Seong Tan

Transcriptome analysis of ankylosed primary molars with infraocclusion

Annie Tong, Yuh-Lit Chow, Katie Xu, Rita Hardiman, Paul Schneider, Seong-Seng Tan

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF ORAL SCIENCE

Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread ..

Ubiquitin Regulation of Trk Receptor Trafficking and Degradation

SS Murray, AW Wong, J Yang, Y Li, U Putz, S-S Tan, J Howitt

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The regulation of Trk receptors is critical for orchestrating multiple signalling pathways required for developing and maintaining..

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8( ) T Cell Tolerance Checkpoint to High-Dose Antigen

Mayura Wagle, Julia M Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C Goodnow, Ian A Parish

Journal article  |  2018  |  CELL REPORTS

Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimm..

A method for isolating cortical interneurons sharing the same birthdays for gene expression studies

Hui Xuan Ng, Ean Phing Lee, Brenton L Cavanagh, Joanne M Britto, Seong-Seng Tan

Journal article  |  2017  |  EXPERIMENTAL NEUROLOGY

The two neuronal populations in the cortex, pyramidal neurons and interneurons, can be separated based on neurotransmitter identit..

Engineered Exosomes as Vehicles for Biologically Active Proteins

Ulrich Sterzenbach, Ulrich Putz, Ley-Hian Low, John Silke, Seong-Seng Tan, Jason Howitt

Journal article  |  2017  |  MOLECULAR THERAPY

Exosomes represent an attractive vehicle for the delivery of biomolecules. However, mechanisms for loading functional molecules in..

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss

Journal article  |  2017  |  CEREBRAL CORTEX

Mutations of the reelin gene cause severe defects in cerebral cortex development and profound intellectual impairment. While many ..

The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome

Shan Shan Li, Zhengdong Qu, Matilda Haas, Ngo Linh, You Jeong Heo, Hyo Jung Kang, Joanne Maria Britto, Hayley Daniella Cullen, Hannah Kate Vanyai, Seong-Seng Tan, Tailoi Chan-Ling, Jenny Margaret Gunnersen, Julian Ik-Tsen Heng

Journal article  |  2016  |  SCIENTIFIC REPORTS

Copy number variations to chromosome 21 (HSA21) cause intellectual disability and Down Syndrome, but our understanding of the HSA2..

An aesthetic approach towards the temporary restoration of missing upper lateral incisors during orthodontic treatment

Katie Xu, Seong-Seng Tan

Journal article  |  2015  |  AUSTRALIAN ORTHODONTIC JOURNAL

PTEN secretion in exosomes

Ulrich Putz, Sophia Mah, Choo-Peng Goh, Ley-Hian Low, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  METHODS

PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secre..

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

Jason Howitt, Ley-Hian Low, Ulrich Putz, Anh Doan, Jenny Lackovic, Choo-Peng Goh, Jenny Gunnersen, John Silke, Seong-Seng Tan

Journal article  |  2015  |  JOURNAL OF MOLECULAR CELL BIOLOGY

Pten controls a signaling axis that is implicated to regulate cell proliferation, growth, survival, migration, and metabolism. The..