Aimee Tan

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

Zhenyao Luo, Jacqueline R Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G Pederick, James C Paton, Thorben Cordes, Jeffrey R Harmer, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  MBIO

Zinc is an essential element in all domains of life. Nonetheless, how prokaryotes achieve selective acquisition of zinc from the e..

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

David MP De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Phan Minh-Duy, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, et al.

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a cri..

Random Switching of the ModA11 Type III DNA Methyltransferase of Neisseria meningitidis Regulates Entner-Doudoroff Aldolase Expression by a Methylation Change in the eda Promoter Region

Freda E-C Jen, Adeana L Scott, Aimee Tan, Kate L Seib, Michael P Jennings

Journal article  |  2020  |  JOURNAL OF MOLECULAR BIOLOGY

Phase-variable DNA methyltransferases (Mods) mediate epigenetic regulation of gene expression. These phase-variable regulons, call..

Moraxella catarrhalisphase-variable loci show differences in expression during conditions relevant to disease

Aimee Tan, Luke V Blakeway, undefined Taha, Yuedong Yang, Yaoqi Zhou, John M Atack, Ian R Peak, Kate L Seib

Journal article  |  2020  |  PLOS ONE

Moraxella catarrhalis is a human-adapted, opportunistic bacterial pathogen of the respiratory mucosa. Although asymptomatic coloni..

Transcriptome RNA Sequencing Data Set of Gene Expression in Moraxella catarrhalis On- and Off-Phase Variants of the Type III DNA Methyltransferase ModM3

Luke V Blakeway, Aimee Tan, Ian R Peak, John M Atack, Kate L Seib

Journal article  |  2020  |  MICROBIOLOGY RESOURCE ANNOUNCEMENTS

Moraxella catarrhalis is a leading bacterial cause of otitis media and exacerbations of chronic obstructive pulmonary disease. Her..

Proteome of a Moraxella catarrhalis Strain under Iron-Restricted Conditions

Luke Blakeway, Aimee Tan, Ian R Peak, John M Atack, Kate L Seib

Journal article  |  2020  |  MICROBIOLOGY RESOURCE ANNOUNCEMENTS

Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; however, its ..

The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media

Luke V Blakeway, Aimee Tan, Joseph A Jurcisek, Lauren O Bakaletz, John M Atack, Ian R Peak, Kate L Seib

Journal article  |  2019  |  BMC MICROBIOLOGY

BACKGROUND: Moraxella catarrhalis is a leading cause of otitis media (OM) and chronic obstructive pulmonary disease (COPD). M. cat..

The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae

Evgeny A Semchenko, Aimee Tan, Ray Borrow, Kate L Seib

Journal article  |  2019  |  CLINICAL INFECTIOUS DISEASES

BACKGROUND: Neisseria gonorrhoeae and Neisseria meningitidis are closely-related bacteria that cause a significant global burden o..

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A Eijkelkamp, Jacqueline R Morey, Stephanie L Neville, Aimee Tan, Victoria G Pederick, Nerida Cole, Prashina P Singh, Cheryl-Lynn Y Ong, Raquel Gonzalez de Vega, David Clases, Bliss A Cunningham, Catherine E Hughes, Iain Comerford, Erin B Brazel, Jonathan J Whittall, Charles D Plumptre, Shaun R McColl, James C Paton, Alastair G McEwan, Philip A Doble, et al.

Journal article  |  2019  |  PLOS PATHOGENS

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impa..

Moraxella catarrhalis NucM is an entry nuclease involved in extracellular DNA and RNA degradation, cell competence and biofilm scaffolding

Aimee Tan, Wing-Sze Li, Anthony D Verderosa, Luke Blakeway, Tsitsi D Mubaiwa, Makrina Totsika, Kate L Seib

Journal article  |  2019  |  SCIENTIFIC REPORTS

Moraxella catarrhalis is a host-adapted bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmo..