Dr Philippe Boeuf is a research fellow at the Department of Medicine at The University of Melbourne. During his PhD at the Pasteur Institute in Paris, and using a combination of lab-based and field research, he showed that severe anaemia and cerebral malaria, the two main forms of severe paediatric malaria, were associated with specific immune profiles.
In 2005, he joined the lab of Pr Stephen Rogerson and focused his efforts on gaining a better understanding of the pathogenetic mechanisms underlying the poor outcomes associated with placental malaria. He has generated seminal data on decreased transplacental transport of maternal nutrients as a mechanism of disease in malaria in pregnancy. This discovery opens the way to intervention studies to alleviate the burden of malaria in pregnancy.
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Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity ..
Displaying the 3 most recent projects by Philippe Boeuf.
Internal Research Grant
Displaying the 31 most recent scholarly works by Philippe Boeuf.
Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children
Cleopatra K Mugyenyi, Salenna R Elliott, Xi Zen Yap, Gaoqian Feng, Philippe Boeuf, Gregory Fegan, Faith FH Osier, Freya JI Fowkes, Marion Avril, Thomas N Williams, Kevin Marsh, James G Beeson
Journal article | 2017 | The Journal of Infectious Diseases
Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight
Kris Genelyn Dimasuay, Elizabeth H Aitken, Fredrick Rosario, Madi Njie, Jocelyn Glazier, Stephen J Rogerson, Freya JI Fowkes, James G Beeson, Theresa Powell, Thomas Jansson, Philippe Boeuf
Journal article | 2017 | BMC Medicine
IFPA meeting 2015 workshop report IV: placenta and obesity; stem cells of the feto-maternal interface; placental immunobiology and infection
MH Abumaree, A Almutairi, S Cash, P Boeuf, LW Chamley, T Gamage, JL James, B Kalionis, TY Khong, KS Kolahi, R Lim, S Liong, TK Morgan, K Motomura, HN Peiris, RA Pelekanos, E Pelzer, A Shafiee, GE Lash, D Natale
Conference Proceedings | 2016 | Placenta
Azithromycin-containing intermittent preventive treatment in pregnancy affects gestational weight gain, an important predictor of birthweight in Papua New Guinea - an exploratory analysis
Holger W Unger, Regina A Wangnapi, Maria Ome-Kaius, Philippe Boeuf, Stephan Karl, Ivo Mueller, Stephen J Rogerson
Journal article | 2016 | Maternal & Child Nutrition
High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancy
Caroline Lin Lin Chua, Leanne J Robinson, Francesca Baiwog, Danielle I Stanisic, John A Hamilton, Graham V Brown, Stephen J Rogerson, Philippe Boeuf
Journal article | 2015 | International Journal for Parasitology
Insight Into the Pathogenesis of Fetal Growth Restriction in Placental Malaria: Decreased Placental Glucose Transporter Isoform 1 Expression
Upeksha P Chandrasiri, Caroline LL Chua, Alexandra J Umbers, Ebbie Chaluluka, Jocelyn D Glazier, Stephen J Rogerson, Philippe Boeuf
Journal article | 2014 | Journal of Infectious Diseases
IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta
MS Ahmed, LM Aleksunes, P Boeuf, MK Chung, G Daoud, G Desoye, P Diaz, TG Golos, NP Illsley, K Kikuchi, R Komatsu, T Lao, DM Morales-Prieto, T Nanovskaya, T Nobuzane, CT Roberts, R Saffery, I Tamura, K Tamura, NG Than, et al.
Journal article | 2013 | Placenta
Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport
Philippe Boeuf, Elizabeth H Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J Rogerson
Journal article | 2013 | PLoS Pathogens
Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport
PS Boeuf, E AITKEN, UP Chandrasiri, L CHUA, undefined McInerney, undefined McQuade, M Duffy, undefined Molyneux, GV Brown, undefined Glazier, SJ Rogerson
Journal article | 2013 | PLoS Pathogens
DO MALARIA PARASITES BIND TO THE PLACENTA EARLY IN PREGNANCY? EVIDENCE FROM A RELEVANT PLACENTAL ADHESION ASSAY
Alexandra Umbers, Sarah Hanieh, Maria Ome, Regina Wagnapi, Inoni Betuela, Peter Siba, Ivo Mueller, Jocelyn Glazier, Stephen Rogerson, Phillippe Boeuf
Conference Proceedings | 2012 | PLACENTA
Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia.
Philippe S Boeuf, Séverine Loizon, Gordon A Awandare, John KA Tetteh, Michael M Addae, George O Adjei, Bamenla Goka, Jørgen AL Kurtzhals, Odile Puijalon, Lars Hviid, Bartholomew D Akanmori, Charlotte Behr
Journal article | 2012 | Malaria Journal
BACKGROUND: Severe malarial anaemia (SMA) is a major life-threatening complication of paediatric malaria. Protracted production of..
Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation
Alexandra J Umbers, Philippe Boeuf, Caroline Clapham, Danielle I Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher L King, James G Beeson, Jocelyn Glazier, Stephen J Rogerson
Journal article | 2011 | Journal of Infectious Diseases
V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stability
Severine Loizon, Philippe Boeuf, John KA Tetteh, Bamenla Goka, George Obeng-Adjei, Jorgen AL Kurtzhals, Christophe Rogier, Bartholomew D Akanmori, Odile Mercereau-Puijalon, Lars Hviid, Charlotte Behr
Journal article | 2007 | Microbes and Infection
Increased levels of inflammatory mediators in children with severe Plasmodium falciparum malaria with respiratory distress
Gordon A Awandare, Bamenla Goka, Philippe Boeuf, John KA Tetteh, Jorgen AL Kurtzhals, Charlotte Behr, Bartholomew D Akanmori
Journal article | 2006 | Journal of Infectious Diseases
Honours, Awards and Fellowships
Medicine - Royal Melbourne Hospital
Australian Society for Medical Research
Australian Society for Parasitology
American Association for the Advancement of Science
International Federation of Placenta Associations
ARC/NHMRC Research Network for Parasitology
Maitrise de Biologie Cellulaire et Physiologie - Option Immunologie
University of Paris VII: Jussieu
Diplome d'Etudes Approfondies en Parasitologie
University of Montpellier
These de Doctorat en Immunologie
Universite Denis Diderot (Paris VII)