Joan Heath

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Journal article  |  2023  |  ELIFE

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly an..

PHLPP1 regulates CFTR activity and lumen expansion through AMPK

Viola H Lobert, Maren L Skardal, Lene Malerod, Julia E Simensen, Hermine A Algra, Aram N Andersen, Thomas Fleischer, Hilde A Enserink, Knut Liestol, Joan K Heath, Tor Erik Rusten, Harald A Stenmark

Journal article  |  2022  |  DEVELOPMENT

Complex organ development depends on single lumen formation and its expansion during tubulogenesis. This can be achieved by correc..

Joan Heath interviews Suzanne Cory and Joan Steitz: a female perspective of science in the swinging '60s

Joan Heath, Suzanne Cory, Joan Steitz

Journal article  |  2022  |  DISEASE MODELS & MECHANISMS

Prompted by the occasion of International Women's Day, Joan Heath and DMM reunited Professors Suzanne Cory and Joan Steitz via Zoo..

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette Jacobsen, Emma Morrish, Natasha Silke, James M Murphy, Joan K Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12F36V (dTAGs) or HaloTag7 (HaloP..

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  NATURE CELL BIOLOGY

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia

Journal article  |  2021  |  NUCLEIC ACIDS RESEARCH

Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes, respecti..

Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defective Rnpc3-deficient mice

Karen Doggett, Ben B Williams, Sebastian Markmiller, Fan-Suo Geng, Janine Coates, Stephen Mieruszynski, Matthias Ernst, Tim Thomas, Joan K Heath

Journal article  |  2018  |  RNA

Splicing is an essential step in eukaryotic gene expression. While the majority of introns is excised by the U2-dependent, or majo..

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  NATURE

Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function1. Among the genes..

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Esther JY Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J Majewski, Fan-Suo Geng, Jaber Firas, David CS Huang, Mark F van Delft, Joan K Heath

Journal article  |  2018  |  STEM CELL REPORTS

Despite intensive efforts to optimize the process, reprogramming differentiated cells to induced pluripotent stem cells (iPSCs) re..

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension

Lee B Miles, Charbel Darido, Jan Kaslin, Joan K Heath, Stephen M Jane, Sebastian Dworkin

Journal article  |  2017  |  SCIENTIFIC REPORTS

The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis, neural ..