Tracy Nero

A novel receptor, and compounds which bind thereto

WJ LOUIS, EL CONWAY, AL GUNDLACH, D IAKOVIDIS, SNS LOUIS, PMK KING, TL NERO

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  Nature Metabolism

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments

Marcos Perini, Rhynelle S Dmello, Tracy L Nero, Ashwini L Chand

Journal article  |  2020  |  Pharmacology & Therapeutics

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cellular membrane receptors identified and character..

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis

Luke A Miles, Stefan J Hermans, Gabriela AN Crespi, Jonathan H Gooi, Larissa Doughty, Tracy L Nero, Jasmina Markulic, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andres A Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C Hancock, Michael W Parker

Journal article  |  2019  |  ISCIENCE

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of ..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  Cell Host & Microbe

EPO does not promote interaction between the erythropoietin and beta-common receptors (vol 8, 12457, 2018)

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2019  |  SCIENTIFIC REPORTS

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

Journal article  |  2019  |  EMBO Molecular Medicine

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

Protein structure and computational drug discovery

Tracy L Nero, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biochemical Society Transactions

EPO does not promote interaction between the erythropoietin and beta-common receptors

Karen S Cheung Tung Shing, Sophie E Broughton, Tracy L Nero, Kevin Gillinder, Melissa D Ilsley, Hayley Ramshaw, Angel F Lopez, Michael DW Griffin, Michael W Parker, Andrew C Perkins, Urmi Dhagat

Journal article  |  2018  |  SCIENTIFIC REPORTS

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  NATURE COMMUNICATIONS