Melissa Southey

DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case-control Study

James A Chamberlain, Pierre-Antoine Dugue, Julie K Bassett, Roger L Milne, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Geoffrey W Stuart, Alex Boussioutas, Melissa C Southey, Graham G Giles, Hazel Mitchell, Dallas R English, Allison M Hodge

Journal article  |  2021  |  CANCER PREVENTION RESEARCH

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..

Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure

Tuong L Nguyen, Daniel F Schmidt, Enes Makalic, Gertraud Maskarinec, Shuai Li, Gillian S Dite, Ye K Aung, Christopher F Evans, Ho N Trinh, Laura Baglietto, Jennifer Stone, Yun-Mi Song, Joohon Sung, Robert J MacInnis, Pierre-Antoine Dugue, James G Dowty, Mark A Jenkins, Roger L Milne, Melissa C Southey, Graham G Giles, et al.

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CANCER

Mammograms contain information that predicts breast cancer risk. We developed two novel mammogram-based breast cancer risk measure..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF HUMAN GENETICS

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

Journal article  |  2020  |  CLINICAL EPIGENETICS

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..

Palm reading and water divining: A cross-sectional study of the accuracy of palmar hyperlinearity and transepidermal water loss to identify individuals with a filaggrin gene null mutation

Adrian John Lowe, Bambie Lee, David Orchard, Emma King, Michael J Abramson, Katrina J Allen, Jennie Hui, Melissa C Southey, Caroline J Lodge, Shyamali C Dharmage

Journal article  |  2020  |  JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Julia D Labadie, Tabitha A Harrison, Barbara Banbury, Efrat L Amtay, Sonja Bernd, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Dallas English, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Yi Lin, et al.

Journal article  |  2020  |  JNCI CANCER SPECTRUM

Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Amedeo Gagliardi, Pierre-Antoine Dugue, Therese H Nost, Melissa C Southey, Daniel D Buchanan, Daniel F Schmidt, Enes Makalic, Allison M Hodge, Dallas R English, Nicole W Doo, John L Hopper, Gianluca Severi, Laura Baglietto, Alessio Naccarati, Sonia Tarallo, Luigia Pace, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, et al.

Journal article  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer

Taru A Muranen, Sofia Khan, Rainer Fagerholm, Kristiina Aittomaeki, Julie M Cunningham, Joe Dennis, Goska Leslie, Lesley McGuffog, Michael T Parsons, Jacques Simard, Susan Slager, Penny Soucy, Douglas F Easton, Marc Tischkowitz, Amanda B Spurdle, Rita K Schmutzler, Barbara Wappenschmidt, Eric Hahnen, Maartje J Hooning, Christian F Singer, et al.

Journal article  |  2020  |  NPJ BREAST CANCER

Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology..

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Louise Brinton, Daniel D Buchanan, Stephen J Chanock, Chu Chen, Maxine M Chen, Timothy HT Cheng, Linda S Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, et al.

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CANCER

Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For en..

Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Valentina Silvestri, Goska Leslie, Daniel R Barnes, undefined CIMBA Group, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Rosa B Barkardottir, Alicia Barroso, Daniel Barrowdale, Javier Benitez, Bernardo Bonanni, Ake Borg, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Carlo Capalbo, Ian Campbell, Wendy K Chung, et al.

Journal article  |  2020  |  JAMA Oncol

Importance: The limited data on cancer phenotypes in men with germline BRCA1 and BRCA2 pathogenic variants (PVs) have hampered the..