Gordon Lynch

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice.

Justin P Hardee, Marissa K Caldow, Audrey SM Chan, Stuart K Plenderleith, Jennifer Trieu, René Koopman, Gordon S Lynch

Journal article  |  2021  |  Am J Physiol Cell Physiol

Impaired oxidative capacity and mitochondrial function contribute to the dystrophic pathology in muscles of patients with Duchenne..

Murine models of Duchenne muscular dystrophy: is there a best model?

Kristy Swiderski, Gordon S Lynch

Journal article  |  2021  |  Am J Physiol Cell Physiol

N/A.

Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy.

Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch

Journal article  |  2021  |  Am J Physiol Cell Physiol

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways

Kate J Sadler, Paul A Della Gatta, Timur Naim, Marita A Wallace, Albert Lee, Thiri Zaw, Angus Lindsay, Roger S Chung, Luca Bello, Elena Pegoraro, Severine Lamon, Gordon S Lynch, Aaron P Russell

Journal article  |  2021  |  EXPERIMENTAL PHYSIOLOGY

NEW FINDINGS: What is the central question of this study? Striated muscle activator of rho signalling (STARS) is an actin-binding ..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice.

Audrey SM Chan, Narelle E McGregor, Ingrid J Poulton, Justin P Hardee, Ellie H-J Cho, T John Martin, Paul Gregorevic, Natalie A Sims, Gordon S Lynch

Journal article  |  2021  |  JBMR Plus

The development of the musculoskeletal system and its maintenance depends on the reciprocal relationship between muscle and bone. ..

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..

Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model

Rebecca A Ellwood, Jennifer E Hewitt, Roberta Torregrossa, Ashleigh M Philp, Justin P Hardee, Samantha Hughes, David van de Klashorst, Nima Gharahdaghi, Taslim Anupom, Luke Slade, Colleen S Deane, Michael Cooke, Timothy Etheridge, Mathew Piasecki, Adam Antebi, Gordon S Lynch, Andrew Philp, Siva A Vanapalli, Matthew Whiteman, Nathaniel J Szewczyk

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness ..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Defective lysosome reformation during autophagy causes skeletal muscle disease.

Meagan J McGrath, Matthew J Eramo, Rajendra Gurung, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Sonia Raveena Lourdes, Frank Koentgen, Sandra J Feeney, Michael Lazarou, Catriona A McLean, Christina A Mitchell

Journal article  |  2021  |  J Clin Invest

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phospha..

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Savant S Thakur, Kristy Swiderski, Victoria L Chhen, Janine L James, Nicki J Cranna, AM Taufiqual Islam, James G Ryall, Gordon S Lynch

Journal article  |  2020  |  BIOLOGY OPEN

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..