Graham Giles

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.

Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Hermann Brenner, et al.

Journal article  |  2021  |  Gastroenterology

BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide as..

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Blaker, Matthias Kloor, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  American Journal of Human Genetics

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

Journal article  |  2020  |  Clinical Epigenetics

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..

Folate and folic acid intake in relation to molecular subtypes of colorectal cancer; a pooled analysis of 7542 cases

Bethany Van Guelpen, Bjorn Gylling, Sophia Harlid, Anna Winkvist, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Roger L Milne, Polly A Newcomb, Shuji Ogino, John D Potter, Conghui Qu, et al.

Conference Proceedings  |  2020  |  Epidemiology

Serum cytokine concentrations and asthma persistence to middle age

Jingwen Zhang, Eugene H Walters, Mimi LK Tang, Adrian J Lowe, Caroline J Lodge, Dinh Bui, Rangi Kandane-Rathnayake, Bircan Erbas, Garun S Hamilton, Bruce R Thompson, Michael J Abramson, Graham G Giles, Jennifer L Perret, Shyamali C Dharmage

Journal article  |  2020  |  Allergy

Cytokines play a key role as mediators in the immuno-pathogenesis of asthma.1 Age at asthma onset and the presence of T-helper 2 m..

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Haoyu Zhan, Thomas U Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Guanghao Qi, Xia Jiang, Tracy A O'Mara, Ni Zhao, Manjeet K Bolla, Alison M Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Banu K Arun, et al.

Journal article  |  2020  |  Nature Genetics

Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, w..

Rare germline genetic variants and risk of aggressive prostate cancer

Tu Nguyen-Dumont, Robert J MacInnis, Jason A Steen, Derrick Theys, Helen Tsimiklis, Fleur Hammet, Maryam Mahmoodi, Bernard J Pope, Daniel J Park, Khalid Mahmood, Gianluca Severi, Damien Bolton, Roger L Milne, Graham G Giles, Melissa C Southey

Journal article  |  2020  |  International Journal of Cancer

Few genetic risk factors have been demonstrated to be specifically associated with aggressive prostate cancer (PrCa). Here, we rep..

A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation

Robert J Ellis, Sharon J Del Vecchio, Kevin MJ Gallagher, Danielle N Aliano, Neil Barber, Damien M Bolton, Etienne TS Chew, Jeff S Coombes, Michael D Coory, Ian D Davis, James F Donaldson, Ross S Francis, Graham G Giles, Glenda C Gobe, Carmel M Hawley, David W Johnson, Alexander Laird, Steve Leung, Manar Malki, David JT Marco, et al.

Journal article  |  2020  |  Journal of the American Society of Nephrology

BACKGROUND: Clinically significant CKD following surgery for kidney cancer is associated with increased morbidity and mortality, b..

Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stephane Bezieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey, et al.

Journal article  |  2020  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in t..