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Dr

Luke Miles

Honorary
Amyloid beta
Immunotherapy
Alzheimer's Disease
Protein Engineering
science & technology
humans
amyloid beta-peptides
alzheimer disease
life sciences & biomedicine
Luke Miles's Profile Picture
Dr

Luke Miles

 
Division
Science
 
Primary Interest
Immunotherapy
Luke Miles's Profile Picture
Dr

Luke Miles

 

Dr. Luke Miles has led a National Health and Medical Research Council of Australia -funded laboratory since 2008 at St. Vincent's Institute of Medical Research, Melbourne, Australia. Dr.

Miles is also an Honorary Fellow of the University of Melbourne. His lab is dedicated to understanding the function and processing of the amyloid precursor protein (APP), and mechanisms of promoting clearance of pathological species that drive Alzheimer's disease (AD). This work relies on biophysical methods of investigation including solution state NMR, 3D-structure determination by X-ray crystallography and small angle X-ray scattering, kinetic measurements, circular dichroism and fluorimetry. Such data informs experiments in vivo supported by collaboration with neuroscientists at the Florey Institute of Neuroscience and Mental Health in Melbourne. Dr. Miles gained expertise in recombinant protein expression, purification and biophysical analysis as a postdoctoral fellow at the Walter and Eliza Hall Institute of Medical Research and as a Japan Society Promotion of Science Fellow at Tokyo Metropolitan University. Dr. Miles solved one of the first anti-amyloid-antibody atomic structures reported in 2008 and has since solved more than half a dozen AD-related antibody complex structures including the most developed immunotherapy candidate, bapineuzumab. These structures form the templates for an antibody engineering program to develop immunotherapies with high affinity and exquisite specificity for different structures of both the amyloid beta peptide and the downstream related biomarker, hyperphosphorylated Tau protein.

Scholarly Works

Displaying the 16 most recent scholarly works by Luke Miles.

Honours, Awards and Fellowships

2003

FJSPS - Fellow of the Japan Society for the Promotion of Science


1

Award

Credentials

Positions


Honorary

Bio21 Institute

Education


Doctor of Philosophy (Physical Chemistry)

La Trobe University

Bachelor of Science with Honours

La Trobe University