Andrew Giraud

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations

Jon N Buzzelli, Louise O'Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z Ng, Masanobu Oshima, Hiroko Oshima, Andrew S Giraud, Philip Sutton, Louise M Judd, Trevelyan R Menheniott

Journal article  |  2019  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

Garrett Z Ng, Trevelyan R Menheniott, Alison L Every, Andrew Stent, Louise M Judd, Yok Teng Chionh, Poshmaal Dhar, Jasper C Komen, Andrew S Giraud, Timothy C Wang, Michael A McGuckin, Philip Sutton

Journal article  |  2016  |  Gut

Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

KP Patel, AS Giraud, CS Samuel, SG Royce

Journal article  |  2016  |  British Journal of Pharmacology

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

Trevelyan R Menheniott, Louise O'Connor, Yok Teng Chionh, Jan Daebritz, Michelle Scurr, Benjamin N Rollo, Garrett Z Ng, Shelley Jacobs, Angelique Catubig, Bayzar Kurklu, Stephen Mercer, Toshinari Minamoto, David E Ong, Richard L Ferrero, James G Fox, Timothy C Wang, Philip Sutton, Louise M Judd, Andrew S Giraud

Journal article  |  2016  |  Journal of Clinical Investigation

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

Jan Daebritz, Louise M Judd, Heather V Chalinor, Trevelyan R Menheniott, Andrew S Giraud

Journal article  |  2016  |  Scientific Reports

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice

LM Judd, RG Heine, TR Menheniott, J Buzzelli, N O'Brien-Simpson, D Pavlic, L O'Connor, K Al Gazali, O Hamilton, M Scurr, AM Collison, J Mattes, KJ Allen, AS Giraud

Journal article  |  2016  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

STAT3: a critical component in the response to Helicobacter pylori infection

Trevelyan R Menheniott, Louise M Judd, Andrew S Giraud

Journal article  |  2015  |  Cellular Microbiology

Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

B Kurklu, RH Whitehead, EK Ong, T Minamoto, JG Fox, JR Mann, LM Judd, AS Giraud, TR Menheniott

Journal article  |  2015  |  Oncogene

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

Jon N Buzzelli, Heather V Chalinor, Daniel I Pavlic, Philip Sutton, Trevelyan R Menheniott, Andrew S Giraud, Louise M Judd

Journal article  |  2015  |  Cellular and Molecular Gastroenterology and Hepatology

IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment

Jon N Buzzelli, Dan I Pavlic, Heather V Chalinor, Louise O'Connor, Trevelyan R Menheniott, Andrew S Giraud, Louise M Judd

Journal article  |  2015  |  Oncotarget

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Daniel L Worthley, Michael Churchill, Jocelyn T Compton, Yagnesh Tailor, Meenakshi Rao, Yiling Si, Daniel Levin, Matthew G Schwartz, Aysu Uygur, Yoku Hayakawa, Stefanie Gross, Bernhard W Renz, Wanda Setlik, Ashley N Martinez, Xiaowei Chen, Saqib Nizami, Heon Goo Lee, H Paco Kang, Jon-Michael Caldwell, Samuel Asfaha, et al.

Journal article  |  2015  |  Cell

TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow

Louise M Judd, Heather V Chalinor, Anna Walduck, Daniel I Pavlic, Jan Daebritz, Zinaida Dubeykovskaya, Timothy C Wang, Trevelyan R Menheniott, Andrew S Giraud

Journal article  |  2015  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

RUNX3 methylation and anti-tumor immunity.

Trevelyan R Menheniott, Louise M Judd, Andrew S Giraud

Journal article  |  2015  |  Oncoscience

Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Giraud

Journal article  |  2014  |  PLoS ONE

Increased immunoexpression of trefoil factors in salivary gland tumors

Ponlatham Chaiyarit, Poramaporn Klanrit, Pensri Photipakdee, Ajiravudh Subarnbhesaj, Andrew S Giraud

Journal article  |  2014  |  Clinical Oral Investigations

Mechanistic Insights into the Contribution of Epithelial Damage to Airway Remodeling Novel Therapeutic Targets for Asthma

Simon G Royce, Xuelei Li, Stephanie Tortorella, Liana Goodings, Bryna SM Chow, Andrew S Giraud, Mimi LK Tang, Chrishan S Samuel

Journal article  |  2014  |  American Journal of Respiratory Cell and Molecular Biology

Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles

Trevelyan R Menheniott, Bayzar Kurklu, Andrew S Giraud

Journal article  |  2013  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma

Ponlatham Chaiyarit, Akasith Utrawichian, Chanvit Leelayuwat, Patrawut Vatanasapt, Nattharee Chanchareonsook, Mie Hessellund Samson, Andrew S Giraud

Journal article  |  2012  |  Clinical Oral Investigations

IL-11 is a parietal cell cytokine that induces atrophic gastritis

Meegan Howlett, Heather V Chalinor, Jon N Buzzelli, Nguyen Nhung, Ian R van Driel, Katrina M Bell, James G Fox, Eva Dimitriadis, Trevelyan R Menheniott, Andrew S Giraud, Louise M Judd

Journal article  |  2012  |  Gut

Targeting STAT3 in gastric cancer

Andrew S Giraud, Trevelyan R Menheniott, Louise M Judd

Journal article  |  2012  |  Expert Opinion On Therapeutic Targets

A novel TFF2 splice variant (Delta EX2TFF2) correlates with longer overall survival time in cholangiocarcinoma

Surasee Kamlua, Siriporn Patrakitkomjorn, Patcharee Jearanaikoon, Trevelyan R Menheniott, Andrew S Giraud, Temduang Limpaiboon

Journal article  |  2012  |  Oncology Reports

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3 gamma via Gastric STAT3 Activation

Kai Syin Lee, Anastasia Kalantzis, Cameron B Jackson, Louise O'Connor, Naoko Murata-Kamiya, Masanori Hatakeyama, Louise M Judd, Andrew S Giraud, Trevelyan R Menheniott

Journal article  |  2012  |  PLoS One

Trefoil factors: Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma

Kanuengnuch Kosriwong, Trevelyan R Menheniott, Andrew S Giraud, Patcharee Jearanaikoon, Banchob Sripa, Temduang Limpaiboon

Journal article  |  2011  |  World Journal of Gastroenterology

Impact on hearing of routine ear suctioning at the tympanic membrane

Jeffrey J Nelson, Andrew Giraud, Ronald Walsh, Anthony J Mortelliti

Journal article  |  2011  |  American Journal of Otolaryngology: head and neck medicine and surgery

Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing

Hiroyuki Tomita, Shigeo Takaishi, Trevelyan R Menheniott, Xiangdong Yang, Wataru Shibata, Guangchun Jin, Kelly S Betz, Kazuyuki Kawakami, Toshinari Minamoto, Catherine Tomasetto, Marie-Christine Rio, Nataporn Lerkowit, Andrea Varro, Andrew S Giraud, Timothy C Wang

Journal article  |  2011  |  Gastroenterology

Chronic IL-11 Promotes Proliferation, Bmp1 Signalling and Activation of the Mucosal Alarmin IL-33 in the Colon

LM Judd, V Chalinor, T Menheniott, M Howlett, AS Giraud

Journal article  |  2011  |  Gastroenterology

Interleukin-1beta is a Signal for Trefoil Factor 2 Promoter Methylation in Gastric Preneoplasia

undefined Menheniott, undefined O'Connor, undefined Minamoto, undefined Kawakami, undefined Tomita, undefined Fox, undefined Wang, LM Judd, AS Giraud

Journal article  |  2011  |  Gastroenterology

Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

Anthony J Peterson, Trevelyan R Menheniott, Louise O'Connor, Anna K Walduck, James G Fox, Kazuyuki Kawakami, Toshinari Minamoto, Eng Kok Ong, Timothy C Wang, Louise M Judd, Andrew S Giraud

Journal article  |  2010  |  Gastroenterology

The extracellular matrix in digestive cancer

DL Worthley, AS Giraud, TC Wang

Journal article  |  2010  |  Cancer Microenvironment

Stromal fibroblasts in digestive cancer

DL Worthley, AS Giraud, TC Wang

Journal article  |  2010  |  Cancer Microenvironment

A Novel Gastrokine, Gkn3, Marks Gastric Atrophy and Shows Evidence of Adaptive Gene Loss in Humans

Trevelyan R Menheniott, Anthony J Peterson, Louise O'Connor, Kai Syin Lee, Anastasia Kalantzis, Ivanela Kondova, Ronald E Bontrop, Katrina M Bell, Andrew S Giraud

Journal article  |  2010  |  Gastroenterology

Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis

Anthony J Peterson, Nhung Nguyen, Hiroshi Okamoto, Andrew S Giraud, Ian R van Driel, Louise M Judd

Journal article  |  2010  |  Regulatory Peptides

Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP(1-46)), the primary GRP gene-derived peptide product of the pregnant ovine endometrium

AS Giraud, C Dumesny, JC Whitley, LM Parker, I Jennings, B Kemp, TW Moody, V Sancho, RT Jensen, A Shulkes

Journal article  |  2010  |  Peptides

Cytokine signalling via gp130 in gastric cancer

M Howlett, TR Menheniott, LM Judd, AS Giraud

Journal article  |  2009  |  Biochimica et Biophysica Acta - Molecular Cell Research

The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development

Meegan Howlett, Andrew S Giraud, Helen Lescesen, Cameron B Jackson, Anastasia Kalantzis, Ian R Van Driel, Lorraine Robb, Mark Van der Hoek, Matthias Ernst, Toshinari Minamoto, Alex Boussioutas, Hiroko Oshima, Masanobu Oshima, Louise M Judd

Journal article  |  2009  |  Gastroenterology

Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression

Louise M Judd, Meera Ulaganathan, Meegan Howlett, Andrew S Giraud

Journal article  |  2009  |  Journal of Pathology

Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression

CB Jackson, LM Judd, TR Menheniott, I Kronborg, C Dow, ND Yeomans, A Boussioutas, L Robb, AS Giraud

Journal article  |  2007  |  Journal of Pathology

Metaplasia as a premalignant pathology in the stomach

Andrew S Giraud

Journal article  |  2007  |  Gastroenterology

Differentiation of the gastric mucosa IV. Role of trefoil peptides and IL-6 cytokine family signaling in gastric homeostasis

AS Giraud, C Jackson, TR Menheniott, LM Judd

Journal article  |  2007  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis

Louise M Judd, Karin Bredin, Anastasia Kalantzis, Brendan J Jenkins, Matthias Ernst, Andrew S Giraud

Journal article  |  2006  |  Gastroenterology

Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo

N Houli, SW Loh, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2006  |  Regulatory Peptides

Regulation of Gastric Acid Secretion

Arthur Shulkes, Graham S Baldwin, Andrew S Giraud

Book Chapter  |  2006

Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP)

C Dumesny, O Patel, S Lachal, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2006  |  Endocrinology

Multiple regulatory pathways for trefoil factor (TFF) genes

M Baus-Loncar, AS Giraud

Journal article  |  2005  |  Cellular and Molecular Life Sciences

Trefoil factor expression graft-versus-host disease of in biliary epithelium of the liver after allogeneic hematopoietic cell transplantation

R Idilman, E Erden, M Arat, E Soydan, O Erkan, I Kuzu, Y Sahin, S Coban, M Bozdayi, A Giraud, H Akan, S Karayalcin, A Ozden

Journal article  |  2005  |  Transplantation

Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammation

TV Franic, IR van Driel, PA Gleeson, AS Giraud, LM Judd

Journal article  |  2005  |  Journal of Pathology

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130

M Howlett, LM Judd, B Jenkins, NL La Gruta, D Grail, M Ernst, AS Giraud

Journal article  |  2005  |  Gastroenterology

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

BJ Jenkins, D Grail, T Nheu, M Najdovska, B Wang, P Waring, M Inglese, RM McLoughlin, SA Jones, N Topley, H Baumann, LM Judd, AS Giraud, A Boussioutas, HJ Zhu, M Ernst

Journal article  |  2005  |  Nature Medicine

Cross-fostering in Macropus eugenii leads to increased weight but not accelerated gastrointestinal maturation

R Waite, A Giraud, J Old, M Howlett, G Shaw, K Nicholas, M Familari

Journal article  |  2005  |  Journal of Experimental Zoology

Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor

O Patel, C Dumesny, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2004  |  Biochemical Pharmacology

Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis

TV Franic, LM Judd, NV Nguyen, LC Samuelson, KL Loveland, AS Giraud, PA Gleeson, IR van Driel

Journal article  |  2004  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney

C Dumesny, JC Whitley, GS Baldwin, AS Giraud, A Shulkes

Journal article  |  2004  |  American Journal of Physiology: Renal Physiology

TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis

AS Giraud, PM Pereira, L Thim, LM Parker, LM Judd

Journal article  |  2004  |  Peptides

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130

LM Judd, BM Alderman, M Howlett, A Shulkes, C Dow, J Moverley, D Grail, BJ Jenkins, M Ernst, AS Giraud

Journal article  |  2004  |  Gastroenterology

Insights into the mechanisms of gastric adaptation to aspirin-induced injury: A role for regenerating protein but not trefoil peptides

BM Alderman, M Ulaganathan, LM Judd, M Howlett, LM Parker, ND Yeomans, AS Giraud

Journal article  |  2003  |  Laboratory Investigation

Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis

Y Kimura, PSC Leung, TP Kenny, J Van de Water, M Nishioka, AS Giraud, J Neuberger, G Benson, R Kaul, AA Ansari, RL Coppel, ME Gershwin

Journal article  |  2002  |  Hepatology

Isolation and characterisation of the ovine gastrin-releasing peptide gene; abundant expression in the pregnant uterus and selective expression in fetal tissues

JC Whitley, C Moore, AS Giraud, A Shulkes

Journal article  |  2002  |  Journal of Endocrinology

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

NC Tebbutt, AS Giraud, M Inglese, B Jenkins, P Waring, FJ Clay, S Malki, BM Alderman, D Grail, F Hollande, JK Heath, M Ernst

Journal article  |  2002  |  Nature Medicine

Biliary epithelial trefoil peptide expression is increased in biliary diseases

G Srivatsa, AS Giraud, M Ulaganathan, ND Yeomans, C Dow, AJ Nicoll

Journal article  |  2002  |  Histopathology

The role of capsulin in the morphogenesis and differentiation of fetal rat gastric mucosa

M Andersson, AS Giraud, M Familari

Journal article  |  2001  |  International Journal of Developmental Biology

Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach

BL Kang, BM Alderman, AJ Nicoll, GA Cook, AS Giraud

Journal article  |  2001  |  Journal of Gastroenterology and Hepatology

Secretion of the trefoil factor TFF3 from the isolated vascularly perfused rat colon

F Moro, F Levenez, S Durual, P Plaisancie, L Thim, AS Giraud, JC Cuber

Journal article  |  2001  |  Regulatory Peptides

Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice

T Marchbank, HM Cox, RA Goodlad, AS Giraud, SF Moss, R Poulsom, NA Wright, J Jankowski, RJ Playford

Journal article  |  2001  |  Journal of Biological Chemistry

Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processes

M Ulaganathan, M Familari, ND Yeomans, AS Giraud, GA Cook

Journal article  |  2001  |  Journal of Gastroenterology and Hepatology

Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium

D Taupin, J Pedersen, M Familari, G Cook, N Yeomans, AS Giraud

Journal article  |  2001  |  Laboratory Investigation

Regulatory peptides: what do they regulate?

A Shulkes, G Baldwin, A Giraud

Journal article  |  2001  |  Trends in Endocrinology and Metabolism

Adaptation of the stomach to injury from nonsteroidal anti-inflammatory drugs.

BM Alderman, AS Giraud, ND Yeomans

Journal article  |  2001  |  Current Gastroenterology Reports