Stephen Locarnini

Analysis of Hepatitis B Virus Haplotype Diversity Detects Striking Sequence Conservation Across Genotypes and Chronic Disease Phase

Josef Wagner, Lilly Yuen, Margaret Littlejohn, Vitina Sozzi, Kathy Jackson, Vithika Suri, Susanna Tan, Becket Feierbach, Anuj Gaggar, Patrick Marcellin, Maria Buti Ferret, Harry LA Janssen, Ed Gane, Henry LY Chan, Danni Colledge, Gillian Rosenberg, Julianne Bayliss, Benjamin P Howden, Stephen A Locarnini, Darren Wong, et al.

Journal article  |  2021  |  HEPATOLOGY

BACKGROUND AND AIMS: We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 36..

Real-world application of the Xpert (R) HBV viral load assay on serum and dried blood spots

Kathy Jackson, Rosemary Tekoaua, Xin Li, Stephen Locarnini

Journal article  |  2020  |  JOURNAL OF MEDICAL VIROLOGY

As we strive towards the WHO goal of elimination of viral hepatitis as a public health threat by 2030, implementation of reliable,..

Hepatitis B related dilemmas in the renal unit

Stephen G Holt, Stephen Locarnini, Joe Sasadeusz

Journal article  |  2020  |  NEPHROLOGY

Testing for hepatitis B in dialysis patients is routine, but newer and more sensitive detection methods mean that there is sometim..

HBV-STOP study: Large hepatitis B virus flares off nucleot(s)ide analog therapy cause large innate immune response

S Hall, G Burns, D Anagnostou, R Morris, B Mooney, M Levy, W Sievert, J Lubel, A Nicoll, S Strasser, P Desmond, M Ngu, P Angus, C Meredith, P Revill, K Jackson, S Bowden, S Locarnini, A Thompson, K Visvanathan

Conference Proceedings  |  2020  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A prospective study of nucleot(s)ide analog discontinuation in non-cirrhotic patients with HBeAg-negative chronic hepatitis B: Interim analysis identifies different viral kinetics after stopping tenofovir versus entecavir

S Hall, G Burns, D Anagnostou, S Vogrin, M Levy, W Sievert, J Lubel, A Nicoll, S Strasser, P Desmond, M Ngu, P Angus, C Meredith, P Revill, K Jackson, S Bowden, S Locarnini, K Visvanathan, A Thompson

Conference Proceedings  |  2020  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

FUNCTIONAL CURE OF CHRONIC HEPATITIS B IS ASSOCIATED WITH CO-OCCURRENCE OF HBsAg/ANTI-HBS IMMUNE COMPLEXES WITH ALT FLARES, AND SEROCONVERSION TO NEUTRALISING ANTI-HBS

Hui Xu, Stephen Locarnini, Darren Wong, Renae Walsh, Sally Soppe, Danni Coledge, Rachel Hammond, Alexander Thompson, Peter Revill, Patrick Marcellin, Anuj Gagger, Nadia Warner

Conference Proceedings  |  2020  |  HEPATOLOGY

Hepatitis B and D in the Pacific Islands of Kiribati

Kathy Jackson, Rosemary Tekoaua, Thomas Holgate, Ros Edwards, Lilly Yuen, Alice Lee, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini, Kabiri Tuneti

Journal article  |  2020  |  JOURNAL OF CLINICAL VIROLOGY

BACKGROUND: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but ..

HBV variants are common in the 'immune-tolerant' phase of chronic hepatitis B

Lilly Yuen, Peter A Revill, Gillian Rosenberg, Josef Wagner, Margaret Littlejohn, Julianne Bayliss, Kathy Jackson, Susanna K Tan, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Ed Gane, Henry LY Chan, Xin Li, Scott Bowden, Stephen Locarnini, Alexander Thompson

Journal article  |  2020  |  JOURNAL OF VIRAL HEPATITIS

Nucleos(t)ide analogues (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However..

The evolution and clinical impact of hepatitis B virus genome diversity

Peter A Revill, Thomas Tu, Hans J Netter, Lilly KW Yuen, Stephen A Locarnini, Margaret Littlejohn

Journal article  |  2020  |  NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons chronically infected, resulting in more than 88..

Glycoengineered hepatitis B virus-like particles with enhanced immunogenicity

Carina CD Joe, Sayantani Chatterjee, George Lovrecz, Timothy E Adams, Morten Thaysen-Andersen, Renae Walsh, Stephen A Locarnini, Peter Smooker, Hans J Netter

Journal article  |  2020  |  VACCINE

Virus-like particles (VLP) represent biological platforms for the development of novel products such as vaccines and delivery plat..