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PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficac..
Displaying the 16 most recent projects by Thomas Gebhardt.
Internal Research Grant
Displaying the 82 most recent scholarly works by Thomas Gebhardt.
CD103 tumor-resident CD8 T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma.
Rehana Hewavisenti, Angela Ferguson, Kevin Wang, Deanna Jones, Thomas Gebhardt, Jarem Edwards, Mei Zhang, Warwick Britton, Jean Yang, Angela Hong, Umaimainthan Palendira
Journal article | 2020 | Journal for ImmunoTherapy of Cancer
BACKGROUND: Human Papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) is one of the fastest growing canc..
Sex-specific adipose tissue imprinting of regulatory T cells
Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.
Journal article | 2020 | Nature
Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis
Journal article | 2020 | The EMBO Journal
PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis
Journal article | 2019
ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells
Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.
Journal article | 2019 | Immunity
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..
The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis
Angus T Stock, Nicholas Collins, Gordon K Smyth, Yifang Hu, Jacinta A Hansen, Damian B D'Silva, Hamdi A Jama, Andrew M Lew, Thomas Gebhardt, Catriona A McLean, Ian P Wicks
Journal article | 2019 | The Journal of Immunology
Tissue-resident memory T cells mediate melanoma surveillance and are targets of immunotherapy
Simone L Park, Anthony Buzzai, Jyh Liang Hor, Maike Effern, Susan N Christo, Scott N Mueller, Michael Holzel, Jason Waithman, Laura K Mackay, Thomas Gebhardt
Conference Proceedings | 2019 | JOURNAL OF IMMUNOLOGY
Tissue-resident memory T cells orchestrate tumour-immune equilibrium.
Simone L Park, Laura K Mackay, Jason Waithman, Thomas Gebhardt
Journal article | 2019 | Cell Stress
The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune ce..
Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection
Christopher M Harpur, Yu Kato, Shinta T Dewi, Sanda Stankovic, Darryl N Johnson, Sammy Bedoui, Paul G Whitney, Mireille H Lahoud, Irina Caminschi, William R Heath, Andrew G Brooks, Thomas Gebhardt
Journal article | 2019 | The Journal of Immunology
Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin
Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.
Journal article | 2019 | Nature
Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis
Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki
Journal article | 2019 | Clinical & Translational Immunology
Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state ..
Optimal protection against Salmonella infection requires noncirculating memory
Joseph M Benoun, Newton G Peres, Nancy Wang, Oanh H Pham, Victoria L Rudisill, Zachary N Fogassy, Paul G Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Pham Quynh-Mai, Lynn Puddington, Sammy Bedoui, Richard A Strugnell, Stephen J McSorley
Journal article | 2018 | Proceedings of the National Academy of Sciences
Staged development of long-lived T-cell receptor alpha beta T(H)17 resident memory T-cell population to Candida albicans after skin infection
Chang Ook Park, Xiujun Fu, Xiaodong Jiang, Youdong Pan, Jessica E Teague, Nicholas Collins, Tian Tian, John T O'Malley, Ryan O Emerson, Ji Hye Kim, Yookyung Jung, Rei Watanabe, Robert C Fuhlbrigge, Francis R Carbone, Thomas Gebhardt, Rachael A Clark, Charles P Lin, Thomas S Kupper
Journal article | 2018 | Journal of Allergy and Clinical Immunology
CD103( ) Tumor-Resident CD8( ) T Cells Are Associated with Improved Survival in Immunotherapy-Naive Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment
Jarem Edwards, James S Wilmott, Jason Madore, Tuba Nur Gide, Camelia Quek, Annie Tasker, Angela Ferguson, Jinbiao Chen, Rehana Hewavisenti, Peter Hersey, Thomas Gebhardt, Wolfgang Weninger, Warwick J Britton, Robyn PM Saw, John F Thompson, Alexander M Menzies, Georgina V Long, Richard A Scolyer, Umaimainthan Palendira
Journal article | 2018 | Clinical Cancer Research
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
Journal article | 2018 | Journal of Virology
Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses
Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay
Journal article | 2018 | Nature Immunology
Compartmentalization of Total and VirusSpecific Tissue-Resident Memory CD8 T Cells in Human Lymphoid Organs
Heng Giap Woon, Asolina Braun, Jane Li, Corey Smith, Jarem Edwards, Frederic Sierro, Carl G Feng, Rajiv Khanna, Michael Elliot, Andrew Bell, Andrew D Hislop, Stuart G Tangye, Alan B Rickinson, Thomas Gebhardt, Warwick J Britton, Umaimainthan Palendira
Journal article | 2016 | PLOS Pathogens
Skin CD4( ) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R Heath, Scott N Mueller, Thomas S Kupper, Thomas Gebhardt, Francis R Carbone
Journal article | 2016 | NATURE COMMUNICATIONS
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Laura K Mackay, Martina Minnich, Natasja AM Kragten, Yang Liao, Benjamin Nota, Cyril Seillet, Ali Zaid, Kevin Man, Simon Preston, David Freestone, Asolina Braun, Erica Wynne-Jones, Felix M Behr, Regina Stark, Daniel G Pellicci, Dale I Godfrey, Gabrielle T Belz, Marc Pellegrini, Thomas Gebhardt, Meinrad Busslinger, et al.
Journal article | 2016 | Science
T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming
Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui
Journal article | 2016 | Cell Reports
Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention
Laura K Mackay, Asolina Braun, Bethany L Macleod, Nicholas Collins, Christina Tebartz, Sammy Bedoui, Francis R Carbone, Thomas Gebhardt
Journal article | 2015 | The Journal of Immunology
Distinct APC Subtypes Drive Spatially Segregated CD4 and CD8 T-Cell Effector Activity during Skin Infection with HSV-1
Bethany L Macleod, Sammy Bedoui, Jyh Liang Hor, Scott N Mueller, Tiffany A Russell, Natasha A Hollett, William R Heath, David C Tscharke, Andrew G Brooks, Thomas Gebhardt
Journal article | 2014 | PLoS Pathogens
The developmental pathway for CD103( )CD8( ) tissue-resident memory T cells of skin
Laura K Mackay, Azad Rahimpour, Joel Z Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, Javier Vega-Ramos, Pilar Lauzurica, Scott N Mueller, Tijana Stefanovic, David C Tscharke, William R Heath, Michael Inouye, Francis R Carbone, Thomas Gebhardt
Journal article | 2013 | Nature Immunology
Long-lived epithelial immunity by tissue-resident memory T (T-RM) cells in the absence of persisting local antigen presentation
Laura K Mackay, Angus T Stock, Joel Z Ma, Claerwen M Jones, Stephen J Kent, Scott N Mueller, William R Heath, Francis R Carbone, Thomas Gebhardt
Journal article | 2012 | Proceedings of the National Academy of Sciences of the United States of America
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8( ) T cells
Andreas Kupz, Greta Guarda, Thomas Gebhardt, Leif E Sander, Kirsty R Short, Dimitri A Diavatopoulos, Odilia LC Wijburg, Hanwei Cao, Jason C Waithman, Weisan Chen, Daniel Fernandez-Ruiz, Paul G Whitney, William R Heath, Roy Curtiss, Juerg Tschopp, Richard A Strugnell, Sammy Bedoui
Journal article | 2012 | Nature Immunology
NLRC4 inflammasomes in dendritic cells evoke non-cognate effector function by memory CD8 T cells that improve immunity to Salmonella typhimurium
Sammy Bedoui, Kupz Andreas, Greta Guarda, Thomas Gebhardt, Leif Sander, Roy Curtis, Jurg Tschopp, Richard Strugnell
Journal article | 2011 | JOURNAL OF IMMUNOLOGY
Characterization of an Immediate Splenic Precursor of CD8( ) Dendritic Cells Capable of Inducing Antiviral T Cell Responses
Sammy Bedoui, Sandro Prato, Justine Mintern, Thomas Gebhardt, Yifan Zhan, Andrew M Lew, William R Heath, Jos A Villadangos, Elodie Segura
Journal article | 2009 | Journal of Immunology
Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
G Sellge, A Lorentz, T Gebhardt, F Levi-Schaffer, H Bektas, MP Manns, D Schuppan, SC Bischoff
Journal article | 2004 | Journal of Immunology
Honours, Awards and Fellowships
Senior Medical Research Fellowship
CR Roper Fellowship
Career Development Award
Sylvia & Charles Viertel Principal Research Fellow
Microbiology And Immunology
American Association of Immunologists
Australasian Society of Immunology
German Society of Immunology
Doctor of Philosophy
Hannover Medical School
Graduation in Medicine (MBBS equivalent)
Hannover Medical School