Stephen Locarnini

Glycoengineered hepatitis B virus-like particles with enhanced immunogenicity

Carina CD Joe, Sayantani Chatterjee, George Lovrecz, Timothy E Adams, Morten Thaysen-Andersen, Renae Walsh, Stephen A Locarnini, Peter Smooker, Hans J Netter

Journal article  |  2020  |  Vaccine

Virus-like particles (VLP) represent biological platforms for the development of novel products such as vaccines and delivery plat..

HBV variants are common in the "immune-tolerant"phase of chronic hepatitis B.

Lilly Yuen, Peter A Revill, Gillian Rosenberg, Josef Wagner, Margaret Littlejohn, Julianne Bayliss, Kathy Jackson, Susanna K Tan, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Ed Gane, Henry Ly Chan, Xin Li, Scott Bowden, Stephen Locarnini, Alexander Thompson

Journal article  |  2020  |  Journal of Viral Hepatitis

Nucleos(t)ide analouges (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However..

Direct-acting antivirals and viral RNA targeting for hepatitis B cure.

Janine French, Stephen Locarnini, Fabien Zoulim

Journal article  |  2020  |  Current Opinion in HIV and AIDS

PURPOSE OF REVIEW: The current aim in the HBV landscape is to develop therapeutic strategies to achieve a functional cure of infec..

RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Man-Fung Yuen, Ingolf Schiefke, Jung-Hwan Yoon, Sang Hoon Ahn, Jeong Heo, Ju Hyun Kim, Henry Lik Yuen Chan, Ki Tae Yoon, Hartwig Klinker, Michael Manns, Joerg Petersen, Thomas Schluep, James Hamilton, Bruce D Given, Carlo Ferrari, Ching-Lung Lai, Stephen A Locarnini, Robert G Gish

Journal article  |  2020  |  Hepatology

BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived..

Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference‡.

Markus Cornberg, Anna Suk-Fong Lok, Norah A Terrault, Fabien Zoulim, undefined 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty

Journal article  |  2020  |  Journal of Hepatology

Representatives from academia, industry, regulatory agencies, and patient groups convened in March 2019 with the primary goal of d..

Analysis of the in vitro replication phenotype of African hepatitis B virus (HBV) genotypes and subgenotypes present in Australia identifies marked differences in DNA and protein expression

E Bannister, V Sozzi, H Mason, S Locarnini, W Hardikar, PA Revill

Journal article  |  2020  |  Virology

Hepatitis B virus infection in Africa is characterised by distinct genotypes with observed differences in natural history and clin..

Durability of Hepatitis B Surface Antigen Loss With Nucleotide Analogue and Peginterferon Therapy in Patients With Chronic Hepatitis B

Anna S Lok, Fabien Zoulim, Geoffrey Dusheiko, Henry LY Chan, Maria Buti, Marc G Ghany, Anuj Gaggar, Jenny C Yang, George Wu, John F Flaherty, G Mani Subramanian, Stephen Locarnini, Patrick Marcellin

Journal article  |  2020  |  Hepatology Communications

Point of care and oral fluid hepatitis B testing in remote Indigenous communities of northern Australia

Richard P Sullivan, Jane Davies, Paula Binks, Roslyn Gundjirryiir Dhurrkay, George Garambaka Gurruwiwi, Sarah Mariyalawuy Bukulatjpi, Melita McKinnon, Kelly Hosking, Margaret Littlejohn, Kathy Jackson, Stephen Locarnini, Joshua S Davis, Steven YC Tong

Journal article  |  2019  |  Journal of Viral Hepatitis

Many Indigenous Australians in northern Australia living with chronic Hepatitis B are unaware of their diagnosis due to low screen..

FIRST CLINICAL EXPERIENCE WITH RNA INTERFERENCE [RNAi]-BASED TRIPLE COMBINATION THERAPY IN CHRONIC HEPATITIS B (CHB): JNJ-73763989 (JNJ-3989), JNJ-56136379 (JNJ-6379) AND A NUCLEOS(T)IDE ANALOGUE (NA)

Man-Fung Yuen, Stephen Locarnini, Bruce Given, Thomas Schluep, James Hamilton, Michael Biermer, Ronald Kalmeijer, Maria Beumont-Mauviel, Oliver Lenz, Gavin Cloherty, Kathy Jackson, Carlo Ferrari, Ching Lung Lai, Kevin Sze-Hang Liu, Lung Yi Mak, Danny Ka Ho Wong, Wai Pan To, Kwan-Lung Ko, Robert G Gish

Conference Proceedings  |  2019  |  HEPATOLOGY

Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference.

Markus Cornberg, Anna Suk-Fong Lok, Norah A Terrault, Fabien Zoulim, undefined 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty

Journal article  |  2019  |  Hepatology

Representatives from academia, industry, regulatory agencies, and patient groups convened in March 2019 with the primary goal of d..

Towards Genotype-Specific Care for Chronic Hepatitis B: The First 6 Years Follow Up From the CHARM Cohort Study

Jane Davies, Emma L Smith, Margaret Littlejohn, Rosalind Edwards, Vitina Sozzi, Kathy Jackson, Katie McGuire, Paula Binks, Benjamin C Cowie, Stephen Locarnini, Joshua S Davis, Steven YC Tong

Journal article  |  2019  |  Open Forum Infectious Diseases

DOSE RESPONSE WITH THE RNA INTERFERENCE (RNAi) THERAPY JNJ-3989 COMBINED WITH NUCLEOS(T)IDE ANALOGUE (NA) TREATMENT IN EXPANDED COHORTS OF PATIENTS (PTS) WITH CHRONIC HEPATITIS B (CHB)

Edward J Gane, Stephen Locarnini, Tien Huey Lim, Simone I Strasser, William Sievert, Wendy Cheng, Alexander Thompson, Bruce D Given, Thomas Schluep, James Hamilton, Michael Biermer, Ronald Kalmeijer, Maria Beumont-Mauviel, Oliver Lenz, Gavin Cloherty, Danny Ka Ho Wong, Christian Schwabe, Kathy Jackson, Carlo Ferrari, Ching Lung Lai, et al.

Conference Proceedings  |  2019  |  HEPATOLOGY

Predicting HBsAg clearance in genotype A chronic hepatitis B using HBsAg epitope profiling: A biomarker for functional cure

Renae Walsh, Rachel Hammond, Lilly Yuen, Joshua Deerain, Tanya O'Donnell, Thomas Leary, Gavin Cloherty, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Darren Wong, Stephen Locarnini

Journal article  |  2019  |  Liver International

Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Giovanni Raimondo, Stephen Locarnini, Teresa Pollicino, Massimo Levrero, Fabien Zoulim, Anna S Lok, Jean-Pierre Allain, Thomas Berg, Antonio Bertoletti, Maurizia Rossana Brunetto, Raffaele Bruno, Ding-Shinn Chen, Nicola Coppola, Markus Cornberg, Antonio Craxi, Maura Dandri, Vito Di Marco, Carlo Ferrari, Giovanni Battista Gaeta, Dieter Glebe, et al.

Journal article  |  2019  |  Journal of Hepatology

Tracing Ancient Human Migrations into Sahul Using Hepatitis B Virus Genomes

Lilly KW Yuen, Margaret Littlejohn, Sebastian Duchene, Rosalind Edwards, Sarah Bukulatjpi, Paula Binks, Kathy Jackson, Jane Davies, Joshua S Davis, Steven YC Tong, Stephen Locarnini

Journal article  |  2019  |  Molecular Biology and Evolution

Evaluation of dried blood spots for hepatitis B and D serology and nucleic acid testing.

Kathy Jackson, Thomas Holgate, Rosemary Tekoaua, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini

Journal article  |  2019  |  Journal of Medical Virology

Areas with the highest burden of hepatitis B virus (HBV) infection are often low-middle-income countries with limited access to di..

Human liver organoids culture as a novel in vitro model of HBV infection

Chuan Kok Lim, Bang M Tran, Byron Shue, Nicholas Eyre, Dustin Flanagan, Elizabeth Vincan, Danni Colledge, Stephen Locarnini, Erin McCartney, Edmund Tse, Andrew Ruszkiewicz, Michael Beard

Conference Proceedings  |  2019  |  JOURNAL OF HEPATOLOGY

Short term RNA interference therapy in chronic hepatitis B using JNJ-3989 brings majority of patients to HBsAg < 100 IU/ml threshold

Man-Fung Yuen, Stephen Locarnini, Tien Huey Lim, Simone Strasser, William Sievert, Wendy Cheng, Alex Thompson, Bruce Given, Thomas Schluep, James Hamilton, Gavin Cloherty, Danny Wong, Christian Schwabe, Kathy Jackson, Carlo Ferrari, Ching Lung Lai, Robert G Gish, Edward Gane

Conference Proceedings  |  2019  |  Journal of Hepatology

Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein

Natalie J Kingston, Liriye Kurtovic, Renae Walsh, Carina Joe, George Lovrecz, Stephen Locarnini, James G Beeson, Hans J Netter

Journal article  |  2019  |  Vaccine

Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia

Jocelyn Turpin, David Yurick, Georges Khoury, Pham Hai, Stephen Locarnini, Anat Melamed, Aviva Witkover, Kim Wilson, Damian Purcell, Charles RM Bangham, Lloyd Einsiedel

Journal article  |  2019  |  The Journal of Infectious Diseases

How infectious is the hepatitis B virus? Readings from the occult

Stephen Locarnini, Giovanni Raimondo

Journal article  |  2019  |  Gut

First Results with RNA Interference (RNAi) in Chronic Hepatitis B (CHB) Using ARO-HBV

Edward J Gane, Stephen Locarnini, Tien Huey Lim, Simone I Strasser, William Sievert, Wendy Cheng, Alexander Thompson, Bruce D Given, Thomas Schluep, James Hamilton, Zhen Li, Gavin Cloherty, Danny Ka Ho Wong, Christian Schwabe, Kathy Jackson, Carlo Ferrari, Ching Lung Lai, Robert G Gish, Man-Fung Yuen

Conference Proceedings  |  2018  |  HEPATOLOGY

Epidemiology and phylogenetic analysis of hepatitis D virus infection in Australia

Kathy Jackson, Jennifer MacLachlan, Benjamin Cowie, Stephen Locarnini, Scott Bowden, Nasra Higgins, Theo Karapanagiotidis, Suellen Nicholson, Margaret Littlejohn

Journal article  |  2018  |  Internal Medicine Journal

Inarigivir Demonstrates Potent Dose Dependent Anti-Viral Activity in HBV Treatment-Naive Patients: Role of HBeAg Status and Baseline HBsAg in Anti-Viral Response

Man-Fung Yuen, Magdy Elkhashab, Chi-Yi Chen, Yung Fa Chen, Carla S Coffin, Scott K Fung, Susan Greenbloom, Jeong Won Jang, Wen-Juei Jeng, Dong Joon Kim, Yoon Jun Kim, Won Kim, Kwan Sik Lee, Young-Suk Lim, Chun-Jen Liu, Alnoor Ramji, Radhakrishnan Iyer, Chelsea Macfarlane, Kathy Jackson, Stephen Locarnini, et al.

Conference Proceedings  |  2018  |  HEPATOLOGY

Inarigivir Is a Novel Selective Inhibitor of the HBV Replicase Complex in Vitro

Danni Colledge, Kathy Jackson, Vitina Sozzi, Xin Li, Michael R Beard, Nicholas Eyre, Junjie Zhang, Haitao Guo, Nezam H Afdhal, Radhakrishnan Iyer, Stephen Locarnini

Conference Proceedings  |  2018  |  HEPATOLOGY

ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B

Darren Wong, Margaret Littlejohn, Rosalind Edwards, Kathy Jackson, Peter Revill, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Patrick Marcellin, Maria Buti-Ferret, Harry Janssen, Ed Gane, Stephen Locarnini, Alexander Thompson

Journal article  |  2018  |  Liver International

Outcomes of the First 44 Patients at 48 Weeks in the HBV-STOP Study, a Prospective Study of Nucleot(s)Ide Analogue Discontinuation in Non-Cirrhotic Hbeag-Negative Chronic Hepatitis B Patients Who Have Achieved Long Term Virological Suppression

Samuel Hall, Gareth Burns, Miriam T Levy, John S Lubel, Amanda Nicoll, Gail Matthews, Paul V Desmond, William Sievert, Scott Bowden, Stephen Locarnini, Kumar Visvanathan, Alexander Thompson

Conference Proceedings  |  2018  |  HEPATOLOGY

Molecular characterization of hepatitis B virus (HBV) in African children living in Australia identifies genotypes and variants associated with poor clinical outcome

Elizabeth G Bannister, Lilly Yuen, Margaret Littlejohn, Rosalind Edwards, Vitina Sozzi, Danni Colledge, Xin Li, Stephen Locarnini, Winita Hardikar, Peter A Revill

Journal article  |  2018  |  Journal of General Virology

Mother-to-child transmission of hepatitis B: Examining viral cut-offs, maternal HBsAg serology and infant testing

Cynthuja Thilakanathan, Gabrielle Wark, Michael Maley, Scott Davison, Joseph Lawler, Aimei Lee, Nicholas Shackel, Nguyen Vi, Kathy Jackson, Anne Glass, Stephen A Locarnini, Miriam T Levy

Journal article  |  2018  |  Liver International

Diagnostics of Hepatitis B Virus: Standard of Care and Investigational

K Jackson, S Locarnini, R Gish

Journal article  |  2018  |  Clinical Liver Disease

Sub-optimal protection against past hepatitis B virus infection where subtype mismatch exists between vaccine and circulating viral genotype in northern Australia

Benjamin C Cheah, Jane Davies, Gurmeet R Singh, Nicholas Wood, Kathy Jackson, Margaret Littlejohn, Belinda Davison, Peter McIntyre, Stephen Locarnini, Joshua S Davis, Steven YC Tong

Journal article  |  2018  |  Vaccine

Hepatitis B virus infection

Man-Fung Yuen, Ding-Shinn Chen, Geoffrey M Dusheiko, Harry LA Janssen, Daryl TY Lau, Stephen A Locarnini, Marion G Peters, Ching-Lung Lai

Journal article  |  2018  |  Nature Reviews Disease Primers

In vitro studies identify a low replication phenotype for hepatitis B virus genotype H generally associated with occult HBV and less severe liver disease

Vitina Sozzi, Fang Shen, Jieliang Chen, Danni Colledge, Kathy Jackson, Stephen Locarnini, Zhenghong Yuan, Peter A Revill

Journal article  |  2018  |  Virology

A research agenda for curing chronic hepatitis B virus infection.

Harvey Alter, Timothy Block, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong-Mi Chang, Pei-Jer Chen, Francis V Chisari, Chari Cohen, Hashem El-Serag, Jordan Feld, Robert Gish, Jeffrey Glenn, Tim Greten, Haitao Guo, Ju-Tao Guo, Yujin Hoshida, Jianming Hu, Kris V Kowdley, Wenhui Li, et al.

Journal article  |  2018  |  Hepatology

HBeAg levels at week 24 predict response to 8years of tenofovir in HBeAg-positive chronic hepatitis B patients

D Wong, M Littlejohn, L Yuen, K Jackson, H Mason, J Bayliss, G Rosenberg, A Gaggar, K Kitrinos, M Subramanian, P Marcellin, M Buti, HLA Janssen, E Gane, S Locarnini, A Thompson, PA Revill

Journal article  |  2018  |  Alimentary Pharmacology & Therapeutics

Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B

Julianne Bayliss, Lilly Yuen, Gillian Rosenberg, Darren Wong, Margaret Littlejohn, Kathleen Jackson, Anuj Gaggar, Kathryn M Kitrinos, G Mani Subramanian, Patrick Marcellin, Maria Buti, Harry LA Janssen, Ed Gane, Vitina Sozzi, Danni Colledge, Rachel Hammond, Rosalind Edwards, Stephen Locarnini, Alexander Thompson, Peter A Revill

Journal article  |  2017  |  Gut

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

Christine I Wooddell, Man-Fung Yuen, Henry Lik-Yuen Chan, Robert G Gish, Stephen A Locarnini, Deborah Chavez, Carlo Ferrari, Bruce D Given, James Hamilton, Steven B Kanner, Ching-Lung Lai, Johnson YN Lau, Thomas Schluep, Zhao Xu, Robert E Lanford, David L Lewis

Journal article  |  2017  |  Science Translational Medicine

Reply: 'More viral mutants, less HBsAg clearance? One size may not fit all'

Alex Thompson, Stephen Locarnini, Peter Revill

Journal article  |  2017  |  Gut

More than a virus: a qualitative study of the social implications of hepatitis B infection in China.

J Wallace, M Pitts, C Liu, V Lin, B Hajarizadeh, J Richmond, S Locarnini

Journal article  |  2017  |  International Journal for Equity in Health

BACKGROUND: China has the largest absolute number of people living with hepatitis B with up to 300,000 people estimated to die eac..

Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

Thomas Schluep, Jason Lickliter, James Hamilton, David L Lewis, Ching-Lung Lai, Johnson YN Lau, Stephen A Locarnini, Robert G Gish, Bruce D Given

Journal article  |  2017  |  Clinical Pharmacology in Drug Development

Five-year efficacy and safety of tenofovir-based salvage therapy for patients with chronic hepatitis B who previously failed LAM/ADV therapy

Lucy Lim, Alexander Thompson, Scott Patterson, Jacob George, Simone Strasser, Alice Lee, William Sievert, Amanda Nicoll, Paul Desmond, Stuart Roberts, Kaye Marion, Scott Bowden, Stephen Locarnini, Peter Angus

Journal article  |  2017  |  Liver International

New direct-Acting antiviral agents and immunomodulators for hepatitis b virus infection

MG Peters, S Locarnini

Journal article  |  2017  |  Gastroenterology and Hepatology

The virological aspects of hepatitis B

Zina S Valaydon, Stephen A Locarnini

Journal article  |  2017  |  Best Practice & Research Clinical Gastroenterology

Use of Current and New Endpoints in the Evaluation of Experimental Hepatitis B Therapeutics

Timothy M Block, Stephen Locarnini, Brian J McMahon, Barbara Rehermann, Marion G Peters

Journal article  |  2017  |  Clinical Infectious Diseases

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

Romina Salpini, Matteo Surdo, Nadia Warner, Maria Francesca Cortese, Danny Colledge, Sally Soppe, Maria Concetta Bellocchi, Daniele Armenia, Luca Carioti, Fabio Continenza, Domenico Di Carlo, Patrizia Saccomandi, Carmen Mirabelli, Michela Pollicita, Roberta Longo, Sara Romano, Giuseppina Cappiello, Alberto Spano, Pascale Trimoulet, Herve Fleury, et al.

Journal article  |  2017  |  Oncotarget

The role of quantitative hepatitis B surface antigen revisited

Markus Cornberg, Vincent Wai-Sun Wong, Stephen Locarnini, Maurizia Brunetto, Harry LA Janssen, Henry Lik-Yuen Chan

Journal article  |  2017  |  Journal of Hepatology

Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis

Danielle Colledge, Sally Soppe, Lilly Yuen, Lucy Selleck, Renae Walsh, Stephen Locarnini, Nadia Warner

Journal article  |  2017  |  Virology

Releasing the Genomic RNA Sequestered in the Mumps Virus Nucleocapsid

Chelsea Severin, James R Terrell, James R Zengel, Robert Cox, Richard K Plemper, Biao He, Ming Luo

Journal article  |  2016  |  Journal of Virology

ABSTRACT In a negative-strand RNA virus, the genomic RNA is sequestered inside the nucleocapsid when the viral RNA-depen..

In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes

Vitina Sozzi, Renae Walsh, Margaret Littlejohn, Danni Colledge, Kathy Jackson, Nadia Warner, Lilly Yuen, Stephen A Locarnini, Peter A Revill

Journal article  |  2016  |  Journal of Virology

Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA)

Peter Revill, Stephen Locarnini

Journal article  |  2016  |  Current Opinion in Pharmacology

Effects of long-term tenofovir-based combination antiretroviral therapy in HIV-hepatitis B virus coinfection on persistent hepatitis B virus viremia and the role of hepatitis B virus quasispecies diversity

Jennifer Audsley, Stephen J Bent, Margaret Littlejohn, Anchalee Avihingsanon, Gail Matthews, Scott Bowden, Julianne Bayliss, Fabio Luciani, Lilly Yuen, Christopher K Fairley, Stephen Locarnini, Sharon R Lewin, Joe Sasadeusz

Journal article  |  2016  |  AIDS

No more excuses: viral hepatitis can be eliminated

Stephen Locarnini, Ding-Shinn Chen, Kenji Shibuya

Journal article  |  2016  |  The Lancet

Global strategies are required to cure and eliminate HBV infection (vol 13, pg 239, 2016)

Peter Revill, Barbara Testoni, Stephen Locarnini, Fabien Zoulim

Journal article  |  2016  |  NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

Global strategies are required to cure and eliminate HBV infection

Peter Revill, Barbara Testoni, Stephen Locarnini, Fabien Zoulim

Journal article  |  2016  |  Nature Reviews Gastroenterology & Hepatology

New perspectives on the hepatitis B virus life cycle in the human liver

Peter A Revill, Stephen A Locarnini

Journal article  |  2016  |  Journal of Clinical Investigation

Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patients

K Visvanathan, T Lang, K Ryan, R Wilson, NA Skinner, AJV Thompson, SH Ahn, F Weilert, W Abbott, E Gane, D Colledge, K Li, S Locarnini, A Mansell, PA Revill

Journal article  |  2016  |  Journal of Viral Hepatitis

Essential components in developing public policy to control viral hepatitis: lessons from Taiwan

Jack Wallace, Marian Pitts, Stephen Locarnini, Jeanne Ellard, Marina Carman, Ding-Shinn Chen

Journal article  |  2016  |  Hepatology International

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

SK Sarin, M Kumar, GK Lau, Z Abbas, HLY Chan, CJ Chen, DS Chen, HL Chen, PJ Chen, RN Chien, AK Dokmeci, Ed Gane, JL Hou, W Jafri, J Jia, JH Kim, CL Lai, HC Lee, SG Lim, CJ Liu, et al.

Journal article  |  2016  |  Hepatology International

Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus

Margaret Littlejohn, Stephen Locarnini, Lilly Yuen

Journal article  |  2016  |  Cold Spring Harbor Perspectives in Medicine

CD4( ) T Cells Are Not Required for Suppression of Hepatitis B Virus Replication in the Liver of Vaccinated Chimpanzees

Jolanta Rybczynska, Katherine Campbell, Saleem Kamili, Stephen Locarnini, Krzysztof Krawczynski, Christopher M Walker

Journal article  |  2016  |  Journal of Infectious Diseases

Present and Future Therapies of Hepatitis B: From Discovery to Cure

T Jake Liang, Timothy M Block, Brian J McMahon, Marc G Ghany, Stephan Urban, Ju-Tao Guo, Stephen Locarnini, Fabien Zoulim, Kyong-Mi Chang, Anna S Lok

Journal article  |  2015  |  Hepatology

Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy

Bin Zhou, Hui Dong, Yungang He, Jian Sun, Weirong Jin, Qing Xie, Rong Fan, Minxian Wang, Ran Li, Yangyi Chen, Shaoqing Xie, Yan Shen, Xin Huang, Shengyue Wang, Fengming Lu, Jidong Jia, Hui Zhuang, Stephen Locarnini, Guo-Ping Zhao, Li Jin, et al.

Journal article  |  2015  |  Scientific Reports

Modification of Asparagine-Linked Glycan Density for the Design of Hepatitis B Virus Virus-Like Particles with Enhanced Immunogenicity

Michiko Hyakumura, Renae Walsh, Morten Thaysen-Andersen, Natalie J Kingston, Mylinh La, Louis Lu, George Lovrecz, Nicolle H Packer, Stephen Locarnini, Hans J Netter

Journal article  |  2015  |  Journal of Virology

Clinical and virological predictors of hepatic flares in pregnant women with chronic hepatitis B

Michelle Giles, Kumar Visvanathan, Sharon Lewin, Scott Bowden, Stephen Locarnini, Tim Spelman, Joe Sasadeusz

Journal article  |  2015  |  Gut

Estimating the global prevalence of hepatitis B

Jennifer H MacLachlan, Stephen Locarnini, Benjamin C Cowie

Journal article  |  2015  |  The Lancet

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

Robert G Gish, Man-Fung Yuen, Henry Lik Yuen Chan, Bruce D Given, Ching-Lung Lai, Stephen A Locarnini, Johnson YN Lau, Christine I Wooddell, Thomas Schluep, David L Lewis

Journal article  |  2015  |  Antiviral Research

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

Robert G Gish, Bruce D Given, Ching-Lung Lai, Stephen A Locarnini, Johnson YN Lau, David L Lewis, Thomas Schluep

Journal article  |  2015  |  Antiviral Research

From the big three to the big four.

Ding-Shinn Chen, Stephen Locarnini, Jack Wallace

Journal article  |  2015  |  The Lancet Infectious Diseases

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

Scott Bowden, Stephen Locarnini, Ting-Tsung Chang, You-Chen Chao, Kwang-Hyub Han, Robert G Gish, Robert A de Man, Miao Yu, Cyril Llamoso, Hong Tang

Journal article  |  2015  |  World Journal of Gastroenterology

Strategies to control hepatitis B: Public policy, epidemiology, vaccine and drugs

Stephen Locarnini, Angelos Hatzakis, Ding-Shinn Chen, Anna Lok

Journal article  |  2015  |  Journal of Hepatology

Viral factors and predicting disease outcomes in chronic hepatitis B

Peter Revill, Stephen Locarnini

Journal article  |  2015  |  Gut

Corrigendum to "efficacy and safety of tenofovir disoproxil fumarate (TDF) in pregnancy to prevent perinatal transmission of hepatitis B virus" (J Hepatol (2014) 61:502-507)

AJ Greenup, PK Tan, V Nguyen, A Glass, S Davison, U Chatterjee, S Holdaway, D Samarasinghe, K Jackson, SA Locarnini, MT Levy

Journal article  |  2015  |  Journal of Hepatology

Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations

Amanda L Aloia, Nicholas S Eyre, Stuart Black, Stephen J Bent, Adriana Gaeguta, Zhuyan Guo, Sumudu K Narayana, Robert Chase, Stephen Locarnini, Jill M Carr, John A Howe, Michael R Beard

Journal article  |  2015  |  Antiviral Therapy

Elucidating the role of the HBV e antigen in manipulating the innate immune response

Peter A Revill, Kumar Visvanathan, Stephen A Locarnini

Journal article  |  2015  |  Future Virology

A simple and inexpensive point-of-care test for hepatitis B surface antigen detection: serological and molecular evaluation.

RG Gish, JA Gutierrez, N Navarro-Cazarez, K Giang, D Adler, B Tran, S Locarnini, R Hammond, S Bowden

Journal article  |  2014  |  Journal of Viral Hepatitis

Early identification of chronic hepatitis B is important for optimal disease management and prevention of transmission. Cost and l..

Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: lack of potency and selection of resistance mutations

A Ayres, L Yuen, KM Jackson, S Manoharan, A Glass, M Maley, W Yoo, SP Hong, S-O Kim, F Luciani, DS Bowden, J Bayliss, MT Levy, SA Locarnini

Journal article  |  2014  |  Journal of Viral Hepatitis

Molecular epidemiology of hepatitis delta virus in the Western Pacific region

Meifang Han, Margaret Littlejohn, Lilly Yuen, Rosalind Edwards, Uma Devi, Scott Bowden, Qin Ning, Stephen Locarnini, Kathy Jackson

Journal article  |  2014  |  Journal of Clinical Virology

Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of hepatitis B virus

Astrid-Jane Greenup, Pok Kern Tan, Vi Nguyen, Anne Glass, Scott Davison, Ushmi Chatterjee, Susan Holdaway, Dev Samarasinghe, Kathy Jackson, Stephen A Locarnini, Miriam T Levy

Journal article  |  2014  |  Journal of Hepatology

Should Aboriginals in the "Top End" of the Northern Territory be vaccinated against hepatitis A?

Francis J Bowden, Bart J Currie, Nan C Miller, Stephen A Locarnini, Vicki L Krause

Journal article  |  2014  |  The Medical journal of Australia

Commonly Found Variations/Mutations in the HBsAg of Hepatitis B Virus in the Context of Effective Immunization Programs: Questionable Clinical and Public Health Significance

Stephen Locarnini, Daniel Shouval

Journal article  |  2014  |  Journal of Virology

Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare.

V Nguyen, PK Tan, A-J Greenup, A Glass, S Davison, D Samarasinghe, S Holdaway, SI Strasser, U Chatterjee, K Jackson, SA Locarnini, MT Levy

Journal article  |  2014  |  Alimentary Pharmacology & Therapeutics

BACKGROUND: Antepartum anti-viral therapy (AVT) is often administered to prevent perinatal transmission of hepatitis B virus (HBV)..

Clinical significance of hepatitis B virion and SVP productivity: relationships between intrahepatic and serum markers in chronic hepatitis B patients

Cosmas Rinaldi Adithya Lesmana, Kathy Jackson, Seng Gee Lim, Ali Sulaiman, Levina S Pakasi, Rino A Gani, Irsan Hasan, Andri Sanityoso Sulaiman, Laurentius A Lesmana, Rachel Hammond, Peter Revill, Stephen Locarnini, Scott David Bowden

Journal article  |  2014  |  United European Gastroenterology Journal

Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV))

Stephen A Locarnini, Michael Roggendorf

Book Chapter  |  2014

Mechanisms of Hepatitis B Virus Resistance Development

Nadia Warner, Stephen Locarnini

Journal article  |  2014  |  Intervirology

Erratum: Report from a Viral Hepatitis Policy Forum on implementing the WHO framework for global action on viral hepatitis in North Asia (Journal of Hepatology (2013) 59 (1073-1080))

DS Chen, S Locarnini, S Wait, SH Bae, PJ Chen, JYY Fung, HS Kim, SN Lu, J Sung, J Tanaka, T Wakita, J Ward, J Wallace

Journal article  |  2014  |  Journal of Hepatology

Epidemiology and prevention

Benjamin Cowie, Stephen A Locarnini

Book Chapter  |  2014

Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis.

Sarah R Calabro, Annette E Maczurek, Alison J Morgan, Thomas Tu, Victoria W Wen, Christine Yee, Auvro Mridha, Maggie Lee, William d'Avigdor, Stephen A Locarnini, Geoffrey W McCaughan, Fiona J Warner, Susan V McLennan, Nicholas A Shackel

Journal article  |  2014  |  PLoS ONE

BACKGROUND: The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abn..

Possible origins and evolution of the hepatitis B virus (HBV)

Stephen Locarnini, Margaret Littlejohn, Muhammad Nazri Aziz, Lilly Yuen

Journal article  |  2013  |  Seminars in Cancer Biology

Report from a Viral Hepatitis Policy Forum on implementing the WHO framework for global action on viral hepatitis in North Asia

Ding-Shinn Chen, Stephen Locarnini, Suzanne Wait, Si-Hyun Bae, Pei-Jer Chen, James YY Fung, Hong Soo Kim, Sheng-Nan Lu, Joseph Sung, Junko Tanaka, Takaji Wakita, John Ward, Jack Wallace

Journal article  |  2013  |  Journal of Hepatology

Hepatitis B antivirals and resistance

Uma Devi, Stephen Locarnini

Journal article  |  2013  |  Current Opinion in Virology

Longitudinal observation of viral load changes in untreated HBeAg negative chronic hepatitis B

Catherine MN Croagh, Sally J Bell, Robert Y Chen, Stephen Locarnini, Paul V Desmond

Journal article  |  2013  |  Acta Gastro-Enterologica Belgica

Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion

Yan Cheng, Stephane Guindon, Allen Rodrigo, Lin Ying Wee, Masafumi Inoue, Alex JV Thompson, Stephen Locarnini, Seng Gee Lim

Journal article  |  2013  |  Gut

Viral Hepatitis: Fourth Edition

HC Thomas, ASF Lok, SA Locarnini, AJ Zuckerman

Book  |  2013

The New Front-Line in Hepatitis B/D Research: Identification and Blocking of a Functional Receptor

Nadia Warner, Stephen Locarnini

Journal article  |  2013  |  Hepatology

Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype

Wenpeng Li, Nadia Warner, Vitina Sozzi, Lilly Yuen, Danni Colledge, Tong Li, Hui Zhuang, Stephen Locarnini, Peter A Revill

Journal article  |  2013  |  Hepatology International

Current Perspectives on Chronic Hepatitis B Foreword

Stephen Locarnini, Alex Thompson

Journal article  |  2013  |  Seminars in Liver Disease

Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance

Fabien Zoulim, Stephen Locarnini

Journal article  |  2013  |  Liver International

Epidemiology, virology and pathogenesis of viral hepatitis with a focus on Latin America

Joao R Rebello Pinho, Monica V Alvarado-Mora, Stephen Locarnini

Journal article  |  2013  |  Antiviral Therapy

An update on HDV: virology, pathogenesis and treatment

Monica V Alvarado-Mora, Stephen Locarnini, Mario Rizzetto, Joao R Rebello Pinho

Journal article  |  2013  |  Antiviral Therapy

Treatment of Chronic Viral Hepatitis B and Drug Resistant Variants

Tin Nguyen, Paul Desmond, Stephen Locarnini

Book Chapter  |  2013

Replication of Hepatitis B Virus

N Warner, S Locarnini

Book Chapter  |  2012

Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update (vol 6, pg 531, 2012)

Yun-Fan Liaw, Jia-Horng Kao, Teerha Piratvisuth, Henry Lik Yuen Chan, Rong-Nan Chien, Chun-Jen Liu, Ed Gane, Stephen Locarnini, Seng-Gee Lim, Kwang-Hyub Han, Deepak Amarapurkar, Graham Cooksley, Wasim Jafri, Rosmawati Mohamed, Jin-Lin Hou, Wan-Long Chuang, Laurentius A Lesmana, Jose D Sollano, Dong-Jin Suh, Masao Omata

Journal article  |  2012  |  Hepatology International

Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise

Renae Walsh, Stephen Locarnini

Journal article  |  2012  |  Yonsei Medical Journal

Increased Prevalence of HBV Envelope Mutants in Taiwan: An Emerging Public Health Risk or a False Alarm?

Daniel Shouval, Stephen Locarnini

Journal article  |  2012  |  Gastroenterology

Hepatitis B surface antigen quantification: Not what it seems on the surface

Stephen Locarnini, Scott Bowden

Journal article  |  2012  |  Hepatology

Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update

Yun-Fan Liaw, Jia-Horng Kao, Teerha Piratvisuth, Henry Lik Yuen Chan, Rong-Nan Chien, Chun-Jen Liu, Ed Gane, Stephen Locarnini, Seng-Gee Lim, Kwang-Hyub Han, Deepak Amarapurkar, Graham Cooksley, Wasim Jafri, Rosmawati Mohamed, Jin-Lin Hou, Wan-Long Chuang, Laurentius A Lesmana, Jose D Sollano, Dong-Jin Suh, Masao Omata

Journal article  |  2012  |  Hepatology International

Role of resistance testing during oral antiviral therapy of chronic hepatitis B

U Devi, S Locarnini

Journal article  |  2012  |  Current Hepatitis Reports

New insight in the pathobiology of hepatitis B virus infection

Maura Dandri, Stephen Locarnini

Journal article  |  2012  |  Gut

Selection of chronic hepatitis B therapy with high barrier to resistance

Robert Gish, Ji-Dong Jia, Stephen Locarnini, Fabien Zoulim

Journal article  |  2012  |  The Lancet Infectious Diseases

Assessment of HBV flare in a randomized clinical trial in HIV/HBV coinfected subjects initiating HBV-active antiretroviral therapy in Thailand

Anchalee Avihingsanon, Gail V Matthews, Sharon R Lewin, Pip Marks, Jose Sasadeusz, David A Cooper, Scott Bowden, Stephen Locarnini, Greg J Dore, Kiat Ruxrungtham

Journal article  |  2012  |  AIDS Research and Therapy

Modulation of the immunogenicity of virus-like particles composed of mutant hepatitis B virus envelope subunits

Wan-Shoo Cheong, Michiko Hyakumura, Lilly Yuen, Nadia Warner, Stephen Locarnini, Hans J Netter

Journal article  |  2012  |  Antiviral Research

Antiviral resistance and direct- acting antiviral agents for HCV

Amanda L Aloia, Stephen Locarnini, Michael R Beard

Journal article  |  2012  |  Antiviral Therapy

Management of treatment failure in chronic hepatitis B

Fabien Zoulim, Stephen Locarnini

Journal article  |  2012  |  Journal of Hepatology

Direct-acting antiviral agents for the treatment of HCV

Alexander J Thompson, Stephen Locarnini

Journal article  |  2012  |  Antiviral Therapy

Antiviral drug resistance testing in patients with chronic hepatitis B.

Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Chi-Hang Tse, Lilly KW Yuen, Hoi-Yun Chan, Stephen A Locarnini, Henry Lik-Yuen Chan

Journal article  |  2012  |  Digestive Diseases and Sciences

BACKGROUND: Antiviral drugs against hepatitis B virus are limited by the emergence of drug resistance. AIMS: We aimed to study the..

Resistance to anti-HCV protease inhibitors

Alexander J Thompson, Stephen A Locarnini, Michael R Beard

Journal article  |  2011  |  Current Opinion in Virology

Hepatitis B surface antigen quantification: Why and how to use it in 2011-A core group report

Henry Lik-Yuen Chan, Alex Thompson, Michelle Martinot-Peignoux, Teerha Piratvisuth, Markus Cornberg, Maurizia Rossana Brunetto, Hans L Tillmann, Jia-Horng Kao, Ji-Dong Jia, Heiner Wedemeyer, Stephen Locarnini, Harry LA Janssen, Patrick Marcellin

Journal article  |  2011  |  Journal of Hepatology

Factors Associated with Elevated ALT in an International HIV/HBV Co-Infected Cohort on Long-Term HAART

Jennifer Audsley, Eric C Seaberg, Joe Sasadeusz, Gail V Matthews, Anchalee Avihingsanon, Kiat Ruxrungtham, Kit Fairley, Robert Finlayson, Hyon S Hwang, Margaret Littlejohn, Stephen Locarnini, Gregory J Dore, Chloe L Thio, Sharon R Lewin

Journal article  |  2011  |  PLoS ONE

The hepatitis B e antigen suppresses IL-1 beta-mediated NF-kappa B activation in hepatocytes

R Wilson, N Warner, K Ryan, L Selleck, D Colledge, S Rodgers, K Li, P Revill, S Locarnini

Journal article  |  2011  |  Journal of Viral Hepatitis

Phylogenetic Analysis of Hepatitis B Virus Genotype F Complete Genome Sequences From Chilean Patients With Chronic Infection

Mauricio Venegas, Monica V Alvarado-Mora, Rodrigo A Villanueva, Joao R Rebello Pinho, Flair J Carrilho, Stephen Locarnini, Lilly Yuen, Javier Brahm

Journal article  |  2011  |  Journal of Medical Virology

Hepatitis C virus resistance to protease inhibitors

Philippe Halfon, Stephen Locarnini

Journal article  |  2011  |  Journal of Hepatology

Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody

Renae Walsh, Stewart Nuttall, Peter Revill, Danni Colledge, Liza Cabuang, Sally Soppe, Olan Dolezal, Kate Griffiths, Angeline Bartholomeusz, Stephen Locarnini

Journal article  |  2011  |  Virology

Mutation Pattern of Lamivudine Resistance in Relation to Hepatitis B Genotypes: Hepatitis B Genotypes Differ in Their Lamivudine Resistance Associated Mutation Pattern

Hans Damerow, Lilly Yuen, Johannes Wiegand, Christine Walker, C-Thomas Bock, Stephen Locarnini, Hans L Tillmann

Journal article  |  2010  |  Journal of Medical Virology

High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.

MC Mendes-Correa, JRR Pinho, S Locarnini, L Yuen, R Sitnik, RAF Santana, MS Gomes-Gouvêa, OM Leite, LG Martins, MH Silva, RJ Gianini, DE Uip

Journal article  |  2010  |  Journal of Medical Virology

This study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a grou..

Drug Resistance in Antiviral Therapy

Stephen Locarnini, Scott Bowden

Journal article  |  2010  |  Clinics in Liver Disease

Molecular and Clinical Characteristics of Hepatitis B Virus in Korea

Sang Hoon Ahn, Lilly Yuen, Kwang-Hyub Han, Margaret Littlejohn, Hye Young Chang, Hans Damerow, Anna Ayres, Jeong Heo, Stephen Locarnini, Peter A Revi

Journal article  |  2010  |  Journal of Medical Virology

Coinfection of Hepatic Cell Lines with Human Immunodeficiency Virus and Hepatitis B Virus Leads to an Increase in Intracellular Hepatitis B Surface Antigen

David M Iser, Nadia Warner, Peter A Revill, Ajantha Solomon, Fiona Wightman, Suha Saleh, Megan Crane, Paul U Cameron, Scott Bowden, Tin Nguyen, Candida F Pereira, Paul V Desmond, Stephen A Locarnini, Sharon R Lewin

Journal article  |  2010  |  Journal of Virology

Transmission of antiviral drug resistant hepatitis B virus: Implications for public health and patient management

Stephen Locarnini

Journal article  |  2010  |  Journal of Gastroenterology and Hepatology

HBV in the Poorly Compliant Patient: Dare we Start Oral Drugs?

T Nguyen, P Desmond, S Locarnini

Book Chapter  |  2010

No Increase in Hepatitis B Virus (HBV)-Specific CD8( ) T Cells in Patients with HIV-1-HBV Coinfections following HBV-Active Highly Active Antiretroviral Therapy

Megan Crane, Sunee Sirivichayakul, J Judy Chang, Anchalee Avihingsanon, Sasiwimol Ubolyam, Supranee Buranapraditkun, Pattarawat Thantiworasit, Fiona Wightman, Stephen Locarnini, Gail Matthews, Gregory J Dore, Kiat Ruxrungtham, Sharon R Lewin

Journal article  |  2010  |  Journal of Virology

Molecular genesis of drug-resistant and vaccine-escape HBV mutants

Stephen A Locarnini, Lilly Yuen

Journal article  |  2010  |  Antiviral Therapy

Potential threat of drug-resistant and vaccine-escape HBV mutants to public health

Chong-Gee Teo, Stephen A Locarnini

Journal article  |  2010  |  Antiviral Therapy

Molecular genetics of HBV infection

Stephen Locarnini, Fabien Zoulim

Journal article  |  2010  |  Antiviral Therapy

Bioinformatic Analysis of the Hepadnavirus e-Antigen and Its Precursor Identifies Remarkable Sequence Conservation in All Orthohepadnaviruses

Peter Revill, Lilly Yuen, Renae Walsh, Marie Perrault, Stephen Locarnini, Anna Kramvis

Journal article  |  2010  |  Journal of Medical Virology

The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B

Tin Nguyen, Paul Desmond, Stephen Locarnini

Journal article  |  2009  |  Hepatology International

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

Fabien Zoulim, Stephen Locarnini

Journal article  |  2009  |  Gastroenterology

Hepatitis: Monitoring drug therapy for hepatitis B--a global challenge?

Tin Nguyen, Stephen Locarnini

Journal article  |  2009  |  Nature Reviews Gastroenterology & Hepatology

Hepatitis B virus and hepatitis C virus interaction in Huh-7 cells.

Nicholas S Eyre, Renee J Phillips, Scott Bowden, Evelyn Yip, Ben Dewar, Stephen A Locarnini, Michael R Beard

Journal article  |  2009  |  Journal of Hepatology

BACKGROUND/AIMS: Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) increases the risk of development and the s..

Combination HBV therapy is linked to greater HBV DNA suppression in a cohort of lamivudine-experienced HIV/HBV coinfected individuals

Gail V Matthews, Eric Seaberg, Gregory J Dore, Scott Bowden, Sharon R Lewin, Joe Sasadeusz, Pip Marks, Zachary Goodman, Frances H Philp, Yiwei Tang, Stephen Locarnini, Chloe L Thio

Journal article  |  2009  |  AIDS

Anti-viral medication to prevent HCC development: Where are we now?

N Warner, S Locarnini, T Nguyen

Journal article  |  2009  |  Cancer Forum

Corrigendum to "96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B". J Hepatol 48 (2008) 714-720 (DOI:10.1016/j.jhep.2007.10.013)

CK Hui, HY Zhang, S Bowden, S Locarnini, JM Luk, KW Leung, YH Yueng, A Wong, F Rousseau, KY Yuen, NN Naoumov, GKK Lau

Journal article  |  2009  |  Journal of Hepatology

Perinatal transmission of hepatitis B virus: an Australian experience

Elke Wiseman, Melissa A Fraser, Sally Holden, Anne Glass, Bronwynne L Kidson, Leon G Heron, Michael W Maley, Anna Ayres, Stephen A Locarnini, Miriam T Levy

Journal article  |  2009  |  Medical Journal of Australia

Efficacy of Hepatitis B Vaccine Against Antiviral Drug-Resistant Hepatitis B Virus Mutants in the Chimpanzee Model

Saleem Kamili, Vitini Sozzi, Geoff Thompson, Katie Campbell, Christopher M Walker, Stephen Locarnini, Krzysztof Krawczynski

Journal article  |  2009  |  Hepatology

Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations

J Audsley, N Arrifin, LKW Yuen, A Ayres, SM Crowe, A Bartholomeusz, SA Locarnini, A Mijch, SR Lewin, J Sasadeusz

Journal article  |  2009  |  HIV Medicine

Viral Dynamics of Hepatitis B Virus DNA in Human Immunodeficiency Virus-1-Hepatitis B Virus Coinfected Individuals: Similar Effectiveness of Lamivudine, Tenofovir, or Combination Therapy

Sharon R Lewin, Ruy M Ribeiro, Anchalee Avihingsanon, Scott Bowden, Gail Matthews, Pip Marks, Stephen A Locarnini, Kiat Ruxrungtham, Alan S Perelson, Gregory J Dore

Journal article  |  2009  |  Hepatology

Genetic variability of hepatitis B virus and response to antiviral treatments: Searching for a bigger picture

Lilly KW Yuen, Stephen A Locarnini

Journal article  |  2009  |  Journal of Hepatology

Chronic Hepatitis B Viral Infection

RG Gish, S Locarnini

Book Chapter  |  2009

Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma?

Nadia Warner, Stephen Locarnini

Journal article  |  2009  |  Antiviral Therapy

Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease

H Poustchi, A Mohamadkhani, S Bowden, G Montazeri, A Ayres, P Revill, GC Farrell, S Locarnini, J George, R Malekzadeh

Journal article  |  2008  |  Journal of Viral Hepatitis

A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naive individuals in Thailand

Gail V Matthews, Anchalee Avihingsanon, Sharon R Lewin, Janaki Amin, Rungsun Rerknimitr, Panusit Petcharapirat, Pip Marks, Joe Sasadeusz, David A Cooper, Scott Bowden, Stephen Locarnini, Kiat Ruxrungtham, Gregory J Dore

Journal article  |  2008  |  Hepatology

Statements from the Taormina expert meeting on occult hepatitis B virus infection

Giovanni Raimondo, Jean-Pierre Allain, Maurizia R Brunetto, Marie-Annick Buendia, Ding-Shinn Chen, Massimo Colombo, Antonio Craxi, Francesco Donato, Carlo Ferrari, Giovanni B Gaeta, Wolfram H Gerlich, Massimo Levrero, Stephen Locarnini, Thomas Michalak, Mario U Mondelli, Jean-Michel Pawlotsky, Teresa Pollicino, Daniele Prati, Massimo Puoti, Didier Samuel, et al.

Journal article  |  2008  |  Journal of Hepatology

Erratum: Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update (Hepatology International 10.1007/s12072-008-9080-3)

YF Liaw, N Leung, JH Kao, P Teerha, E Gane, KH Han, R Guan, GKK Lau, S Locarnini

Journal article  |  2008  |  Hepatology International

Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update

Yun-Fan Liaw, Nancy Leung, Jia-Horng Kao, Teerha Piratvisuth, Edward Gane, Kwang-Hyub Han, Richard Guan, George KK Lau, Stephen Locarnini

Journal article  |  2008  |  Hepatology International

The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound

Nadia Warner, Stephen Locarnini

Journal article  |  2008  |  Hepatology

Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure

S Locarnini

Journal article  |  2008  |  Hepatology International

Introduction

Stephen Locarnini

Journal article  |  2008  |  Hepatology International

96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic heptitis B

Chee-Kin Hui, Hai-Ying Zhang, Scott Bowden, Stephen Locarnini, John M Luk, Kar-Wai Leung, Yui-Hung Yueng, April Wong, Frank Rousseau, Kwok-Yung Yuen, Nikolai N Naoumov, George KK Lau

Journal article  |  2008  |  Journal of Hepatology

Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.

Joseph JY Sung, Stephen KW Tsui, Chi-Hang Tse, Eddie YT Ng, Kwong-Sak Leung, Kin-Hong Lee, Tony SK Mok, Angeline Bartholomeusz, Thomas CC Au, Kelvin KF Tsoi, Stephen Locarnini, Henry LY Chan

Journal article  |  2008  |  Journal of Virology

We aimed to identify genomic markers in hepatitis B virus (HBV) that are associated with hepatocellular carcinoma (HCC) developmen..

Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach.

Jean-Michel Pawlotsky, Geoffrey Dusheiko, Angelos Hatzakis, Daryl Lau, George Lau, T Jake Liang, Stephen Locarnini, Paul Martin, Douglas D Richman, Fabien Zoulim

Journal article  |  2008  |  Gastroenterology

Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing viral replication to the lowest possible level, and..

Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-Infected and HBV/HIV-Coinfected patients failing Antiretroviral drugs with Anti-HBV activity

Julie Sheldon, Belen Ramos, Javier Garcia-Samaniego, Pilar Rios, Angeline Bartholomeusz, Miriam Romero, Stephen Locarnini, Tabien Zoulim, Vincent Soriano

Conference Proceedings  |  2007  |  JAIDS Journal of Acquired Immune Deficiency Syndromes

Genotyping and genomic sequencing in clinical practice.

Robert G Gish, Stephen Locarnini

Journal article  |  2007  |  Clinics in Liver Disease

The global prevalence of chronic hepatitis B and its associated serious sequelae demand technologically advanced techniques of man..

The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging.

JJ Feld, D Colledge, V Sozzi, R Edwards, M Littlejohn, SA Locarnini

Journal article  |  2007  |  Antiviral Research

Nucleos(t)ide analogue antiviral therapy for chronic hepatitis B has proven to be effective in the short term but the frequent dev..

Antiviral drug resistance: Implications for treatment of HBV infection and similarities with HIV disease

DD Richman, R Wasserman, SA Locarnini

Journal article  |  2007  |  Gastroenterology and Hepatology

The natural history and the staging of chronic hepatitis B: Time for reevaluation of the virus-host relationship based on molecular virology and immunopathogenesis considerations?

Alex Thompson, Stephen Locarnini, Kumar Visvanathan

Journal article  |  2007  |  Gastroenterology

Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals

Peter A Revill, Margaret Littlejohn, Anna Ayres, Lilly Yuen, Danni Colledge, Angeline Bartholomeusz, Joe Sasaduesz, Chloe L Thio, Stephen A Locarnini

Journal article  |  2007  |  AIDS

Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response

Alex Jv Thompson, Stephen A Locarnini

Journal article  |  2007  |  Immunology & Cell Biology

SEQHEPB: A sequence analysis program and relational database system for chronic hepatitis B

Lilly KW Yuen, Anna Ayres, Margaret Littlejohn, Danielle Colledge, Andrew Edgely, William J Maskill, Stephen A Locarnini, Angeline Bartholomeusz

Journal article  |  2007  |  Antiviral Research

The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro

Nadia Warner, Stephen Locarnini, Michael Kuiper, Angeline Bartholomeusz, Anna Ayres, Lilly Yuen, Tim Shaw

Journal article  |  2007  |  Antimicrobial Agents and Chemotherapy

Antiviral drug-resistant HBV: Standardization of nomenclature and assays and recommendations for management

Anna S Lok, Fabien Zoulim, Stephen Locarnini, Angeline Bartholomeusz, Marc G Ghany, Jean-Michel Pawlotsky, Yun-Fan Liaw, Masashi Mizokami, Carla Kuiken

Journal article  |  2007  |  Hepatology

In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication

Richard A Heipertz, Thomas G Miller, Colleen M Kelley, William E Delaney, Stephen A Locarnini, Harriet C Isom

Journal article  |  2007  |  Journal of Virology

Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Kumar Visvanathan, Narelle A Skinner, Alex JV Thompson, Stephen M Riordan, Vitini Sozzi, Roslyn Edwards, Sally Rodgers, Jelica Kurtovic, Judy Chang, Sharon Lewin, Paul Desmond, Stephen Locarnini

Journal article  |  2007  |  Hepatology

Major causes of antiviral drug resistance and implications for treatment of hepatitis B virus monoinfection and coinfection with HIV.

Stephen Locarnini, Nadia Warner

Journal article  |  2007  |  Antiviral Therapy

The two key events in the life-cycle of the hepatitis B virus (HBV) involve (1) the generation from viral genomic DNA of the coval..

Comparison of real-time PCR assays for monitoring serum hepatitis B virus DNA levels during antiretroviral therapy (vol 44, pg 2983, 2006)

Chee-Kin Hui, Scott Bowden, Hai-Ying Zhang, Anita Wong, Sharon Lewin, Frank Rousseau, Herve Mornmeja-Marin, Nikki P Lee, John M Luk, Stephen Locarnini, Nancy Leung, Nikolai V Naoumov, George KK Lau

Journal article  |  2007  |  Journal of Clinical Microbiology

Treatment of HIV/HBV coinfection: Clinical and virologic issues

Chloe L Thio, Stephen Locarnini

Journal article  |  2007  |  AIDS Reviews

Molecular virology of hepatitis B virus and the development of antiviral drug resistance

Stephen Locarnini, Masao Omata

Journal article  |  2006  |  Liver International

Replication of Hepatitis B Virus and Pathogenesis of Disease

A Bartholomeusz, J Chang, S Locarnini, S Lewin

Book Chapter  |  2006

Chronic hepatitis B: treatment alert

Ting-Tsung Chang, Hui Zhang, Jidong Jia, Nancy Wai-Yee Leung, Richard Guan, SM Wasim Jafri, Laurentlus A Lesmana, Yun-Fan Liaw, Stephen Locarnini, Masao Omata, Jose D Sollano, Dong Jin Suh, Varocha Mahachai, Pham Hoang Phiet, Shiv K Sarin, Guangbi Yao, Seung Kew Yoon

Journal article  |  2006  |  Liver International

Molecular diagnostics in hepatitis B

S Bowden, S Locarnini

Book Chapter  |  2006

Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.

Stephen M Riordan, Narelle Skinner, Jelica Kurtovic, Stephen Locarnini, Kumar Visvanathan

Journal article  |  2006  |  Clinical and Vaccine Immunology

Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepa..

Toll-like receptor expression in chronic hepatitis C: Correlation with pro-inflammatory cytokine levels and liver injury

SM Riordan, NA Skinner, J Kurtovic, S Locarnini, CJ McIver, R Williams, K Visvanathan

Journal article  |  2006  |  Inflammation Research

Chronic hepatitis B: Current testing strategies

RG Gish, SA Locarnini

Journal article  |  2006  |  Clinical Gastroenterology and Hepatology

Antiviral drug resistance: Clinical consequences and molecular aspects

A Bartholorneusz, SA Locarnini

Journal article  |  2006  |  Seminars in Liver Disease

The control of chronic hepatitis B: The role for chemoprevention

SA Locarnini

Journal article  |  2006  |  Seminars in Liver Disease

Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy

GV Matthews, A Bartholomeusz, S Locarnini, A Ayres, J Sasaduesz, E Seaberg, DA Cooper, S Lewin, GJ Dore, CL Thio

Journal article  |  2006  |  AIDS

HBV drug resistance: mechanisms, detection and interpretation.

Tim Shaw, Angeline Bartholomeusz, Stephen Locarnini

Journal article  |  2006  |  Journal of Hepatology

Cellular and virological mechanisms of HBV drug resistance.

Stephen Locarnini, William S Mason

Journal article  |  2006  |  Journal of Hepatology

Hepatitis B virus mutations associated with antiviral therapy.

A Bartholomeusz, S Locarnini

Journal article  |  2006  |  Journal of Medical Virology

The hepatitis B virus (HBV) replicates via an error prone viral reverse transcriptase resulting in a large pool of quasispecies wi..

Hepatitis C and hepatitis E vaccines: research update.

S Locarnini

Journal article  |  2005  |  The Medical journal of Malaysia

Interpretation and application of virological testing including resistance in chronic hepatitis B.

S Locarnini

Journal article  |  2005  |  The Medical journal of Malaysia

Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C.

Henry LY Chan, Stephen KW Tsui, Chi-Hang Tse, Eddie YT Ng, Thomas CC Au, Lilly Yuen, Angeline Bartholomeusz, Kwong-Sak Leung, Kin-Hong Lee, Stephen Locarnini, Joseph JY Sung

Journal article  |  2005  |  The Journal of Infectious Diseases

BACKGROUND: We aimed to investigate the characteristics of hepatitis B virus (HBV) genotype C subgroups in Hong Kong and their rel..

Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy.

Joseph JY Sung, May-Ling Wong, Scott Bowden, Choong-Tsek Liew, Alex Y Hui, Vincent WS Wong, Nancy WY Leung, Stephen Locarnini, Henry LY Chan

Journal article  |  2005  |  Gastroenterology

BACKGROUND & AIMS: This study aimed to determine whether intrahepatic hepatitis B virus (HBV) covalently closed circular (ccc) DNA..

Therapies for hepatitis B: where to from here?

Stephen Locarnini

Journal article  |  2005  |  Gastroenterology

Cellular response to conditional expression of the hepatitis B virus precore and core proteins in cultured hepatoma (Huh-7) cells.

S Locarnini, T Shaw, J Dean, D Colledge, A Thompson, K Li, SM Lemon, GGK Lau, MR Beard

Journal article  |  2005  |  Journal of Clinical Virology

BACKGROUND: The expression of the hepatitis Be antigen (HBeAg) is one of several strategies used by hepatitis B virus (HBV) to ens..

Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation.

Chee-Kin Hui, John Yu, Wing Yan Au, Hai-ying Zhang, Angeline Bartholomeusz, Stephen Locarnini, Yok-lam Kwong, Raymond Liang, George KK Lau

Journal article  |  2005  |  Journal of Clinical Virology

BACKGROUND: After hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the in..

Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.

Julie Sheldon, Nuria Camino, Berta Rodés, Angeline Bartholomeusz, Michael Kuiper, Frank Tacke, Marina Núñez, Stefan Mauss, Thomas Lutz, Gerd Klausen, Stephen Locarnini, Vincent Soriano

Journal article  |  2005  |  Antiviral Therapy

BACKGROUND: Tenofovir (TDF) is an adenosine nucleotide analogue that has been approved for the treatment of HIV-1 infection. It al..

Avihepadnaviridae

Allison R Jilbert, Stephen A Locarnini

Book Chapter  |  2005

Molecular virology and the development of resistant mutants: implications for therapy.

Stephen Locarnini

Journal article  |  2005  |  Seminars in Liver Disease

Two of the key events in the viral life cycle of the hepatitis B virus (HBV) involve (1) generation from genomic DNA of the covale..

Epidemiology

Mike G Catton, Stephen A Locarnini

Book Chapter  |  2005

Entecavir for the treatment of chronic hepatitis B.

Tim Shaw, Stephen Locarnini

Journal article  |  2004  |  Expert Review of Anti-infective Therapy

Chronic infection with the hepatitis B virus remains a serious and life-threatening disease for approximately 5% of the world's po..

HBV core sequence: definition of genotype-specific variability and correlation with geographical origin.

SM Jazayeri, AA Basuni, N Sran, R Gish, G Cooksley, S Locarnini, WF Carman

Journal article  |  2004  |  Journal of Viral Hepatitis

There are eight genotypes and nine subtypes of HBV. Small differences in geographical origin are associated with sequence changes ..

Management of antiviral resistance in patients with chronic hepatitis B.

Stephen Locarnini, Angelos Hatzakis, Jenny Heathcote, Emmet B Keeffe, T Jake Liang, David Mutimer, Jean-Michel Pawlotsky, Fabien Zoulim

Journal article  |  2004  |  Antiviral Therapy

A meeting of physicians and scientists involved in the management of chronic hepatitis B (CHB) was held to review current scientif..

Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.

DJ Tenney, SM Levine, RE Rose, AW Walsh, SP Weinheimer, L Discotto, M Plym, K Pokornowski, CF Yu, P Angus, A Ayres, A Bartholomeusz, W Sievert, G Thompson, N Warner, S Locarnini, RJ Colonno

Journal article  |  2004  |  Antimicrobial Agents and Chemotherapy

Entecavir (ETV) exhibits potent antiviral activity in patients chronically infected with wild-type or lamivudine (3TC)-resistant (..

Hepatic failure due to fibrosing cholestatic hepatitis in a patient with pre-surface mutant hepatitis B virus and mixed connective tissue disease treated with prednisolone and chloroquine

SA Zanati, SA Locarnini, JP Dowling, PW Angus, FJ Dudley, SK Roberts

Journal article  |  2004  |  Journal of Clinical Virology

Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of lamivudine-resistant hepatitis B virus strains

F Wightman, T Walters, A Ayres, S Bowden, A Bartholomeusz, D Lau, S Locarnini, SR Lewin

Journal article  |  2004  |  Journal of Clinical Microbiology

Prevalence of HBsAg mutants and impact of hepatitis B infant immunisation in four Pacific Island countries.

Ashraf A Basuni, Lesley Butterworth, G Cooksley, S Locarnini, WF Carman

Journal article  |  2004  |  Vaccine

The prevalence rate of hepatitis B virus (HBV) infection in Pacific Island countries is amongst the highest in the world. Hepatiti..

Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region.

Mohammed S Jazayeri, Ashraf A Basuni, Graham Cooksley, Stephen Locarnini, William F Carman

Journal article  |  2004  |  Journal of Hepatology

BACKGROUND/AIMS: The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence..

Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.

Bettina Werle-Lapostolle, Scott Bowden, Stephen Locarnini, Karsten Wursthorn, Jorg Petersen, George Lau, Christian Trepo, Patrick Marcellin, Zachary Goodman, William E Delaney, Shelly Xiong, Carol L Brosgart, Shan-Shan Chen, Craig S Gibbs, Fabien Zoulim

Journal article  |  2004  |  Gastroenterology

BACKGROUND & AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate r..

Lamivudine-resistant hepatitis B virus and ongoing lamivudine therapy: stop the merry-go-round, it's time to get off!

Peter Angus, Stephen Locarnini

Journal article  |  2004  |  Antiviral Therapy

Pre-emptive use of lamivudine in bone marrow transplantation with chronic hepatitis B virus infection.

M Deschênes, Pierre Laneuville

Journal article  |  2004  |  Hepatology

Molecular virology of hepatitis B virus.

Stephen Locarnini

Conference Proceedings  |  2004  |  Seminars in Liver Disease

Hepatitis B virus (HBV) has evolved a unique life cycle that results in the production of enormous viral loads during active repli..

Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes.

Helene Norder, Anne-Marie Couroucé, Pierre Coursaget, José M Echevarria, Shou-Dong Lee, Isa K Mushahwar, Betty H Robertson, Stephen Locarnini, Lars O Magnius

Journal article  |  2004  |  Intervirology

Sequences of 234 complete genomes and 631 hepatitis B surface antigen genes were used to assess the worldwide diversity of hepatit..

Studying the treatment of chronic hepatitis B viral infection in special populations.

Robert G Gish, Stephen Locarnini

Journal article  |  2004  |  Methods in molecular medicine

A parsimonious method for screening drug combinations for antihepadnaviral activity using a parametric dose-response surface approach.

Tim Shaw, Stephen Locarnini

Journal article  |  2004  |  Methods in molecular medicine

HBV genotyping and analysis for unique mutations.

Anna Ayres, Stephen Locarnini, Angeline Bartholomeusz

Journal article  |  2004  |  Methods in molecular medicine

Quantification of HBV covalently closed circular DNA from liver tissue by real-time PCR.

Scott Bowden, Kathy Jackson, Margaret Littlejohn, Stephen Locarnini

Journal article  |  2004  |  Methods in molecular medicine

Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy?

Tim Shaw, Scott Bowden, Stephen Locarnini

Journal article  |  2004  |  Gastroenterology

Hepatitis B virus: pathogenesis, viral intermediates, and viral replication

J Lee, S Locarnini

Journal article  |  2004  |  Clinics in Liver Disease

Hepatitis B virus (HBV) is an enveloped, double-stranded DNA virus that is the prototype member of the family Hepadnaviridae. The ..

Monitoring gene expression using DNA microarrays during hepatitis B virus infection.

Michael R Beard, Stephen Locarnini

Journal article  |  2004  |  Methods in molecular medicine

Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.

Peter Angus, Rhys Vaughan, Shelly Xiong, Huiling Yang, William Delaney, Craig Gibbs, Carol Brosgart, Danielle Colledge, Rosalind Edwards, Anna Ayres, Angeline Bartholomeusz, Stephen Locarnini

Journal article  |  2003  |  Gastroenterology

BACKGROUND & AIMS: Adefovir dipivoxil effectively inhibits both hepatitis B virus (HBV) replication and disease activity in patien..

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

Christian Klein, C Thomas Bock, Heiner Wedemeyer, Torsten Wüstefeld, Stephen Locarnini, Hans Peter Dienes, Stefan Kubicka, Michael P Manns, Christian Trautwein

Journal article  |  2003  |  Gastroenterology

BACKGROUND & AIMS: Hepatitis B virus (HBV) causes acute and chronic infections that may result in severe liver diseases. Animal mo..

Treatment of chronic hepatitis B: current challenges and future directions.

Ruth Chin, Stephen Locarnini

Journal article  |  2003  |  Reviews in Medical Virology

The clinical management of chronic hepatitis B infection has entered a new era with the introduction and widespread use of oral nu..

Evidence of patient-to-patient transmission of hepatitis C virus through contaminated intravenous anaesthetic ampoules

GF Tallis, GM Ryan, SB Lambert, DS Bowden, R McCaw, CJ Birch, M Moloney, JA Carnie, SA Locarnini, GJ Rouch, MG Catton

Journal article  |  2003  |  Journal of Viral Hepatitis

Lamivudine resistant occult HBV: implications for public health?

Scott Bowden, Angeline Bartholomeusz, Stephen Locarnini

Journal article  |  2003  |  Journal of Hepatology

The hepatitis B virus and common mutants.

Stephen Locarnini, Janine McMillan, Angeline Bartholomeusz

Journal article  |  2003  |  Seminars in Liver Disease

Most biological systems have developed complex mechanisms to maintain the stability of their genetic information. Exceptions to th..

Hepatitis B viral resistance: mechanisms and diagnosis.

Stephen Locarnini

Conference Proceedings  |  2003  |  Journal of Hepatology

EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002 Geneva, Switzerland. Consensus statement (long version).

Roberto de Franchis, Antoine Hadengue, George Lau, Daniel Lavanchy, Anna Lok, Neil McIntyre, Alfonso Mele, Gustav Paumgartner, Antonello Pietrangelo, Juan Rodés, William Rosenberg, Dominique Valla, undefined EASL Jury

Conference Proceedings  |  2003  |  Journal of Hepatology

Novel approaches in the management of chronic HBV infection

A Bartholomeusz, P Furman, S Locarnini

Book Chapter  |  2003

Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure

A Ayres, A Bartholomeusz, G Lau, K Lam, J Lee, S Locarnini

Journal article  |  2003  |  Journal of Clinical Virology

Background: Lamivudine (LMV) is the only nucleoside analogue approved for the treatment of chronic hepatitis B (CHB). LMV, as with..

Nomenclature for antiviral resistant human hepatitis B virus mutations in the polymerase region

LJ Stuyver, SA Locarnini, A Lok, DD Richman, WF Carman, JL Dienstag, RF Schinazi

Book Chapter  |  2003

New targets and possible new therapeutic approaches in the chemotherapy of chronic hepatitis B

J Feld, J Lee, S Locarnini

Journal article  |  2003  |  Hepatology

Chronic hepatitis B (CH-B) is characterized by in-flammatory liver disease of variable severity driven by persistent replication o..

Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions

R Schilling, S Ijaz, M Davidoff, JY Lee, S Locarnini, R Williams, NV Naoumov

Journal article  |  2003  |  Journal of Virology

Hepatitis B immunoglobulin is used for prophylaxis against hepatitis B virus (HBV) and is thought to act by neutralization of viri..

Antiviral therapy for hepatitis B virus infections: new targets and technical challenges.

Jordan Feld, Stephen Locarnini

Journal article  |  2002  |  Journal of Clinical Virology

There are presently only two licensed therapies for treating liver disease caused by infection with the hepatitis B virus (HBV). T..

Chemotherapy for hepatitis B: new treatment options necessitate reappraisal of traditional endpoints.

Tim Shaw, Scott Bowden, Stephen Locarnini

Journal article  |  2002  |  Gastroenterology

Monitoring drug resistance in chronic hepatitis B virus (HBV)-infected patients during lamivudine therapy: evaluation of performance of INNO-LiPA HBV DR assay.

Anna SF Lok, Fabien Zoulim, Stephen Locarnini, Alessandra Mangia, Grazia Niro, Hilde Decraemer, Geert Maertens, Frank Hulstaert, Karen De Vreese, Erwin Sablon

Journal article  |  2002  |  Journal of Clinical Microbiology

Sensitive and early detection of emerging hepatitis B virus (HBV) drug resistance may not only help monitor the viral dynamics ass..

Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro.

William E Delaney, Ros Edwards, Danni Colledge, Tim Shaw, Phil Furman, George Painter, Stephen Locarnini

Journal article  |  2002  |  Antimicrobial Agents and Chemotherapy

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. T..

Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies

S Lewin, T Walters, S Locarnini

Journal article  |  2002  |  Antiviral Research

Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation.

George KK Lau, Ming-Liang He, Daniel YT Fong, Angeline Bartholomeusz, Wing-Yan Au, Albert KW Lie, Stephen Locarnini, Raymond Liang

Journal article  |  2002  |  Hepatology

Exacerbation of hepatitis B virus (HBV) is a serious cause of morbidity and mortality in hepatitis B surface antigen (HBsAg)-posit..

Advances in hepatitis C: What is coming in the next 5 years?

SA Locarnini, A Bartholomeusz

Conference Proceedings  |  2002  |  Journal of Gastroenterology and Hepatology

Hepatic iron overload does not prevent a sustained virological response to interferon-alpha therapy: a long term follow-up study in hepatitis C-infected patients with beta thalassemia major.

William Sievert, Stephen Pianko, Shernyne Warner, Scott Bowden, Ian Simpson, Don Bowden, Stephen Locarnini

Journal article  |  2002  |  American Journal of Gastroenterology

OBJECTIVES: Transfusion-acquired chronic hepatitis C infection and systemic iron overload are common in patients with beta thalass..

Evolving therapies for the treatment of chronic hepatitis B virus infection

WE Delaney, A Bartholomeusz, SA Locarnini

Journal article  |  2002  |  Expert Opinion on Investigational Drugs

Clinical relevance of viral dynamics and genotypes in hepatitis B virus

SA Locarnini

Conference Proceedings  |  2002  |  Journal of Gastroenterology and Hepatology

Journal of Clinical Virology: Editorial

PV Coyle, M Koopmans, A Linde, S Locarnini, HGM Niesters, JSM Peiris, JT Meulen, M Watson, A Pasteur, B Carman

Journal article  |  2002  |  Journal of Clinical Virology

Fulminant hepatitis B due to a lamivudine-resistant mutant of HBV in a patient coinfected with HIV.

Maurizio Bonacini, Alan Kurz, Stephen Locarnini, Anna Ayres, Craig Gibbs

Journal article  |  2002  |  Gastroenterology

Mechanisms of drug resistance and novel approaches to therapy for chronic hepatitis C

SA Locarnini

Conference Proceedings  |  2002  |  Journal of Gastroenterology and Hepatology

Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection.

RJ Colonno, EV Genovesi, I Medina, L Lamb, SK Durham, ML Huang, L Corey, M Littlejohn, S Locarnini, BC Tennant, B Rose, JM Clark

Journal article  |  2001  |  The Journal of Infectious Diseases

Entecavir (ETV) is a guanosine nucleoside analogue with potent antiviral efficacy in woodchucks chronically infected with woodchuc..

Hepatitis B virus mutants and fulminant hepatitis B: fitness plus phenotype.

A Bartholomeusz, S Locarnini

Journal article  |  2001  |  Hepatology

Structural organization of the hepatitis B virus minichromosome.

CT Bock, S Schwinn, S Locarnini, J Fyfe, MP Manns, C Trautwein, H Zentgraf

Journal article  |  2001  |  Journal of Molecular Biology

The replicative intermediate of hepatitis B virus (HBV), the covalently closed, circular DNA, is organized into minichromosomes in..

Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

LJ Stuyver, SA Locarnini, A Lok, DD Richman, WF Carman, JL Dienstag, RF Schinazi

Journal article  |  2001  |  Hepatology

Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.

WE Delaney, S Locarnini, T Shaw

Journal article  |  2001  |  Antiviral Chemistry and Chemotherapy

Despite the existence of vaccines, chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. Interferon ..

Combination chemotherapy for hepatitis B virus: the path forward?

T Shaw, S Locarnini

Journal article  |  2000  |  Drugs

Hepatitis B virus (HBV) was identified as a cause of viral hepatitis more than 30 years ago and hepatitis B vaccines have been ava..

Molecular analysis of human immunodeficiency virus strains associated with a case of criminal transmission of the virus

CJ Birch, RF McCaw, DM Bulach, PA Revill, JT Carter, J Tomnay, B Hatch, TV Middleton, D Chibo, MG Catton, JL Pankhurst, AM Bresckin, SA Locarnini, DS Bowden

Journal article  |  2000  |  The Journal of Infectious Diseases

Combination chemotherapy for hepatitis B virus: the final solution?

T Shaw, S Locarnini

Journal article  |  2000  |  Hepatology

The effectiveness of the infant hepatitis B immunisation program in Fiji, Kiribati, Tonga and Vanuatu.

N Wilson, TA Ruff, BJ Rana, J Leydon, S Locarnini

Journal article  |  2000  |  Vaccine

The aims of this project were: (1) to determine the extent to which infant hepatitis B immunisation is preventing chronic hepatiti..

A virological perspective on the need for vaccination.

S Locarnini

Journal article  |  2000  |  Journal of Viral Hepatitis

Superinfecton of chronic carriers of hepatitis B virus (HBV) or hepatitis C virus (HCV) with hepatitis A virus (HAV) is often asso..

An efficient extraction method from blood clots for studies requiring both host and viral DNA.

AA Basuni, LA Butterworth, G Cooksley, S Locarnini, WF Carman

Journal article  |  2000  |  Journal of Viral Hepatitis

The clot from blood is usually discarded after the collection of serum. Yet, it contains nucleated white blood cells and substanti..

In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.

D Colledge, G Civitico, S Locarnini, T Shaw

Journal article  |  2000  |  Antimicrobial Agents and Chemotherapy

Penciclovir (9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine [PCV]), lamivudine ([-]-beta-L-2',3'-dideoxy-3'-thiacytidine [3TC..

Antiviral chemotherapy for the treatment of hepatitis B virus infections

J Torresi, S Locarnini

Journal article  |  2000  |  Gastroenterology

Molecular pathogenesis of viral hepatitis

S Locarnini

Conference Proceedings  |  2000  |  Journal of Gastroenterology and Hepatology

Effect of nucleoside analogue therapy on duck hepatitis B viral replication in hepatocytes and bile duct epithelial cells in vivo

A Nicoll, S Locarnini, ST Chou, R Smallwood, P Angus

Journal article  |  2000  |  Journal of Gastroenterology and Hepatology

Hepatitis C: Diagnosis and monitoring

DJ Siebert, AM Breschkin, DS Bowden, SA Locarnini

Journal article  |  1999  |  Australian Prescriber

Lamivudine therapy in patients undergoing liver transplantation for hepatitis B virus precore mutant-associated infection: high resistance rates in treatment of recurrence but universal prevention if used as prophylaxis with very low dose hepatitis B immune globulin.

GW McCaughan, J Spencer, D Koorey, S Bowden, A Bartholomeusz, M Littlejohn, D Verran, AK Chui, AG Sheil, RM Jones, SA Locarnini, PW Angus

Journal article  |  1999  |  Liver Transplantation and Surgery

Recurrent hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality after liver transplantation. Recently..

Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1- yl)purines as potential prodrugs of penciclovir.

DK Kim, N Lee, DH Ryu, YW Kim, JS Kim, K Chang, GJ Im, WS Choi, YB Cho, KH Kim, D Colledge, S Locarnini

Journal article  |  1999  |  Bioorganic & Medicinal Chemistry

A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alko..

Hepatitis G: viroprevalence and seroconversion in a high-risk group of children.

W Hardikar, LD Moaven, DS Bowden, SA Locarnini, AL Smith

Journal article  |  1999  |  Journal of Viral Hepatitis

Hepatitis G virus (HGV), a recently discovered flavivirus, is parenterally transmitted and significantly associated with hepatitis..

Only the non-glycosylated fraction of hepatitis E virus capsid (open reading frame 2) protein is stable in mammalian cells

J Torresi, F Li, SA Locarnini, DA Anderson

Journal article  |  1999  |  Journal of General Virology

Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.

AG Loi, A Faraj, C Pierra, G Gosselin, JL Imbach, SA Locarnini, EV Groman, RF Schinazi, JP Sommadossi

Conference Proceedings  |  1999  |  Nucleosides and Nucleotides

We have investigated the effects of several beta-D-ddA 5'-monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers ..

New therapeutic strategies in the treatment of hepatitis B virus infection.

J Torresi, SA Locarnini

Journal article  |  1999  |  Expert Opinion on Investigational Drugs

Principally, because of the association of the chronic carrier state with the development of cirrhotic liver disease and hepatocel..

Preclinical aspects of lamivudine and famciclovir against hepatitis B virus.

T Shaw, SA Locarnini

Journal article  |  1999  |  Journal of Viral Hepatitis

Chemotherapy for chronic hepatitis B virus (HBV) infection is inherently difficult for a variety of reasons that are related to un..

Antiviral chemotherapy for chronic hepatitis B infection: lessons learned from treating HIV-infected patients.

S Locarnini, C Birch

Journal article  |  1999  |  Journal of Hepatology

TT virus: An agent of transfusion-associated hepatitis or yellow herring?

S Bowden, S Locarnini

Journal article  |  1999  |  Journal of Gastroenterology and Hepatology

Treatment of chronic hepatitis B virus infection: An Asia-Pacific perspective

GKK Lau, WF Carman, SA Locarnini, K Okuda, ZM Lu, R Williams, SK Lam

Journal article  |  1999  |  Journal of Gastroenterology and Hepatology

Mutations in the hepatitis B virus DNA polymerase associated with antiviral resistance

D Pillay, A Bartholomeusz, P Cane, D Mutimer, RF Schinazi, S Locarnini

Journal article  |  1998  |  International Antiviral News

Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue.

AJ Nicoll, DL Colledge, JJ Toole, PW Angus, RA Smallwood, SA Locarnini

Journal article  |  1998  |  Antimicrobial Agents and Chemotherapy

The use of regimens that use nucleoside analogues for the treatment of chronic hepatitis B virus infection is often limited becaus..

The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss.

RA de Man, AI Bartholomeusz, HG Niesters, PE Zondervan, SA Locarnini

Journal article  |  1998  |  Journal of Hepatology

BACKGROUND/AIMS: The purpose of this study was to characterize the clinical, histological and virological events in an orthotopic ..

Long-term therapy with the guanine nucleoside analog penciclovir controls chronic duck hepatitis B virus infection in vivo.

E Lin, C Luscombe, D Colledge, YY Wang, S Locarnini

Journal article  |  1998  |  Antimicrobial Agents and Chemotherapy

Ducks congenitally infected with duck hepatitis B virus (DHBV) were treated with the antiviral guanine nucleoside analog penciclov..

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection.

G Ostapowicz, KJ Watson, SA Locarnini, PV Desmond

Journal article  |  1998  |  Hepatology

In patients with chronic hepatitis C, alcohol consumption has been proposed as a risk factor for the progression of liver disease;..

Hepatitis B virus surface antigen and polymerase gene variants: potential virological and clinical significance.

SA Locarnini

Journal article  |  1998  |  Hepatology

New therapies for the treatment of chronic hepatitis B infection

R Chin, S Locarnini

Journal article  |  1998  |  Current Opinion in Infectious Diseases

Targets for inhibition of hepatitis C virus replication.

M Littlejohn, S Locarnini, A Bartholomeusz

Conference Proceedings  |  1998  |  Antiviral Therapy

Considerable progress has been made in characterizing the proteins involved in hepatitis C virus (HCV) replication, despite the la..

Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis.

MG Ghany, B Ayola, FG Villamil, RG Gish, S Rojter, JM Vierling, AS Lok

Journal article  |  1998  |  Hepatology

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted..

Significance of mutations in the hepatitis B virus polymerase selected by nucleoside analogues and implications for controlling chronic disease

A Bartholomeusz, RF Schinazi, SA Locarnini

Journal article  |  1998  |  Viral Hepatitis Reviews

Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.

U Protzer-Knolle, U Naumann, R Bartenschlager, T Berg, U Hopf, KH Meyer zum Büschenfelde, P Neuhaus, G Gerken

Journal article  |  1998  |  Hepatology

"Escape" variants of hepatitis B virus (HBV) can cause infection despite previous immunization. These viruses show alterations of ..

High level expression of the capsid protein of hepatitis E virus in diverse eukaryotic cells using the Semliki Forest virus replicon

J Torresi, J Meanger, P Lambert, F Li, SA Locarnini, DA Anderson

Journal article  |  1997  |  Journal of Virological Methods

Hepatitis G virus and fulminant hepatic failure: evidence for transfusion-related infection.

LD Moaven, SA Locarnini, DS Bowden, JP Kim, A Breschkin, R McCaw, A Yun, J Wages, B Jones, P Angus

Journal article  |  1997  |  Journal of Hepatology

BACKGROUND/AIMS: In the majority of cases of fulminant "viral" hepatitis in Australia, no known aetiological agent can be isolated..

Hepatitis C virus genotypes in Australia.

R McCaw, L Moaven, SA Locarnini, DS Bowden

Journal article  |  1997  |  Journal of Viral Hepatitis

The relative distribution of Australian hepatitis C virus (HCV) genotypes was determined for 500 isolates. Genotyping was performe..

Transmission of human and feline immunodeficiency viruses via reused suture material.

JD Druce, WF Robinson, SA Locarnini, MT Kyaw-Tanner, SF Sommerlad, CJ Birch

Journal article  |  1997  |  Journal of Medical Virology

Several documented cases of human immunodeficiency virus (HIV) infection have involved unconventional or unknown modes of transmis..

Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro.

D Colledge, S Locarnini, T Shaw

Journal article  |  1997  |  Hepatology