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Dr

Genevieve Evin

Honorary
Clinical Pathology
science & technology
life sciences & biomedicine
humans
animals
biochemistry & molecular biology
alzheimer disease
neurosciences & neurology
neurosciences
amyloid beta-protein precursor
Genevieve Evin's Profile Picture
Dr

Genevieve Evin

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Proteases implicated in Alzheimer and other neurodegenerative diseases
Genevieve Evin's Profile Picture
Dr

Genevieve Evin

 
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Genevieve's  Short Profile
 

Projects

Displaying the 9 most recent projects by Genevieve Evin.

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THE POTENTIAL OF BACE AS A BLOOD BIOMARKER FOR EARLY DETECTION OF ALZHEIMER'S DISEASE

With support from two successive, framework V, EU sponsored consortia, we have developed a targeted immunodeficiency virus-like particle vac..

2010 - 2012
Completed
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DESIGNING NEW DRUGS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

2010 - 2012
Completed
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REGULATION OF AMYLOID-BETA PRODUCTION BY GLYCOSPHINGOLIPID SYNTHESIS INHIBITION

Alzheimer's disease (AD) prevalence is rising and there is currently no curative treatment. Production of neurotoxic amyloid-beta peptide (A..

2009 - 2011
Completed
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Gamma-secretase and Alzheimer amyloid production

Alzheimer's disease is a devastating illness of the aged population and represents a major socio-economic problem in Australia. There is no ..

2009 - 2011
Completed
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Developing new blood test for Alzheimer's disease based on beta-secretase activity

2008 - 2009
Completed
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DESIGNING AND TESTING NOVEL PRECURSORS FOR ALZHEIMERS DISEASE BASED ON BACE1 INHIBITION

2007 - 2008
Completed
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"Gamma-secretase complex: molecular characterization, and moduation of enzymatic activity"

A small protein fragment terned A-beta accumulates as amyloid plaques in the brain of patients with Alzheimer's disease. A-beta is toxic, it..

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COLLABORATION AGREEMENT

Completed
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NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS

nan

9

Projects

Project Types

6

Research Grant

3

Research Contracts

Scholarly Works

Displaying the 10 most recent scholarly works by Genevieve Evin.

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Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors

Genevieve Evin

Journal article  |  2016  |  BIODRUGS

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Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing

Jiangli Tan, Qiao-Xin Li, Genevieve Evin

Journal article  |  2016  |  Methods in Molecular Biology

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BACE Inhibition as a Therapeutic Strategy for Alzheimer’s Disease

G Evin, SJ Fuller, JM Gunnersen

Book Chapter  |  2015

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and the most common cause of dementia. One of th..

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How accelerated Golgi trafficking may drive Alzheimer's disease

Genevieve Evin

Report  |  2015  |  BioEssays

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BACE1 as a Therapeutic Target in Alzheimer's Disease: Rationale and Current Status

Genevieve Evin, Christopher Hince

Journal article  |  2013  |  DRUGS & AGING

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Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLOS ONE

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Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Geneviève Evin, Qiao-Xin Li

Journal article  |  2012  |  World Journal of Psychiatry

Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the proteolytic machinery to produce Aβ..

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Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Hongyun Li, Genevieve Evin, Andrew F Hill, Ya Hui Hung, Ashley I Bush, Brett Garner

Journal article  |  2012  |  CLINICAL SCIENCE

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ss-Site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis

Jiangli Tan, Genevieve Evin

Journal article  |  2012  |  Journal of Neurochemistry

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Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A Bellingham, Michael Ho, Jiangli Tan, Andrew F Hill, Colin L Masters, Catriona McLean, Genevieve Evin

Journal article  |  2011  |  Neurobiology of Disease

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Scholarly Works

Keyword Analysis

Neurosciences
Public Health
Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical (organs, Diseases and Abnormal Conditions)
Medical Biochemistry and Clinical Chemistry
Biochemistry and Cell Biology
Other Health
Other Medical and Health Sciences
Public Health and Health Services
Medical Biochemistry and Metabolomics

Credentials

Positions

Honorary

Clinical Pathology

Themis Dept Access

Florey Department of Neuroscience and Mental Health

Education

Doctor of Science

University of Nancy I

Master of Science

University of Nancy I

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