Marc Achen

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

Musarat Ishaq, Nadeeka Bandara, Steven Morgan, Cameron Nowell, Ahmad M Mehdi, Ruqian Lyu, Davis McCarthy, Dovile Anderson, Darren J Creek, Marc G Achen, Ramin Shayan, Tara Karnezis

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF OBESITY

OBJECTIVES: Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes si..

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis

Valeria Arcucci, Steven A Stacker, Marc G Achen

Journal article  |  2021  |  BIOMOLECULES

Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumo..

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen

Journal article  |  2019  |  CELL REPORTS

Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebr..

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2019  |  CANCER RESEARCH

Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymph..

Modulation of Immunity by Lymphatic Dysfunction in Lymphedema

Yinan Yuan, Valeria Arcucci, Sidney M Levy, Marc G Achen

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treat..

Exit Stage Left: A Tumor Cell's Journey from Lymph Node to Beyond

Marc G Achen, Steven A Stacker

Journal article  |  2018  |  TRENDS IN CANCER

Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental..

The evolving role of lymphatics in cancer metastasis

Rae H Farnsworth, Marc G Achen, Steven A Stacker

Journal article  |  2018  |  CURRENT OPINION IN IMMUNOLOGY

While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying ..

A kinome-wide CRISPR screen reveals BET inhibition-associated endothelial cell resistance to anti-angiogenic therapy

Michael Y He, Michael M Halford, Marc G Achen, Steven A Stacker

Conference Proceedings  |  2018  |  CANCER RESEARCH

Abstract Angiogenesis inhibition is a useful strategy for treating cancer. However, the efficacy of anti-angiogenic..

Emerging Roles for VEGF-D in Human Disease

Steven A Stacker, Marc G Achen

Journal article  |  2018  |  BIOMOLECULES

Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide..