIS, EL CONWAY, AL GUNDLACH, D IAKOVIDIS, SNS LOUIS, PMK KING, TL NERO

Patent  |  2003

Synthesis, beta-adrenoceptor pharmacology and toxicology of S-(-)-1-(4-(2-ethoxyethoxy)phenoxy)-2-hydroxy-3-(2-(3,4-dimethoxyphenyl)ethylamino)propane hydrochloride, a short acting beta(1)-specific antagonist

GP Jackman, D Iakovidis, TL Nero, NS Anavekar, LA Rezmann-Vitti, SNS Louis, M Mori, OH Drummer, WJ Louis

Journal article  |  2002  |  European Journal of Medicinal Chemistry

CoMFA analysis of the human beta(1)-adrenoceptor binding affinity of a series of phenoxypropanolamines

SN Louis, LA Rezmann-Vitti, TL Nero, D Iakovidis, GP Jackman, WJ Louis

Journal article  |  2002  |  European Journal of Medicinal Chemistry

Role of beta-adrenergic receptor subtypes in lipolysis

SNS Louis, GP Jackman, TL Nero, D Iakovidis, WJ Louis

Journal article  |  2000  |  Cardiovascular Drugs and Therapy

beta(1)- and beta(2)-adrenoceptor antagonist activity of a series of para-substituted N-isopropylphenoxypropanolamines

SN Louis, TL Nero, D Iakovidis, FM Colagrande, GP Jackman, WJ Louis

Journal article  |  1999  |  European Journal of Medicinal Chemistry

beta(1)- and beta(2)-Adrenoceptor antagonist activity of a series of para-substituted N-isopropylphenoxypropanolamines.

SN Louis, TL Nero, D Iakovidis, FM Colagrande, GP Jackman, WJ Louis

Journal article  |  1999  |  European journal of medicinal chemistry

To further explore the structure-activity relationships of beta-adrenoceptor (beta-AR) antagonists, a series of 25 para-substitute..

Synthesis and beta-adrenoceptor agonist properties of ( /-)-1-(3 ',4 ' -dihydroxyphenoxy)-3-(3 '',4 ''-dimethoxyphenyl) ethylamino-2-propanol hydrochloride, ( /-)-RO363.HCl, and the (2S)-(-)-isomer

D Iakovidis, SNS Louis, LA Rezmann, F Colagrande, TL Nero, GP Jackman, WJ Louis

Journal article  |  1999  |  European Journal of Medicinal Chemistry

LK 204-545, a highly selective beta(1)-adrenoceptor antagonist at human beta-adrenoceptors

SNS Louis, TL Nero, D Iakovidis, GP Jackman, WJ Louis

Journal article  |  1999  |  European Journal of Pharmacology

[H-3]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [H-3]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney

PR King, S Suzuki, AR Hosseini, D Iakovidis, TL Nero, GP Jackman, WJ Louis, AL Gundlach

Conference Proceedings  |  1998  |  Journal of the Autonomic Nervous System

Synthesis, NMR studies and conformational analysis of oxazolidine derivatives of the beta-adrenoreceptor antagonists metoprolol, atenolol and timolol

GP Moloney, DJ Craik, MN Iskander, TL Nero

Journal article  |  1998  |  Journal of the Chemical Society, Perkin Transactions 2

MOLECULAR STUDIES OF ALPHA-2-ADRENOCEPTOR AND CATECHOLAMINE-INSENSITIVE IMIDAZOLINE-RECEPTOR BINDING-SITES USING [H-3] RILMENIDINE IN RAT-BRAIN AND KIDNEY

PR KING, S SUZUKI, TL NERO, AL GUNDLACH, WJ LOUIS

Conference Proceedings  |  1993  |  Journal of Hypertension

β-Adrenoceptor agonists and antagonists: conformational analysis of the ethanolamine and propanolamine side-chain

TL Nero, WJ Louis, D Iakovidis

Journal article  |  1993  |  Journal of Molecular Structure: THEOCHEM

TRANSAMINATION OF GAMMA-AMINOBUTYRIC-ACID - A SEMIEMPIRICAL MOLECULAR-ORBITAL STUDY OF THE TRANSAMINASE MECHANISM

TL NERO, MN ISKANDER, MG WONG

Journal article  |  1993  |  J. Chem. Soc., Perkin Trans. 2

COMPUTER-AIDED MAPPING OF THE BETA-ADRENOCEPTOR .1. EXPLANATION FOR EFFECT OF PARASUBSTITUTION ON BLOCKING ACTIVITY AT THE BETA-1-ADRENOCEPTOR

JB BALL, TL NERO, D IAKOVIDIS, L TUNG, G JACKMAN, WJ LOUIS

Journal article  |  1992  |  Journal of Medicinal Chemistry

EVALUATION OF THE PREDICTED SECONDARY STRUCTURE OF BACTERIORHODOPSIN - PREDICTION OF THE BOVINE RHODOPSIN SECONDARY STRUCTURE AND ITS SEQUENCE SIMILARITY WITH BACTERIORHODOPSIN

TL NERO, WJ LOUIS

Journal article  |  1992  |  Biochemistry International

ASPARTATE-AMINOTRANSFERASE - INVESTIGATION OF THE ACTIVE-SITES

TL NERO, MG WONG, SW OLIVER, MN ISKANDER, PR ANDREWS

Journal article  |  1990  |  Journal of Molecular Graphics

THE Q-BAND ABSORPTION-SPECTRA OF HEMATOPORPHYRIN MONOMER AND AGGREGATE IN AQUEOUS-SOLUTION

GJ SMITH, KP GHIGGINO, LE BENNETT, TL NERO

Journal article  |  1989  |  Photochemistry and Photobiology