Lynda Campbell

Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

Ruth N MacKinnon, Joanne Peverall, Lynda J Campbell, Meaghan Wall

Journal article  |  2020  |  MOLECULAR CYTOGENETICS

BACKGROUND: The U937 cell line is widely employed as a research tool. It has a complex karyotype. A PICALM-MLLT10 fusion gene form..

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  SCIENTIFIC REPORTS

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological ma..

"Reversible" myelodysplastic syndrome or ineffectual clonal haematopoiesis? - add(6p) myeloid neoplasm with a spontaneous cytogenetic remission

K Rady, P Blombery, DA Westerman, M Wall, M Curtis, LJ Campbell, JF Seymour

Journal article  |  2018  |  LEUKEMIA RESEARCH

Cytotoxic chemotherapy has inherent mutagenic potential and alters the bone marrow microenvironment after therapy. In some cases, ..

Cytogenetics of lymphomas

M Wall, LJ Campbell

Book Chapter  |  2018

Cytogenetic analysis relies on the production of banded metaphase chromosomes for analysis, but chronic lymphoid malignancies have..

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

Kenneth F Bradstock, Emma Link, Juliana Di Iulio, Jeff Szer, Paula Marlton, Andrew H Wei, Arno Enno, Anthony Schwarer, Ian D Lewis, James D'Rozario, Luke Coyle, Gavin Cull, Phillip Campbell, Michael F Leahy, Uwe Hahn, Paul Cannell, Campbell Tiley, Ray M Lowenthal, John Moore, Kimberly Cartwright, et al.

Journal article  |  2017  |  JOURNAL OF CLINICAL ONCOLOGY

Purpose Higher doses of the anthracycline daunorubicin during induction therapy for acute myeloid leukemia (AML) have been shown t..

The Dicentric Chromosome dic(20;22) Is a Recurrent Abnormality in Myelodysplastic Syndromes and Is a Product of Telomere Fusion

Ruth N MacKinnon, Hendrika M Duivenvoorden, Lynda J Campbell, Meaghan Wall

Journal article  |  2016  |  CYTOGENETIC AND GENOME RESEARCH

We describe a recurrent dicentric chromosome formed by telomere fusion between chromosome 20 and chromosome 22 in 4 cases of myelo..

Monosomal karyotype predicts inferior survival independently of a complex karyotype in patients with myelodysplastic syndromes

Zoe K McQuilten, Vijaya Sundararajan, Nick Andrianopoulos, David J Curtis, Erica M Wood, Lynda J Campbell, Meaghan Wall

Journal article  |  2015  |  CANCER

BACKGROUND: Conflicting data exist about the impact of a monosomal karyotype (MK) on overall survival (OS) for patients with myelo..

Use of arsenic trioxide in remission induction and consolidation therapy for acute promyelocytic leukaemia in the Australasian Leukaemia and Lymphoma Group (ALLG) APML4 study: a non-randomised phase 2 trial

Harry J Iland, Marnie Collins, Ken Bradstock, Shane G Supple, Alberto Catalano, Mark Hertzberg, Peter Browett, Andrew Grigg, Frank Firkin, Lynda J Campbell, Amanda Hugman, John Reynolds, Juliana Di Iulio, Campbell Tiley, Kerry Taylor, Robin Filshie, Michael Seldon, John Taper, Jeff Szer, John Moore, et al.

Journal article  |  2015  |  LANCET HAEMATOLOGY

BACKGROUND: Initial treatment of acute promyelocytic leukaemia traditionally involves tretinoin (all-trans retinoic acid) combined..

Src family kinases and their role in hematological malignancies

Matthew Ku, Meaghan Wall, Ruth N MacKinnon, Carl R Walkley, Louise E Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng, Harshal Nandurkar

Journal article  |  2015  |  LEUKEMIA & LYMPHOMA

The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoie..

A rare case of IGH/MYC and IGH/BCL2 double hit primary plasma cell leukemia

Anna Kalff, Tiffany Khong, Meaghan Wall, Malgorzata Gorniak, Sridurga Mithraprabhu, Lynda J Campbell, Andrew Spencer

Journal article  |  2015  |  HAEMATOLOGICA