Genevieve Evin

Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors

Genevieve Evin

Journal article  |  2016  |  BioDrugs

Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing

Jiangli Tan, Qiao-Xin Li, Genevieve Evin

Journal article  |  2016  |  Methods in Molecular Biology

BACE Inhibition as a Therapeutic Strategy for Alzheimer’s Disease

G Evin, SJ Fuller, JM Gunnersen

Book Chapter  |  2015

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and the most common cause of dementia. One of th..

How accelerated Golgi trafficking may drive Alzheimer's disease

Genevieve Evin

Report  |  2015  |  BioEssays

BACE1 as a Therapeutic Target in Alzheimer's Disease: Rationale and Current Status

Genevieve Evin, Christopher Hince

Journal article  |  2013  |  DRUGS & AGING

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLOS ONE

Platelets and Alzheimer's disease: Potential of APP as a biomarker.

Geneviève Evin, Qiao-Xin Li

Journal article  |  2012  |  World Journal of Psychiatry

Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the proteolytic machinery to produce Aβ..

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Hongyun Li, Genevieve Evin, Andrew F Hill, Ya Hui Hung, Ashley I Bush, Brett Garner

Journal article  |  2012  |  CLINICAL SCIENCE

ss-Site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis

Jiangli Tan, Genevieve Evin

Journal article  |  2012  |  Journal of Neurochemistry

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A Bellingham, Michael Ho, Jiangli Tan, Andrew F Hill, Colin L Masters, Catriona McLean, Genevieve Evin

Journal article  |  2011  |  Neurobiology of Disease

BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity.

Genevieve Evin, Guillaume Lessene, Simon Wilkins

Journal article  |  2011  |  Recent Patents on CNS Drug Discovery

Current drug development for the treatment of Alzheimer's Disease is principally based on the amyloid cascade theory, and aims to ..

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

Mark A Greenough, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Genevieve Evin, Michael Ho, Andrew H Dalziel, James Camakaris, Ashley I Bush

Journal article  |  2011  |  Journal of Biological Chemistry

p75NTR Regulates A beta Deposition by Increasing A beta Production But Inhibiting A beta Aggregation with Its Extracellular Domain

Yan-Jiang Wang, Xin Wang, Jian-Jun Lu, Qiao-Xin Li, Chang-Yue Gao, Xiao-Hong Liu, Yin Sun, Miao Yang, Yoon Lim, Genevieve Evin, Jin-Hua Zhong, Colin Masters, Xin-Fu Zhou

Journal article  |  2011  |  Journal of Neuroscience

Investigation of Matrix Metalloproteinases, MMP-2 and MMP-9, in Plasma Reveals a Decrease of MMP-2 in Alzheimer's Disease

Nastasia K-H Lim, Victor L Villemagne, Cynthia PW Soon, Katrina M Laughton, Christopher C Rowe, Catriona A McLean, Colin L Masters, Genevieve Evin, Qiao-Xin Li

Journal article  |  2011  |  Journal of Alzheimer's Disease

Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-beta Production Independent of Cholesterol Efflux Activity

Woojin S Kim, Andrew F Hill, Michael L Fitzgerald, Mason W Freeman, Genevieve Evin, Brett Garner

Journal article  |  2011  |  Journal of Alzheimer's Disease

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.

Michael Ho, David E Hoke, Yee Jia Chua, Qiao-Xin Li, Janetta G Culvenor, Colin Masters, Anthony R White, Geneviève Evin

Journal article  |  2010  |  International Journal of Alzheimer's Disease

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor..

Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia

Adel Barakat, Brian Dean, Elizabeth Scarr, Genevieve Evin

Journal article  |  2010  |  Schizophrenia Research

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

Genevieve Evin, Adel Barakat, Colin L Masters

Journal article  |  2010  |  The International Journal of Biochemistry & Cell Biology

Modulation of amyloid precursor protein processing by synthetic ceramide analogues

Hongyun Li, Woojin S Kim, Gilles J Guillemin, Andrew F Hill, Genevieve Evin, Brett Garner

Journal article  |  2010  |  Biochimica et Biophysica Acta: Molecular and Cell biology of Lipids

A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease

Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.

Journal article  |  2010  |  Proteomics

DECREASED NEUREGULIN C-TERMINAL FRAGMENTS IN SCHIZOPHRENIA PREFRONTAL CORTEX BRODMANN'S AREA 6

Adel Barakat, Elizabeth L Scarr, Brian Dean, Genevieve Evin

Conference Proceedings  |  2010  |  Schizophrenia Research

Modulation of amyloid precursor protein processing by synthetic ceramide analogues.

H Li, WS Lom, G Guillemin, AF Hill, GM Evin, B Ganner

Journal article  |  2010  |  Biochimica et Biophysica Acta: Molecular and Cell biology of Lipids

Paradoxical Condensation of Copper with Elevated beta-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions IMPLICATIONS FOR ALZHEIMER DISEASE

Ya Hui Hung, Elysia L Robb, Irene Volitakis, Michael Ho, Genevieve Evin, Qiao-Xin Li, Janetta G Culvenor, Colin L Masters, Robert A Cherny, Ashley I Bush

Journal article  |  2009  |  Journal of Biological Chemistry

Gamma-secretase modulators: hopes and setbacks for the future of Alzheimer's treatment.

Genevieve Evin

Journal article  |  2008  |  Expert Review of Neurotherapeutics

Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation

Maria-Ximena Silveyra, Genevieve Evin, Maria-Fernanda Montenegro, Cecilio J Vidal, Salvador Martinez, Janetta G Culvenor, Javier Saez-Valero

Journal article  |  2008  |  Molecular and Cellular Biology

BACE inhibitors as potential therapeutics for Alzheimer's disease.

Genevieve Evin, Vijaya B Kenche

Journal article  |  2007  |  Recent Pat CNS Drug Discov

Accumulation of Abeta peptide in the brain results in the formation of amyloid plaques characteristic of Alzheimer's disease (AD) ..

Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases

AR White, T Du, KM Laughton, I Volitakis, RA Sharples, DE Hoke, RMD Holsinger, G Evin, RA Cherny, AF Hill, KJ Barnham, QX Li, A Bush, CL Masters

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

Anthony R White, Tai Du, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Michel E Xilinas, David E Hoke, RM Damian Holsinger, Genevieve Evin, Robert A Cherny, Andrew F Hill, Kevin J Barnham, Qiao-Xin Li, Ashley I Bush, Colin L Masters

Journal article  |  2006  |  Journal of Biological Chemistry

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease - Prospects, limitations and strategies

G EVIN, M SERNEE, C MASTERS

Journal article  |  2006  |  CNS Drugs

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease - Prospects, limitations and strategies

Genevieve Evin, Marijke Fleur Sernee, Colin L Masters

Journal article  |  2006  |  CNS Drugs

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

DE Hoke, JL Tan, NT Ilaya, JG Culvenor, SJ Smith, AR White, CL Masters, GM Evin

Journal article  |  2005  |  The FEBS Journal

Comparison of endogenous gamma-secretase activity in mouse peripheral tissues and brain

NT Ilaya, D Hoke, G Evin, CL Masters, JG Culvenor

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex

G Evin, LD Canterford, DE Hoke, RA Sharples, JG Culvenor, CL Masters

Journal article  |  2005  |  Biochemistry

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

MJ Chiocco, LS Kulnane, L Younkin, S Younkin, G Evin, BT Lamb

Journal article  |  2004  |  Journal of Biological Chemistry

Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle

NT Ilaya, G Evin, CL Masters, JG Culvenor

Journal article  |  2004  |  Journal of Neurochemistry

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex

MJ Smith, RA Sharples, G Evin, CA McLean, B Dean, G Pavey, E Fantino, RGH Cotton, K Imaizumi, CL Masters, R Cappai, JG Culvenor

Journal article  |  2004  |  Molecular Brain Research

Analysis of BACE protein and activity in human cerebrospinal fluid

RMD Holsinger, CA McLean, CL Masters, G Evin

Conference Proceedings  |  2004  |  NEUROBIOLOGY OF AGING

Nicastrin expression is not coordinated with presenilin level in mouse systemic tissues

NT Ilaya, G Evin, CL Masters, JG Culvenor

Conference Proceedings  |  2004  |  Neurobiology of Aging

Gamma-secretase inhibitors stabilize a 900 KDA presenilin complex: A tetrameric model for gamma-secretase

G Evin, LD Canterford, DE Hoke, RMD Holsinger, JG Culvenor, CL Masters

Conference Proceedings  |  2004  |  Neurobiology of Aging

Increased beta-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects

RMD Holsinger, CA McLean, SJ Collins, CL Masters, GV Evin

Journal article  |  2004  |  Annals of Neurology

APP intracellular domain is increased and soluble A beta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

AJ George, RMD Holsinger, CA McLean, KM Laughton, K Beyreuther, G Evin, CL Masters, QX Li

Journal article  |  2004  |  Neurobiology of Disease

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages - Modulation of APLP-1 processing by N-glycosylation

S Eggert, K Paliga, P Soba, G Evin, CL Masters, A Weidemann, K Beyreuther

Journal article  |  2004  |  Journal of Biological Chemistry

Effects of rhodiola on Alzheimer pathology and open field activity in APP-C100 transgenic mice

A ZHU, Q LI, XS ZHANG, CQ TENG, YD CHU, CL MASTERS, AJ GEORGE, K CARDAMONE, GM EVIN

Journal article  |  2004  |  Chinese Journal of Gerontology

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

JG Culvenor, NT Ilaya, MT Ryan, L Canterford, DE Hoke, NA Williamson, CA McLean, CL Masters, G Evin

Journal article  |  2004  |  European Journal of Biochemistry

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-link cleavages

S EGGERT, K PALIGA, P SOBA, GM EVIN, CL MASTERS, A WEIDEMANN, K BEYREUTHER

Journal article  |  2004  |  Journal of Biological Chemistry

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets

G Evin, AQ Zhu, RMD Holsinger, CL Masters, QX Li

Journal article  |  2003  |  Journal of Neuroscience Research

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS - Differential effect of presenilin exon 9 deletion on gamma- and epsilon-cleavage

MF Sernee, G Evin, JG Culvenor, JA Villadangos, K Beyreuther, CL Masters, R Cappai

Journal article  |  2003  |  European Journal of Biochemistry

Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

Biogenesis and metabolism of Alzheimer's disease A beta amyloid peptides

G Evin, A Weidemann

Journal article  |  2002  |  Peptides

The proteolytic processing of the APP gene family members APLP-1 and APLP-2

S Eggert, A Weidemann, P Soba, S Kins, K Beyreuther, K Paliga, G Evin, C Masters

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

APP C-terminal fragments in Alzheimer's disease brain

G Evin, RMD Holsinger, L Canterford, DE Hoke, CL Masters, S Eggert, A Weidemann, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

BACE and beta-secretase product CTF beta are increased in sporadic Alzheimer's disease brain

RMD Holsinger, CA McLean, CL Masters, G Evin, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

A fluorescent assay to monitor gamma-secretase activity on APP and notch substrates

F Sernee, G Evin, J Culvenor, C Masters, R Cappai, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

RMD Holsinger, CA McLean, K Beyreuther, CL Masters, G Evin

Journal article  |  2002  |  Annals of Neurology

Erratum: Alternative transcripts of presenilin-1 associated with frontotemporal dementia (NeuroReport 13:5 (719-723))

G Evin

Journal article  |  2002  |  NeuroReport

Alternative transcripts of presenilin-I associated with frontotemporal dementia

G Evin, MJ Smith, AF Tziotis, C McLean, L Canterford, RA Sharples, R Cappai, A Weidemann, K Beyreuther, RGH Cotton, CL Masters, JG Culvenor

Journal article  |  2002  |  NeuroReport

Alternative transcripts of presenilin-1 associated with frontotemporal dementia

Geneviève Evin, Margaret J Smith, Angela Tziotis, Catriona McLean, Louise Canterford, Robyn A Sharples, Roberto Cappai, Andreas Weidemann, Konrad Beyreuther, Richard GH Cotton, Colin L Masters, Janetta G Culvenor

Journal article  |  2002  |  NeuroReport

Alternative transcripts of presenilin-I associated with frontotemporal dementia

G Evin, MJ Smith, A Tziotis, C McLean, L Canterford, RA Sharples, R Cappai, A Weidemann, K Beyreuther, RGH Cotton, CL Masters, JG Culvenor

Journal article  |  2002  |  Neuroreport

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with notch processing

A Weidemann, S Eggert, FBM Reinhard, M Vogel, K Paliga, G Baier, CL Masters, K Beyreuther, G Evin

Journal article  |  2002  |  Biochemistry

Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer's disease brain: detection of [gamma]-secretase products

GM EVIN, RMD HOLSINGER, S EGGERT, A WEIDEMANN, LD CANTERFORD, DE HOKE, S GANDY, CA MCLEAN, K BEYREUTHER, CL MASTERS

Journal article  |  2002  |  Brain Aging International Journal

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology

D Beher, JDJ Wrigley, A Nadin, G Evin, CL Masters, T Harrison, JL Castro, MS Shearman

Journal article  |  2001  |  Journal of Biological Chemistry

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

J Nunan, MS Shearman, F Checler, R Cappai, G Evin, K Beyreuther, CL Masters, DH Small

Journal article  |  2001  |  European Journal of Biochemistry

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease

G Evin, RA Sharples, A Weidemann, FBM Reinhard, V Carbone, JG Culvenor, RMD Holsinger, MF Sernee, K Beyreuther, CL Masters

Journal article  |  2001  |  Biochemistry

Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue

RN Martins, K Taddei, C Kendall, G Evin, KA Bates, AR Harvey

Journal article  |  2001  |  Neuroscience

Pharmacological knock-down of the Presenilin 1 heterodimer by a novel [gamma]-secretase inhibitor

D BEHER, JDJ WRIGLEY, A NADIN, GM EVIN, CL MASTERS, T HARRISON, JL CASTRO, MS SHEARMAN

Journal article  |  2001  |  Journal of Biological Chemistry

Presenilin 2 expression in neuronal cells: Induction during differentiation of embryonic carcinoma cells

JG Culvenor, G Evin, MA Gooney, H Wardan, RA Sharples, F Maher, G Reed, A Diehlmann, A Weidemann, K Beyreuther, CL Masters

Journal article  |  2000  |  Experimental Cell Research

Presenilin I expression in yeast lowers secretion of the amyloid precursor protein

G Evin, D Le Brocque, JG Culvenor, D Galatis, A Weidemann, K Beyreuther, CL Masters, R Cappai

Journal article  |  2000  |  NeuroReport

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases

A Weidemann, K Paliga, U Durrwang, FBM Reinhard, O Schuckert, G Evin, CL Masters

Journal article  |  1999  |  Journal of Biological Chemistry

Cleavage of the Alzheimer's disease amyloid precursor protein during apoptosis by activated caspases

A Weidemann, K Paliga, U Durrwang, FBM Reinhard, G Evin, CL Masters, K Beyreuther

Conference Proceedings  |  1999  |  ALZHEIMER'S DISEASE AND RELATED DISORDERS

Characterization of gamma-secretase candidates from human brain using a new Western blot assay

G Evin, G Reed, JE Tanner, QX Li, JG Culvenor, SJ Fuller, H Wadsworth, D Allsop, RV Ward, EH Karran, CW Gray, T Hartmann, SF Lichtenthaler, A Weidemann, K Beyreuther, CL Masters

Conference Proceedings  |  1999  |  ALZHEIMER'S DISEASE AND RELATED DISORDERS

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: Immunodetection of alpha-, beta-, and gamma-secretase products

D Le Brocque, A Henry, R Cappai, QX Li, JE Tanner, D Galatis, C Gray, S Holmes, JR Underwood, K Beyreuther, CL Masters, G Evin

Journal article  |  1998  |  Biochemistry

Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system

JG Culvenor, A Henry, T Hartmann, G Evin, D Galatis, A Friedhuber, ULHR Jayasena, JR Underwood, K Beyreuther, CL Masters, R Cappai

Journal article  |  1998  |  Amyloid

Secretion of Alzheimer's disease A beta amyloid peptide by activated human platelets

QX Li, S Whyte, JE Tanner, G Evin, K Beyreuther, CL Masters

Journal article  |  1998  |  Laboratory Investigation

Products of the Alzheimer's disease amyloid precursor protein generated by,β-secretase are present in human platelets, and secreted upon degranulation

QX Li, R Cappai, G Evin, JE Tanner, CW Gray, K Beyreuther, CL Masters

Journal article  |  1998  |  American Journal of Alzheimer's Disease

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum Golgi intermediate compartment

JG Culvenor, F Maher, G Evin, F MalchiodiAlbedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters

Journal article  |  1997  |  Journal of Neuroscience Research

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.

JG Culvenor, F Maher, G Evin, F Malchiodi-Albedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters

Journal article  |  1997  |  Journal of Neuroscience Research

The recently identified Alzheimer's disease-associated presenilin 1 and 2 (PS1 and PS2) genes encode two homologous multi membrane..

Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and beta-amyloid precursor protein

A Weidemann, K Paliga, U Durrwang, C Czech, G Evin, CL Masters, K Beyreuther

Journal article  |  1997  |  Nature Medicine

A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments

SS Mok, G Evin, QX Li, AI Smith, K Beyreuther, CL Masters, DH Small

Journal article  |  1997  |  Biochemistry

The amyloidogenic A beta fragment of Alzheimer's disease is released from human platelets

QX Li, S Whyte, JE Tanner, G Evin, K Beyreuther, CL Masters

Journal article  |  1997  |  JOURNAL OF NEUROCHEMISTRY

A metalloprotease isolated from rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments.

SS Mok, G Evin, QX Li, K Beyreuther, CL Masters, DH Small

Journal article  |  1997  |  JOURNAL OF NEUROCHEMISTRY

Studies on inhibition of beta-amyloid formation in APP751-transfected IMR-32 cells, and SPA4CT-transfected SHSY5Y cells

D Allsop, G Christie, C Gray, S Holmes, R Markwell, D Owen, L Smith, H Wadsworth, RV Ward, T Hartmann, SF Lichtenthaler, G Evin, S Fuller, J Tanner, CL Masters, K Beyreuther, GW Roberts

Conference Proceedings  |  1997  |  ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS

Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease

RN LePage, AJ Fosang, SJ Fuller, G Murphy, G Evin, K Beyreuther, CL Masters, DH Small

Journal article  |  1995  |  FEBS Letters

CANDIDATE GAMMA-SECRETASES IN THE GENERATION OF THE CARBOXYL-TERMINUS OF THE ALZHEIMERS-DISEASE BETA-A4 AMYLOID - POSSIBLE INVOLVEMENT OF CATHEPSIN-D

G EVIN, R CAPPAI, QX LI, JG CULVENOR, DH SMALL, K BEYREUTHER, CL MASTERS

Journal article  |  1995  |  Biochemistry

PROTEOLYTIC PROCESSING OF ALZHEIMERS-DISEASE BETA-A4 AMYLOID PRECURSOR PROTEIN IN HUMAN PLATELETS

QX LI, G EVIN, DH SMALL, G MULTHAUP, K BEYREUTHER, CL MASTERS

Journal article  |  1995  |  Journal of Biological Chemistry

A synthetic substrate assay for the gamma-secretase of the beta-A4 amyloid of Alzheimer's disease.

G Evin, K Beyreuther, CL Masters

Journal article  |  1995  |  Journal of Peptide Science

gamma-secretase, the endoprotease which releases the C-terminus of beta A4 amyloid peptide, cleaves within the hydrophobic transme..

ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN (A-BETA-PP) - PROTEOLYTIC PROCESSING, SECRETASES AND BETA-A4 AMYLOID PRODUCTION

G EVIN, K BEYREUTHER, CL MASTERS

Journal article  |  1994  |  Amyloid

A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine (J. Immunol. Methods 140 (1991) 249-258)

LM Khachigian, G Evin, FJ Morgan, DA Owensby, CN Chesterman

Journal article  |  1992  |  Journal of Immunological Methods

A CROSS-REACTIVE ANTIPEPTIDE MONOCLONAL-ANTIBODY WITH SPECIFICITY FOR LYSYL-LYSINE

LM KHACHIGIAN, G EVIN, FJ MORGAN, DA OWENSBY, CN CHESTERMAN

Journal article  |  1991  |  Journal of Immunological Methods

AN ALTERNATIVE STRATEGY FOR THE RADIOIMMUNOASSAY OF ANGIOTENSIN PEPTIDES USING AMINO-TERMINAL-DIRECTED ANTISERA - MEASUREMENT OF 8 ANGIOTENSIN PEPTIDES IN HUMAN PLASMA

AC LAWRENCE, G EVIN, A KLADIS, DJ CAMPBELL

Journal article  |  1990  |  Journal of Hypertension

THE BA4 AMYLOID PROTEIN AND ITS PRECURSORS AS BIOLOGICAL MARKERS FOR ALZHEIMERS-DISEASE

CL MASTERS, A BUSH, G EVIN, S FULLER, QX LI, I MACKENZIE, E MILWARD, R MOIR, D SMALL, K BEYREUTHER

Journal article  |  1990  |  Neurobiology of Aging

PRELIMINARY-X-RAY DIFFRACTION ANALYSIS OF HUMAN CHORIONIC-GONADOTROPIN

DC HARRIS, KJ MACHIN, GM EVIN, FJ MORGAN, NW ISAACS

Journal article  |  1989  |  Journal of Biological Chemistry

PRODUCTION AND CHARACTERIZATION OF HUMAN RENIN ANTIBODIES PREPARED WITH SYNTHETIC IMMUNOGENS

FX GALEN, G EVIN, C CARELLI, J BOUHNIK, JB MICHEL, JA FERHENTZ, D LENGUYEN, R SEYER, WD CARLSON, E HABER, B CASTRO, P CORVOL

Journal article  |  1988  |  Archives des Maladies du Coeur et des Vaisseaux

CHARACTERIZATION OF 5 EPITOPES OF HUMAN RENIN FROM A COMPUTER-MODEL

G EVIN, FX GALEN, WD CARLSON, M HANDSCHUMACHER, J NOVOTNY, J BOUHNIK, J MENARD, P CORVOL, E HABER

Journal article  |  1988  |  Biochemistry

Production and characterization of human renin antibodies prepared with synthetic immunogens.

FX Galen, G Evin, C Carelli, J Bouhnik, JB Michel, JA Ferhentz, D Le N'Guyen, R Seyer, WD Carlson, E Haber

Journal article  |  1987  |  Journal of Hypertension

Renin is an aspartyl protease that plays a key role in regulating blood pressure. The aim of this study was to use synthetic pepti..

CHEMICAL APPROACH OF SYNTHETIC IMMUNOGENS FROM HUMAN RENIN

FX GALEN, G EVIN, C CARELLI, J BOUHNIK, JB MICHEL, JA FERHENTZ, D LENGUYEN, R SEYER, WD CARLSON, B CASTRO, P CORVOL

Journal article  |  1987  |  International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

IDENTIFICATION OF 4 EPITOPES OF HUMAN RENIN AND DEFINITION OF THE CONFORMATIONAL REQUIREMENT FOR ONE EPITOPE

G EVIN, WD CARLSON, M HANDSCHUMACHER, J NOVOTNY, GR MATSUEDA, E HABER, FX GALEN, J BOUHNIK, J MENARD, P CORVOL

Conference Proceedings  |  1986  |  JOURNAL OF HYPERTENSION

HUMAN-PLASMA AND KIDNEY INACTIVE RENIN IS PRORENIN

FX GALEN, JA FEHRENTZ, J BOUHNIK, R SEYER, G EVIN, B CASTRO, J MENARD, P CORVOL

Conference Proceedings  |  1986  |  Journal of Hypertension

PEPSTATIN ANALOGS AS NOVEL RENIN INHIBITORS

R GUEGAN, J DIAZ, C CAZAUBON, M BEAUMONT, C CARLET, J CLEMENT, H DEMARNE, M MELLET, JP RICHAUD, D SEGONDY, M VEDEL, JP GAGNOL, R RONCUCCI, B CASTRO, P CORVOL, G EVIN, BP ROQUES

Journal article  |  1986  |  Journal of Medicinal Chemistry

IMMUNOHISTOCHEMICAL VISUALIZATION OF SEROTONIN AND MELATONIN IN THE SHEEP PINEAL-GLAND USING SPECIFIC ANTIBODIES

Y TILLET, JP RAVAULT, C SELVE, G EVIN, B CASTRO, MP DUBOIS

Journal article  |  1986  |  Comptes Rendus de l'Academie des Sciences - Serie III

INACTIVE RENIN IS PRORENIN

FX GALEN, JA FEHRENTZ, J BOUHNIK, R SEYER, G EVIN, B CASTRO, J MENARD, P CORVOL

Conference Proceedings  |  1986  |  ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX

STUDY OF THE ANTIGENIC DETERMINANTS OF HUMAN RENIN

G EVIN, WD CARLSON, M HANDSCHUMACHER, J NOVOTNY, GR MATSUEDA, E HABER, J BOUHNIK, FX GALEN, J MENARD, P CORVOL

Journal article  |  1986  |  HYPERTENSION

Study of the antigenic determinants of human renin.

G Evin, WD Carlson, M Handschumacher, J Novotný, GR Matsueda, E Haber, J Bouhnik, FX Galen, J Ménard, P Corvol

Journal article  |  1986  |  Hypertension

The primary structure of human renin, recently established from the complementary DNA sequence of its messenger RNA, shows a stron..

INVITRO AND INVIVO INHIBITION OF HUMAN AND PRIMATE RENIN BY A NEW POTENT RENIN INHIBITOR - SR 42128

M DECLAVIERE, C CAZAUBON, C LACOUR, D NISATO, JP GAGNOL, G EVIN, P CORVOL

Journal article  |  1985  |  Journal of Cardiovascular Pharmacology

IMMUNOLOGICAL IDENTIFICATION OF BOTH PLASMA AND HUMAN RENAL INACTIVE RENIN AS PRORENIN

J BOUHNIK, JA FEHRENTZ, FX GALEN, R SEYER, G EVIN, B CASTRO, J MENARD, P CORVOL

Journal article  |  1985  |  The Journal of Clinical Endocrinology & Metabolism

In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor: SR 42128.

M De Claviere, C Cazaubon, C Lacour, D Nisato, JP Gagnol, G Evin, P Corvol

Journal article  |  1985  |  Journal of Cardiovascular Pharmacology

A new potent renin inhibitor, Iva-Phe-Nle-Sta-Ala-Sta-OH (SR 42128), and its arginine salt (SR 42128A) have been synthesized. This..

INHIBITION OF HUMAN RENIN BY SYNTHETIC PEPTIDES DERIVED FROM ITS PROSEGMENT

F CUMIN, G EVIN, JA FEHRENTZ, R SEYER, B CASTRO, J MENARD, P CORVOL

Journal article  |  1985  |  Journal of Biological Chemistry

STUDY OF THE ANTIGENIC DETERMINANTS OF HUMAN RENIN

G EVIN, W CARLSON, M HANDSCHUMACHER, J NOVOTNY, G MATSUEDA, E HABER, J BOUHNIK, FX GALEN, J MENARD, P CORVOL

Conference Proceedings  |  1985  |  CIRCULATION

Renin inhibition by synthetic peptides related to mouse and human renin prosegments.

G Evin, F Cumin, J Ménard, P Corvol, JA Fehrentz, R Seyer, B Castro

Journal article  |  1984  |  Journal of Hypertension

Recently the nucleotide sequences of the genes coding for mouse and human renins have been elucidated and the primary structures o..

SYNTHESIS OF PEPTIDES RELATED TO THE PROSEGMENT OF MOUSE SUBMAXILLARY-GLAND RENIN PRECURSOR - AN APPROACH TO RENIN INHIBITORS

G EVIN, J DEVIN, B CASTRO, J MENARD, P CORVOL

Journal article  |  1984  |  Proceedings of the National Academy of Sciences

INHIBITION OF THE RENIN SYSTEM AT THE LEVEL OF THE RENIN-SUBSTRATE REACTION

P CORVOL, JB MICHEL, G EVIN, J GARDES, B CASTRO, J MENARD

Journal article  |  1983  |  Annales d'Endocrinologie

NEW RENIN INHIBITORS HOMOLOGOUS WITH PEPSTATIN

M EID, G EVIN, B CASTRO, J MENARD, P CORVOL

Journal article  |  1981  |  Biochemical Journal

SYNTHESIS AND RENIN INHIBITORY PROPERTIES OF A NEW SOLUBLE PEPSTATIN DERIVATIVE

J GARDES, G EVIN, B CASTRO, P CORVOL, J MENARD

Journal article  |  1980  |  Journal of Cardiovascular Pharmacology

A SUBSTRATE-ANALOG INHIBITOR OF RENIN THAT IS EFFECTIVE INVIVO

RJ CODY, J BURTON, G EVIN, K POULSEN, JA HERD, E HABER

Journal article  |  1980  |  Biochemical and Biophysical Research Communications

SOLUBLE PEPSTATINS - NEW APPROACH TO BLOCKADE INVIVO OF THE RENIN-ANGIOTENSIN SYSTEM

G EVIN, J GARDES, C KREFT, B CASTRO, P CORVOL, J MENARD

Journal article  |  1978  |  Clinical Science

PEPTIDE COUPLING REAGENTS .8. HIGH-YIELD PREPARATION OF PHENYL ESTERS OF AMINO-ACIDS USING BENZOTRIAZOLYLOXYTRIS[DIMETHYLAMINO]PHOSPHONIUM HEXAFLUOROPHOSPHATE (BOP REAGENT)

B CASTRO, G EVIN, C SELVE, R SEYER

Journal article  |  1977  |  Synthesis

PEPTIDE COUPLING REAGENTS .6. NOVEL, CHEAPER PREPARATION OF BENZOTRIAZOLYLOXYTRIS[DIMETHYLAMINO]PHOSPHONIUM HEXAFLUOROPHOSPHATE (BOP REAGENT)

B CASTRO, JR DORMOY, B DOURTOGLOU, G EVIN, C SELVE, JC ZIEGLER

Journal article  |  1976  |  Synthesis

REACTIONS OF PEPTIDE BOND .4. BENZOTRIAZONYL-N-OXYTRIDIMELTHYLAMINO PHOSPHONIUM HEXAFLUOROPHOSPHATE (BOP)

B CASTRO, JR DORMOY, G EVIN, C SELVE

Journal article  |  1975  |  TETRAHEDRON LETTERS

Reactifs de couplage peptidique I (1) - l'hexafluorophosphate de benzotriazolyl N-oxytrisdimethylamino phosphonium (B.O.P.)

B Castro, JR Dormoy, G Evin, C Selve

Journal article  |  1975  |  Tetrahedron Letters