Christopher Rowe

PET Imaging of brain muscarinic receptors with 18F-Fluorobenzyl-Dexetimide: A first in human study.

Christopher C Rowe, Natasha Krishnadas, Uwe Ackermann, Vincent Doré, Rachel YW Goh, Rodney Guzman, Lee Chong, Svetlana Bozinovski, Rachel Mulligan, Richard Kanaan, Brian Dean, Victor L Villemagne

Journal article  |  2021  |  Psychiatry Res Neuroimaging

M1 and M4 muscarinic receptor (mAChR) agonists are under development for the treatment of schizophrenia, Alzheimer's and Parkinson..

Head-to-head comparison of cerebral blood flow single-photon emission computed tomography and F-18-fluoro-2-deoxyglucose positron emission tomography in the diagnosis of Alzheimer disease

David P Nadebaum, Natasha Krishnadas, Aurora MT Poon, Victor Kalff, Meir Lichtenstein, Victor L Villemagne, Gareth Jones, Christopher C Rowe

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Clinical diagnosis of Alzheimer disease (AD) is only 70% accurate. Reduced cerebral blood flow (CBF) and metabolism in..

Synthetic microbleeds generation for classifier training without ground truth

Saba Momeni, Amir Fazlollahi, Paul Yates, Christopher Rowe, Yongsheng Gao, Alan Wee-Chung Liew, Olivier Salvado

Journal article  |  2021  |  COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

BACKGROUND AND OBJECTIVE: Cerebral microbleeds (CMB) are important biomarkers of cerebrovascular diseases and cognitive dysfunctio..

Toward a Universal Readout for 18F-Labeled Amyloid Tracers: The CAPTAINs Study.

Gérard N Bischof, Peter Bartenstein, Henryk Barthel, Bart van Berckel, Vincent Doré, Thilo van Eimeren, Norman Foster, Jochen Hammes, Adriaan A Lammertsma, Satoshi Minoshima, Chris Rowe, Osama Sabri, John Seibyl, Koen Van Laere, Rik Vandenberghe, Victor Villemagne, Igor Yakushev, Alexander Drzezga

Journal article  |  2021  |  J Nucl Med

To date, 3 18F-labeled PET tracers have been approved for assessing cerebral amyloid plaque pathology in the diagnostic workup of ..

What Is T plus ? A Gordian Knot of Tracers, Thresholds, and Topographies

Victor L Villemagne, Brian J Lopresti, Vincent Dore, Dana Tudorascu, Milos D Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A Pascoal, N Scott Mason, Beth Snitz, Howard Aizenstein, Chester A Mathis, Oscar Lopez, Christopher C Rowe, William E Klunk, Ann D Cohen

Journal article  |  2021  |  JOURNAL OF NUCLEAR MEDICINE

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potenti..

Optimising participation of persons with cognitive impairment in a national dementia registry: challenges and solutions

Xiaoping Lin, Kasey Wallis, Susannah Ahern, Henry Brodaty, Christopher Rowe, Barbara Kain, Sally Lambourne, John McNeil, Stephanie A Ward

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

Clinical quality registries are increasingly utilised to monitor and improve healthcare quality. Opt-out consent is recommended to..

Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

Bruno Dubois, Nicolas Villain, Giovanni B Frisoni, Gil D Rabinovici, Marwan Sabbagh, Stefano Cappa, Alexandre Bejanin, Stephanie Bombois, Stephane Epelbaum, Marc Teichmann, Marie-Odile Habert, Agneta Nordberg, Kaj Blennow, Douglas Galasko, Yaakov Stern, Christopher C Rowe, Stephen Salloway, Lon S Schneider, Jeffrey L Cummings, Howard H Feldman

Journal article  |  2021  |  LANCET NEUROLOGY

In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a purely biological definition of Alzheimer's..

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Claire E Sexton, Kaarin J Anstey, Filippo Baldacci, CJ Barnum, Anna M Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M Elahi, Jurgen Gotz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M Landau, Nicola T Lautenschlager, Simon M Laws, Darren M Lipnicki, Hanzhang Lu, Colin L Masters, Wendy Moyle, Akinori Nakamura, et al.

Journal article  |  2021  |  ALZHEIMERS & DEMENTIA

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting..

Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition

Sherilyn Tan, Tenielle Porter, Romola S Bucks, Michael Weinborn, Lidija Milicic, Ailsa Brown, Stephanie R Rainey-Smith, Kevin Taddei, David Ames, Colin L Masters, Paul Maruff, Greg Savage, Christopher C Rowe, Victor L Villemagne, Belinda Brown, Hamid R Sohrabi, Simon M Laws, Ralph N Martins

Journal article  |  2021  |  HORMONES AND BEHAVIOR

Age-related decrease in testosterone levels is a potential risk factor for cognitive decline in older men. However, observational ..

Advances in Brain Amyloid Imaging

Natasha Krishnadas, Victor L Villemagne, Vincent Dore, Christopher C Rowe

Journal article  |  2021  |  SEMINARS IN NUCLEAR MEDICINE

Amyloid-β (Aβ) PET imaging has now been available for over 15 years. The ability to detect Aβ in vivo has greatly improved the cli..