Genevieve Evin

Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors

Genevieve Evin

Journal article  |  2016  |  BIODRUGS

Alzheimer's disease (AD) is the primary cause of dementia in the elderly. It remains incurable and poses a huge socio-economic cha..

Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing

Jiangli Tan, Qiao-Xin Li, Genevieve Evin

Journal article  |  2016  |  SYSTEMS BIOLOGY OF ALZHEIMER'S DISEASE

This chapter describes methods for establishing oxidative stress conditions that do not induce cell death in a neuronal cell cultu..

BACE Inhibition as a Therapeutic Strategy for Alzheimer’s Disease

G Evin, SJ Fuller, JM Gunnersen

Book Chapter  |  2015

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and the most common cause of dementia. One of th..

How accelerated Golgi trafficking may drive Alzheimer's disease

Genevieve Evin

Report  |  2015  |  BioEssays

BACE1 as a Therapeutic Target in Alzheimer's Disease: Rationale and Current Status

Genevieve Evin, Christopher Hince

Journal article  |  2013  |  DRUGS & AGING

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that causes dementia in a large percentage o..

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLOS ONE

BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the produ..

Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Geneviève Evin, Qiao-Xin Li

Journal article  |  2012  |  World J Psychiatry

Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the proteolytic machinery to produce Aβ..

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Hongyun Li, Genevieve Evin, Andrew F Hill, Ya Hui Hung, Ashley I Bush, Brett Garner

Journal article  |  2012  |  CLINICAL SCIENCE

Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that..

ss-Site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis

Jiangli Tan, Genevieve Evin

Journal article  |  2012  |  JOURNAL OF NEUROCHEMISTRY

β-Site APP-cleaving enzyme (BACE1) cleaves the amyloid precursor protein (APP) at the β-secretase site to initiate the production ..

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A Bellingham, Michael Ho, Jiangli Tan, Andrew F Hill, Colin L Masters, Catriona McLean, Genevieve Evin

Journal article  |  2011  |  NEUROBIOLOGY OF DISEASE

BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides a..