Catriona McLean

cAMP Response Element Binding Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy.

So-Yoon Won, Soon-Tae You, Seung-Won Choi, Catriona McLean, Eun-Young Shin, Eung-Gook Kim

Journal article  |  2021  |  Mol Cells

Parkinson's disease (PD) is characterized by a progressive loss of dopamine-producing neurons in the midbrain, which results in de..

INPP4B promotes PI3K alpha-dependent late endosome formation and Wnt/beta-catenin signaling in breast cancer

Samuel J Rodgers, Lisa M Ooms, Viola MJ Oorschot, Ralf B Schittenhelm, Elizabeth Nguyen, Sabryn A Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J Eramo, Absorn Sriratana, Clare G Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E Abud, Georg Ramm, Antonella Papa, Andrew M Ellisdon, Roger J Daly, Catriona A McLean, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast..

Defective lysosome reformation during autophagy causes skeletal muscle disease.

Meagan J McGrath, Matthew J Eramo, Rajendra Gurung, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Sonia Raveena Lourdes, Frank Koentgen, Sandra J Feeney, Michael Lazarou, Catriona A McLean, Christina A Mitchell

Journal article  |  2021  |  J Clin Invest

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phospha..

A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy

Macarena Cabrera-Serrano, David Joseph Coote, Dimitar Azmanov, Hayley Goullee, Erik Andersen, Catriona McLean, Mark Davis, Ryosuke Ishimura, Zornitza Stark, Jean-Michel Vallat, Masaaki Komatsu, Andrew Kornberg, Monique Ryan, Nigel G Laing, Gina Ravenscroft

Journal article  |  2020  |  JOURNAL OF MEDICAL GENETICS

BACKGROUND: UBA5 is the activating enzyme of UFM1 in the ufmylation post-translational modification system. Different neurological..

The function and composition of brain tissue derived exosomes in human Alzheimer’s disease

Laura J Vella, Huaqi Su, Tiana Koukoulis, Lesley Cheng, Adityas Purnianto, Leah Beauchamp, Catriona McLean, Ashley I Bush, Colin L Masters, Gavin Reid, Andrew F Hill, Kevin J Barnham

Journal article  |  2020  |  Alzheimer's & Dementia

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

Steven X Cho, Ina Rudloff, Jason C Lao, Merrin A Pang, Rimma Goldberg, Christine B Bui, Catriona A McLean, Magdalena Stock, Tilman E Klassert, Hortense Slevogt, Niamh E Mangan, Wei Cheng, Doris Fischer, Stefan Gfroerer, Manjeet K Sandhu, Devi Ngo, Alexander Bujotzek, Laurent Lariviere, Felix Schumacher, Georg Tiefenthaler, et al.

Journal article  |  2020  |  Nature Communications

Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants a..

PtdIns(3,4,5)P-3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Nuthasuda Srijakotre, Heng-jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E Abud, Kurt I Anderson, Heidi CE Welch, Tony Tiganis, Paul Timpson, Catriona A McLean, Lisa M Ooms, Christina A Mitchell

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression prom..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

Hon Yan K Yip, Annabel Chee, Ching-Seng Ang, Sung-Young Shin, Lisa M Ooms, Zainab Mohammadi, Wayne A Phillips, Roger J Daly, Timothy J Cole, Roderick T Bronson, Lan K Nguyen, Tony Tiganis, Robin M Hobbs, Catriona A McLean, Christina A Mitchell, Antonella Papa

Journal article  |  2020  |  MOLECULAR CELL

The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of..

Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals

Adam P Gunn, Bruce X Wong, Catriona McLean, Chris Fowler, Peter J Barnard, James A Duce, Blaine R Roberts

Journal article  |  2020  |  JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with ..