Professor Tan and his group of scientists are interested in keeping neurons alive after brain injury from stroke or trauma. They recently discovered a natural protein in brain cells that can keep neurons alive during stress.
This protein, called Ndfip1, is also important for protecting cells from cancer development. Professor Tan and his group are urgently engaged in finding a drug that can increase levels of Ndfip1 for use in human trials.
Professor Tan was born in Malaysia where he trained as a dentist. He subsequently studied for a D Phil degree from Oxford University and worked for Nobel Laureate Gerald Edelman at Rockefeller University in New York. Professor Tan is presently appointed as NH&MRC Senior Principal Research Fellow. For his research activities, Professor Tan was awarded the 1997 Amgen Australia Award.
Find out more about Seong Tan's experience
Seong Tan's highlights
Seong Tan's selected work
The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8( ) T Cell Tolerance Checkpo..
A method for isolating cortical interneurons sharing the same birthdays for gene expressio..
Displaying the 15 most recent projects by Seong Tan.
Displaying the 89 most recent scholarly works by Seong Tan.
Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7
Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss
Journal article | 2017 | Cerebral Cortex
The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome
Shan Shan Li, Zhengdong Qu, Matilda Haas, Ngo Linh, You Jeong Heo, Hyo Jung Kang, Joanne Maria Britto, Hayley Daniella Cullen, Hannah Kate Vanyai, Seong-Seng Tan, Tailoi Chan-Ling, Jenny Margaret Gunnersen, Julian Ik-Tsen Heng
Journal article | 2016 | Scientific Reports
Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response
Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Tan
Journal article | 2015 | Journal of Biological Chemistry
The Zinc Finger Transcription Factor RP58 Negatively Regulates Rnd2 for the Control of Neuronal Migration During Cerebral Cortical Development
Julian Ik-Tsen Heng, Zhengdong Qu, Chiaki Ohtaka-Maruyama, Haruo Okado, Masataka Kasai, Diogo Castro, Francois Guillemot, Seong-Seng Tan
Journal article | 2015 | Cerebral Cortex
A Unified Nomenclature and Amino Acid Numbering for Human PTEN
Rafael Pulido, Suzanne J Baker, Joao T Barata, Arkaitz Carracedo, Victor J Cid, Ian D Chin-Sang, Vrushank Dave, Jeroen den Hertog, Peter Devreotes, Britta J Eickholt, Charis Eng, Frank B Furnari, Maria-Magdalena Georgescu, Arne Gericke, Benjamin Hopkins, Xeujun Jiang, Seung-Rock Lee, Mathias Loesche, Prerna Malaney, Xavier Matias-Guiu, et al.
Journal article | 2014 | Science Signaling
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4( ) T cells
John A Altin, Stephen R Daley, Jason Howitt, Helen J Rickards, Alison K Batkin, Keisuke Horikawa, Simon J Prasad, Keats A Nelms, Sharad Kumar, Lawren C Wu, Seong-Seng Tan, Matthew C Cook, Christopher C Goodnow
Journal article | 2014 | Proceedings of the National Academy of Sciences of the United States of America
Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice
Matilda Haas, Zhengdong Qu, Tae Hwan Kim, Ernesto Vargas, Kenneth Campbell, Steven Petrou, Seong-Seng Tan, Christopher A Reid, Julian Heng
Journal article | 2013 | European Journal of Neuroscience
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan
Journal article | 2012 | Journal of Cell Biology
Spatiotemporal Regulation of Multiple Overlapping Sense and Novel Natural Antisense Transcripts at the Nrgn and Camk2n1 Gene Loci during Mouse Cerebral Corticogenesis
King-Hwa Ling, Chelsee A Hewitt, Tim Beissbarth, Lavinia Hyde, Pike-See Cheah, Gordon K Smyth, Seong-Seng Tan, Christopher N Hahn, Tim Thomas, Paul Q Thomas, Hamish S Scott
Journal article | 2011 | Cerebral Cortex
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons
Jason Howitt, Ulrich Putz, Jenny Lackovic, Anh Doan, Loretta Dorstyn, Hong Cheng, Baoli Yang, Chan-Ling Tailoi, John Silke, Sharad Kumar, Seong-Seng Tan
Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling
King-Hwa Ling, Chelsee A Hewitt, Tim Beissbarth, Lavinia Hyde, Kakoli Banerjee, Pike-See Cheah, Ping Z Cannon, Christopher N Hahn, Paul Q Thomas, Gordon K Smyth, Seong-Seng Tan, Tim Thomas, Hamish S Scott
Journal article | 2009 | Genome Biology
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons
Jenny M Gunnersen, Mary H Kim, Stephanie J Fuller, Melanie De Silva, Joanne M Britto, Vicki E Hammond, Philip J Davies, Steve Petrou, ES Louise Faber, Pankaj Sah, Seong-Seng Tan
Journal article | 2007 | Neuron
Automated analysis of neurite branching in cultured cortical neurons using HCA-Vision
Pascal Vallotton, Ryan Lagerstrom, Changming Sun, Michael Buckley, Dadong Wang, Melanie De Silva, Seong-Seng Tan, Jenny A Gunnersen
Journal article | 2007 | Cytometry. Part A : the journal of the International Society for Analytical Cytology
Control of cortical neuron layering: lessons from mouse chimeras.
Vicki Hammond, Joanne Britto, Eva So, Holly Cate, Seong-Seng Tan
Conference Proceedings | 2007 | Cortical Development: Genes and Genetic Abnormalities
How is the activation of Reelin signalling within neurons translated into the layering of cortical neurons? To address this questi..
Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium
JM Collinson, L Morris, AI Reid, T Ramaesh, MA Keighren, JH Flockhart, RE Hill, SS Tan, K Ramaesh, B Dhillon, JD West
Journal article | 2002 | Developmental Dynamics
Honours, Awards and Fellowships
FRACDS - Fellow of the Royal Australian College of Dental Surgeons
Anatomy And Neuroscience
Medicine - Royal Melbourne Hospital
Doctor of Philosophy
University of Oxford
Master of Dental Science
Bachelor of Dental Science
Institution not known