Andrew Giraud

Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer

Sharleen Chung Nien Chin, Louise O'Connor, Michelle Scurr, Jonathan T Busada, Alison N Graham, Ghazal Alipour Talesh, Chau P Tran, Sohinee Sarkar, Toshinari Minamoto, Andrew S Giraud, John A Cidlowski, Philip Sutton, Trevelyan R Menheniott

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gastrokines (GKNs) are anti-inflammatory proteins secreted by gastric epithelial (surface mucous and pit) cells, with their aberra..

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations

Jon N Buzzelli, Louise O'Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z Ng, Masanobu Oshima, Hiroko Oshima, Andrew S Giraud, Philip Sutton, Louise M Judd, Trevelyan R Menheniott

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gas..

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

Garrett Z Ng, Trevelyan R Menheniott, Alison L Every, Andrew Stent, Louise M Judd, Yok Teng Chionh, Poshmaal Dhar, Jasper C Komen, Andrew S Giraud, Timothy C Wang, Michael A McGuckin, Philip Sutton

Journal article  |  2016  |  GUT

OBJECTIVES: The mucin MUC1, best known for providing an epithelial barrier, is an important protective host factor in both humans ..

Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

KP Patel, AS Giraud, CS Samuel, SG Royce

Journal article  |  2016  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: We evaluated the extent to which individual versus combination treatments that specifically target airway ..

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

Trevelyan R Menheniott, Louise O'Connor, Yok Teng Chionh, Jan Daebritz, Michelle Scurr, Benjamin N Rollo, Garrett Z Ng, Shelley Jacobs, Angelique Catubig, Bayzar Kurklu, Stephen Mercer, Toshinari Minamoto, David E Ong, Richard L Ferrero, James G Fox, Timothy C Wang, Philip Sutton, Louise M Judd, Andrew S Giraud

Journal article  |  2016  |  JOURNAL OF CLINICAL INVESTIGATION

Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by su..

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

Jan Daebritz, Louise M Judd, Heather V Chalinor, Trevelyan R Menheniott, Andrew S Giraud

Journal article  |  2016  |  SCIENTIFIC REPORTS

STAT3 regulates the expansion of myeloid-derived suppressor cells (MDSCs) during inflammation, infection and cancer. Hyperactivati..

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice

LM Judd, RG Heine, TR Menheniott, J Buzzelli, N O'Brien-Simpson, D Pavlic, L O'Connor, K Al Gazali, O Hamilton, M Scurr, AM Collison, J Mattes, KJ Allen, AS Giraud

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

We tested whether the T helper (Th) type 2 (Th2) cell agonist and allergenic ligand IL-33 was associated with eosinophilic esophag..

STAT3: a critical component in the response to Helicobacter pylori infection

Trevelyan R Menheniott, Louise M Judd, Andrew S Giraud

Journal article  |  2015  |  CELLULAR MICROBIOLOGY

STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of k..

Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

B Kurklu, RH Whitehead, EK Ong, T Minamoto, JG Fox, JR Mann, LM Judd, AS Giraud, TR Menheniott

Journal article  |  2015  |  ONCOGENE

Runt domain transcription factor 3 (RUNX3) is widely regarded as a tumour-suppressor gene inactivated by DNA hypermethylation of i..

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

Jon N Buzzelli, Heather V Chalinor, Daniel I Pavlic, Philip Sutton, Trevelyan R Menheniott, Andrew S Giraud, Louise M Judd

Journal article  |  2015  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently ..