Christopher Hovens

A polygenic two-hit hypothesis for prostate cancer.

Kathleen E Houlahan, Julie Livingstone, Natalie S Fox, Natalie Kurganovs, Helen Zhu, Jocelyn Sietsma Penington, Chol-Hee Jung, Takafumi N Yamaguchi, Lawrence E Heisler, Richard Jovelin, Anthony J Costello, Bernard J Pope, Amar U Kishan, Niall M Corcoran, Robert G Bristow, Sebastian M Waszak, Joachim Weischenfeldt, Housheng H He, Rayjean J Hung, Christopher M Hovens, et al.

Journal article  |  2023  |  J Natl Cancer Inst

Prostate cancer is one of the most heritable cancers. Hundreds of germline polymorphisms have been linked to prostate cancer diagn..

Author Correction: Inferring structural variant cancer cell fraction.

Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, undefined PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, undefined PCAWG Consortium

Journal article  |  2022  |  Nat Commun

In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortiumwere listed in t..

Molecular Mechanisms Driving the Formation of Brain Metastases

Bethany K Campbell, Zijie Gao, Niall M Corcoran, Stanley S Stylli, Christopher M Hovens

Journal article  |  2022  |  CANCERS

Targeted therapies for cancers have improved primary tumor response rates, but concomitantly, brain metastases (BM) have become th..

Phase 2 Study of Neoadjuvant FGFR Inhibition and Androgen Deprivation Therapy Prior to Prostatectomy.

Elizabeth Liow, Nicholas Howard, Chol-Hee Jung, Bernard Pope, Bethany K Campbell, Anne Nguyen, Michael Kerger, Jonathan B Ruddle, Angelyn Anton, Benjamin Thomas, Kevin Chu, Philip Dundee, Justin S Peters, Anthony J Costello, Andrew S Ryan, Christopher M Hovens, Ben Tran, Niall M Corcoran

Journal article  |  2022  |  Clin Genitourin Cancer

BACKGROUND: Disease recurrence is common following prostatectomy in patients with localised prostate cancer with high-risk feature..

Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study.

Daniel Burns, Ezequiel Anokian, Edward J Saunders, Robert G Bristow, Michael Fraser, Jüri Reimand, Thorsten Schlomm, Guido Sauter, Benedikt Brors, Jan Korbel, Joachim Weischenfeldt, Sebastian M Waszak, Niall M Corcoran, Chol-Hee Jung, Bernard J Pope, Chris M Hovens, Géraldine Cancel-Tassin, Olivier Cussenot, Massimo Loda, Chris Sander, et al.

Journal article  |  2022  |  Eur Urol

BACKGROUND: Germline variants explain more than a third of prostate cancer (PrCa) risk, but very few associations have been identi..

The Prostate Cancer Immune Microenvironment, Biomarkers and Therapeutic Intervention

Yangyi Zhang, Bethany K Campbell, Stanley S Stylli, Niall M Corcoran, Christopher M Hovens

Journal article  |  2022  |  Uro

Advanced prostate cancers have a poor survival rate and a lack of effective treatment options. In order to broaden the available t..

Biomarkers of Response to Neoadjuvant Androgen Deprivation in Localised Prostate Cancer

Maree Pechlivanis, Bethany K Campbell, Christopher M Hovens, Niall M Corcoran

Journal article  |  2022  |  CANCERS

Prostate cancer (PCa) is a hormone driven cancer, characterised by defects in androgen receptor signalling which drive the disease..

A phase 1b open-label study of sodium selenate as a disease-modifying treatment for possible behavioral variant frontotemporal dementia

Lucy Vivash, Charles B Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao-Xin Li, Stuart McDonald, William T O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien

Journal article  |  2022  |  ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS

INTRODUCTION: Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open-lab..

Identification and isolation of slow-cycling glioma stem cells

Liam Furst, Ryan J Atkins, Marija Dinevska, Stanley S Stylli, Niall M Corcoran, Christopher M Hovens, Theo Mantamadiotis

Book Chapter  |  2022  |  Methods in Cell Biology

Cancer stem cells are defined as low-abundance, quiescent cells and are considered a major cellular source of tumor recurrence fol..

Perish and publish: Dynamics of biomedical publications by deceased authors.

Chol-Hee Jung, Paul C Boutros, Daniel J Park, Niall M Corcoran, Bernard J Pope, Christopher M Hovens

Journal article  |  2022  |  PLoS One

The question of whether it is appropriate to attribute authorship to deceased individuals of original studies in the biomedical li..