Thomas Gebhardt

CD8 T Cells Promote Pathological Angiogenesis in Ocular Neovascular Disease.

Devy Deliyanti, William A Figgett, Thomas Gebhardt, Joseph A Trapani, Fabienne Mackay, Jennifer L Wilkinson-Berka

Journal article  |  2023  |  Arterioscler Thromb Vasc Biol

BACKGROUND: CD4+ and CD8+ T cells are increased in the ocular fluids of patients with neovascular retinopathy, yet their role in t..

Self-Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design.

Michelle L Bookstaver, Qin Zeng, Robert S Oakes, Senta M Kapnick, Vikas Saxena, Camilla Edwards, Nishedhya Venkataraman, Sheneil K Black, Xiangbin Zeng, Eugene Froimchuk, Thomas Gebhardt, Jonathan S Bromberg, Christopher M Jewell

Journal article  |  2022  |  Adv Sci (Weinh)

Recent clinical studies show activating multiple innate immune pathways drives robust responses in infection and cancer. Biomateri..

Unappreciated complexity in T cell help for dendritic cells.

Sammy Bedoui, Thomas Gebhardt

Journal article  |  2022  |  Nat Immunol

CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models.

Maike Effern, Nicole Glodde, Emma Bawden, Jana Liebing, Daniel Hinze, Thomas Tüting, Thomas Gebhardt, Michael Hölzel

Journal article  |  2022  |  STAR Protoc

This protocol details the procedure for CRISPR-assisted insertion of epitopes (CRISPitope), a flexible approach for generating tum..

CD4( ) T cell immunity to Salmonella is transient in the circulation

Newton G Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M Shreenivas, Ian Comerford, Dianna M Hocking, Anna B Erazo, Irmgard Foerster, Andreas Kupz, Thomas Gebhardt, Shaun R McColl, Stephen J McSorley, Sammy Bedoui, Richard A Strugnell

Journal article  |  2021  |  PLOS PATHOGENS

While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD..

Tumor reactivity of CD8( ) T cells favors acquisition of dysfunctional states in human melanoma

Katharina Hochheiser, David E Gyorki, Thomas Gebhardt

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

A recent study by Oliveira et al. provides, in unprecedented detail, novel insights into the relationship between tumorreactivity ..

Protein tyrosine phosphatase non-receptor type 2 and killer cell lectin-like receptor G1 regulate the generation and function of tissue-resident memory T cells in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias Hans Enders, Moshe Olshansky, Brendan Russ, Claerwen Jones, David Gyorki, Stephen Turner, Marco Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs

Rehana Hewavisenti, Angela L Ferguson, Georgia Gasparini, Tomoki Ohashi, Asolina Braun, Thomas S Watkins, John J Miles, Michael Elliott, Frederic Sierro, Carl G Feng, Warwick J Britton, Thomas Gebhardt, Stuart Tangye, Umaimainthan Palendira

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Sex-specific adipose tissue imprinting of regulatory T cells (vol 579, pg 581, 2020)

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2021  |  NATURE

In Fig. 1a of this Article, the y-axis label should read ‘Fat to lean mass (ratio)’ rather than ‘Lean to fat mass (ratio)’. In add..