Christopher Rowe

Association of β-amyloid level, clinical progression and longitudinal cognitive change in normal older individuals.

Laura M van der Kall, Thanh Truong, Samantha C Burnham, Vincent Doré, Rachel S Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y Lim, Simon M Laws, David Ames, Christopher Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L Masters, et al.

Journal article  |  2020  |  Neurology

OBJECTIVE: To determine the effect of Aβ level on progression risk to MCI or dementia and longitudinal cognitive change in cogniti..

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Adam Alexander T Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Nature Communications

Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex mo..

Impact of APOE-epsilon 4 carriage on the onset and rates of neocortical A beta-amyloid deposition

Samantha C Burnham, Simon M Laws, Charley A Budgeon, Vincent Dore, Tenielle Porter, Pierrick Bourgeat, Rachel F Buckley, Kevin Murray, Kathryn A Ellis, Berwin A Turlach, Olivier Salvado, David Ames, Ralph N Martins, Dorene Rentz, Colin L Masters, Christopher C Rowe, Victor L Villemagne

Journal article  |  2020  |  Neurobiology of Aging

Neocortical Aβ-amyloid deposition, one of the hallmark pathologic features of Alzheimer's disease (AD), begins decades prior to th..

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism.

Leah C Beauchamp, Victor L Villemagne, David I Finkelstein, Vincent Doré, Ashley I Bush, Kevin J Barnham, Christopher C Rowe

Journal article  |  2020  |  Scientific Reports

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapi..

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E Marioni, Margaret J Wright, Alison M Goate, Edoardo Marcora, Kuan-lin Huang, Tenielle Porter, Simon M Laws, Perminder S Sachdev, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R Wray, Allan F McRae, Peter M Visscher

Journal article  |  2020  |  Nature Communications

Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD)...

Risk of Dementia in Posttraumatic Stress Disorder

Alby Elias, Christopher Rowe, Malcolm Hopwood

Journal article  |  2020  |  Journal of Geriatric Psychiatry and Neurology

Several studies have investigated the risk of dementia in posttraumatic stress disorder (PTSD) using a varying methodology. Epidem..

The protocol of a clinical quality registry for dementia and mild cognitive impairment (MCI): the Australian dementia network (ADNeT) Registry

Xiaoping Lin, Kasey Wallis, Stephanie A Ward, Henry Brodaty, Perminder S Sachdev, Sharon L Naismith, Karolina Krysinska, John McNeil, Christopher C Rowe, Susannah Ahern

Journal article  |  2020  |  BMC Geriatrics

BACKGROUND: Dementia was identified as a priority area for the development of a Clinical Quality Registry (CQR) in Australia in 20..

Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment.

Nicholas I Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames

Journal article  |  2020  |  Journal of the International Neuropsychological Society

OBJECTIVES: The criteria for objective memory impairment in mild cognitive impairment (MCI) are vaguely defined. Aggregating the n..

Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing

Mohammad Sabbir Siddiqui, Maxime Francois, Stephanie Rainey-Smith, Ralph Martins, Colin L Masters, David Ames, Christopher C Rowe, Lance S Macaulay, Michael F Fenech, Wayne R Leifert

Journal article  |  2020  |  Life

In response to double-stranded breaks (DSBs) in chromosomal DNA, H2AX (a member of histone H2A family) becomes phosphorylated to f..

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

Stephanie A Schultz, Jeremy F Strain, Adedamola Adedokun, Qing Wang, Oliver Preische, Jens Kuhle, Shaney Flores, Sarah Keefe, Aylin Dincer, Beau M Ances, Sarah B Berman, Adam M Brickman, David M Cash, Jasmeer Chhatwal, Carlos Cruchaga, Michael Ewers, Nick N Fox, Bernardino Ghetti, Alison Goate, Neill R Graff-Radford, et al.

Journal article  |  2020  |  Neurobiology of Disease

Neurofilament light chain (NfL) is a protein that is selectively expressed in neurons. Increased levels of NfL measured in either ..