Christina Cortez-Jugo

Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan‐Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez‐Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  Angewandte Chemie

Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types.

Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D Kelleher, Chantelle L Ahlenstiel

Journal article  |  2023  |  Mol Pharm

For over two decades, nanomaterials have been employed to facilitate intracellular delivery of small interfering RNA (siRNA), both..

Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..

mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso

Journal article  |  2022  |  MOLECULAR PHARMACEUTICS

Messenger RNA (mRNA) holds great potential as a disease-modifying treatment for a wide array of monogenic disorders. Niemann-Pick ..

Nebulization of siRNA for inhalation therapy based on a microfluidic surface acoustic wave platform.

Christina Cortez-Jugo, Sarah Masoumi, Peggy PY Chan, James Friend, Leslie Yeo

Journal article  |  2022  |  Ultrason Sonochem

The local delivery of therapeutic small interfering RNA or siRNA to the lungs has the potential to improve the prognosis for patie..

Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles

Y Hu, J Li, Y Ju, ZH Houston, NL Fletcher, R De Rose, S Fernandes, CE Hagemeyer, K Alt, KJ Thurecht, C Cortez-Jugo, F Caruso

Journal article  |  2022  |  Chemistry of Materials

The clinical success of monoclonal antibody therapy has inspired research in understanding the fundamental molecular basis of anti..

Immobilization and Intracellular Delivery of Structurally Nanoengineered Antimicrobial Peptide Polymers Using Polyphenol-Based Capsules

Jiaying Song, Christina Cortez-Jugo, Steven J Shirbin, Zhixing Lin, Shuaijun Pan, Greg G Qiao, Frank Caruso

Journal article  |  2022  |  ADVANCED FUNCTIONAL MATERIALS

Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) are an emerging class of antimicrobials against multidrug-resi..

Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor

Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D Kelleher, Sharon R Lewin, Francesca Cavalieri, Frank Caruso

Journal article  |  2022  |  NANOSCALE

Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

Agata Radziwon, Sukhvir K Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

Journal article  |  2022  |  NANOSCALE

Engineered nanoparticles for the encapsulation of bioactive agents hold promise to improve disease diagnosis, prevention and thera..

Luminescent Metal‐Phenolic Networks for Multicolor Particle Labeling

Zhixing Lin, Jiajing Zhou, Yijiao Qu, Shuaijun Pan, Yiyuan Han, René PM Lafleur, Jingqu Chen, Christina Cortez‐Jugo, Joseph J Richardson, Frank Caruso

Journal article  |  2021  |  Angewandte Chemie