Antony Burgess

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2019  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2019  |  Cell Death & Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

Registry-based randomized clinical trials as a method to improve cancer care in Australia

Siavash Foroughi, Hui-li Wong, Lucy Gately, Margaret Lee, Koen Simons, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs

Journal article  |  2019  |  Asia-Pacific Journal of Clinical Oncology

Re-inventing the randomized controlled trial in medical oncology: The registry-based trial

Siavash Foroughi, Hui-li Wong, Lucy Gately, Margaret Lee, Koen Simons, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics

Ruth A Mitchell, Rodney B Luwor, Antony W Burgess

Journal article  |  2018  |  Experimental Cell Research

ColinWesleyWard 1943-2017

Peter M Colman, Antony W Burgess

Journal article  |  2018  |  Historical Records of Australian Science

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts

Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess

Journal article  |  2018  |  PLOS ONE

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  Gastroenterology

Evolution of anti-HER2 therapies for cancer treatment

Sagun Parakh, Hui K Gan, Adam C Parslow, Ingrid JG Burvenich, Antony W Burgess, Andrew M Scott

Journal article  |  2017  |  Cancer Treatment Reviews

Bispecific protein targets prostate cancer

Antony W Burgess

Journal article  |  2017  |  Oncotarget

YAP IS ESSENTIAL FOR GLIOBLASTOMA PROLIFERATION AND SURVIVAL IN VITRO AND IN VIVO

AJ Gogos, H Zhu, K Drummond, AP Morokoff, AH Kaye, AW Burgess

Conference Proceedings  |  2017  |  NEURO-ONCOLOGY

Mathematical model of TGF-beta signalling: feedback coupling is consistent with signal switching

Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess

Journal article  |  2017  |  BMC Systems Biology

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor

Nicholas M Gough, Jill Gough, Donald Metcalf, Anne Kelso, Dianne Grail, Nicos A Nicola, Antony W Burgess, Ashley R Dunn

Journal article  |  2017  |  Journal of Immunology

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  Growth Factors

Dual targeting of EGFR: ready for prime time?

Hui K Gan, Antony W Burgess, Adam C Parslow, Andrew M Scott

Journal article  |  2016  |  Translational Cancer Research

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Lauren E King, Christopher G Love, Oliver M Sieber, Maree C Faux, Antony W Burgess

Journal article  |  2016  |  Genomics Data

Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line

Meng-xin Yin, Bruno Catimel, Mark Gregory, Melanie Condron, Eugene Kapp, Andrew B Holmes, Antony W Burgess

Journal article  |  2016  |  Integrative Biology

Synthesis of a Tethered myo-Inositol (1,3,4,5,6)Pentakisphosphate (IP5) Derivative as a Probe for Biological Studies

Mark Gregory, Bruno Catimel, Meng-Xin Yin, Melanie Condron, Antony W Burgess, Andrew B Holmes

Journal article  |  2016  |  Synlett

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components

Bruce S Gardiner, Kelvin KL Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith

Journal article  |  2015  |  PLOS Computational Biology

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.

Journal article  |  2015  |  British Journal of Cancer

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Mohashin Pathan, Shivakumar Keerthikumar, Ching-Seng Ang, Lahiru Gangoda, Camelia YJ Quek, Nicholas A Williamson, Dmitri Mouradov, Oliver M Sieber, Richard J Simpson, Agus Salim, Antony Bacic, Andrew F Hill, David A Stroud, Michael T Ryan, Johnson I Agbinya, John M Mariadason, Antony W Burgess, Suresh Mathivanan

Journal article  |  2015  |  PROTEOMICS

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease

Benjamin B Williams, Niall C Tebbutt, Michael Buchert, Tracy L Putoczki, Karen Doggett, Shisan Bao, Cameron N Johnstone, Frederick Masson, Frederic Hollande, Antony W Burgess, Andrew M Scott, Matthias Ernst, Joan K Heath

Journal article  |  2015  |  Disease Models & Mechanisms

Analysis of Wnt signalling dynamics during colon crypt development in 3D culture

Chin Wee Tan, Yumiko Hirokawa, Antony W Burgess

Journal article  |  2015  |  Scientific Reports

LRIG1 Extracellular Domain: Structure and Function Analysis

Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A Nicola, Timothy E Adams, Thomas P Garrett, Jian-Guo Zhang, Antony W Burgess

Journal article  |  2015  |  Journal of Molecular Biology

Notch ligand delta-like1: X-ray crystal structure and binding affinity

Nadia J Kershaw, Nicole L Church, Michael DW Griffin, Cindy S Luo, Timothy E Adams, Antony W Burgess

Journal article  |  2015  |  Biochemical Journal

Blood-Based Protein Biomarker Panel for the Detection of Colorectal Cancer

Kim YC Fung, Bruce Tabor, Michael J Buckley, Ilka K Priebe, Leanne Purins, Celine Pompeia, Gemma V Brierley, Trevor Lockett, Peter Gibbs, Jeanne Tie, Paul McMurrick, James Moore, Andrew Ruszkiewicz, Edouard Nice, Timothy E Adams, Antony Burgess, Leah J Cosgrove

Journal article  |  2015  |  PLOS ONE

Dual role of Src kinase in governing neuronal survival

M Iqbal Hossaina, Ashfaqul Hoquel, Guillaume Lessene, M Aizuddin Kamaruddin, Percy WY Chu, Ivan HW Ng, Sevgi Irtegun, Dominic CH Ng, Marie A Bogoyevitch, Antony W Burgess, Andrew F Hill, Heung-Chin Cheng

Journal article  |  2015  |  Brain Research

Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

Mark Gregory, Meng-Xin Yin, Malcolm J McConville, Eleanor Williams, Alex N Bullock, Stuart J Conway, Antony W Burgess, Bruno Catimel, Andrew B Holmes

Journal article  |  2015  |  Australian Journal of Chemistry

A Mathematical Model for Eph/Ephrin-Directed Segregation of Intermingled Cells

Rotem Aharon, Peter W Janes, Anthony W Burgess, Kais Hamza, Fima Klebaner, Martin Lackmann

Journal article  |  2014  |  PLoS ONE

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration

Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay, et al.

Journal article  |  2014  |  Science Signaling

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

Dmitri Mouradov, Clare Sloggett, Robert N Jorissen, Christopher G Love, Shan Li, Antony W Burgess, Diego Arango, Robert L Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L Wilding, David Bicknell, Ian PM Tomlinson, Walter F Bodmer, John M Mariadason, Oliver M Sieber

Journal article  |  2014  |  Cancer Research

Complexities of lysophospholipid signalling in glioblastoma

Wayne Ng, Alice Pebay, Katharine Drummond, Antony Burgess, Andrew H Kaye, Andrew Morokoff

Journal article  |  2014  |  Journal of Clinical Neuroscience

Quantitative intratumoural microdistribution and kinetics of I-131-huA33 antibody in patients with colorectal carcinoma

Marika Ciprotti, Geoffrey Chong, Hui K Gan, Anthony Chan, Carmel Murone, Duncan MacGregor, Fook-Thean Lee, Terrance G Johns, Joan K Heath, Matthias Ernst, Antony W Burgess, Andrew M Scott

Journal article  |  2014  |  EJNMMI Research

Structure and function of LGR5: An enigmatic G-protein coupled receptor marking stem cells

Kaavya Krishna Kumar, Antony W Burgess, Jacqueline M Gulbis

Journal article  |  2014  |  Protein Science

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers

Noga Kozer, Dipak Barua, Christine Henderson, Edouard C Nice, Antony W Burgess, William S Hlavacek, Andrew HA Clayton

Journal article  |  2014  |  Biochemistry

Analysis of Wnt signaling beta-catenin spatial dynamics in HEK293T cells

Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, David W Smith, Antony W Burgess

Journal article  |  2014  |  BMC Systems Biology

Colonic myofibroblast cell line stimulates colonoid formation

Yumiko Hirokawa, Kelvin Hon Yan Yip, Chin Wee Tan, Antony W Burgess

Journal article  |  2014  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

EGF receptor family: twisting targets for improved cancer therapies

Antony W Burgess, Yoav I Henis, Nancy E Hynes, Thomas Jovin, Alexander Levitzki, Ronit Pinkas-Kramarski, Yosef Yarden

Journal article  |  2014  |  Growth Factors

Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled

Kim YC Fung, Edouard Nice, Ilka Priebe, Damien Belobrajdic, Aloke Phatak, Leanne Purins, Bruce Tabor, Celine Pompeia, Trevor Lockett, Timothy E Adams, Antony Burgess, Leah Cosgrove

Journal article  |  2014  |  World Journal of Gastroenterology

Chain-specific antibodies for laminin-511

Laura Zamurs, Normand Pouliot, Nicole Kusuma, Edouard C Nice, Antony W Burgess

Journal article  |  2013  |  Growth Factors

Colon Cryptogenesis: Asymmetric Budding

Chin Wee Tan, Yumiko Hirokawa, Bruce S Gardiner, David W Smith, Antony W Burgess

Journal article  |  2013  |  PLoS One

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis

M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson, et al.

Journal article  |  2013  |  Oncogene

Cell Organisation in the Colonic Crypt: A Theoretical Comparison of the Pedigree and Niche Concepts

Richard C van der Wath, Bruce S Gardiner, Antony W Burgess, David W Smith

Journal article  |  2013  |  PLoS One

The PI(3)P interactome from a colon cancer cell

Bruno Catimel, Eugene Kapp, Meng-Xin Yin, Mark Gregory, Leon S-M Wong, Melanie Condron, Nicole Church, Nadia Kershaw, Andrew B Holmes, Antony W Burgess

Journal article  |  2013  |  Journal of Proteomics

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.

Journal article  |  2013  |  Cancer Research

Serum concentrations of brain-derived neurotrophic factor (BDNF) are decreased in colorectal cancer patients

GV Brierley, IK Priebe, L Purins, KYC Fung, B Tabor, T Lockett, E Nice, P Gibbs, J Tie, P McMurrick, J Moore, A Ruszkiewicz, A Burgess, LJ Cosgrove

Journal article  |  2013  |  Cancer Biomarkers

Exploring higher-order EGFR oligomerisation and phosphorylation-a combined experimental and theoretical approach

Noga Kozer, Dipak Barua, Suzanne Orchard, Eduoard C Nice, Antony W Burgess, William S Hlavacek, Andrew HA Clayton

Journal article  |  2013  |  Molecular BioSystems

Performance of serum lipocalin 2 as a diagnostic marker for colorectal cancer

Kim YC Fung, Ilka Priebe, Leanne Purins, Bruce Tabor, Gemma V Brierley, Trevor Lockett, Edouard Nice, Peter Gibbs, Jeannie Tie, Paul McMurrick, James Moore, Andrew Ruszkiewicz, Antony Burgess, Leah J Cosgrove

Journal article  |  2013  |  Cancer Biomarkers

Ligand binding induces a conformational change in epidermal growth factor receptor dimers

Francesca Walker, Julie Rothacker, Christine Henderson, Edouard C Nice, Bruno Catimel, Hui-Hua Zhang, Andrew M Scott, Michael F Bailey, Suzanne G Orchard, Timothy E Adams, Zhanqi Liu, Thomas PJ Garrett, Andrew HA Clayton, Antony W Burgess

Journal article  |  2012  |  Growth Factors

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

Eva J Koziolek, Jacqueline F Donoghue, John D Bentley, George Lovrecz, Olan Dolezal, Colin W Ward, Julie Rothacker, Edouard C Nice, Antony W Burgess, M Hafner, Terrance G Johns, Timothy E Adams

Journal article  |  2012  |  Growth Factors

Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of beta-catenin

Meredith J Layton, Maree C Faux, Nicole L Church, Bruno Catimel, Nadia J Kershaw, Eugene A Kapp, Cameron Nowell, Janine L Coates, Antony W Burgess, Richard J Simpson

Journal article  |  2012  |  Biochimica et Biophysica Acta-Proteins and Proteomics

Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4

Justin WE Lim, Rommel A Mathias, Eugene A Kapp, Meredith J Layton, Maree C Faux, Antony W Burgess, Hong Ji, Richard J Simpson

Journal article  |  2012  |  Electrophoresis

Solubilisation of the armadillo-repeat protein beta-catenin using a zwitterionic detergent allows resolution of phosphorylated forms by 2DE

Meredith J Layton, Nicole L Church, Maree C Faux, Hong Ji, Robert JA Goode, Eugene A Kapp, Antony W Burgess, Richard J Simpson

Journal article  |  2012  |  Electrophoresis

Targeting of a Conformationally Exposed, Tumor-Specific Epitope of EGFR as a Strategy for Cancer Therapy

Hui K Gan, Antony W Burgess, Andrew HA Clayton, Andrew M Scott

Journal article  |  2012  |  Cancer Research

Wnt Signalling Pathway Parameters for Mammalian Cells

Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, Meredith J Layton, David W Smith, Antony W Burgess

Journal article  |  2012  |  PLoS One

Evidence for extended YFP-EGFR dimers in the absence of ligand on the surface of living cells.

Noga Kozer, Christine Henderson, Jacob T Jackson, Edouard C Nice, Antony W Burgess, Andrew HA Clayton

Journal article  |  2011  |  Physical Biology

The epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family of receptors. Structural studies have r..

Wnt signaling and colon tumorigenesis - A view from the periphery

Antony W Burgess, Maree C Faux, Meredith J Layton, Robert G Ramsay

Journal article  |  2011  |  Experimental Cell Research

Use of multiple reaction monitoring for multiplex analysis of colorectal cancer-associated proteins in human feces

Ching-Seng Ang, Julie Rothacker, Heather Patsiouras, Peter Gibbs, Antony W Burgess, Edouard C Nice

Journal article  |  2011  |  Electrophoresis

LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines

Francesca Walker, Hui-Hua Zhang, Annalisa Odorizzi, Antony W Burgess

Journal article  |  2011  |  PLoS One

Conformational Dynamics in a Truncated Epidermal Growth Factor Receptor Ectodomain

Noga Kozer, Julie Rothacker, Antony W Burgess, Edouard C Nice, Andrew HA Clayton

Journal article  |  2011  |  Biochemistry

Differential and Synergistic Effects of Epidermal Growth Factor Receptor Antibodies on Unliganded ErbB Dimers and Oligomers

Noga Kozer, Marcus P Kelly, Suzanne Orchard, Antony W Burgess, Andrew M Scott, Andrew HA Clayton

Journal article  |  2011  |  Biochemistry

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

Jeanne Tie, Peter Gibbs, Lara Lipton, Michael Christie, Robert N Jorissen, Antony W Burgess, Matthew Croxford, Ian Jones, Rachel Langland, Suzanne Kosmider, Daniel McKay, Gideon Bollag, Keith Nolop, Oliver M Sieber, Jayesh Desai

Journal article  |  2011  |  International Journal of Cancer

Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability

David S Williams, Matthew J Bird, Robert N Jorissen, Yen Lin Yu, Franscesa Walker, Hui Hua Zhang, Edouard C Nice, Antony W Burgess

Journal article  |  2010  |  PLoS One

Independent Interactions of Phosphorylated beta-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions

Maree C Faux, Janine L Coates, Nadia J Kershaw, Meredith J Layton, Antony W Burgess

Journal article  |  2010  |  PLoS One

Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy

Michelle Palmieri, Cameron J Nowell, Melanie Condron, James Gardiner, Andrew B Holmes, Jayesh Desai, Antony W Burgess, Bruno Catimel

Journal article  |  2010  |  Analytical Biochemistry

Creation and Biophysical Characterization of a High-Affinity, Monomeric EGF Receptor Ectodomain Using Fluorescent Proteins

Noga Kozer, Christine Henderson, Michael F Bailey, Julie Rothacker, Edouard C Nice, Anthony W Burgess, Andrew HA Clayton

Journal article  |  2010  |  Biochemistry

Murine fecal proteomics: A model system for the detection of potential biomarkers for colorectal cancer

Ching-Seng Ang, Julie Rothacker, Heather Patsiouras, Antony W Burgess, Edouard C Nice

Journal article  |  2010  |  Journal of Chromatography A

Incentives: Encouraging Adventurous Ideas

Joseph A Trapani, Antony W Burgess, David J Hill

Journal article  |  2010  |  Science

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

Stuart J Conway, James Gardiner, Simon JA Grove, Melloney K Johns, Ze-Yi Lim, Gavin F Painter, Diane EJE Robinson, Christine Schieber, Jan W Thuring, Leon S-M Wong, Meng-Xin Yin, Antony W Burgess, Bruno Catimel, Phillip T Hawkins, Nicholas T Ktistakis, Leonard R Stephens, Andrew B Holmes

Journal article  |  2010  |  Organic & Biomolecular Chemistry

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf

Hui-Hua Zhang, Francesca Walker, Sara Kiflemariam, Robert H Whitehead, David Williams, Wayne A Phillips, Thomas Mikeska, Alexander Dobrovic, Antony W Burgess

Journal article  |  2009  |  International Journal of Cancer

PI(3,4,5)P3 Interactome

Bruno Catimel, Meng-Xin Yin, Christine Schieber, Melanie Condron, Heather Patsiouras, Jenny Catimel, Diane EJE Robinson, Leon S-M Wong, Edouard C Nice, Andrew B Holmes, Antony W Burgess

Journal article  |  2009  |  Journal of Proteome Research

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas PJ Garrett, Antony W Burgess, Hui K Gan, Rod B Luwor, Glenn Cartwright, Francesca Walker, Suzanne G Orchard, Andrew HA Clayton, Edouard C Nice, Julie Rothacker, Bruno Catimel, Webster K Cavenee, Lloyd J Old, Elisabeth Stockert, Gerd Ritter, Timothy E Adams, Peter A Hoyne, K Dane Wittrup, Ginger Chao, Jennifer R Cochran, et al.

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

Timothy E Adams, Eva J Koziolek, Peter H Hoyne, John D Bentley, Louis Lu, George Lovrecz, Colin W Ward, FT Lee, Andrew M Scott, Andrew D Nash, Julie Rothacker, Edouard C Nice, Antony W Burgess, Terrance G Johns

Journal article  |  2009  |  Growth Factors

The PI(3,5)P2 and PI(4,5)P2 Interactomes

Bruno Cadmel, Christine Schleber, Melanie Condron, Heather Patsiouras, Lisa Connolly, Jenny Catimel, Edouard C Nice, Antony W Burgess, Andrew B Holmes

Journal article  |  2008  |  Journal of Proteome Research

Recruitment of adenomatous polyposis coli and beta-catenin to axin-puncta

MC Faux, JL Coates, B Catimel, S Cody, AHA Clayton, MJ Layton, AW Burgess

Journal article  |  2008  |  Oncogene

Haemopoietic growth factors: Structure and receptor interactions

AW Burgess

Book Chapter  |  2008  |  Novartis Foundation symposium

IL6/slIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice

Journal article  |  2008  |  Blood

EGFR family: Structure physiology signalling and therapeutic targets

Antony W Burgess

Journal article  |  2008  |  Growth Factors

Predominance of activated EGFR higher-order oligomers on the cell surface

Andrew HA Clayton, Suzanne G Orchard, Edouard C Nice, Richard G Posner, Antony W Burgess

Journal article  |  2008  |  Growth Factors

A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors (vol 104, pg 4071, 2007)

Andrew M Scott, Fook-Thean Lee, Niall Tebbutt, Rebecca Herbertson, Sanjeev S Gill, Zhanqi Liu, Effie Skrinos, Carmel Murone, Timothy H Saunder, Bridget Chappell, Anthony T Papenfuss, Aurora MT Poon, Wendie Hopkins, Fiona E Smyth, Duncan MacGregor, Lawrence M Cher, Achim A Jungbluth, Gerd Ritter, Martin W Brechbiel, Roger Murphy, et al.

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF

Hui Hua Zhang, Sunanda Basu, Fenqiang Wu, C Glenn Begley, Christiaan JM Saris, Ashley R Dunn, Antony W Burgess, Francesca Walker

Journal article  |  2007  |  Journal of Leukocyte Biology

Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and Granulocytes and mount sterile model of peritonitis

Margaret L Hibbs, Cathy Quilici, Nicole Kountouri, John F Seymour, Jane E Armes, Antony W Burgess, Ashley R Dunn

Journal article  |  2007  |  Journal of Immunology

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers - Implications for combination therapy with monoclonal antibody 806

Hui K Gan, Francesca Walker, Antony W Burgess, Angela Rigopoulos, Andrew M Scott, Terrance G Johns

Journal article  |  2007  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel EGF-sensitive cell cycle checkpoint

Francesca Walker, Hui-Hua Zhang, Antony W Burgess

Journal article  |  2007  |  Experimental Cell Research

De novo design of beta-helical polypeptides

Gideon Kowadlo, Nathan E Hall, Antony W Burgess

Journal article  |  2007  |  Growth Factors

The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor AG1478 Increases the Formation of Inactive Untethered EGFR Dimers

K GAN, F WALKER, A BURGESS, undefined RIGOPOULOS, A SCOTT, T JOHNS

Journal article  |  2007  |  Journal of Biological Chemistry

In situ phosphorylation of immobilized receptors on biosensor surfaces: Application to E-cadherin/beta-catenin interactions

Bruno Catimel, Meredith Layton, Nicole Church, Janine Ross, Melanie Condron, Maree Faux, Richard J Simpson, Antony W Burgess, Edouard C Nice

Journal article  |  2006  |  Analytical Biochemistry

In situ phosphorylation of immobilized receptors on biosensor surfaces: Application to E-cadherin/β-catenin interactions

Bruno Catimel, Meredith Layton, Nicole Church, Janine Ross, Melanie Condron, Maree Faux, Richard J Simpson, Antony W Burgess, Edouard C Nice

Journal article  |  2006  |  Analytical Biochemistry

Designing amino acid residues with single-conformations

Tran T Tran, Herbert Treutlein, Antony W Burgess

Journal article  |  2006  |  Protein Engineering Design & Selection

Purification and characterization of a high specificity polyclonal antibody to the adenomatous polyposis coli tumour suppressor protein

Bruno Catimel, Edouard C Nice, Maria Karrlander, Janine Ross, Jenny Catimel, Antony W Burgess, Maree Faux

Journal article  |  2006  |  Biomedical Chromatography

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

AG Ellis, MM Doherty, F Walker, J Weinstock, M Nerrie, A Vitali, R Murphy, TG Johns, AM Scott, A Levitzki, G McLachlan, LK Webster, AW Burgess, EC Nice

Journal article  |  2006  |  Biochemical Pharmacology

The tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (AG1478) is a potent and specific inhibitor of EGFR tyrosine kinase wh..

Enhanced efficacy of radioimmunotherapy with Y-90-CHX-A ''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

FT Lee, AJ Mountain, MP Kelly, C Hall, A Rigopoulos, TG Johns, FE Smyth, MW Brechbiel, EC Nice, AW Burgess, AM Scott

Journal article  |  2005  |  Clinical Cancer Research

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity

RM Perera, Y Narita, FB Furnari, HK Gan, C Murone, M Ahikvist, RB Luwor, AW Burgess, E Stockert, AA Jungbluth, LJ Old, WK Cavenee, AM Scott, TG Johns

Journal article  |  2005  |  Clinical Cancer Research

Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes

B Catimel, J Rothacker, J Catimel, M Faux, J Ross, L Connolly, A Clippingdale, AW Burgess, E Nice

Journal article  |  2005  |  Journal of Proteome Research

Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis

AHA Clayton, F Walker, SG Orchard, C Henderson, D Fuchs, J Rothacker, EC Nice, AW Burgess

Journal article  |  2005  |  Journal of Biological Chemistry

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG1478-mesylate, with albumin

AHA Clayton, MA Perugini, J Weinstock, J Rothacker, KG Watson, AW Burgess, EC Nice

Journal article  |  2005  |  Analytical Biochemistry

A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: Biodistribution, pharmacokinetics, and quantitative tumor uptake

AM Scott, FT Lee, R Jones, W Hopkins, D MacGregor, JS Cebon, A Hannah, G Chong, P U, A Papenfuss, A Rigopoulos, S Sturrock, R Murphy, V Wirth, C Murone, FE Smyth, S Knight, S Welt, G Ritter, E Richards, et al.

Journal article  |  2005  |  Clinical Cancer Research

Phase I trial of I-131-huA33 in patients with advanced colorectal carcinoma

G Chong, F Lee, W Hopkins, N Tebbutt, JS Cebon, AJ Mountain, B Chappel, A Papenfuss, P Schleyer, P U, R Murphy, V Wirth, FE Smyth, N Potasz, A Poon, ID Davis, T Saunder, GJ O'Keefe, AW Burgess, EW Hoffman, et al.

Journal article  |  2005  |  Clinical Cancer Research

The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF)

D Alewood, K Nielsen, PF Alewood, DJ Craik, P Andrews, M Nerrie, S White, T Domagala, F Walker, J Rothacker, AW Burgess, EC Nice

Journal article  |  2005  |  Growth Factors

The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor.

Terrance G Johns, Ira Mellman, Glenn A Cartwright, Gerd Ritter, Lloyd J Old, Antony W Burgess, Andrew M Scott

Journal article  |  2005  |  FASEB Journal

Overexpression of the EGFR is commonly caused by EGFR gene amplification and is sometimes associated with expression of a variant ..

Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

C Panousis, VM Rayzman, TG Johns, C Renner, Z Liu, G Cartwright, FT Lee, D Wang, H Gan, D Cao, A Kypridis, FE Smyth, MW Brechbiel, AW Burgess, LJ Old, AM Scott

Journal article  |  2005  |  British Journal of Cancer

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR

RB Luwor, HJ Zhu, F Walker, AA Vitali, RM Perera, AW Burgess, AM Scott, TG Johns

Journal article  |  2004  |  Oncogene

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

TG Johns, TE Adamas, JR Cochran, NE Hall, PA Hoyne, MJ Olsen, YS Kim, J Rothacker, EC Nice, F Walker, G Ritter, AJ Jungbluth, LJ Old, CW Ward, AW Burgess, KD Wittrup, AM Scott

Journal article  |  2004  |  Journal of Biological Chemistry

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor

F Walker, SG Orchard, RN Jorissen, NE Hall, HH Zhang, PA Hoyne, TE Adams, TG Johns, C Ward, TPJ Garrett, HJ Zhu, M Nerrie, AM Scott, EC Nice, AW Burgess

Journal article  |  2004  |  Journal of Biological Chemistry

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion

MC Faux, JL Ross, C Meeker, T Johns, H Ji, RJ Simpson, MJ Layton, AW Burgess

Journal article  |  2004  |  Journal of Cell Science

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478

TG Johns, RB Luwor, C Murone, F Walker, J Weinstock, AA Vitali, RM Perera, AA Jungbluth, E Stockert, LJ Old, EC Nice, AW Burgess, AM Scott

Journal article  |  2003  |  Proceedings of the National Academy of Sciences of the United States of America

Epidermal growth factor receptor: Mechanisms of activation and signalling

RN Jorissen, F Walker, N Pouliot, TPJ Garrett, CW Ward, AW Burgess

Book Chapter  |  2003

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

AW Burgess, HS Cho, C Eigenbrot, KM Ferguson, TPJ Garrett, DJ Leahy, MA Lemmon, MX Sliwkowski, CW Ward, S Yokoyama

Journal article  |  2003  |  Molecular Cell

An audit of radiographic reporting in a dental teaching hospital

K House, A Burgess, R Jones, J Morris, JR Rout

Journal article  |  2003  |  Clinical Governance

Epidermal growth factor receptor: Association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand

HJ Zhu, J Iaria, S Orchard, F Walker, AW Burgess

Journal article  |  2003  |  Growth Factors

Epidermal growth factor receptor: mechanisms of activation and signalling

RN Jorissen, F Walker, N Pouliot, TPJ Garrett, CW Ward, AW Burgess

Journal article  |  2003  |  Experimental Cell Research

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

TPJ Garrett, NM McKern, MZ Lou, TC Elleman, TE Adams, GO Lovrecz, M Kofler, RN Jorissen, EC Nice, AW Burgess, CW Ward

Journal article  |  2003  |  Molecular Cell

Cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity mediated by chimeric anti-GD3 monoclonal antibody KM871.

Zhanqi Liu, Fook-Thean Lee, Nobuo Hanai, Fiona E Smyth, Antony W Burgess, Lloyd J Old, Andrew M Scott

Journal article  |  2002  |  Cancer Immunity

The chimeric KM871 monoclonal antibody targets the GD3 disialoganglioside antigen and is under investigation for its immunotherape..

Cytokine enhancement of in vitro antibody-dependent cellular cytotoxicitymediated by chimeric anti-GD3 monoclonal antibody KM871

Z Liu, FT Lee, N Hanai, FE Smyth, AW Burgess, LJ Old, AM Scott

Journal article  |  2002  |  Cancer Immunity

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

TPJ Garrett, NM McKern, MZ Lou, TC Elleman, TE Adams, GO Lovrecz, HJ Zhu, F Walker, MJ Frenkel, PA Hoyne, RN Jorissen, EC Nice, AW Burgess, CW Ward

Journal article  |  2002  |  Cell

Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies

Y Wang, KJ Han, XW Pang, HA Vaughan, W Qu, XY Dong, JR Peng, HT Zhao, JA Rui, XS Leng, J Cebon, AW Burgess, WF Chen

Journal article  |  2002  |  Journal of Immunology

The K252a derivatives, inhibitors for the PAK/MLK kinase family, selectively block the growth of RAS transformants

TV Nheu, H He, Y Hirokawa, K Tamaki, L Florin, ML Schmitz, I Suzuki-Takahashi, RN Jorissen, AW Burgess, S Nishimura, J Wood, H Maruta

Journal article  |  2002  |  Cancer

Rapid microscale enzymic semisynthesis of Epidermal Growth Factor (EGF) analogues

EC Nice, T Domagala, L Fabri, M Nerrie, F Walker, RN Jorissen, AW Burgess, DF Cui, YS Zhang

Journal article  |  2002  |  Growth Factors

Modeling the epidermal growth factor -- epidermal growth factor receptor l2 domain interaction: implications for the ligand binding process.

Robert N Jorissen, Herbert R Treutlein, V Chandana Epa, Antony W Burgess

Journal article  |  2002  |  Journal of Biomolecular Structure and Dynamics

Signaling from the epidermal growth factor (EGF) receptor is triggered by the binding of ligands such as EGF or transforming growt..

Effects of thioamide substitutions on the conformation and stability of alpha- and 3(10)-helices.

Tran Trung Tran, Jun Zeng, Herbert Treutlein, Antony W Burgess

Journal article  |  2002  |  Journal of the American Chemical Society

Thiopeptides, formed by replacing the amide oxygen atom with a sp(2) sulfur atom, are useful in protein engineering and drug desig..

Novel monoclonal antibody specific for the DE2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

TG Johns, E Stockert, G Ritter, AA Jungbluth, HJS Huang, WK Cavenee, FE Smyth, CM Hall, N Watson, EC Nice, WJ Gullick, LJ Old, AW Burgess, AM Scott

Journal article  |  2002  |  International Journal of Cancer

A novel monoclonal antibody specific for the De2-7 EGFR that also recognises the EGFRexpressed in cells containing amplification of the EGFR gene.

TG Johns, E Stockert, G Ritter, AA Jungbluth, HJS Huang, WK Cavenee, FE Smyth, CM Hall, N WATSON, EC Nice, WJ Gullick, LJ Old, A BURGESS, AM Scott

Journal article  |  2002  |  International Journal of Cancer

Modeling the epidermal growth factor - epidermal growth factor receptor L2 domain interaction: implications for the ligand binding process.

RN Jorissen, HR Treutlein, VC Epa, A BURGESS

Journal article  |  2002  |  Journal of Biomolecular Structure and Dynamics

Regulation of transforming growth factor-beta signaling.

HJ Zhu, AW Burgess

Journal article  |  2001  |  Molecular Cell Biology Research Communications

Members of transforming growth factor beta (TGF-beta) family are potent regulators of multiple cellular functions, including cell ..

Specific targeting, biodistribution, and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma: Results of a phase I trial

AM Scott, FT Lee, W Hopkins, JS Cebon, JM Wheatley, ZQ Liu, FE Smyth, C Murone, S Sturrock, D MacGregor, N Hanai, K Inoue, M Yamasaki, MW Brechbiel, ID Davis, R Murphy, A Hannah, M Lim-Joon, T Chan, G Chong, et al.

Journal article  |  2001  |  Journal of Clinical Oncology

Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor

M Nagane, Y Narita, K Mishima, A Levitzki, AW Burgess, WK Cavenee, HJS Huang

Journal article  |  2001  |  Journal of Neurosurgery

Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes

JD Wade, B Catimel, MC Faux, AW Burgess, E Nice, L Otvos

Journal article  |  2001  |  Journal of Peptide Research

Conformational analysis of thiopeptides: (φ, ψ) maps of thio-substituted dipeptides

TT Tran, H Treutlein, AW Burgess

Journal article  |  2001  |  Journal of Computational Chemistry

Conformational analysis of thiopeptides: derivation of Sp(2) sulfur parameters for the CFF91 force field

TT Tran, H Treutlein, AW Burgess

Journal article  |  2001  |  Journal of Computational Chemistry

Conformational analysis of thiopeptides: Derivation of sp2 sulfur parameters for the CFF91 force field

TT Tran, H Treutlein, AW Burgess

Journal article  |  2001  |  Journal of Computational Chemistry

Conformational analysis of thiopeptides: (??,ψ) maps of thio‐substituted dipeptides

Tran Trung Tran, Herbert Treutlein, Antony W Burgess

Journal article  |  2001  |  Journal of Computational Chemistry

Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases

H He, A Levitzki, HJ Zhu, F Walker, A Burgess, H Maruta

Journal article  |  2001  |  Journal of Biological Chemistry

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR

RB Luwor, TG Johns, C Murone, HJS Huang, WK Cavenee, G Ritter, LJ Old, AW Burgess, AM Scott

Journal article  |  2001  |  Cancer Research

Synthesis, X-ray crystallographic structures of thio substituted N-acetyl N '-methylamide alanine and evaluation of sp(2) sulfur parameters of the CFF91 force field

TT Tran, AW Burgess, H Treutlein, J Perich

Journal article  |  2001  |  Journal of Peptide Research

Specific localization, gamma camera imaging, and intracellular trafficking of radiolabelled chimeric anti-G(D3) ganglioside monoclonal antibody KM871 in SK-MEL-28 melanoma xenografts

FT Lee, A Rigopoulos, C Hall, K Clarke, SH Cody, FE Smyth, ZQ Liu, MW Brechbiel, N Hanai, EC Nice, B Catimel, AW Burgess, S Welt, G Ritter, LJ Old, AM Scott

Journal article  |  2001  |  Cancer Research

Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins

N Pouliot, EC Nice, AW Burgess

Journal article  |  2001  |  Experimental Cell Research

High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma

AG Ellis, EC Nice, J Weinstock, A Levitzki, AW Burgess, LK Webster

Journal article  |  2001  |  Journal of Chromatography B: Biomedical Sciences and Applications

Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm

J Zeng, T Nheu, A Zorzet, B Catimel, E Nice, H Maruta, AW Burgess, HR Treutlein

Journal article  |  2001  |  Protein Engineering

Conformational analysis of thiopeptides: free energy calculations on the effects of thio-substitutions on the conformational distributions of alanine dipeptides

TT Tran, AW Burgess, H Treutlein, J Zeng

Journal article  |  2001  |  Journal of Molecular Graphics and Modelling

The use of a synthetic biotinylaged peptide probe for the isolation of adenoatous polyposis coli (APC) tumur suppressor protein complexes.

BL CATIMEL, JDC WADE, M FAUX, AW BURGESS, L OTVOS, EC NICE

Conference Proceedings  |  2001  |  Peptides. The Wave of the Future.

c-Raf-1 RBD associates with a subset of active v-H-Ras

M Fridman, F Walker, B Catimel, T Domagala, E Nice, A Burgess

Journal article  |  2000  |  Biochemistry

Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation

N Pouliot, LM Connolly, RL Moritz, RJ Simpson, AW Burgess

Journal article  |  2000  |  Experimental Cell Research

Expression of the MAGE-1 gene in human hepatocellular carcinomas

HS Chen, SL Cai, Y Wang, HT Zhao, J Peng, XW Pang, JY Zhu, Y Cong, J Rui, XS Leng, RY Du, Y Wang, H Vaughan, J Cebon, AW Burgess, WF Chen

Journal article  |  2000  |  Chinese Medical Journal

Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras.

M Fridman, H Maruta, J Gonez, F Walker, H Treutlein, J Zeng, A Burgess

Journal article  |  2000  |  Journal of Biological Chemistry

A mutational analysis of the Ras-binding domain (RBD) of c-Raf-1 identified three amino acid positions (Asn(64), Ala(85), and Val(..

Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells

CN Johnstone, NC Tebbutt, HE Abud, SJ White, KL Stenvers, NE Hall, SH Cody, RH Whitehead, B Catimel, EC Nice, AW Burgess, JK Heath

Journal article  |  2000  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors.

AM Scott, D Geleick, M Rubira, K Clarke, EC Nice, FE Smyth, E Stockert, EC Richards, FJ Carr, WJ Harris, KL Armour, J Rood, A Kypridis, V Kronina, R Murphy, FT Lee, Z Liu, K Kitamura, G Ritter, K Laughton, et al.

Journal article  |  2000  |  Cancer Research

The Lewis Y (Ley) antigen is a blood group-related antigen that is expressed in a high proportion of epithelial cancers (including..

PEPCAT - A new tool for conformational analysis of peptides

MF O'Donohue, E Minasian, SJ Leach, AW Burgess, HR Treutlein

Journal article  |  2000  |  Journal of Computational Chemistry

Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor

RN Jorissen, VC Epa, HR Treutlein, TPJ Garrett, CW Ward, AW Burgess

Journal article  |  2000  |  Protein Science

The Epidermal Growth Factor (EGF) receptor is a tyrosine kinase that mediates the biological effects of ligands such as EGF and tr..

Multiple autocrine factors including an extracellular matrix protein are required for the proliferation and spreading of human colon carcinoma cells in vitro

N Pouliot, AW Burgess

Journal article  |  2000  |  Growth Factors

Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor

T Domagala, N Konstantopoulos, F Smyth, RN Jorissen, L Fabri, D Geleick, I Lax, J Schlessinger, W Sawyer, GJ Howlett, AW Burgess, EC Nice

Journal article  |  2000  |  Growth Factors

Phase I study of humanised antibody A33 (Hua33) in patients with colorectal carcinoma - Preliminary whole body clearance and tumour dosimetry: Short title: Dosimetric analysis of [I-131]huA33

A Hanna, P U, A Wallace, P Schleyer, FT Lee, R Jones, W Hopkins, D MacGregor, J Cebon, A Rigopoulos, D Thomas, WJ McKay, S Welt, E Richards, KS Kolbert, G Sgouros, L Old, AW Burgess, AM Scott

Journal article  |  1999  |  ANZ Nuclear Medicine

Affinity purification of plasma membranes

J deBlaquiere, AW Burgess

Journal article  |  1999  |  Journal of Biomolecular Techniques

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

F Walker, A Kato, LJ Gonez, ML Hibbs, N Pouliot, A Levitzki, AW Burgess

Journal article  |  1998  |  Molecular and Cellular Biology

Direct immobilization of gangliosides onto gold-carboxymethyldextran sensor surfaces by hydrophobic interaction: applications to antibody characterization

B Catimel, AM Scott, FT Lee, N Hanai, G Ritter, S Welt, LJ Old, AW Burgess, EC Nice

Journal article  |  1998  |  Glycobiology

Growth control mechanisms in normal and transformed intestinal cells.

AW Burgess

Journal article  |  1998  |  Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

The cells populating the intestinal crypts are part of a dynamic tissue system which involves the self-renewal of stem cells, a co..

Characterization of rat brain stathmin isoforms by two-dimensional gel electrophoresis matrix assisted laser desorption/ionization and electrospray ionization ion trap mass spectrometry

LM Zugaro, GE Reid, H Ji, JS Eddes, AC Murphy, AW Burgess, RJ Simpson

Journal article  |  1998  |  Electrophoresis

Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium

RL Moritz, G Ritter, B Catimel, LS Cohen, S Welt, LJ Old, AW Burgess, EC Nice, RJ Simpson

Journal article  |  1998  |  Journal of Chromatography A

Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3.

F Walker, ML Hibbs, HH Zhang, LJ Gonez, AW Burgess

Journal article  |  1998  |  Growth Factors

The Epidermal Growth Factor (EGF) receptor appears to require a fully active tyrosine kinase domain to transmit mitogenic signals...

Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium

G Ritter, LS Cohen, EC Nice, B Catimel, AW Burgess, RL Moritz, H Ji, JK Heath, SJ White, S Welt, LJ Old, RJ Simpson

Journal article  |  1997  |  Biochemical and Biophysical Research Communications

Kinetic analysis of the interaction between the monoclonal antibody A33 and its colonic epithelial antigen by the use of an optical biosensor - A comparison of immobilisation strategies

B Catimel, M Nerrie, FT Lee, AM Scott, G Ritter, S Welt, LJ Old, AW Burgess, EC Nice

Conference Proceedings  |  1997  |  Journal of Chromatography A

Strategies for the identification and purification of ligands for orphan biomolecules

E Nice, B Catimel, M Lackmann, S Stacker, A Runting, A Wilks, N Nicola, A Burgess

Journal article  |  1997  |  Letters in Peptide Science

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?

LC Groenen, F Walker, AW Burgess, HR Treutlein

Journal article  |  1997  |  Biochemistry

The binding of epidermal growth factor (EGF) to its receptor leads to receptor dimerization, which activates the intracellular kin..

A two-dimensional gel database of human colon carcinoma proteins

H Ji, GE Reid, RL Moritz, JS Eddes, AW Burgess, RJ Simpson

Journal article  |  1997  |  Electrophoresis

Electrophoretic analysis of the novel antigen for the gastrointestinal-specific monoclonal antibody, A33

H Ji, RL Moritz, GE Reid, G Ritter, B Catimel, E Nice, JK Heath, SJ White, S Welt, LJ Old, AW Burgess, RJ Simpson

Journal article  |  1997  |  Electrophoresis

The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily

JK Heath, SJ White, CN Johnstone, B Catimel, RJ Simpson, RL Moritz, GF Tu, H Ji, RH Whitehead, LC Groenen, AM Scott, G Ritter, L Cohen, S Welt, LJ Old, EC Nice, AW Burgess

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

Strategies for the identification and purification of ligands for orphan biomolecules

E Nice, B Catimel, M Lackmann, S Stacker, A Runting, A Wilks, N Nicola, A Burgess

Journal article  |  1997  |  International Journal of Peptide Research and Therapeutics

Ninth Lorne Cancer Conference

N Konstantopoulos, A Burgess

Conference Proceedings  |  1997  |  Cancer Forum

Purification and characterization of a novel restricted antigen expressed by normal and transformed human colonic epithelium

B Catimel, G Ritter, S Welt, LJ Old, L Cohen, MA Nerrie, SJ White, JK Heath, B Demediuk, T Domagala, FT Lee, AM Scott, GF Tu, H Ji, RL Moritz, RJ Simpson, AW Burgess, EC Nice

Journal article  |  1996  |  Journal of Biological Chemistry

Synergy between Apc(min) and an activated ras mutation is sufficient to induce colon carcinomas

GM DAbaco, RH Whitehead, AW Burgess

Journal article  |  1996  |  Molecular and Cellular Biology

Tissue factor expression in human leukemic cells

GA Hair, S Padula, R Zeff, M Schmeizl, J Contrino, DL Kreutzer, P deMoerloose, AW Boyd, I Stanley, AW Burgess, FR Rickles

Journal article  |  1996  |  Leukemia Research

Modeling conformational changes in cyclosporin A.

MF O'Donohue, AW Burgess, MD Walkinshaw, HR Treutlein

Journal article  |  1995  |  Protein Science

NMR and X-ray structures for the immunosuppressant cyclosporin A (CsA) reveal a remarkable difference between the unbound (free) c..

Reduction in platelet-derived growth factor receptor mRNA in v-src-transformed fibroblasts.

QX Zhang, F Walker, AW Burgess, GS Baldwin

Journal article  |  1995  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

The status of the platelet-derived growth factor (PDGF) receptor in normal rat kidney (NRK) fibroblasts and in NRK fibroblasts tra..

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

KJ Fowler, F Walker, W Alexander, ML Hibbs, EC Nice, RM Bohmer, GB Mann, C Thumwood, R Maglitto, JA Danks

Journal article  |  1995  |  Proceedings of the National Academy of Sciences

The mutant mouse waved-2 (wa-2) is strikingly similar to transforming growth factor alpha-deficient mice generated by gene targeti..

A potent human interleukin-4 antagonist stimulates the proliferation of murine cells expressing the human interleukin-4 binding chain.

ID Davis, HR Treutlein, K Friedrich, AW Burgess

Journal article  |  1995  |  Growth Factors

A single-amino-acid substitution mutant form of human interleukin-4 (hIL-4), Y124D.hIL-4, has been described previously as an anta..

A BRAVE-NEW-WORLD OF CANCER SCREENING

MA ROSENTHAL, AW BURGESS

Journal article  |  1994  |  Australian and New Zealand Journal of Medicine

The Sixth George Swanson Christie Memorial Lecture: growth factors and their receptors: new opportunities for cancer treatment.

AW Burgess, CM Thumwood

Journal article  |  1994  |  Pathology

Regulation of the Ras signalling network.

H Maruta, AW Burgess

Journal article  |  1994  |  BioEssays

The mitogenic action of cytokines such as epidermal growth factor (EGF) or platelet derived growth factor (PDGF) involves the stim..

Designing amino acids to determine the local conformations of peptides.

AW Burgess

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

The local conformations of proteins and peptides are determined by the amino acid sequence. However, the 20 amino acids encoded by..

Platelet-derived growth factor stimulates the release of protein kinase A from the cell membrane.

J deBlaquiere, F Walker, VP Michelangeli, L Fabri, AW Burgess

Journal article  |  1994  |  Journal of Biological Chemistry

The mitogenic action of growth factors involves the stimulation of intracellular protein kinases. In this report we have character..

Synergies between micropreparative high-performance liquid chromatography and an instrumental optical biosensor.

E Nice, M Lackmann, F Smyth, L Fabri, AW Burgess

Journal article  |  1994  |  Journal of Chromatography A

The recent development of an automated surface plasmon resonance technology for the measurement of biomolecular interactions (Phar..

Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature.

AR Dunn, GB Mann, KJ Fowler, D Grail, ML Hibbs, WS Alexander, F Walker, AW Burgess

Journal article  |  1994  |  Princess Takamatsu symposia

Transforming growth factor alpha (TGF alpha) is one of a group of structurally-related growth factors (the epidermal growth factor..

Sixth Lorne Cancer Conference, 1994

A Burgess

Conference Proceedings  |  1994  |  Cancer Forum

STRUCTURE-FUNCTION-RELATIONSHIPS FOR THE EGF/TGF-ALPHA FAMILY OF MITOGENS

LC GROENEN, EC NICE, AW BURGESS

Journal article  |  1994  |  Growth Factors

Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor.

F Walker, J deBlaquiere, AW Burgess

Journal article  |  1993  |  Journal of Biological Chemistry

The src family of protein-tyrosine kinases has long been implicated in signal transduction by growth factor receptors. In particul..

STRUCTURAL CHARACTERIZATION OF NATIVE AND RECOMBINANT FORMS OF THE NEUROTROPHIC CYTOKINE MK

L FABRI, H MARUTA, H MURAMATSU, T MURAMATSU, AW BURGESS, EC NICE

Journal article  |  1993  |  Journal of Chromatography A

Mapping of the antibody- and receptor-binding domains of granulocyte colony-stimulating factor using an optical biosensor. Comparison with enzyme-linked immunosorbent assay competition studies.

E Nice, J Layton, L Fabri, U Hellman, A Engstrom, B Persson, AW Burgess

Journal article  |  1993  |  Journal of Chromatography A

An automated optical biosensor instrument for measuring molecular interactions (Pharmacia BIAcore) has been used to characterise t..

EPIDERMAL GROWTH-FACTOR INDUCES SERINE PHOSPHORYLATION OF STATHMIN IN A HUMAN COLON-CARCINOMA CELL-LINE (LIM-1215)

H JI, GS BALDWIN, AW BURGESS, RL MORITZ, LD WARD, RJ SIMPSON

Journal article  |  1993  |  Journal of Biological Chemistry

MIDKINE (MK), A RETINOIC ACID (RA)-INDUCIBLE GENE-PRODUCT, PRODUCED IN E-COLI ACTS ON NEURONAL AND HL-60 LEUKEMIA-CELLS

H MARUTA, PF BARTLETT, V NURCOMBE, MSA NUREKAMAL, C CHOMIENNE, T MURAMATSU, H MURAMATSU, L FABRI, E NICE, AW BURGESS

Journal article  |  1993  |  Growth Factors

Erratum: Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints (Biochemistry (January 14, 1992) 31:1 (236-249))

GT Montelione, K Wuthrich, AW Burgess, EC Nice, G Wagner, KD Gibson, HA Scheraga

Journal article  |  1992  |  Biochemistry

Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line.

AM Sizeland, AW Burgess

Journal article  |  1992  |  Molecular Biology of the Cell

Many carcinoma cells secrete transforming growth factor alpha (TGF alpha). A 23 base anti-sense oligonucleotide that recognizes th..

CHARACTERIZATION OF BOVINE HEPARIN-BINDING NEUROTROPHIC FACTOR (HBNF) - ASSIGNMENT OF DISULFIDE BONDS

L FABRI, EC NICE, LD WARD, H MARUTA, AW BURGESS, RJ SIMPSON

Journal article  |  1992  |  Biochemistry International

Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (2).

GJ Lieschke, AW Burgess

Journal article  |  1992  |  New England Journal of Medicine

Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1).

GJ Lieschke, AW Burgess

Journal article  |  1992  |  New England Journal of Medicine

THE PURIFICATION OF A RAP1 GTPASE-ACTIVATING PROTEIN FROM BOVINE BRAIN CYTOSOL

EC NICE, L FABRI, A HAMMACHER, J HOLDEN, RJ SIMPSON, AW BURGESS

Journal article  |  1992  |  Journal of Biological Chemistry

Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints.

GT Montelione, K Wüthrich, AW Burgess, EC Nice, G Wagner, KD Gibson, HA Scheraga

Journal article  |  1992  |  Biochemistry

The solution structure of murine epidermal growth factor (mEGF) at pH 3.1 and a temperature of 28 degrees C has been determined fr..

IDENTIFICATION OF A FUNCTIONAL DOMAIN OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR USING NEUTRALIZING MONOCLONAL-ANTIBODIES

JE LAYTON, G MORSTYN, LJ FABRI, GE REID, AW BURGESS, RJ SIMPSON, EC NICE

Journal article  |  1991  |  Journal of Biological Chemistry

The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors.

AM Sizeland, AW Burgess

Journal article  |  1991  |  Molecular and Cellular Biology

The role of autocrine growth factors in tumor cell growth has been difficult to prove. Our results indicate that more than one aut..

Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor.

F Walker, AW Burgess

Journal article  |  1991  |  Journal of Biological Chemistry

We have prepared plasma membranes from Balb/c 3T3 fibroblasts to study the transmodulation of the high affinity epidermal growth f..

Stimulation of myoblast proliferation in culture by leukaemia inhibitory factor and other cytokines.

L Austin, AW Burgess

Journal article  |  1991  |  Journal of the Neurological Sciences

Significant stimulation of growth of myoblasts in culture is achieved by leukemia inhibitory factor (LIF). The optimum activity of..

The action of epidermal growth factor (EGF) is limited to specific phases of the cell cycle in an EGF dependent colonic cell line.

A Sizeland, S Bol, AW Burgess

Journal article  |  1991  |  Growth Factors

In the presence of epidermal growth factor (EGF) a human colon cell line, LIM 1215, proliferates in serum-free medium. Under these..

Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocyte macrophage colony-stimulating factor: altered biological responses to GM-CSF during development.

CM Heyworth, J Hampson, TM Dexter, F Walker, AW Burgess, O Kan, N Cook, SJ Vallance, AD Whetton

Journal article  |  1991  |  Growth Factors

Interleukin-3 (IL-3) dependent multipotent haemopoietic stem cells FDCP-Mix A4 (A4) were induced to differentiate and develop into..

Glycosylation of Human Granulocyte-Macrophage Colony Stimulating Factor Alters Receptor Binding and Biological Activity

J Cebon, AW Burgess

Journal article  |  1991  |  Trends in Glycoscience and Glycotechnology

MONOCLONAL-ANTIBODIES THAT RECOGNIZE HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND NEUTRALIZE ITS BIOACTIVITY INVITRO

PJ DEMPSEY, JE LAYTON, U DUHRSEN, NA NICOLA, J CEBON, AW BURGESS, G MORSTYN

Journal article  |  1990  |  Hybridoma

Resistance to receptor-mediated degradation of a murine epidermal growth factor analogue (EGF-Val-47) potentiates its mitogenic activity.

F Walker, E Nice, L Fabri, FJ Moy, JF Liu, R Wu, HA Scheraga, AW Burgess

Journal article  |  1990  |  Biochemistry

In most cell types two classes of epidermal growth factor (EGF) receptors can be found: a major class that binds EGF with relative..

Detection of colonic growth factors using a human colonic carcinoma cell line (LIM1215).

RH Whithead, EC Nice, CJ Lloyd, R James, AW Burgess

Journal article  |  1990  |  International Journal of Cancer

Although the colonic mucosa is one of the most rapidly proliferating epithelial tissues in the body, little is known about the fac..

Autocrine growth factors and tumourigenic transformation.

RA Lang, AW Burgess

Journal article  |  1990  |  Immunology Today

The development of tumours requires the simultaneous presence of a number of molecular perturbations. It is becoming increasingly ..

GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR FROM HUMAN-LYMPHOCYTES - THE EFFECT OF GLYCOSYLATION ON RECEPTOR-BINDING AND BIOLOGICAL-ACTIVITY

J CEBON, N NICOLA, M WARD, I GARDNER, P DEMPSEY, J LAYTON, U DUHRSEN, AW BURGESS, E NICE, G MORSTYN

Journal article  |  1990  |  Journal of Biological Chemistry

Phase I study of intravenously administered bacterially synthesized granulocyte-macrophage colony-stimulating factor and comparison with subcutaneous administration.

GJ Lieschke, D Maher, M O'Connor, M Green, W Sheridan, M Rallings, E Bonnem, AW Burgess, K McGrath, RM Fox

Journal article  |  1990  |  Cancer Research

A Phase I study of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was under..

Autocrine growth factors and tumourigenic transformation

RA Lang, AW Burgess

Journal article  |  1990  |  Immunology Today

Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF): Identification of a Binding Site for a Neutralizing Antibody

Edouard Nice, Peter Dempsey, Judith Layton, George Morstyn, Da-Fu Cui, Richard Simpson, Louis Fabri, Antony Burgess

Journal article  |  1990  |  Growth Factors

One approach to the localization of functionally active regions of human granulocyte-macrophage colony-stimulating factor (hGM-CSF..

Growth factors and the gut.

AW Burgess, AM Sizeland

Journal article  |  1990  |  Journal of Gastroenterology and Hepatology

Life after LIF?

AW Burgess

Journal article  |  1989  |  BioEssays

Epidermal growth factor and transforming growth factor alpha.

AW Burgess

Journal article  |  1989  |  British Medical Bulletin

This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth fa..

Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract.

LT Malden, U Novak, AW Burgess

Journal article  |  1989  |  International Journal of Cancer

The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the nor..

EFFECTS OF BACTERIALLY SYNTHESIZED RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PATIENTS WITH ADVANCED MALIGNANCY

GJ LIESCHKE, D MAHER, J CEBON, M OCONNOR, M GREEN, W SHERIDAN, A BOYD, M RALLINGS, E BONNEM, D METCALF, AW BURGESS, K MCGRATH, RM FOX, G MORSTYN

Journal article  |  1989  |  Annals of Internal Medicine

Haemopoietic growth factor control of normal and neoplastic cellular proliferation.

AW Burgess, J Cebon, S Smith

Journal article  |  1989  |  Biochemical Society Symposia

Endotoxin induces the appearance of granulocyte colony stimulating factor (G-CSF) and macrophage (M)-CSF in the serum of mice. No ..

The origins of growth factors: tethelin lost

AW Burgess

Journal article  |  1989  |  Trends in Biochemical Sciences

Growth Factor-Induced Phosphorylation of c-ras p21 in Normal Hemopoietic Progenitor Cells

IJ Stanley, NA Nicola, AW Burgess

Journal article  |  1989  |  Growth Factors

Normal murine hemopoietic progenitor cells (colony-forming cells, CFC), representing 0.2% of the bone marrow cell population, were..

An autocrine activity capable of substituting for serum in cell cultures.

RM Böhmer, AW Burgess

Journal article  |  1989  |  Growth Factors

Provided that high cell densities (above 10(6)/ml) are maintained, a factor-dependent murine hemopoietic progenitor cell line (FDC..

Cell surface heparan sulphate implicated in haemopoietic growth factor signalling

AW Burgess

Journal article  |  1988  |  Trends in Immunology

Transmodulation of the epidermal-growth-factor receptor in permeabilized 3T3 cells.

F Walker, AW Burgess

Journal article  |  1988  |  Biochemical Journal

Binding of murine epidermal growth factor (EGF) to its high-affinity receptor can be modulated by a variety of structurally unrela..

Hemopoietic growth factors: a review.

G Morstyn, AW Burgess

Journal article  |  1988  |  Cancer Research

Several hemopoietic growth factors have now been purified, cloned, and produced in bacteria. Granulocyte colony stimulating factor..

PHARMACOKINETICS OF HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR USING A SENSITIVE IMMUNOASSAY

J CEBON, P DEMPSEY, R FOX, G KANNOURAKIS, E BONNEM, AW BURGESS, G MORSTYN

Journal article  |  1988  |  Blood

Cell surface heparan sulphate implicated in haemopoietic growth factor signalling.

AW Burgess

Journal article  |  1988  |  Immunology Today

Granulocytic colony-stimulating factor (G-CSF) does not induce differentiation of WEHI3B(D ) cells but is required for the survival of the mature progeny.

RM Böhmer, AW Burgess

Journal article  |  1988  |  International Journal of Cancer

It has been reported previously that cells of the murine myelomonocytic leukaemia cell line WEHI3B(D+) can be induced to different..

MURINE EPIDERMAL GROWTH-FACTOR - STRUCTURE AND FUNCTION

AW BURGESS, CJ LLOYD, S SMITH, E STANLEY, F WALKER, L FABRI, RJ SIMPSON, EC NICE

Journal article  |  1988  |  Biochemistry

ACTIVATION AND PROLIFERATION SIGNALS IN MURINE MACROPHAGES - SYNERGISTIC INTERACTIONS BETWEEN THE HEMATOPOIETIC GROWTH-FACTORS AND WITH PHORBOL ESTER FOR DNA-SYNTHESIS

JA HAMILTON, G VAIRO, NA NICOLA, A BURGESS, D METCALF, SR LINGELBACH

Journal article  |  1988  |  Blood

SELECTIVE AMPLIFICATION OF THE CYTOPLASMIC DOMAIN OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR GENE IN GLIOBLASTOMA-MULTIFORME

LT MALDEN, U NOVAK, AH KAYE, AW BURGESS

Journal article  |  1988  |  Cancer Research

Growth factors: the beginnings.

AW Burgess

Journal article  |  1988  |  Growth Factors

Int-1 and int-2: oncogenic proteins, mitogens and morphogens?

AW Burgess

Journal article  |  1988  |  BioEssays

PRIMARY STRUCTURE OF OVINE PITUITARY BASIC FIBROBLAST GROWTH-FACTOR

RJ SIMPSON, RL MORITZ, CJ LLOYD, LJ FABRI, EC NICE, MR RUBIRA, AW BURGESS

Journal article  |  1987  |  FEBS Letters

Solution structure of murine epidermal growth factor: determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry.

GT Montelione, K Wüthrich, EC Nice, AW Burgess, HA Scheraga

Journal article  |  1987  |  Proceedings of the National Academy of Sciences

The polypeptide backbone fold in the solution structure of murine epidermal growth factor has been determined by nuclear magnetic ..

SYNTHESIS OF BIOLOGICALLY-ACTIVE HUMAN TRANSFORMING GROWTH FACTOR-ALPHA BY FLUORENYLMETHOXYCARBONYL SOLID-PHASE PEPTIDE CHEMISTRY

DB SCANLON, MA EEFTING, CJ LLOYD, AW BURGESS, RJ SIMPSON

Journal article  |  1987  |  Journal of the Chemical Society, Chemical Communications

Internalisation and recycling of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on a murine myelomonocytic leukemia.

F Walker, AW Burgess

Journal article  |  1987  |  Journal of Cellular Physiology

Radioiodinated granulocyte-macrophage colony-stimulating factor (125I-GM-CSF) binds to specific receptors (molecular weight approx..

Growth factors and their receptors: specific roles in development.

AW Burgess

Journal article  |  1987  |  BioEssays

PURIFICATION AND PROPERTIES OF BACTERIALLY SYNTHESIZED HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR

AW BURGESS, CG BEGLEY, GR JOHNSON, AF LOPEZ, DJ WILLIAMSON, JJ MERMOD, RJ SIMPSON, A SCHMITZ, JF DELAMARTER

Journal article  |  1987  |  Blood

Identification of two anti-parallel beta-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance.

GT Montelione, K Wüthrich, EC Nice, AW Burgess, HA Scheraga

Journal article  |  1986  |  Proceedings of the National Academy of Sciences

Epidermal growth factor (EGF) is a small mitogenic protein. Proteins with sequence homology with EGF or with its membrane-bound pr..

INVITRO ACTIONS ON HEMATOPOIETIC-CELLS OF RECOMBINANT MURINE GM-CSF PURIFIED AFTER PRODUCTION IN ESCHERICHIA-COLI - COMPARISON WITH PURIFIED NATIVE GM-CSF

D METCALF, AW BURGESS, GR JOHNSON, NA NICOLA, EC NICE, J DELAMARTER, DR THATCHER, JJ MERMOD

Journal article  |  1986  |  Journal of Cellular Physiology

Production and characterization of monoclonal antibodies reactive with subsets of epidermal cells.

ID Gardner, RH Whitehead, AW Burgess

Journal article  |  1986  |  Pathology

Monoclonal antibodies were raised against an extract of human callus to provide markers of cell differentiation. Three antibodies,..

Growth factors, receptors and cancer.

AW Burgess

Journal article  |  1986  |  BioEssays

BINDING OF FLUORESCEINATED EPIDERMAL GROWTH-FACTOR TO A431 CELL SUBPOPULATIONS STUDIED USING A MODEL-INDEPENDENT ANALYSIS OF FLOW CYTOMETRIC FLUORESCENCE DATA

RC CHATELIER, RG ASHCROFT, CJ LLOYD, EC NICE, RH WHITEHEAD, WH SAWYER, AW BURGESS

Journal article  |  1986  |  The EMBO Journal

GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR FROM MOUSE LUNG CONDITIONED MEDIUM - PURIFICATION OF MULTIPLE FORMS AND RADIOIODINATION

AW BURGESS, D METCALF, LG SPARROW, RJ SIMPSON, EC NICE

Journal article  |  1986  |  Biochemical Journal

The control of blood cell production

AW Burgess

Journal article  |  1986  |  Immunology Today

RAT EPIDERMAL GROWTH-FACTOR - COMPLETE AMINO-ACID-SEQUENCE HOMOLOGY WITH THE CORRESPONDING MURINE AND HUMAN PROTEINS - ISOLATION OF A FORM TRUNCATED AT BOTH ENDS WITH FULL INVITRO BIOLOGICAL-ACTIVITY

RJ SIMPSON, JA SMITH, RL MORITZ, MJ OHARE, PS RUDLAND, JR MORRISON, CJ LLOYD, B GREGO, AW BURGESS, EC NICE

Journal article  |  1985  |  European Journal of Biochemistry

Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium.

AW Burgess, D Metcalf, IJ Kozka, RJ Simpson, G Vairo, JA Hamilton, EC Nice

Journal article  |  1985  |  Journal of Biological Chemistry

A modified procedure for the purification of the colony-stimulating factors (CSFs) in mouse L-cell-conditioned medium is used to i..

Specific binding of radioiodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells.

F Walker, AW Burgess

Journal article  |  1985  |  The EMBO Journal

The hemopoietic growth factor granulocyte-macrophage colony-stimulating factor, GM-CSF, specifically controls the production of gr..

Growth factors and cancer.

AW Burgess

Journal article  |  1985  |  ANZ Journal of Surgery

Recent advances in protein chemistry and genetic engineering have revealed new information about the molecular lesions involved in..

Haemopoietic growth factors: structure and receptor interactions.

AW Burgess

Journal article  |  1985  |  Ciba Foundation symposium

The proteins which regulate the production of blood cells appear to have overlapping functions. There are several forms of the hae..

HIERARCHICAL DOWN-MODULATION OF HEMATOPOIETIC GROWTH-FACTOR RECEPTORS

F WALKER, NA NICOLA, D METCALF, AW BURGESS

Journal article  |  1985  |  Cell

MALIGNANT TRANSFORMATION OF A GROWTH FACTOR-DEPENDENT MYELOID CELL-LINE BY ABELSON VIRUS WITHOUT EVIDENCE OF AN AUTOCRINE MECHANISM

WD COOK, D METCALF, NA NICOLA, AW BURGESS, F WALKER

Journal article  |  1985  |  Cell

Growth factors and oncogenes

A Burgess

Journal article  |  1985  |  Immunology Today

PURIFICATION AND PARTIAL AMINO-ACID SEQUENCE OF ASIALO MURINE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR

LG SPARROW, D METCALF, MW HUNKAPILLER, LE HOOD, AW BURGESS

Journal article  |  1985  |  Proceedings of the National Academy of Sciences

BIOSYNTHETIC LABELING WITH P-32 - RADIATION-DAMAGE TO MAMMALIAN-CELLS

PC COOPER, AW BURGESS

Journal article  |  1985  |  Analytical Biochemistry

Murine granulocyte-macrophage colony-stimulating factor.

AW Burgess, EC Nice

Journal article  |  1985  |  Methods in Enzymology

THE ROLE OF SHORT MICROBORE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY COLUMNS FOR PROTEIN SEPARATION AND TRACE ENRICHMENT

EC NICE, CJ LLOYD, AW BURGESS

Journal article  |  1984  |  Journal of Chromatography A

MOLECULAR-CLONING OF CDNA-ENCODING A MURINE HEMATOPOIETIC GROWTH-REGULATOR, GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR

NM GOUGH, J GOUGH, D METCALF, A KELSO, D GRAIL, NA NICOLA, AW BURGESS, AR DUNN

Journal article  |  1984  |  Nature

BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF A SERUM FACTOR THAT STIMULATES SPLENIC HEMATOPOIESIS IN MICE

FG STABER, AW BURGESS, NA NICOLA, D METCALF

Journal article  |  1984  |  Experimental Hematology

Hematopoietic growth factors.

AW Burgess

Journal article  |  1984  |  Symposium on Fundamental Cancer Research

ELECTROPHORETIC ANALYSIS OF THE CYTOPLASMIC AND NUCLEAR-PROTEIN CHANGES AFTER INDUCTION OF DIFFERENTIATION IN WEHI-3B MYELOMONOCYTIC LEUKEMIA-CELLS

PC COOPER, AW BURGESS

Journal article  |  1984  |  Journal of Cellular Biochemistry

The complex mediators of cell growth and differentiation

AW Burgess

Journal article  |  1984  |  Immunology Today

EFFECTS OF 12-0-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON THE PROLIFERATION OF GRANULOCYTE-MACROPHAGE COLONY-FORMING CELLS

AW BURGESS, NA NICOLA

Journal article  |  1983  |  Blood

ACTIVATION OF GRANULOCYTE CYTO-TOXIC FUNCTION BY PURIFIED MOUSE COLONY-STIMULATING FACTORS

AF LOPEZ, NA NICOLA, AW BURGESS, D METCALF, FL BATTYE, WA SEWELL, M VADAS

Journal article  |  1983  |  Journal of Immunology

Effect of colony-stimulating factors on the proteins synthesized by normal and leukemic myeloid progenitor cells.

AW Burgess, PC Cooper, IJ Stanley, NA Nicola

Journal article  |  1983  |  Hamatologie und Bluttransfusion

MURINE EPIDERMAL GROWTH-FACTOR - HETEROGENEITY ON HIGH-RESOLUTION ION-EXCHANGE CHROMATOGRAPHY

AW BURGESS, CJ LLOYD, EC NICE

Journal article  |  1983  |  The EMBO Journal

GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR STIMULATES THE SYNTHESIS OF MEMBRANE AND NUCLEAR PROTEINS IN MURINE NEUTROPHILS

IJ STANLEY, AW BURGESS

Journal article  |  1983  |  Journal of Cellular Biochemistry

Prebiotic evolution: conformational perspectives.

AW Burgess

Journal article  |  1982  |  Journal of Theoretical Biology

COLONY-FORMING CELL-PROLIFERATION - A RAPID AND SENSITIVE ASSAY SYSTEM FOR MURINE GRANULOCYTE AND MACROPHAGE COLONY-STIMULATING FACTORS

AW BURGESS, NA NICOLA, GR JOHNSON, EC NICE

Journal article  |  1982  |  Blood

BIOCHEMICAL AND FUNCTIONAL-CHARACTERIZATION OF MATURE PROGENY PURIFIED FROM A MYELOMONOCYTIC LEUKEMIA-CELL LINE

PC COOPER, D METCALF, AW BURGESS

Journal article  |  1982  |  Leukemia Research

CLONAL ANALYSIS OF PROGENITOR-CELL COMMITMENT TO GRANULOCYTE OR MACROPHAGE PRODUCTION

D METCALF, AW BURGESS

Journal article  |  1982  |  Journal of Cellular Physiology

SIMULTANEOUS DETECTION OF S-35-LABELED AND P-32-LABELED PROTEINS ON ELECTROPHORETIC GELS

PC COOPER, AW BURGESS

Journal article  |  1982  |  Analytical Biochemistry

2 FORMS OF MURINE EPIDERMAL GROWTH-FACTOR - RAPID SEPARATION BY USING REVERSE-PHASE HPLC

AW BURGESS, J KNESEL, LG SPARROW, NA NICOLA, EC NICE

Journal article  |  1982  |  Proceedings of the National Academy of Sciences

PHOSPHORYLATION OF A SYNTHETIC GASTRIN PEPTIDE BY THE TYROSINE KINASE OF A431 CELL-MEMBRANES

GS BALDWIN, AW BURGESS, BE KEMP

Journal article  |  1982  |  Biochemical and Biophysical Research Communications

ISOLATION OF MURINE FETAL HEMATOPOIETIC PROGENITOR CELLS AND SELECTIVE FRACTIONATION OF VARIOUS ERYTHROID PRECURSORS

NA NICOLA, D METCALF, H VONMELCHNER, AW BURGESS

Journal article  |  1981  |  Blood

HIGH-RESOLUTION TWO-DIMENSIONAL ELECTROPHORETIC ANALYSIS OF ACIDIC, BASIC AND SURFACE-PROTEINS OF MOUSE NEUTROPHILS

SM WATT, AW BURGESS

Journal article  |  1981  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Surface antigens on normal and leukaemic human cells detected by monoclonal antibodies.

G Morstyn, D Metcalf, A Burgess, JW Fabre

Journal article  |  1981  |  Scandinavian Journal of Haematology

Surface antigens were analyzed on normal human marrow and chronic myeloid leukaemic cells using 4 monoclonal mouse anti-human anti..

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PRODUCED BY AN INDUCIBLE MURINE T-CELL HYBRIDOMA - MOLECULAR-PROPERTIES AND CELLULAR SPECIFICITY

AW BURGESS, PF BARTLETT, D METCALF, NA NICOLA, I CLARKLEWIS, JW SCHRADER

Journal article  |  1981  |  Experimental Hematology

Granulocyte/macrophage-, megakaryocyte-, eosinophil- and erythroid-colony-stimulating factors produced by mouse spleen cells.

AW Burgess, D Metcalf, SH Russell, NA Nicola

Journal article  |  1980  |  Biochemical Journal

The formation of mature haemopoietic cells is controlled by hormones that specifically stimulate the progenitor cells of the granu..

DIFFERENTIAL EXPRESSION OF LECTIN RECEPTORS DURING HEMATOPOIETIC DIFFERENTIATION - ENRICHMENT FOR GRANULOCYTE-MACROPHAGE PROGENITOR CELLS

NA NICOLA, AW BURGESS, FG STABER, GR JOHNSON, D METCALF, FL BATTYE

Journal article  |  1980  |  Journal of Cellular Physiology

ISOLATION OF MOUSE BONE-MARROW NEUTROPHILS BY LIGHT SCATTER AND AUTOFLUORESCENCE

SM WATT, AW BURGESS, D METCALF, FL BATTYE

Journal article  |  1980  |  Journal of Histochemistry & Cytochemistry

STIMULATION OF MACROPHAGE PLASMINOGEN-ACTIVATOR ACTIVITY BY COLONY-STIMULATING FACTORS

JA HAMILTON, ER STANLEY, AW BURGESS, RK SHADDUCK

Journal article  |  1980  |  Journal of Cellular Physiology

PREPARATION AND SURFACE LABELING OF MURINE EOSINOPHILS

AW BURGESS, KM CRUISE, GF MITCHELL, SM WATT

Journal article  |  1980  |  Experimental Hematology

CHARACTERIZATION OF A SERUM FACTOR STIMULATING THE DIFFERENTIATION OF MYELOMONOCYTIC LEUKEMIC-CELLS

AW BURGESS, D METCALF

Journal article  |  1980  |  International Journal of Cancer

DIRECT STIMULATION BY PURIFIED GM-CSF OF THE PROLIFERATION OF MULTIPOTENTIAL AND ERYTHROID PRECURSOR CELLS

D METCALF, GR JOHNSON, AW BURGESS

Journal article  |  1980  |  Blood

THE NATURE AND ACTION OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS

AW BURGESS, D METCALF

Journal article  |  1980  |  Blood

THE EFFECT OF MOUSE LUNG GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND OTHER COLONY-STIMULATING ACTIVITIES ON THE PROLIFERATION AND DIFFERENTIATION OF MURINE BONE-MARROW CELLS IN LONG-TERM CULTURES

N WILLIAMS, AW BURGESS

Journal article  |  1980  |  Journal of Cellular Physiology

SERUM OF LIPOPOLYSACCHARIDE-TREATED MICE CONTAINS 2 TYPES OF COLONY-STIMULATING FACTOR, SEPARABLE BY AFFINITY-CHROMATOGRAPHY

FG STABER, AW BURGESS

Journal article  |  1980  |  Journal of Cellular Physiology

T-cell hybridoma secreting hemopoietic regulatory molecules: granulocyte-macrophage and eosinophil colony-stimulating factors.

M Howard, A Burgess, D McPhee, D Metcalf

Journal article  |  1979  |  Cell

SEPARATION OF FUNCTIONALLY DISTINCT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS

NA NICOLA, D METCALF, GR JOHNSON, AW BURGESS

Journal article  |  1979  |  Blood

STIMULATION BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR OF LEISHMANIA-TROPICA KILLING BY MACROPHAGES

E HANDMAN, AW BURGESS

Journal article  |  1979  |  Journal of Immunology

ISOLATION AND SURFACE LABELING OF MURINE POLYMORPHONUCLEAR NEUTROPHILS

SM WATT, AW BURGESS, D METCALF

Journal article  |  1979  |  Journal of Cellular Physiology

The antigen binding dendritic cell of the lymphoid follicles: evidence indicating its role in the maintenance and regulation of serum antibody levels.

JG Tew, T Mandel, A Burgess, JD Hicks

Journal article  |  1979  |  Advances in Experimental Medicine and Biology