Erica Fletcher

The Contribution of Microglia to the Development and Maturation of the Visual System

Michael A Dixon, Ursula Greferath, Erica L Fletcher, Andrew I Jobling

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Microglia, the resident immune cells of the central nervous system (CNS), were once considered quiescent cells that sat in readine..

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

Journal article  |  2021  |  FRONTIERS IN MEDICINE

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout

Anna YM Wang, Vickie HY Wong, Pei Ying Lee, Bang V Bui, Stefanie Dudczig, Kirstan A Vessey, Erica L Fletcher

Journal article  |  2021  |  SCIENTIFIC REPORTS

There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in ani..

Subthreshold Nano-Second Laser Treatment and Age-Related Macular Degeneration

Amy C Cohn, Zhichao Wu, Andrew I Jobling, Erica L Fletcher, Robyn H Guymer

Journal article  |  2021  |  JOURNAL OF CLINICAL MEDICINE

The presence of drusen is an important hallmark of age-related macular degeneration (AMD). Laser-induced regression of drusen, fir..

Dorsal-Ventral Differences in Retinal Structure in the Pigmented Royal College of Surgeons Model of Retinal Degeneration

Una Greferath, Mario Huynh, Andrew Ian Jobling, Kirstan Anne Vessey, Gene Venables, Denver Surrao, Helen Christine O'Neill, Ioannis J Limnios, Erica Lucy Fletcher

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Retinitis pigmentosa is a family of inherited retinal degenerations associated with gradual loss of photoreceptors, that ultimatel..

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

Journal article  |  2020  |  Genomics Proteomics Bioinformatics

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat str..

Advances in understanding the mechanisms of retinal degenerations

Erica L Fletcher

Journal article  |  2020  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

Photoreceptor death is an important contributor to irreversible vision loss worldwide. In this review, I outline our work examinin..

Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma

Anna YM Wang, Pei Ying Lee, Bang Bui, Andrew Jobling, Ursula Greferath, Alice Brandli, Michael A Dixon, Quan Findlay, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2020  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neuro..

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

Samuel Mills, Andrew Jobling, Michael Dixon, Bang Bui, Kirstan Vessey, Joanna Phipps, Ursula Greferath, Gene Venables, Vickie HY Wong, Connie HY Wong, Zheng He, Flora Hui, James Young, Josh Tonc, Elena Ivanova, Botir Sagdullaev, Erica Fletcher

Journal article  |  2020

Local blood flow control within the CNS is critical to proper function and is dependent on coordination between neurons, glia and ..