Wayne Phillips

Inhibition of BMP2 and BMP4 Represses Barrett's Esophagus While Enhancing the Regeneration of Squamous Epithelium in Preclinical Models.

Ana CP Correia, Danielle Straub, Matthew Read, Sanne JM Hoefnagel, Salvador Romero-Pinedo, Ana C Abadía-Molina, Nicholas J Clemons, Kenneth Wang, Silvia Calpe, Wayne Phillips, Kausilia K Krishnadath

Journal article  |  2023  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: Barrett's esophagus is considered to be a metaplastic lesion that predisposes for esophageal adenocarcinoma. De..

ASO Visual Abstract: Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer

Carlos S Cabalag, Owen WJ Prall, John Ciciulla, Laurence A Galea, Niko Thio, Madawa Jayawardana, Trishe YM Leong, Julia Milne, Kenji M Fujihara, Lynn Chong, Michael W Hii, Gisela Mir Arnau, Paul J Neeson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer

Carlos S Cabalag, Owen WJ Prall, John Ciciulla, Laurence A Galea, Niko Thio, Madawa Jayawardana, Trishe YM Leong, Julia V Milne, Kenji M Fujihara, Lynn Chong, Michael W Hii, Gisela Mir Arnau, Paul J Neeson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

BACKGROUND: In esophageal cancer (EC), there is a paucity of knowledge regarding the interplay between the tumor immune microenvir..

ASO Author Reflections: Are Tumor-Infiltrating Neutrophils Drivers of Metastatic Disease in Esophageal Cancer Patients Treated with Neoadjuvant Therapy?

Carlos S Cabalag, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Carlos S Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q Wong, Bonnie Z Zhang, Kenji M Fujihara, Lynn Chong, Michael W Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGERY

OBJECTIVE: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cos..

Selective targeting BMP2 and 4 in SMAD4 negative esophageal adenocarcinoma inhibits tumor growth and aggressiveness in preclinical models

Shulin Li, Sanne JM Hoefnagel, Matthew Read, Sybren Meijer, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Elena Bonora, David SH Liu, Wayne A Phillips, Silvia Calpe, Ana CP Correia, Maria DC Sancho-Serra, Sandro Mattioli, Kausilia K Krishnadath

Journal article  |  2022  |  CELLULAR ONCOLOGY

PURPOSE: Abnormalities within the Sonic Hedgehog (SHH), Bone Morphogenetic Protein (BMP) and SMAD4 signalling pathways have been a..

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Ian Y Luk, Laura J Jenkins, Kael L Schoffer, Irvin Ng, Janson WT Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D Burrows, Robin L Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F Richardson, Oliver M Sieber, Yang Liao, Jennifer K Mooi, Natalia Vukelic, Camilla M Reehorst, Shoukat Afshar-Sterle, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnin..

Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer

Alexandra M Simond, Tung Bui, Dongmei Zuo, Virginie Sanguin-Gendreau, Trisha Rao, Wayne A Phillips, Robert D Cardiff, William J Muller

Journal article  |  2022  |  ONCOGENE

p110α is a catalytic subunit of phosphoinositide 3-kinase (PI3K), a major downstream effector of receptor tyrosine kinase ErbB2, t..

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage

Jeffrey Molendijk, Cathryn M Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K Shah, Ian Brown, Mark P Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S Richards, Michael Gartside, Kalpana Patel, Nicholas J Clemons, Wayne A Phillips, Andrew Barbour, Johan A Westerhuis, Michelle M Hill

Journal article  |  2022  |  CLINICAL AND TRANSLATIONAL MEDICINE

BACKGROUND: The risk of esophageal adenocarcinoma (EAC) is associated with gastro-esophageal reflux disease (GERD) and obesity. Li..