Ian Wicks

Circulating Small Noncoding RNA Biomarkers of Response to Triple Disease-modifying Antirheumatic Drug Therapy in White Women With Early Rheumatoid Arthritis

Andrew D Foers, Alexandra L Garnham, Gordon K Smyth, Susanna M Proudman, Lesley Cheng, Andrew F Hill, Ken C Pang, Ian P Wicks

Journal article  |  2020  |  The Journal of Rheumatology

OBJECTIVE: To identify small noncoding RNA (sncRNA) serum biomarkers that predict response to triple disease-modifying antirheumat..

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

Maryam Rashidi, Ian P Wicks, James E Vince

Journal article  |  2020  |  Trends in Molecular Medicine

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation..

Leukocyte Tetraspanin CD53 Restrains alpha(3) Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice

Louisa Yeung, Jeremy ML Anderson, Janet L Wee, Maria C Demaria, Michaela Finsterbusch, Yuxin S Liu, Pam Hall, Brodie C Smith, Wendy Dankers, Kirstin D Elgass, Ian P Wicks, Hang Fai Kwok, Mark D Wright, Michael J Hickey

Journal article  |  2020  |  The Journal of Immunology

The importance of tetraspanin proteins in regulating migration has been demonstrated in many diverse cellular systems. However, th..

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Holly Anderton, Ian P Wicks, John Silke

Journal article  |  2020  |  Nature Reviews Rheumatology

Correspondence regarding research letter to the editor by Mathian et al, 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus under long-term treatment with hydroxychloroquine'.

Mandana Nikpour, Benjamin Teh, Ian P Wicks, Marc Pellegrini

Journal article  |  2020  |  Annals of the Rheumatic Diseases

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

TBK1 and IKK epsilon Act Redundantly to Mediate STING-Induced NF-kappa B Responses in Myeloid Cells

Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan, Christopher J Burns, Ian P Wicks, Jonathan J Miner, Benjamin T Kile, Seth L Masters, Dominic De Nardo

Journal article  |  2020  |  Cell Reports

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimm..

Genetic susceptibility to hydroxychloroquine retinal toxicity

Heather G Mack, Tanya Kowalski, Alexis Lucattini, Rc Andrew Symons, Ian Wicks, Anthony Jh Hall

Journal article  |  2020  |  Ophthalmic Genetics

Background: Hydroxychloroquine retinal toxicity can occur in up to 7.5% of patients receiving treatment; however, possible genetic..

Inhibition of interleukin-1 beta signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis

Dragana Dragoljevic, Man Kit Sam Lee, Cynthia Louis, Waled Shihata, Michael J Kraakman, Jacinta Hansen, Seth L Masters, Beatriz Y Hanaoka, Prabhakara R Nagareddy, Graeme Lancaster, Ian P Wicks, Andrew J Murphy

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease ..