Graham Giles

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

Konstantinos K Tsilidis, Nikos Papadimitriou, Niki Dimou, Dipender Gill, Sarah J Lewis, Richard M Martin, Neil Murphy, Georgios Markozannes, Verena Zuber, Amanda J Cross, Kimberley Burrows, David S Lopez, Timothy J Key, Ruth C Travis, Aurora Perez-Cornago, David J Hunter, Fränzel JB van Duijnhoven, Demetrius Albanes, Volker Arndt, Sonja I Berndt, et al.

Journal article  |  2021  |  American Journal of Clinical Nutrition

BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer i..

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects

Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja Berndt, Stephane Bezieau, D Timothy Bishop, Hermann Brenner, et al.

Journal article  |  2021  |  GASTROENTEROLOGY

BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide as..

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Caroline J Bull, Joshua A Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J Timpson, Barbara L Banbury, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellvi-Bel, Andrew T Chan, Jenny Chang-Claude, Amanda J Cross, Albert de la Chapelle, et al.

Journal article  |  2020  |  BMC MEDICINE

BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub..

Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure

Tuong L Nguyen, Daniel F Schmidt, Enes Makalic, Gertraud Maskarinec, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Robert J MacInnis, Pierre-Antoine Dugue, James G Dowty, Mark A Jenkins, Roger L Milne, Melissa C Southey, Graham G Giles, et al.

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CANCER

Mammograms contain information that predicts breast cancer risk. We developed two novel mammogram-based breast cancer risk measure..

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Blaker, Matthias Kloor, et al.

Journal article  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF HUMAN GENETICS

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

Journal article  |  2020  |  CLINICAL EPIGENETICS

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Julia D Labadie, Tabitha A Harrison, Barbara Banbury, Efrat L Amtay, Sonja Bernd, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Dallas English, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Yi Lin, et al.

Journal article  |  2020  |  JNCI CANCER SPECTRUM

Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Amedeo Gagliardi, Pierre-Antoine Dugue, Therese H Nost, Melissa C Southey, Daniel D Buchanan, Daniel F Schmidt, Enes Makalic, Allison M Hodge, Dallas R English, Nicole W Doo, John L Hopper, Gianluca Severi, Laura Baglietto, Alessio Naccarati, Sonia Tarallo, Luigia Pace, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, et al.

Journal article  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Domain-Specific Physical Activity, Pain Interference, and Muscle Pain after Activity

Christopher TV Swain, Julie K Bassett, Allison M Hodge, Fiona J Bruinsma, Shahid Mahmood, Harindra Jayasekara, Robert J Macinnis, Graham G Giles, Roger L Milne, Dallas R English, Brigid M Lynch

Journal article  |  2020  |  MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

PURPOSE: Using the Melbourne Collaborative Cohort Study, we examined the associations of occupation, household, transport, and lei..