Paul Maruff

Undetected Neurodegenerative Disease Biases Estimates of Cognitive Change in Older Adults

Karra D Harrington, Andrew J Aschenbrenner, Paul Maruff, Colin L Masters, Anne M Fagan, Tammie LS Benzinger, Brian A Gordon, Carlos Cruchaga, John C Morris, Jason Hassenstab

Journal article  |  2021  |  PSYCHOLOGICAL SCIENCE

Neurodegenerative disease is highly prevalent among older adults and, if undetected, may obscure estimates of cognitive change amo..

Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition

Sherilyn Tan, Tenielle Porter, Romola S Bucks, Michael Weinborn, Lidija Milicic, Ailsa Brown, Stephanie R Rainey-Smith, Kevin Taddei, David Ames, Colin L Masters, Paul Maruff, Greg Savage, Christopher C Rowe, Victor L Villemagne, Belinda Brown, Hamid R Sohrabi, Simon M Laws, Ralph N Martins

Journal article  |  2021  |  HORMONES AND BEHAVIOR

Age-related decrease in testosterone levels is a potential risk factor for cognitive decline in older men. However, observational ..

Cognitive Go/No-Go decision-making criteria in Alzheimer's disease drug development

Alette M Wessels, Chris J Edgar, Pradeep J Nathan, Eric R Siemers, Paul Maruff, John Harrison

Journal article  |  2021  |  DRUG DISCOVERY TODAY

Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer's disease. Recent ..

Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder

Margaret T Davis, Nicole DellaGiogia, Paul Maruff, Robert H Pietrzak, Irina Esterlis

Journal article  |  2021  |  TRANSLATIONAL PSYCHIATRY

Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and..

The impact of the wake maintenance zone on attentional capacity, physiological drowsiness, and subjective task demands during sleep deprivation

William Ryan McMahon, Suzanne Ftouni, Charmaine Diep, Jinny Collet, Steven W Lockley, Shantha MW Rajaratnam, Paul Maruff, Sean PA Drummond, Clare Anderson

Journal article  |  2021  |  JOURNAL OF SLEEP RESEARCH

We aimed to investigate the impact of the Wake Maintenance Zone (WMZ) on measures of drowsiness, attention, and subjective perform..

Corrigendum to: MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide.

Journal article  |  2021  |  Brain

The authors apologize for a spelling error in the author list, which should read as: Ilya M. Nasrallah. This has now been correcte..

Association of beta-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals

Laura M Van der Kall, Truong Thanh, Samantha C Burnham, Vincent Dore, Rachel S Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y Lim, Simon M Laws, David Ames, Christopher Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L Masters, et al.

Journal article  |  2021  |  NEUROLOGY

OBJECTIVE: To determine the effect of β-amyloid (Aβ) level on progression risk to mild cognitive impairment (MCI) or dementia and ..

Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment

Nicholas Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames

Journal article  |  2021  |  JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

OBJECTIVES: The criteria for objective memory impairment in mild cognitive impairment (MCI) are vaguely defined. Aggregating the n..

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.

James M Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M Brandmaier, Sandra Düzel, Hector A Gonzalez, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Denise C Park, Sara Pudas, Melissa M Rundle, Kristine B Walhovd, Anders M Fjell, René Westerhausen, undefined Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing

Journal article  |  2021  |  Nat Commun

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an orga..

BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease

Yen Ying Lim, Simon M Laws, Stephanie Perin, Robert H Pietrzak, Christopher Fowler, Colin L Masters, Paul Maruff

Journal article  |  2021  |  GENES BRAIN AND BEHAVIOR

The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism has been shown to moderate the extent to which memory ..