David Darby

Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment

Nicholas Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames

Journal article  |  2021  |  Journal of the International Neuropsychological Society

OBJECTIVES: The criteria for objective memory impairment in mild cognitive impairment (MCI) are vaguely defined. Aggregating the n..

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E Marioni, Margaret J Wright, Alison M Goate, Edoardo Marcora, Kuan-lin Huang, Tenielle Porter, Simon M Laws, Perminder S Sachdev, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R Wray, Allan F McRae, Peter M Visscher

Journal article  |  2020  |  Nature Communications

Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD)...

The MSReactor computerized cognitive battery correlates with the processing speed test in relapsing-remitting multiple sclerosis

Charmaine Yam, Daniel Merlo, Jim Stankovich, David Darby, Melissa Gresle, Tomas Kalincik, Trevor J Kilpatrick, Jeanette Lechner-Scott, Bruce Taylor, Michael Barnett, Helmut Butzkueven, Anneke van der Walt

Journal article  |  2020  |  Multiple Sclerosis and Related Disorders

BACKGROUND: Monitoring and screening of cognitive function in the ambulatory setting requires simple, brief cognitive tests that a..

Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies

Allan George, Ruben Kuzniecky, Henry Rusinek, Heath R Pardoe, Jacqueline French, Daniel Lowenstein, Sabrina Cristofaro, Kevin McKenna, Vickie Mays, Darrell Shack, Sarah Barnard, Cheryl Burke, Manu Hegde, Tracy Glauser, Terence O'Brien, John Pollard, Tricia Ting, Kimford Meador, David Darby, Chris Morrison, et al.

Journal article  |  2019  |  Journal of Neuroimaging

BACKGROUND AND PURPOSE: In this study, we used power analysis to calculate required sample sizes to detect group-level changes in ..

The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis

Daniel Merlo, David Darby, Tomas Kalincik, Helmut Butzkueven, Anneke van der Walt

Journal article  |  2019  |  Therapeutic Advances in Neurological Disorders

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent r..

Avoiding methodological bias in studies of amyloid imaging results disclosure

Carl Taswell, Cheryl Donohue, Maree T Mastwyk, Andrea G Louey, Jacqueline Giummarra, Joanne Robertson, David G Darby, Colin L Masters, Christopher C Rowe

Journal article  |  2019  |  Alzheimer's Research and Therapy

Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years

Nicholas I Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames

Journal article  |  2018  |  Alzheimer Disease & Associated Disorders

BACKGROUND: Given the long preclinical disease course of Alzheimer disease (AD) pathology, novel treatments may be more efficaciou..

A pilot study investigating the feasibility of symptom assessment manager (SAM), a Web-based real-time tool for monitoring challenging behaviors

Samantha M Loi, Sangeeth Wanasinghage, Anita Goh, Nicola T Lautenschlager, David G Darby, Dennis Velakoulis

Journal article  |  2018  |  International Journal of Geriatric Psychiatry

OBJECTIVE: Improving and minimizing challenging behaviors seen in psychiatric conditions, including behavioral and psychological s..

Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

James D Doecke, Alan Rembach, Victor L Villemagne, Shiji Varghese, Stephanie Rainey-Smith, Shannon Sarros, Lisbeth A Evered, Christopher J Fowler, Kelly K Pertile, Rebecca L Rumble, Brett Trounson, Kevin Taddei, Simon M Laws, S Lance Macaulay, Ashley I Bush, Kathryn A Ellis, Ralph Martins, David Ames, Brendan Silbert, Hugo Vanderstichele, et al.

Journal article  |  2018  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: To enhance the accuracy of clinical diagnosis for Alzheimer's disease (AD), pre-mortem biomarkers have become increasi..

Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, sporadic, and aggressive form of FTD

Nicholas I Bradfield, Catriona McLean, John Drago, David G Darby, David Ames

Journal article  |  2017  |  International Psychogeriatrics

Fronto-temporal dementia (FTD) associated with Fused in Sarcoma (FUS) protein accumulation is an uncommon cause of FTD with a dist..