Genevieve Evin

Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors

Genevieve Evin

Journal article  |  2016  |  BIODRUGS

Alzheimer's disease (AD) is the primary cause of dementia in the elderly. It remains incurable and poses a huge socio-economic cha..

Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing

Jiangli Tan, Qiao-Xin Li, Genevieve Evin

Journal article  |  2016  |  SYSTEMS BIOLOGY OF ALZHEIMER'S DISEASE

This chapter describes methods for establishing oxidative stress conditions that do not induce cell death in a neuronal cell cultu..

BACE Inhibition as a Therapeutic Strategy for Alzheimer’s Disease

G Evin, SJ Fuller, JM Gunnersen

Book Chapter  |  2015

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and the most common cause of dementia. One of th..

How accelerated Golgi trafficking may drive Alzheimer's disease

Genevieve Evin

Report  |  2015  |  BioEssays

Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease.

Genevieve Evin, Adel Barakat

Journal article  |  2014  |  Degener Neurol Neuromuscul Dis

Alzheimer's disease (AD) is the major cause of dementia in the elderly and an unmet clinical challenge. A variety of therapies tha..

Correction: Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLoS ONE

BACE1 as a Therapeutic Target in Alzheimer's Disease: Rationale and Current Status

Genevieve Evin, Christopher Hince

Journal article  |  2013  |  DRUGS & AGING

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that causes dementia in a large percentage o..

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLOS ONE

BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the produ..

1570 – Cleavage of neuregulin 1 and BACE1 expression in frontal cortex of schizophrenia patients

A Barakat, S Bellingham, A Hill, WC Boon, G Evin

Journal article  |  2013  |  European Psychiatry

Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Geneviève Evin, Qiao-Xin Li

Journal article  |  2012  |  World J Psychiatry

Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the proteolytic machinery to produce Aβ..