John Carlin

A scoping review of studies using observational data to optimise dynamic treatment regimens.

Robert K Mahar, Myra B McGuinness, Bibhas Chakraborty, John B Carlin, Maarten J IJzerman, Julie A Simpson

Journal article  |  2021  |  BMC Medical Research Methodology

BACKGROUND: Dynamic treatment regimens (DTRs) formalise the multi-stage and dynamic decision problems that clinicians often face w..

Multilevel regression and poststratification for estimating population quantities from large health studies: a simulation study based on US population structure.

Marnie Downes, John Carlin

Journal article  |  2020  |  Journal of Epidemiology and Community Health

INTRODUCTION: Recruiting a representative sample of participants is becoming increasingly difficult in large-scale health surveys...

Exposure to adversity and inflammatory outcomes in mid and late childhood

Meredith O'Connor, Anne-Louise Ponsonby, Fiona Collier, Richard Liu, Peter D Sly, Peter Azzopardi, Kate Lycett, Sharon Goldfeld, Sarah J Arnup, David Burgner, Naomi Priest, Peter Vuillermin, Mimi LK Tang, Richard Saffery, John Carlin, Len Harrison

Journal article  |  2020  |  Brain, Behavior, & Immunity - Health

Background: We aimed to estimate the association between exposure to adversity and inflammatory markers in mid (4 years) and late ..

Statistical methods used in the estimation of age-specific paediatric reference intervals for laboratory blood tests: A systematic review

Monsurul Hoq, Louise Canterford, Susan Matthews, Gulshan Khanom, Vera Ignjatovic, Paul Monagle, Susan Donath, John Carlin

Journal article  |  2020  |  Clinical Biochemistry

INTRODUCTION: There is an emerging realisation that paediatric reference intervals (RIs) estimated using discrete age-groups may b..

Validation of the HAPPI Kids Continuous Age-Specific Pediatric Reference Intervals

Monsurul Hoq, Susan Matthews, Vicky Karlaftis, Janet Burgess, Susan Donath, John Carlin, Vera Ignjatovic, Paul Monagle

Journal article  |  2020  |  The Journal of Applied Laboratory Medicine

INTRODUCTION: To facilitate best possible patient care, reference intervals (RIs) adopted by a laboratory must be appropriate for ..

Determinants of placental leptin receptor gene expression and association with measures at birth

Amanda Vlahos, Toby Mansell, David Burgner, Fiona Collier, Boris Novakovic, Richard Saffery

Journal article  |  2020  |  Placenta

INTRODUCTION: The leptin signalling pathway is important in metabolic health during pregnancy. However, few studies have investiga..

Protocol for a single patient therapy plan: A randomised, double-blind, placebo-controlled N-of-1 trial to assess the efficacy of cannabidiol in patients with intractable epilepsy

Katherine S Ong, John B Carlin, Michael Fahey, Jeremy L Freeman, Ingrid E Scheffer, Lynn Gillam, Monique Anderson, Md Hamidul Huque, Donna Legge, Nicole Dirnbauer, Brian Lilley, Simon Slota-Kan, Noel Cranswick

Journal article  |  2020  |  Journal of Paediatrics and Child Health

AIM: This paper describes the use of the single patient therapy plan (SPTP). The SPTP has been designed to assess the efficacy at ..

Sex differences in infant blood metabolite profile in association with weight and adiposity measures

Susan Ellul, Anne-Louise Ponsonby, John B Carlin, Fiona Collier, Toby Mansell, Peter Vuillermin, David Burgner, Richard Saffery

Journal article  |  2020  |  Pediatric Research

BACKGROUND: Nuclear magnetic resonance (NMR) metabolic profiling quantifies a large number of metabolites. From adolescence, speci..

Evaluation of approaches for multiple imputation of three-level data

Rushani Wijesuriya, Margarita Moreno-Betancur, John B Carlin, Katherine J Lee

Journal article  |  2020  |  BMC Medical Research Methodology

BACKGROUND: Three-level data arising from repeated measures on individuals who are clustered within larger units are common in hea..

Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors

Susan Ellul, Wolfgang Marx, Fiona Collier, Richard Saffery, Mimi Tang, David Burgner, John Carlin, Peter Vuillermin, Anne-Louise Ponsonby, Len Harrison, Terry Dwyer, Sarath Ranganathan, Peter Sly

Journal article  |  2020  |  Prostaglandins, Leukotrienes and Essential Fatty Acids

BACKGROUND: Fatty acids have been implicated in early life immune development. Food allergy provides a clear phenotype of early al..