Gillian Dite

Validation of an abridged breast cancer risk prediction model for the general population.

Erika L Spaeth, Gillian S Dite, John L Hopper, Richard Allman

Journal article  |  2023  |  Cancer Prev Res (Phila)

Accurate breast cancer risk prediction could improve risk-reduction paradigms if thoughtfully employed in clinical practice. Ident..

Validation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk

Richard Allman, Yi Mu, Gillian S Dite, Erika Spaeth, John L Hopper, Bernard A Rosner

Journal article  |  2023  |  BREAST CANCER RESEARCH AND TREATMENT

PURPOSE: We compared a simple breast cancer risk prediction model, BRISK (which includes mammographic density, polygenic risk and ..

Improvement of a clinical colorectal cancer risk prediction model integrating polygenic risk.

Erika Leigh Spaeth Tuff, Aviv Gafni, Gillian S Dite, Richard Allman

Journal article  |  2023  |  Journal of Clinical Oncology

81 Background: Improving colorectal cancer risk prediction and stratification is pivotal for implementing better screening and pr..

A combined clinical and genetic model for predicting risk of ovarian cancer.

Gillian S Dite, Erika Spaeth, Nicholas M Murphy, Richard Allman

Journal article  |  2023  |  Eur J Cancer Prev

OBJECTIVE: Women with a family history of ovarian cancer or a pathogenic or likely pathogenic gene variant are at high risk of the..

Polygenic risk scores for cardiovascular diseases and type 2 diabetes

Chi Kuen Wong, Enes Makalic, Gillian S Dite, Lawrence Whiting, Nicholas M Murphy, John L Hopper, Richard Allman

Journal article  |  2022  |  PLOS ONE

Polygenic risk scores (PRSs) are a promising approach to accurately predict an individual's risk of developing disease. The area u..

Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction

Shuai Li, Robert J MacInnis, Andrew Lee, Tu Nguyen-Dumont, Leila Dorling, Sara Carvalho, Gillian S Dite, Mitul Shah, Craig Luccarini, Qin Wang, Roger L Milne, Mark A Jenkins, Graham G Giles, Alison M Dunning, Paul DP Pharoah, Melissa C Southey, Douglas F Easton, John L Hopper, Antonis C Antoniou

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Rare pathogenic variants in known breast cancer-susceptibility genes and known common susceptibility variants do not fully explain..

Genetic Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Shuai Li, Tuong L Nguyen, Nguyen-Dumont Tu, James G Dowty, Gillian S Dite, Zhoufeng Ye, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, John L Hopper, Melissa C Southey

Journal article  |  2022  |  CANCERS

Cumulus, Altocumulus, and Cirrocumulus are measures of mammographic density defined at increasing pixel brightness thresholds, whi..

Validation of a clinical and genetic model for predicting severe COVID-19

Gillian S Dite, Nicholas M Murphy, Erika Spaeth, Richard Allman

Journal article  |  2022  |  EPIDEMIOLOGY AND INFECTION

Using nested case–control data from the Lifelines COVID-19 cohort, we undertook a validation study of a clinical and genetic model..

Early life affects late-life health through determining DNA methylation across the lifespan: A twin study

Shuai Li, Zhoufeng Ye, Karen A Mather, Tuong L Nguyen, Gillian S Dite, Nicola J Armstrong, Ee Ming Wong, Anbupalam Thalamuthu, Graham G Giles, Jeffrey M Craig, Richard Saffery, Melissa C Southey, Qihua Tan, Perminder S Sachdev, John L Hopper

Journal article  |  2022  |  EBIOMEDICINE

BACKGROUND: Previous findings for the genetic and environmental contributions to DNA methylation variation were for limited age ra..

Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Tuong L Nguyen, Shuai Li, James G Dowty, Gillian S Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, Melissa C Southey, John L Hopper

Journal article  |  2022  |  CANCERS

Cumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on..