Andrea O'Connor

Amphiphilic Core Cross-Linked Star Polymers for the Delivery of Hydrophilic Drugs from Hydrophobic Matrices

Katarzyna Somszor, Stephanie Allison-Logan, Fatemeh Karimi, Thomas McKenzie, Qiang Fu, Andrea O'Connor, Greg Qiao, Daniel Heath

Journal article  |  2021  |  BIOMACROMOLECULES

The delivery of hydrophilic drugs from hydrophobic polymers is a long-standing challenge in the biomaterials field due to the limi..

Biomaterials functionalized with nanoclusters of integrin- and syndecan-binding ligands improve cell adhesion and mechanosensing under shear flow conditions

Fatemeh Karimi, Varsha Jagannath Thombare, Craig A Hutton, Andrea J O'Connor, Greg G Qiao, Daniel E Heath

Journal article  |  2021  |  Journal of Biomedical Materials Research Part A

We have engineered biomaterials that display nanoclusters of ligands that bind both integrin and syndecan‐4 cell receptors. These ..

The Challenge of Cartilage Integration: Understanding a Major Barrier to Chondral Repair

Anna Trengove, Claudia Di Bella, Andrea J O'Connor

Journal article  |  2021  |  TISSUE ENGINEERING PART B-REVIEWS

Articular cartilage defects caused by injury frequently lead to osteoarthritis, a painful and costly disease. Despite widely used ..

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

Personalized, Mechanically Strong, and Biodegradable Coronary Artery Stents via Melt Electrowriting

Katarzyna Somszor, Onur Bas, Fatemeh Karimi, Tara Shabab, Navid T Saidy, Andrea J O'Connor, Amanda Ellis, Dietmar Hutmacher, Daniel E Heath

Journal article  |  2020  |  ACS MACRO LETTERS

Biodegradable coronary artery stents are sought-after alternatives to permanent stents. These devices are designed to degrade afte..

Effects of External Stimulators on Engineered Skeletal Muscle Tissue Maturation

Claudia Mueller, Mairon Trujillo-Miranda, Michael Maier, Daniel E Heath, Andrea J O'Connor, Sahar Salehi

Journal article  |  2020  |  ADVANCED MATERIALS INTERFACES

Engineering functional skeletal muscle tissue is an ongoing challenge because of the complexity of the in vivo microenvironment an..

Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects

Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  BIOINTERPHASES

Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..

Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly.

Nicholas Jun-An Chan, Dunyin Gu, Shereen Tan, Qiang Fu, Thomas Geoffrey Pattison, Andrea J O'Connor, Greg G Qiao

Journal article  |  2020  |  Nature Communications

The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of ..

Nerve guidance conduit design based on self-rolling tubes.

TB Aigner, C Haynl, S Salehi, A O'Connor, T Scheibel

Journal article  |  2020  |  Materials Today Bio

The current gold standard in peripheral nerve repair is nerve autografts for bridging gaps larger than a centimeter. However, auto..

Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering

Michelle T Sun, Andrea J O’Connor, Imogen Milne, Dhee Biswas, Robert Casson, John Wood, Dinesh Selva

Journal article  |  2019  |  Tissue Engineering and Regenerative Medicine

Background: Reconstruction of large eyelid defects remains challenging due to the lack of suitable eyelid tarsus tissue substitute..