Gordon Lynch

Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes.

Wenlan Li, Jennifer Trieu, Ronnie Blazev, Benjamin L Parker, Kate T Murphy, Kristy Swiderski, Gordon S Lynch

Journal article  |  2023  |  Am J Physiol Cell Physiol

Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and quality o..

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle

James W McNamara, Benjamin L Parker, Holly K Voges, Neda R Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia TL Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L Pointer, Petros Syrris, Luis R Lopes, Perry M Elliott, Gordon S Lynch, Richard J Mills, James E Hudson, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

AbstractMuscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of mu..

Consensus guidelines for sarcopenia prevention, diagnosis and management in Australia and New Zealand

Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M Girgis, Mathis Grossmann, Alan Hayes, Tim Henwood, Vasant Hirani, Charles Inderjeeth, Sandra Iuliano, Justin Keogh, Josh Lewis, Gordon S Lynch, Julie A Pasco, Steven Phu, Esmee M Reijnierse, et al.

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Sarcopenia is an age-associated skeletal muscle condition characterized by low muscle mass, strength, and physical per..

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Identifying the challenges for successful pharmacotherapeutic management of sarcopenia

Gordon S Lynch

Journal article  |  2022  |  EXPERT OPINION ON PHARMACOTHERAPY

Age-Related Changes in Skeletal Muscle Iron Homeostasis

Francesca M Alves, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sarcopenia is an age-related condition of slow, progressive loss of muscle mass and strength, which contributes to frailty, increa..

Gestational heat stress alters skeletal muscle gene expression profiles and vascularity in fetal pigs in a sexually dimorphic manner

Weicheng Zhao, Mark P Green, Christina D Marth, Fan Liu, Hieu H Le, Gordon S Lynch, Alan W Bell, Brian J Leury, Frank R Dunshea, Jeremy J Cottrell

Journal article  |  2022  |  JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY

BACKGROUND: There is evidence that sow heat stress (HS) during gestation affects fetal development with implications for impaired ..

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ashley J Ovens, Yi Sing Gee, Naomi XY Ling, Dingyi Yu, Justin P Hardee, Jin D Chung, Kevin RW Ngoei, Nicholas J Waters, Nolan J Hoffman, John W Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W Parker, Gordon S Lynch, Fei Huang, Sandra Galic, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill, et al.

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeo..

Screening, Diagnosis and Management of Sarcopenia and Frailty in Hospitalized Older Adults: Recommendations from the Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) Expert Working Group

Robin M Daly, S Iuliano, JJ Fyfe, D Scott, B Kirk, MQ Thompson, E Dent, K Fetterplace, ORL Wright, GS Lynch, J Zanker, S Yu, S Kurrle, R Visvanathan, AB Maier

Journal article  |  2022  |  JOURNAL OF NUTRITION HEALTH & AGING

Sarcopenia and frailty are highly prevalent conditions in older hospitalized patients, which are associated with a myriad of adver..

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Jin D Chung, Jennifer Trieu, Dominic J Hare, Peter J Crouch, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the ..