Gordon Lynch

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  Journal of Cachexia Sarcopenia and Muscle

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..

Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model

Rebecca A Ellwood, Jennifer E Hewitt, Roberta Torregrossa, Ashleigh M Philp, Justin P Hardee, Samantha Hughes, David van de Klashorst, Nima Gharahdaghi, Taslim Anupom, Luke Slade, Colleen S Deane, Michael Cooke, Timothy Etheridge, Mathew Piasecki, Adam Antebi, Gordon S Lynch, Andrew Philp, Siva A Vanapalli, Matthew Whiteman, Nathaniel J Szewczyk

Journal article  |  2021  |  Proceedings of the National Academy of Sciences of the United States of America

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness ..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  Molecular Metabolism

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Defective lysosome reformation during autophagy causes skeletal muscle disease.

Meagan J McGrath, Matthew J Eramo, Rajendra Gurung, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Sonia Raveena Lourdes, Frank Koentgen, Sandra J Feeney, Michael Lazarou, Catriona A McLean, Christina A Mitchell

Journal article  |  2021  |  Journal of Clinical Investigation

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phospha..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

ASM Chan, NE McGregor, IJ Poulton, JP Hardee, EHJ Cho, TJ Martin, P Gregorevic, NA Sims, GS Lynch

Journal article  |  2021  |  JBMR Plus

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Savant S Thakur, Kristy Swiderski, Victoria L Chhen, Janine L James, Nicki J Cranna, AM Taufiqual Islam, James G Ryall, Gordon S Lynch

Journal article  |  2020  |  Biology Open

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..

A Metabolic Roadmap for Somatic Stem Cell Fate

C Hai Ly, Gordon S Lynch, James G Ryall

Journal article  |  2020  |  Cell Metabolism

While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, rece..

First person – Savant Thakur

GS Lynch

Journal article  |  2020  |  Biology Open

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

Journal article  |  2020  |  Journal of Neurogastroenterology and Motility

Background/Aims: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..

Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

Marin E Nelson, Benjamin L Parker, James G Burchfield, Nolan J Hoffman, Elise J Needham, Kristen C Cooke, Timur Naim, Lykke Sylow, Naomi XY Ling, Deanne Francis, Dougall M Norris, Rima Chaudhuri, Jonathan S Oakhill, Erik A Richter, Gordon S Lynch, Jacqueline Stockli, David E James

Journal article  |  2019  |  The EMBO Journal