Stephen Locarnini

Hepatitis B related dilemmas in the renal unit.

Stephen G Holt, Stephen Locarnini, Joe Sasadeusz

Journal article  |  2020  |  Nephrology

Testing for hepatitis B in dialysis patients is routine, but newer and more sensitive detection methods mean that there is sometim..

FUNCTIONAL CURE OF CHRONIC HEPATITIS B IS ASSOCIATED WITH CO-OCCURRENCE OF HBsAg/ANTI-HBS IMMUNE COMPLEXES WITH ALT FLARES, AND SEROCONVERSION TO NEUTRALISING ANTI-HBS

Hui Xu, Stephen Locarnini, Darren Wong, Renae Walsh, Sally Soppe, Danni Coledge, Rachel Hammond, Alexander Thompson, Peter Revill, Patrick Marcellin, Anuj Gagger, Nadia Warner

Conference Proceedings  |  2020  |  HEPATOLOGY

Hepatitis B and D in the Pacific Islands of Kiribati

Kathy Jackson, Rosemary Tekoaua, Thomas Holgate, Ros Edwards, Lilly Yuen, Alice Lee, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini, Kabiri Tuneti

Journal article  |  2020  |  Journal of Clinical Virology

BACKGROUND: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but ..

HBV variants are common in the 'immune-tolerant' phase of chronic hepatitis B

Lilly Yuen, Peter A Revill, Gillian Rosenberg, Josef Wagner, Margaret Littlejohn, Julianne Bayliss, Kathy Jackson, Susanna K Tan, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Ed Gane, Henry LY Chan, Xin Li, Scott Bowden, Stephen Locarnini, Alexander Thompson

Journal article  |  2020  |  Journal of Viral Hepatitis

Nucleos(t)ide analouges (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However..

The evolution and clinical impact of hepatitis B virus genome diversity

Peter A Revill, Thomas Tu, Hans J Netter, Lilly KW Yuen, Stephen A Locarnini, Margaret Littlejohn

Journal article  |  2020  |  Nature Reviews Gastroenterology & Hepatology

The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons chronically infected, resulting in more than 88..

Glycoengineered hepatitis B virus-like particles with enhanced immunogenicity

Carina CD Joe, Sayantani Chatterjee, George Lovrecz, Timothy E Adams, Morten Thaysen-Andersen, Renae Walsh, Stephen A Locarnini, Peter Smooker, Hans J Netter

Journal article  |  2020  |  Vaccine

Virus-like particles (VLP) represent biological platforms for the development of novel products such as vaccines and delivery plat..

The role of hepatitis B surface antibodies in HBV infection, disease and clearance

Nadia Warner, Stephen Locarnini, Hui Xu

Journal article  |  2020  |  Future Virology

The clinical sequelae associated with chronic HBV infection is generally regarded as a consequence of an inadequate and inappropri..

Direct-acting antivirals and viral RNA targeting for hepatitis B cure.

Janine French, Stephen Locarnini, Fabien Zoulim

Journal article  |  2020  |  Current Opinion in HIV and AIDS

PURPOSE OF REVIEW: The current aim in the HBV landscape is to develop therapeutic strategies to achieve a functional cure of infec..

RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Man-Fung Yuen, Ingolf Schiefke, Jung-Hwan Yoon, Sang Hoon Ahn, Jeong Heo, Ju Hyun Kim, Henry Lik Yuen Chan, Ki Tae Yoon, Hartwig Klinker, Michael Manns, Joerg Petersen, Thomas Schluep, James Hamilton, Bruce D Given, Carlo Ferrari, Ching-Lung Lai, Stephen A Locarnini, Robert G Gish

Journal article  |  2020  |  Hepatology

BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived..

Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference‡.

Markus Cornberg, Anna Suk-Fong Lok, Norah A Terrault, Fabien Zoulim, undefined 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty

Journal article  |  2020  |  Journal of Hepatology

Representatives from academia, industry, regulatory agencies, and patient groups convened in March 2019 with the primary goal of d..