Georgina Such

Acid-Responsive Poly(glyoxylate) Self-Immolative Star Polymers.

Changhe Zhang, Sarah Kermaniyan, Samuel A Smith, Elizabeth R Gillies, Georgina K Such

Journal article  |  2021  |  Biomacromolecules

Self-immolative polymers have significant potential for applications such as drug or gene delivery. However, to realize this poten..

Understanding the Polymer Rearrangement of pH-Responsive Nanoparticles

Nayeleh Deirram, Sarah S Kermaniyan, Angus PR Johnston, Georgina K Such

Journal article  |  2021  |  AUSTRALIAN JOURNAL OF CHEMISTRY

The use of self-assembled nanoparticles for drug delivery has received significant attention in recent years. However, the dynamic..

Rationale Design of pH-Responsive Core-Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization

Y Gao, J Xu, C Zhang, H Venugopal, SS Kermaniyan, G Such, C Ritchie

Journal article  |  2020  |  ACS Applied Nano Materials

Herein, we report the rational design of pH-responsive core-shell nanoparticles that incorporate a polyoxometalate (POM) cargo. Co..

Multicompartment Polymeric Nanocarriers for Biomedical Applications

Umeka Nayanathara, Sarah S Kermaniyan, Georgina K Such

Journal article  |  2020  |  MACROMOLECULAR RAPID COMMUNICATIONS

Multicompartment polymeric nanocarriers which mimic the compartmentalized architecture of living cells have received considerable ..

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface

Joshua D Simpson, Samuel A Smith, Kristofer J Thurecht, Georgina Such

Journal article  |  2019  |  POLYMERS

Nanomedicine has generated significant interest as an alternative to conventional cancertherapy due to the ability for nanoparticl..

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram, Changhe Zhang, Sarah S Kermaniyan, Angus PR Johnston, Georgina K Such

Journal article  |  2019  |  MACROMOLECULAR RAPID COMMUNICATIONS

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within th..

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

Samuel A Smith, Laura I Selby, Angus PR Johnston, Georgina K Such

Journal article  |  2019  |  BIOCONJUGATE CHEMISTRY

Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potent..

Controlling endosomal escape using nanoparticle composition: current progress and future perspectives

Kristofer I Cupic, Joshua J Rennick, Angus PR Johnston, Georgina K Such

Journal article  |  2019  |  NANOMEDICINE

Polymer nanoparticles offer significant benefits for improving delivery of biological therapeutics such as DNA and proteins, as th..

Understanding Cell Interactions Using Modular Nanoparticle Libraries

Georgina K Such, Angus PR Johnston

Journal article  |  2019  |  AUSTRALIAN JOURNAL OF CHEMISTRY

Nanoparticle delivery systems have significant potential to facilitate the delivery of novel therapeutics, such as proteins, DNA o..

Controlling Endosomal Escape Using pH-Responsive Nanoparticles with Tunable Disassembly

Nachnicha Kongkatigumjorn, Samuel A Smith, Moore Chen, Katie Fang, Shenglin Yang, Elizabeth R Gillies, Angus PR Johnston, Georgina K Such

Journal article  |  2018  |  ACS APPLIED NANO MATERIALS

Endosomal escape is a bottleneck in the efficient delivery of therapeutics using nanoparticles; therefore understanding how this p..