Charles Gauci

Immunological responses and potency of the EG95NC- recombinant sheep vaccine against cystic echinococcosis.

M Jazouli, MW Lightowlers, Z Bamouh, CG Gauci, K Tadlaoui, MM Ennaji, M Elharrak

Journal article  |  2020  |  Parasitology International

Cystic echinococcosis (CE) is a zoonotic disease caused by the cestode parasite Echinococcus granulosus. The disease has an import..

A hyperendemic focus of porcine cystic echinococcosis in the Banke District of Nepal

Meritxell Donadeu, Charles G Gauci, Ishab Poudel, Keshav Sah, Dinesh Kumar Singh, Abdul Jabbar, Marshall W Lightowlers

Journal article  |  2020  |  Acta Tropica

Detailed post mortem analyses of 68 free-ranging, slaughter-age pigs from two sites in the Banke District of Nepal identified 36% ..

Accurate diagnosis of lesions suspected of being caused by Taenia solium in body organs of pigs with naturally acquired porcine cysticercosis

Charles G Gauci, Chrisostom Ayebazibwe, Zachary Nsadha, Chris Rutebarika, Ishab Poudel, Keshav Sah, Dinesh Kumar Singh, Andrew Stent, Angela Colston, Meritxell Donadeu, Marshall W Lightowlers

Journal article  |  2019  |  PLOS Neglected Tropical Diseases

The definitive method for diagnosis of porcine cysticercosis is the detection of cysticerci at necropsy. Cysts are typically locat..

Long-read sequencing reveals a 4.4kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1

Liina Kinkar, Pasi K Korhonen, Huimin Cai, Charles G Gauci, Marshall W Lightowlers, Urmas Saarma, David J Jenkins, Jiandong Li, Junhua Li, Neil D Young, Robin B Gasser

Journal article  |  2019  |  Parasites & Vectors

The first report of hydatid disease (Echinococcus granulosus) in an Australian water buffalo (Bubalus bubalis)

DJ Jenkins, T Williams, S Raidal, C Gauci, MW Lightowlers

Journal article  |  2019  |  International Journal for Parasitology: Parasites and Wildlife

Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work

Edmundo Larrieu, Guillermo Mujica, Daniel Araya, Jose Luis Labanchi, Marcos Arezo, Eduardo Herrero, Graciela Santillan, Katherina Vizcaychipi, Leonardo Uchiumi, Juan Carlos Salvitti, Claudia Grizmado, Arnoldo Calabro, Gabriel Talmon, Luis Sepulveda, Jose Maria Galvan, Marta Cabrera, Marcos Seleiman, Pablo Crowley, Graciela Cespedes, Mariela Garcia Cachau, et al.

Journal article  |  2019  |  Acta Tropica

Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal

Ishab Poudel, Keshav Sah, Suyog Subedi, Dinesh Kumar Singh, Peetambar Kushwaha, Angela Colston, Charles G Gauci, Meritxell Donadeu, Marshall W Lightowlers

Journal article  |  2019  |  PLOS Neglected Tropical Diseases

Taenia solium is a zoonotic cestode parasite which causes human neurocysticercosis. Pigs transmit the parasite by acting as the in..

Limitations of the Echinococcus granulosus genome sequence assemblies for analysis of the gene family encoding the EG95 vaccine antigen

Charles G Gauci, Cristian A Alvarez Rojas, Conan Chow, Marshall W Lightowlers

Journal article  |  2018  |  Parasitology

Vaccination Against Hydatidosis: Molecular Cloning and Optimal Expression of the EG95NC(-) Recombinant Antigen in Escherichia coli

M Jazouli, M Lightowlers, CG Gauci, K Tadlaoui, A Belmlih, MM Ennaji, M Elharrak

Journal article  |  2017  |  The Protein Journal

Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: Humoral response to the vaccine

Edmundo Larrieu, Thelma Veronica Poggio, Guillermo Mujica, Charles G Gauci, Jose Luis Labanchi, Eduardo Herrero, Daniel Araya, Claudia Grizmado, Arnoldo Calabro, Gabriel Talmon, Pablo Crowley, Graciela Santillan, Katherina Vizcaychipi, Marcos Seleiman, Luis Sepulveda, Marcos Arezo, Mariela Garcia Cachau, Roberto Lamberti, Leonardo Molina, Lilia Gino, et al.

Journal article  |  2017  |  Parasitology International

Reprint of "Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR"

Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriel, Pierre Dorny, RC Andrew Thompson, Marshall W Lightowlers, John Allen

Journal article  |  2017  |  Acta Tropica

Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR

Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriel, Pierre Dorny, RC Andrew Thompson, Marshall W Lightowlers, John Allen

Journal article  |  2016  |  ACTA TROPICA

Microdiversity of Echinococcus granulosus sensu stricto in Australia

CA Alvarez Rojas, D Ebi, CG Gauci, JP Scheerlinck, M Wassermann, DJ Jenkins, MW Lightowlers, T Romig

Journal article  |  2016  |  PARASITOLOGY

Elimination of Taenia solium Transmission in Northern Peru

Hector H Garcia, Armando E Gonzalez, Victor CW Tsang, Seth E O'Neal, Fernando Llanos-Zavalaga, Guillermo Gonzalvez, Jaime Romero, Silvia Rodriguez, Luz M Moyano, Viterbo Ayvar, Andre Diaz, Allen Hightower, Philip S Craig, Marshall W Lightowlers, Charles G Gauci, Elli Leontsini, Robert H Gilman

Journal article  |  2016  |  NEW ENGLAND JOURNAL OF MEDICINE

Anamnestic responses in pigs to the Taenia solium TSOL18 vaccine and implications for control strategies

Marshall W Lightowlers, Meritxell Donadeu, M Elaiyaraja, Kapil Maithal, K Anand Kumar, Charles G Gauci, Simon M Firestone, Patxi Sarasola, Tim G Rowan

Journal article  |  2016  |  PARASITOLOGY

Diagnosis of human taeniasis

Abdul Jabbar, Charles Gauci, Marshall W Lightowlers

Journal article  |  2016  |  Microbiology Australia

Monitoring the outcomes of interventions against Taenia solium: options and suggestions

MW Lightowlers, HH Garcia, CG Gauci, M Donadeu, B Abela-Ridder

Journal article  |  2016  |  PARASITE IMMUNOLOGY

Sensitivity of partial carcass dissection for assessment of porcine cysticercosis at necropsy

MW Lightowlers, E Assana, CM Jayashi, CG Gauci, M Donadeu

Journal article  |  2015  |  International Journal for Parasitology

Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact

Edmundo Larrieu, Guillermo Mujica, Charles G Gauci, Katherina Vizcaychipi, Marcos Seleiman, Eduardo Herrero, Jose Luis Labanchi, Daniel Araya, Luis Sepulveda, Claudia Grizmado, Arnoldo Calabro, Gabriel Talmon, Thelma Veronica Poggio, Pablo Crowley, Graciela Cespedes, Graciela Santillan, Mariela Garcia Cachau, Roberto Lamberti, Lilia Gino, Meritxell Donadeu, et al.

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

Vaccine development against the Taenia solium parasite The role of recombinant protein expression in Escherichia coli

Charles Gauci, Cesar Jayashi, Marshall W Lightowlers

Journal article  |  2013  |  Bioengineered

Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: Early impact and preliminary data

Edmund Larrieu, Eduardo Herrero, Guillermo Mujica, Jose Luis Labanchi, Daniel Araya, Claudia Grizmado, Arnoldo Calabro, Gabriel Talmon, Guillermo Ruesta, Alicia Perez, Antonio Gatti, Graciela Santillan, Marta Cabrera, Marcos Arezzo, Marcos Seleiman, Laura Cavagion, Mariela Garcia Cachau, Cristian A Alvarez Rojas, Lilia Gino, Charles G Gauci, et al.

Journal article  |  2013  |  ACTA TROPICA

Genes encoding homologous antigens in taeniid cestode parasites Implications for development of recombinant vaccines produced in Escherichia coli

Charles Gauci, Marshall W Lightowlers

Journal article  |  2013  |  Bioengineered

Antigenic differences between the EG95-related proteins from Echinococcus granulosus G1 and G6 genotypes: implications for vaccination

CA Alvarez Rojas, CG Gauci, MW Lightowlers

Journal article  |  2013  |  PARASITE IMMUNOLOGY

Characterisation of antibody responses in pigs induced by recombinant oncosphere antigens from Taenia solium

Cesar M Jayashi, Armando E Gonzalez, Ricardo Castillo Neyra, Craig T Kyngdon, Charles G Gauci, Marshall W Lightowlers

Journal article  |  2012  |  Vaccine

Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine

Cesar M Jayashi, Craig T Kyngdon, Charles G Gauci, Armando E Gonzalez, Marshall W Lightowlers

Journal article  |  2012  |  VETERINARY PARASITOLOGY

Vaccines Against Cestode Parasites

MW Lightowlers, CG Gauci, A Jabbar, C Alvarez

Book Chapter  |  2012

Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens

Charles G Gauci, Cesar M Jayashi, Armando E Gonzalez, Julia Lackenby, Marshall W Lightowlers

Journal article  |  2012  |  Vaccine

Characterization of the eg95 gene family in the G6 genotype of Echinococcus granulosus

Cristian A Alvarez Rojas, Charles G Gauci, Matthew J Nolan, Majid Fasihi Harandi, Marshall W Lightowlers

Journal article  |  2012  |  Molecular and Biochemical Parasitology

Strategies for Optimal Expression of Vaccine Antigens from Taeniid Cestode Parasites in Escherichia coli

Charles Gauci, David Jenkins, Marshall W Lightowlers

Journal article  |  2011  |  Molecular Biotechnology

Oncospheral penetration glands are the source of the EG95 vaccine antigen against cystic hydatid disease

A Jabbar, DJ Jenkins, S Crawford, AK Walduck, CG Gauci, MW Lightowlers

Journal article  |  2011  |  Parasitology

Oncospheral Penetration Glands and Secretory Blebs Are the Sources of Taenia ovis Vaccine Antigens

Abdul Jabbar, Simon Crawford, Charles G Gauci, Anna K Walduck, Garry A Anderson, Marshall W Lightowlers

Journal article  |  2010  |  Infection and Immunity

Variation in the cellular localization of host-protective oncospheral antigens in Taenia saginata and Taenia solium

A Jabbar, M Verastegui, JA Lackenby, AK Walduck, CG Gauci, RH Gilman, MW Lightowlers

Journal article  |  2010  |  Parasite Immunology

Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes

E Assana, CG Gauci, CT Kyngdon, AP Zoli, P Dorny, S Geerts, MW Lightowlers

Journal article  |  2010  |  Parasite Immunology

Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

Emmanuel Assana, Craig T Kyngdon, Charles G Gauci, Stanny Geerts, Pierre Dorny, Redgi De Deken, Garry A Anderson, Andre P Zoli, Marshall W Lightowlers

Journal article  |  2010  |  International Journal for Parasitology

Localisation of three host-protective oncospheral antigens of Taenia ovis

Abdul Jabbar, Craig T Kyngdon, Charles G Gauci, Anna K Walduck, Christina McCowan, Malcolm K Jones, Ian Beveridge, Marshall W Lightowlers

Journal article  |  2010  |  International Journal for Parasitology

Preliminary field trial of a vaccine against coenurosis caused by Taenia multiceps

A Varcasia, G Tosciri, GN Sanna Coccone, AP Pipia, G Garippa, A Scala, V Damien, G Vural, CG Gauci, MW Lightowlers

Journal article  |  2009  |  Veterinary Parasitology

Purification of polyclonal anti-conformational antibodies for use in affinity selection from random peptide phage display libraries: A study using the hydatid vaccine EG95

AJ Read, CG Gauci, MW Lightowlers

Journal article  |  2009  |  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby

TS Barnes, LA Hinds, DJ Jenkins, GT Coleman, AL Colebrook, CT Kyngdon, CG Gauci, MW Lightowlers

Journal article  |  2009  |  Parasitology

Isolation of antibodies specific to a single conformation-dependant antigenic determinant on the EG95 hydatid vaccine

AJ Read, JL Casey, AM Coley, M Foley, CG Gauci, DC Jackson, MW Lightowlers

Journal article  |  2009  |  Vaccine

Echinococcus granulosus: Variability of the host-protective EG95 vaccine antigen in G6 and G7 genotypic variants

Conan Chow, Charles G Gauci, Gulay Vural, David J Jenkins, David D Heath, Mara C Rosenzvit, Majid Fasihi Harandi, Marshall W Lightowlers

Journal article  |  2008  |  Experimental Parasitology

Variability in the Echinococcus granulosus Cytochrome C oxidase 1 mitochondrial gene sequence from livestock in Turkey and a re-appraisal of the G1-3 genotype cluster

Gulay Vural, Aysel Unsal Baca, Charles G Gauci, O Bagci, Y Gicik, Marshall W Lightowlers

Journal article  |  2008  |  Veterinary Parasitology

Vaccination with recombinant oncosphere antigens reduces the susceptibility of sheep to infection with Taenia multiceps

Charles Gauci, Gulay Vural, Taraneh Oencel, Antonio Varcasia, Veronica Damian, Craig T Kyngdon, Philip S Craig, Garry A Anderson, Marshall W Lightowlers

Journal article  |  2008  |  International Journal for Parasitology

Taenia solium and Taenia ovis: Stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres

Charles G Gauci, Manuela R Verastegui, Robert H Gilman, Marshall W Lightowlers

Journal article  |  2006  |  Experimental Parasitology

Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

CT Kyngdon, CG Gauci, AE Gonzalez, A Flisser, A Zoli, AJ Read, J Martinez-Ocana, RA Strugnell, MW Lightowlers

Journal article  |  2006  |  Parasite Immunology

In vitro oncosphere-killing assays to determine immunity to the larvae of Taenia pisiformis, Taenia ovis, Taenia saginata, and Taenia solium

CT Kyngdon, CG Gauci, RA Rolfe, JCV Guzman, MJF Salazar, MRV Pimentel, AE Gonzalez, HH Garcia, RH Gilman, RA Strugnell, MW Lightowlers

Journal article  |  2006  |  Journal of Parasitology

Conservation of the vaccine antigen gene, TSOL18, among genetically variant isolates of Taenia solium

CG Gauci, A Ito, MW Lightowlers

Journal article  |  2006  |  Molecular and Biochemical Parasitology

The effect of antigen targeting sequences on antibody responses to hepatitis E virus DNA vaccines in rats and sheep

F Li, P Loke, A Healy, MW Lightowlers, CG Gauci, DFJ Purcell, DA Anderson

Journal article  |  2006  |  Vaccine

Short report: Vaccination of pigs to control human neurocysticercosis

AE Gonzalez, CG Gauci, D Barber, RH Gilman, VCW Tsang, HH Garcia, M Verastegui, MW Lightowlers

Journal article  |  2005  |  American Journal of Tropical Medicine and Hygiene

Hydatid disease: vaccinology and development of the EG95 recombinant vaccine

C Gauci, D Heath, C Chow, MW Lightowlers

Journal article  |  2005  |  Expert Review of Vaccines

Vaccination against hydatidosis: Anticipating the potential for antigenic variation

MW Lightowlers, G Biyikoglu, C Chow, AF Cowman, CG Gauci, DD Heath, C Vallejo Rodriguez, DJ Woollard

Journal article  |  2004  |  Southeast Asian Journal of Tropical Medicine and Public Health

Gelsolin superfamily proteins: key regulators of cellular functions

P Silacci, L Mazzolai, C Gauci, N Stergiopulos, HL Yin, D Hayoz

Journal article  |  2004  |  Cellular and Molecular Life Sciences

Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens

A Flisser, CG Gauci, A Zoli, J Martinez-Ocana, A Garza-Rodriguez, JL Dominguez-Alpizar, P Maravilla, R Rodriguez-Canul, G Avila, L Aguilar-Vega, C Kyngdon, S Geerts, MW Lightowlers

Journal article  |  2004  |  Infection and Immunity

Cysticercosis/taeniasis in Asia and the Pacific

A Ito, T Wandra, H Yamasaki, M Nakao, Y Sako, K Nakaya, SS Margono, T Suroso, C Gauci, MW Lightowlers

Journal article  |  2004  |  Vector Borne and Zoonotic Diseases

Echinococcus granulosus: oncosphere-specific transcription of genes encoding a host-protective antigen

C Chow, CG Gauci, AF Cowman, MW Lightowlers

Journal article  |  2004  |  Experimental Parasitology

Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites

MW Lightowlers, CG Gauci, C Chow, DR Drew, SM Gauci, DD Heath, DC Jackson, DL Dadley-Moore, AJ Read

Journal article  |  2003  |  International Journal for Parasitology

Vaccination against cestode parasites: anti-helminth vaccines that work and why

MW Lightowlers, AL Colebrook, CG Gauci, SM Gauci, CT Kyngdon, JL Monkhouse, CV Rodriquez, AJ Read, RA Rolfe, C Sato

Journal article  |  2003  |  Veterinary Parasitology

Molecular cloning of genes encoding oncosphere proteins reveals conservation of modular protein structure in cestode antigens

C Gauci, MW Lightowlers

Journal article  |  2003  |  Molecular and Biochemical Parasitology

Molecular cloning of a vaccine antigen against infection with the larval stage of Echinococcus multilocularis

C Gauci, M Merli, V Muller, C Chow, KP Yagi, U Mackenstedt, MW Lightowlers

Journal article  |  2002  |  Infection and Immunity

Vaccines against cysticercosis and hydatidosis

MW Lightowlers, CG Gauci

Journal article  |  2001  |  Veterinary Parasitology

A gene family expressing a host-protective antigen of Echinococcus granulosus

C Chow, CG Gauci, AF Cowman, MW Lightowlers

Journal article  |  2001  |  Molecular and Biochemical Parasitology

Alternative splicing and sequence diversity of transcripts from the oncosphere stage of Taenia solium with homology to the 45W antigen of Taenia ovis

CG Gauci, MW Lightowlers

Journal article  |  2001  |  Molecular and Biochemical Parasitology

Protection against hydatid disease induced with the EG95 vaccine is associated with conformational epitopes

DJ Woollard, CG Gauci, DD Heath, MW Lightowlers

Journal article  |  2000  |  Vaccine

Vaccination against cysticercosis and hydatid disease

MW Lightowlers, A Flisser, CG Gauci, DD Heath, O Jensen, R Rolfe

Journal article  |  2000  |  Parasitology Today

Synthetic peptides induce antibody against a host-protective antigen of Echinococcus granulosus

DJ Woollard, CG Gauci, MW Lightowlers

Journal article  |  1999  |  Vaccine

Synthetic peptides induce antibodies in sheep against Taenia ovis

DL Dadley-Moore, MW Lightowlers, CG Gauci, JS Rothel, DC Jackson

Journal article  |  1999  |  Letters in Peptide Science

Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep

MW Lightowlers, O Jensen, E Fernandez, JA Iriarte, DJ Woollard, CG Cauci, DJ Jenkins, DD Heath

Journal article  |  1999  |  International Journal for Parasitology

Vaccination against Taenia solium cysticercosis in pigs using native and recombinant oncosphere antigens

A Plancarte, A Flisser, CG Gauci, MW Lightowlers

Journal article  |  1999  |  International Journal for Parasitology

Synthetic peptides induce antibodies in sheep against Taenia ovis

DL Dadley-Moore, MW Lightowlers, CG Gauci, JS Rothel, DC Jackson

Conference Proceedings  |  1999  |  Letters in Peptide Science

Epitope specificities and antibody responses to the EG95 hydatid vaccine

DJ Woollard, CG Gauci, DD Heath, MW Lightowlers

Journal article  |  1998  |  Parasite Immunology

A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens

CGP Gauci, A Flisser, MW Lightowlers

Journal article  |  1998  |  International Journal for Parasitology

The use of recombinant ovine IL-1 beta and TNF-alpha as natural adjuvants and their physiological effects in vivo

JS Rothel, HF Seow, MW Lightowlers, BW Parry, C Gauci, L Hurst, MJ Mucha, LA Corner, PR Wood

Journal article  |  1998  |  Immunology and Cell Biology

Codon usage in Taenia species

JG Waterkeyn, C Gauci, AF Cowman, MW Lightowlers

Journal article  |  1998  |  Experimental Parasitology

Sequence analysis of a gene family encoding Taenia ovis vaccine antigens expressed during embryogenesis of eggs

J Waterkeyn, C Gauci, A Cowman, M Lightowlers

Journal article  |  1997  |  Molecular and Biochemical Parasitology

Sequence analysis of a gene family encoding Taenia ovis vaccine antigens expressed during embryogenesis of eggs1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank™ and DDJB data bases under the accession number(s)-U75739-421

Jacqueline Waterkeyn, Charles Gauci, Alan Cowman, Marshall Lightowlers

Journal article  |  1997  |  Molecular and Biochemical Parasitology

Taenia saginata: Vaccination against cysticercosis in cattle with recombinant oncosphere antigens

MW Lightowlers, R Rolfe, CG Gauci

Journal article  |  1996  |  Experimental Parasitology

Host-protective fragments and antibody binding epitopes of the Taenia ovis 45W recombinant antigen

MW Lightowlers, JG Waterkeyn, JS Rothel, CG Gauci, GBL Harrison

Journal article  |  1996  |  Parasite Immunology

Vaccination against hydatidosis using a defined recombinant antigen

MW Lightowlers, SB Lawrence, CG Gauci, J Young, MJ Ralston, D Maas, DD Heath

Journal article  |  1996  |  Parasite Immunology

Identification and cDNA cloning of two novel low molecular weight host-protective antigens from Taenia ovis oncospheres

GBL Harrison, DD Heath, RP Dempster, C Gauci, SE Newton, WG Cameron, CM Robinson, SB Lawrence, MW Lightowlers, MD Rickard

Journal article  |  1996  |  International Journal for Parasitology

DEVELOPMENTAL REGULATION OF TAENIA-OVIS 45W GENE-EXPRESSION

CG GAUCI, MW LIGHTOWLERS

Journal article  |  1995  |  Molecular and Biochemical Parasitology