Prof. Wayne Phillips is a cellular and molecular biologist with a long-standing interest in the role of the phosphoinositide 3-kinase signalling pathway in cancer. His laboratory was one of the first to identify somatic mutations in the phosphoinositide 3-kinase family genes in human tumours and now studies the biological consequences and clinical significance of these mutations.
Currently his work is focussed on using a novel Pik3ca knock-in mouse model to investigate the role, function, and mechanism of action of Pik3ca mutations in a physiologically relevant context in a number of different tumour types. Prof. Phillips' laboratory also has a major interest in the pathogenesis of Barrett's oesophagus and is developing novel 3D cell culture systems and pre-clinical models with which to explore cellular and molecular mechanisms underlying development of Barrett's metaplasia and its progression oesophageal adenocarcinoma. He is also using genomic approaches to understand the genetics of familial Barrett's oesophagus.
Find out more about Wayne Phillips' experience
Wayne Phillips' highlights
Wayne Phillips' selected work
Circulating Dna Biomarkers To Optimise Healthcare Pathways And Outcomes For The Treatment ..
MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid C..
Combining Pi3k, Cdk4/6 Pathway Inhibitors And Checkpoint Blockade In Triple-Negative Breas..
A novel Pik3ca-driven mouse model and syngeneic cancer cell line for the preclinical testi..
Displaying the 23 most recent projects by Wayne Phillips.
Displaying the 141 most recent scholarly works by Wayne Phillips.
MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer
Oussama ElMokh, Vincent Taelman, Piotr Radojewski, Matthias A Roelli, Amandine Stoss, Rebecca A Dumont, Matthias S Dettmer, Wayne A Phillips, Martin A Walter, Roch-Philippe Charles
Journal article | 2019 | Journal of Nuclear Medicine
A novel Pik3ca-driven mouse model and syngeneic cancer cell line for the preclinical testing of targeted and immune therapies for anal squamous cell carcinoma (ASCC)
Glen R Guerra, Sara Roth, Joseph C Kong, Rosemary M Millen, David S Liu, Shienny Sampurno, Vignesh Narasimhan, Toan D Pham, Karen G Montgomery, Alexander G Heriot, Robert G Ramsay, Wayne A Phillips
Conference Proceedings | 2019 | Tumor Biology
Evaluating and manipulating the immune landscape in hepatic verses peritoneal metastases arising from colorectal primary tumors
Robert George Ramsay, Rosemary Millen, Vignesh Narasimhan, Sara Roth, Pham Toan, Joseph Kong, Glen Guerra, Wayne A Phillips, Alexander Graham Heriot
Conference Proceedings | 2019 | Journal of Clinical Oncology
Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus
Alok K Shah, Gunter Hartel, Ian Brown, Clay Winterford, Renhua Na, Kim-Anh Le Cao, Bradley A Spicer, Michelle Dunstone, Wayne A Phillips, Reginald V Lord, Andrew P Barbour, David I Watson, Virendra Joshi, David C Whiteman, Michelle M Hill
Journal article | 2018 | Molecular & Cellular Proteomics
TP53 is not a prognostic marker-clinical consequences of a generally disregarded fact
Tamara Braunschmid, Irene Kuehrer, Martina Mittlboeck, Maria Westerhoff, Sonja Kappel-Latif, Lindsay Brammen, Kausilia K Krishnadath, Wayne A Phillips, Michael Gnant, Daniela Kandioler
Journal article | 2018 | Annals of the New York Academy of Sciences
Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.
Journal article | 2018 | JCO Precision Oncology
Identification of microRNA Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Esophageal Adenocarcinoma Using Next Generation Sequencing
Karen Chiam, George C Mayne, David Watson, Richard J Woodman, Tim F Bright, Michael Z Michael, Christos S Karapetis, Tanya Irvine, Wayne A Phillips, Richard Hummel, Tingting Wang, Letitia K Pimlott, Shashikanth Marri, David St J Astill, Andrew R Ruszkiewicz, Sarah K Thompson, Damian J Hussey
Journal article | 2018 | Annals of Surgical Oncology
Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips
Journal article | 2018 | Cancer Discovery
PIK3CA(H1047R)-induced paradoxical ERK activation results in resistance to BRAF(V600E) specific inhibitors in BRAFV600E PIK3CA(H1047R) double mutant thyroid tumors
Matthias A Roelli, Dorothee Ruffieux-Daidie, Amandine Stooss, Oussama ElMokh, Wayne A Phillips, Matthias S Dettmer, Roch-Philippe Charles
Journal article | 2017 | Oncotarget
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Inma M Berenjeno, Roberto Pineiro, Sandra D Castillo, Wayne Pearce, Nicholas McGranahan, Sally M Dewhurst, Valerie Meniel, Nicolai J Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria ER Parker, Karen G Montgomery, Larissa S Moniz, Cheryl L Scudamore, Wayne A Phillips, Robert K Semple, et al.
Journal article | 2017 | Nature Communications
Combined CDK4/6 and PI3K alpha Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer
Zhi Ling Teo, Stephanie Versaci, Sathana Dushyanthen, Franco Caramia, Peter Savas, Chris P Mintoff, Magnus Zethoven, Balaji Virassamy, Stephen J Luen, Grant A McArthur, Wayne A Phillips, Phillip K Darcy, Sherene Loi
Journal article | 2017 | Cancer Research
Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases.
J Zhao, KMC van Mierlo, J Gómez-Ramírez, H Kim, CHC Pilgrim, P Pessaux, SS Rensen, EP van der Stok, FG Schaap, O Soubrane, T Takamoto, L Viganò, B Winkens, CHC Dejong, SWM Olde Damink, undefined Chemotherapy-Associated Liver Injury (CALI) consortium
Journal article | 2017 | British Journal of Surgery
BACKGROUND: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepa..
PI3K activation in neural stem cells drives tumorigenesis which can be suppressed by targeting CREB
Paul Daniel, Gulay Filiz, Daniel Brown, Michael Christie, Paul Waring, Yi Zhang, John Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance Johns, Karen Montgomery, Wayne Phillips, Theo Mantamadiotis
Journal article | 2017 | BiorXiv
Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma..
Inhibiting the system x((C)over-bar)/glutathione axis selectively targets cancers with mutant-p53 accumulation
David S Liu, Cuong P Duong, Sue Haupt, Karen G Montgomery, Colin M House, Walid J Azar, Helen B Pearson, Oliver M Fisher, Matthew Read, Glen R Guerra, Ygal Haupt, Carleen Cullinane, Klas G Wiman, Lars Abrahmsen, Wayne A Phillips, Nicholas J Clemons
Journal article | 2017 | Nature Communications
Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis
David S Liu, Sanne JM Hoefnagel, Oliver M Fisher, Kausilia K Krishnadath, Karen G Montgomery, Rita A Busuttil, Andrew J Colebatch, Matthew Read, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons
Journal article | 2016 | ONCOTARGET
Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution
Delphine Denoyer, Helen B Pearson, Sharnel AS Clatworthy, Zoe M Smith, Paul S Francis, Roxana M Llanos, Irene Volitakis, Wayne A Phillips, Peter M Meggyesy, Shashank Masaldan, Michael A Cater
Journal article | 2016 | ONCOTARGET
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
Lutz Krause, Katia Nones, Kelly A Loffler, Derek Nancarrow, Harald Oey, Yue Hang Tang, Nicola J Wayte, Ann Marie Patch, Kalpana Patel, Sandra Brosda, Suzanne Manning, Guy Lampe, Andrew Clouston, Janine Thomas, Jens Stoye, Damian J Hussey, David I Watson, Reginald V Lord, Wayne A Phillips, David Gotley, et al.
Journal article | 2016 | Carcinogenesis
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
Sandra D Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M Berenjeno, Victoria ER Parker, Inigo Chivite, Maria Mila-Guasch, Wayne Pearce, Isabelle Solomon, Ana Angulo-Urarte, Ana M Figueiredo, Robert E Dewhurst, Rachel G Knox, Graeme R Clark, Cheryl L Scudamore, Adam Badar, Tammy L Kalber, Julie Foster, Daniel J Stuckey, Anna L David, et al.
Journal article | 2016 | Science Translational Medicine
Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts
Matthew Read, David Liu, Cuong P Duong, Carleen Cullinane, William K Murray, Christina M Fennell, Jake Shortt, David Westerman, Paul Burton, Nicholas J Clemons, Wayne A Phillips
Journal article | 2016 | ANNALS OF SURGICAL ONCOLOGY
APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma
David SH Liu, Matthew Read, Carleen Cullinane, Walid J Azar, Christina M Fennell, Karen G Montgomery, Sue Haupt, Ygal Haupt, Klas G Wiman, Cuong P Duong, Nicholas J Clemons, Wayne A Phillips
Journal article | 2015 | GUT
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis
Helen B Pearson, Edwina McGlinn, Toby J Phesse, Holger Schlueter, Anuratha Srikumar, Nathan J Goedde, Christina B Woelwer, Andrew Ryan, Wayne A Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert
Journal article | 2015 | MOLECULAR CANCER
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Alexandra Van Keymeulen, May Yin Lee, Marielle Ousset, Sylvain Brohee, Sandrine Rorive, Rajshekhar R Giraddi, Aline Wuidart, Gaelle Bouvencourt, Christine Dubois, Isabelle Salmon, Christos Sotiriou, Wayne A Phillips, Cedric Blanpain
Journal article | 2015 | Nature
Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects
Lauren M Hare, Quenten Schwarz, Sophie Wiszniak, Rajendra Gurung, Karen G Montgomery, Christina A Mitchell, Wayne A Phillips
Journal article | 2015 | Developmental Biology
Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly
Kathryn M Kinross, Karen G Montgomery, Salvatore P Mangiafico, Lauren M Hare, Margarete Kleinschmidt, Megan J Bywater, Ingrid J Poulton, Christina Vrahnas, Holger Henneicke, Jordane Malaterre, Paul M Waring, Carleen Cullinane, Natalie A Sims, Grant A McArthur, Sofianos Andrikopoulos, Wayne A Phillips
Journal article | 2015 | FASEB JOURNAL
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Katia Nones, Nicola Waddell, Nicci Wayte, Ann-Marie Patch, Peter Bailey, Felicity Newell, Oliver Holmes, J Lynn Fink, Michael CJ Quinn, Yue Hang Tang, Guy Lampe, Kelly Quek, Kelly A Loffler, Suzanne Manning, Senel Idrisoglu, David Miller, Qinying Xu, Nick Waddell, Peter J Wilson, Timothy JC Bruxner, et al.
Journal article | 2014 | Nature Communications
Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice
Lauren M Hare, Toby J Phesse, Paul M Waring, Karen G Montgomery, Kathryn M Kinross, Kevin Mills, Vincent Roh, Joan K Heath, Robert G Ramsay, Matthias Ernst, Wayne A Phillips
Journal article | 2014 | BIOCHEMICAL JOURNAL
Translational research on Barrett's esophagus
Anushka Baruah, Navtej Buttar, Raghav Chandra, Xiaoxin Chen, Nicholas J Clemons, Debora Compare, Wael El-Rifai, Jian Gu, Courtney W Houchen, Shze Yung Koh, Wenbo Li, Gerardo Nardone, Wayne A Phillips, Anamay Sharma, Ishtpreet Singh, Melissa P Upton, Kenneth J Vega, Xifeng Wu
Conference Proceedings | 2014 | Annals of the New York Academy of Sciences
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors
Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.
Journal article | 2013 | EUROPEAN JOURNAL OF CANCER
Human perforin mutations and susceptibility to multiple primary cancers
Joseph A Trapani, Kevin YT Thia, Miles Andrews, Ian D Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G Campbell, Wayne A Phillips, Ilia Voskoboinik, Jonathan S Cebon
Journal article | 2013 | ONCOIMMUNOLOGY
Barrett's esophagus: cancer and molecular biology
Michael K Gibson, Arashinder S Dhaliwal, Nicholas J Clemons, Wayne A Phillips, Katerina Dvorak, Daniel Tong, Simon Law, E Daniel Pirchi, Jari Raesaenen, Mark J Krasna, Kaushal Parikh, Kausilia K Krishnadath, Yu Chen, Leonard Griffiths, Benjamin J Colleypriest, J Mark Farrant, David Tosh, Kiron M Das, Manisha Bajpai
Journal article | 2013 | Annals of The New York Academy of Sciences
Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity
Meredith J Layton, Mirette Saad, Nicole L Church, Richard B Pearson, Christina A Mitchell, Wayne A Phillips
Journal article | 2012 | BMC Biochemistry
Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus
Nicholas J Clemons, David H Wang, Daniel Croagh, Anjali Tikoo, Christina M Fennell, Carmel Murone, Andrew M Scott, D Neil Watkins, Wayne A Phillips
Journal article | 2012 | American Journal of Physiology - Gastrointestinal and Liver Physiology
A Central Role for RAF -> MEK -> ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Eric A Collisson, Christy L Trejo, Jillian M Silva, Shenda Gu, James E Korkola, Laura M Heiser, Roch-Philippe Charles, Brian A Rabinovich, Byron Hann, David Dankort, Paul T Spellman, Wayne A Phillips, Joe W Gray, Martin McMahon
Journal article | 2012 | Cancer Discovery
Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors
Anjali Tikoo, Vincent Roh, Karen G Montgomery, Ivan Ivetac, Paul Waring, Rebecca Pelzer, Lauren Hare, Mark Shackleton, Patrick Humbert, Wayne A Phillips
Journal article | 2012 | PLOS ONE
Correlations between histopathological diagnosis of chemotherapy-induced hepatic injury, clinical features, and perioperative morbidity
Charles HC Pilgrim, Laveniya Satgunaseelan, Alan Pham, William Murray, Emma Link, Marty Smith, Val Usatoff, Peter M Evans, Simon Banting, Benjamin N Thomson, Wayne A Phillips, Michael Michael
Journal article | 2012 | HPB: the official journal of the IHPBA
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur, et al.
Journal article | 2012 | JOURNAL OF CLINICAL INVESTIGATION
Targeting PI3 kinase/AKT/mTOR signaling in cancer.
Karen Sheppard, Kathryn M Kinross, Benjamin Solomon, Richard B Pearson, Wayne A Phillips
Journal article | 2012 | Critical Reviews in Oncogenesis
The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, proliferation, metabolism, s..
Developing a quantitative in vivo tissue reconstitution assay to assess the relative potency of candidate populations of mouse oesophageal epithelial cells.
Daniel Croagh, Rick Redvers, Wayne A Phillips, Pritinder Kaur
Journal article | 2012 | Methods in Molecular Biology
Proliferation in mouse oesophageal epithelial cells is confined to the basal layer of the epithelium. Within this population, it i..
Pretreatment Transcriptional Profiling for Predicting Response to Neoadjuvant Chemoradiotherapy in Rectal Adenocarcinoma
Kate H Brettingham-Moore, Cuong P Duong, Danielle M Greenawalt, Alexander G Heriot, Jason Ellul, Christopher A Dow, William K Murray, Rodney J Hicks, Joe Tjandra, Michael Chao, Andrew Bui, Daryl Lim Joon, Robert JS Thomas, Wayne A Phillips
Journal article | 2011 | Clinical Cancer Research
Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers
Aslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Richard B Pearson, Anne-Lise Borresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, et al.
Journal article | 2011 | PLoS One
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
Sherene Loi, Benjamin Haibe-Kains, Samira Majjaj, Francoise Lallemand, Virginie Durbecq, Denis Larsimont, Ana M Gonzalez-Angulo, Lajos Pusztai, W Fraser Symmans, Alberto Bardelli, Paul Ellis, Andrew NJ Tutt, Cheryl E Gillett, Bryan T Hennessy, Gordon B Mills, Wayne A Phillips, Martine J Piccart, Terence P Speed, Grant A McArthur, Christos Sotiriou
Journal article | 2010 | Proceedings of the National Academy of Sciences of the United States of America
Aberrant Epithelial-Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia
David H Wang, Nicholas J Clemons, Tomoharu Miyashita, Adam J Dupuy, Wei Zhang, Anette Szczepny, Ian M Corcoran Schwartz, Daniel L Wilburn, Elizabeth A Montgomery, Jean S Wang, Nancy A Jenkins, Neal A Copeland, John W Harmon, Wayne A Phillips, D Neil Watkins
Journal article | 2010 | Gastroenterology
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf
Hui-Hua Zhang, Francesca Walker, Sara Kiflemariam, Robert H Whitehead, David Williams, Wayne A Phillips, Thomas Mikeska, Alexander Dobrovic, Antony W Burgess
Journal article | 2009 | International Journal of Cancer
Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer
Cuong Duong, Danielle M Greenawalt, Adam Kowalczyk, Marianne L Ciavarella, Garvesh Raskutti, William K Murray, Wayne A Phillips, Robert JS Thomas
Journal article | 2007 | Annals of Surgical Oncology
Gene expression profiling of esophageal cancer: Comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma
Danielle M Greenawalt, Cuong Duong, Gordon K Smyth, Marianne L Ciavarella, Natalie J Thompson, Thomas Tiang, William K Murray, Robert JS Thomas, Wayne A Phillips
Journal article | 2007 | International Journal of Cancer
Large validation of anti-learnable signature in classification of response to chemoradiotherapy in Esophageal adenocarcinoma patients
Adam Kowalczyk, Danielle M Greenawalt, Justin Bedo, Cuong Duong, Garvesh Raskutti, Robert JS Thomas, Wayne A Phillips
Conference Proceedings | 2007 | Optimization and Systems Biology
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition
Briony E Cristiano, Joanna C Chan, Katherine M Hannan, Nicole A Lundie, Nelly J Marmy-Conus, Ian G Campbell, Wayne A Phillips, Melissa Robbie, Ross D Hannan, Richard B Pearson
Journal article | 2006 | Cancer Research
Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
Honor Hugo, Alina Cures, Nirosha Suraweera, Yvette Drabsch, Damian Purcell, Theo Mantamadiotis, Wayne Phillips, Alex Dobrovic, Gabriella Zupi, Thomas J Gonda, Barry Iacopetta, Robert G Ramsay
Journal article | 2006 | Genes, Chromosomes & Cancer
The Ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer
TL Lo, P Yusoff, CW Fong, K Guo, BJ McCaw, WA Phillips, H Yang, ESM Wong, HF Leong, Q Zeng, TC Putti, GR Guy
Journal article | 2004 | Cancer Research
Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3 beta activity and increases levels of both membrane-bound and APC/Axin/GSK-3 beta complex-associated pools of beta-catenin
E Vincan, CSF Leet, NI Reyes, RJ Dilley, RJS Thomas, WA Phillips
Journal article | 2000 | Oncology Research
Phosphotyrosine phosphatase activity in the macrophage is enhanced by lipopolysaccharide, tumor necrosis factor alpha, and granulocyte/macrophage-colony stimulating factor: Correlation with priming of the respiratory burst
S Bassal, YS Liu, RJS Thomas, WA Phillips
Journal article | 1997 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
PROTEIN-KINASE-C ISOTYPES AND SIGNALING IN NEUTROPHILS - DIFFERENTIAL SUBSTRATE SPECIFICITIES OF A TRANSLOCATABLE, CALCIUM-DEPENDENT AND PHOSPHOLIPID-DEPENDENT BETA-PROTEIN KINASE-C AND A NOVEL CALCIUM-INDEPENDENT, PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE WHICH IS INHIBITED BY LONG-CHAIN FATTY ACYL COENZYME-A
S MAJUMDAR, MW ROSSI, T FUJIKI, WA PHILLIPS, S DISA, CF QUEEN, RB JOHNSTON, OM ROSEN, BE CORKEY, HM KORCHAK
Journal article | 1991 | Journal of Biological Chemistry
INFLUENCE OF CALCIUM ON THE SUBCELLULAR-DISTRIBUTION OF PROTEIN KINASE-C IN HUMAN-NEUTROPHILS - EXTRACTION CONDITIONS DETERMINE PARTITIONING OF HISTONE-PHOSPHORYLATING ACTIVITY AND IMMUNOREACTIVITY BETWEEN CYTOSOL AND PARTICULATE FRACTIONS
WA PHILLIPS, T FUJIKI, MW ROSSI, HM KORCHAK, RB JOHNSTON
Journal article | 1989 | Journal of Biological Chemistry
PRIMING OF NEUTROPHILS AND MACROPHAGES FOR ENHANCED RELEASE OF SUPEROXIDE ANION BY THE CALCIUM IONOPHORE IONOMYCIN - IMPLICATIONS FOR REGULATION OF THE RESPIRATORY BURST
TH FINKEL, MJ PABST, H SUZUKI, LA GUTHRIE, JR FOREHAND, WA PHILLIPS, RB JOHNSTON
Journal article | 1987 | Journal of Biological Chemistry