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Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Proc..
The Potential Of Bace As A Blood Biomarker For Early Detection Of Alzheimer'S Disease
Displaying the 9 most recent projects by Genevieve Evin.
Displaying the 118 most recent scholarly works by Genevieve Evin.
Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein
Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin
Journal article | 2013 | PLOS ONE
Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A Bellingham, Michael Ho, Jiangli Tan, Andrew F Hill, Colin L Masters, Catriona McLean, Genevieve Evin
Journal article | 2011 | Neurobiology of Disease
BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity.
Genevieve Evin, Guillaume Lessene, Simon Wilkins
Journal article | 2011 | Recent Patents on CNS Drug Discovery
Current drug development for the treatment of Alzheimer's Disease is principally based on the amyloid cascade theory, and aims to ..
Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity
Mark A Greenough, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Genevieve Evin, Michael Ho, Andrew H Dalziel, James Camakaris, Ashley I Bush
Journal article | 2011 | Journal of Biological Chemistry
p75NTR Regulates A beta Deposition by Increasing A beta Production But Inhibiting A beta Aggregation with Its Extracellular Domain
Yan-Jiang Wang, Xin Wang, Jian-Jun Lu, Qiao-Xin Li, Chang-Yue Gao, Xiao-Hong Liu, Yin Sun, Miao Yang, Yoon Lim, Genevieve Evin, Jin-Hua Zhong, Colin Masters, Xin-Fu Zhou
Journal article | 2011 | Journal of Neuroscience
Investigation of Matrix Metalloproteinases, MMP-2 and MMP-9, in Plasma Reveals a Decrease of MMP-2 in Alzheimer's Disease
Nastasia K-H Lim, Victor L Villemagne, Cynthia PW Soon, Katrina M Laughton, Christopher C Rowe, Catriona A McLean, Colin L Masters, Genevieve Evin, Qiao-Xin Li
Journal article | 2011 | Journal of Alzheimer's Disease
Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.
Michael Ho, David E Hoke, Yee Jia Chua, Qiao-Xin Li, Janetta G Culvenor, Colin Masters, Anthony R White, Geneviève Evin
Journal article | 2010 | International Journal of Alzheimer's Disease
Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor..
A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease
Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.
Journal article | 2010 | Proteomics
Paradoxical Condensation of Copper with Elevated beta-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions IMPLICATIONS FOR ALZHEIMER DISEASE
Ya Hui Hung, Elysia L Robb, Irene Volitakis, Michael Ho, Genevieve Evin, Qiao-Xin Li, Janetta G Culvenor, Colin L Masters, Robert A Cherny, Ashley I Bush
Journal article | 2009 | Journal of Biological Chemistry
Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases
AR White, T Du, KM Laughton, I Volitakis, RA Sharples, DE Hoke, RMD Holsinger, G Evin, RA Cherny, AF Hill, KJ Barnham, QX Li, A Bush, CL Masters
Conference Proceedings | 2006 | JOURNAL OF NEUROCHEMISTRY
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
Anthony R White, Tai Du, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Michel E Xilinas, David E Hoke, RM Damian Holsinger, Genevieve Evin, Robert A Cherny, Andrew F Hill, Kevin J Barnham, Qiao-Xin Li, Ashley I Bush, Colin L Masters
Journal article | 2006 | Journal of Biological Chemistry
Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
MJ Smith, RA Sharples, G Evin, CA McLean, B Dean, G Pavey, E Fantino, RGH Cotton, K Imaizumi, CL Masters, R Cappai, JG Culvenor
Journal article | 2004 | Molecular Brain Research
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages - Modulation of APLP-1 processing by N-glycosylation
S Eggert, K Paliga, P Soba, G Evin, CL Masters, A Weidemann, K Beyreuther
Journal article | 2004 | Journal of Biological Chemistry
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
JG Culvenor, NT Ilaya, MT Ryan, L Canterford, DE Hoke, NA Williamson, CA McLean, CL Masters, G Evin
Journal article | 2004 | European Journal of Biochemistry
Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS - Differential effect of presenilin exon 9 deletion on gamma- and epsilon-cleavage
MF Sernee, G Evin, JG Culvenor, JA Villadangos, K Beyreuther, CL Masters, R Cappai
Journal article | 2003 | European Journal of Biochemistry
Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.
Book Chapter | 2003
Alternative transcripts of presenilin-1 associated with frontotemporal dementia
Geneviève Evin, Margaret J Smith, Angela Tziotis, Catriona McLean, Louise Canterford, Robyn A Sharples, Roberto Cappai, Andreas Weidemann, Konrad Beyreuther, Richard GH Cotton, Colin L Masters, Janetta G Culvenor
Journal article | 2002 | NeuroReport
Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer's disease brain: detection of [gamma]-secretase products
GM EVIN, RMD HOLSINGER, S EGGERT, A WEIDEMANN, LD CANTERFORD, DE HOKE, S GANDY, CA MCLEAN, K BEYREUTHER, CL MASTERS
Journal article | 2002 | Brain Aging International Journal
Characterization of gamma-secretase candidates from human brain using a new Western blot assay
G Evin, G Reed, JE Tanner, QX Li, JG Culvenor, SJ Fuller, H Wadsworth, D Allsop, RV Ward, EH Karran, CW Gray, T Hartmann, SF Lichtenthaler, A Weidemann, K Beyreuther, CL Masters
Conference Proceedings | 1999 | ALZHEIMER'S DISEASE AND RELATED DISORDERS
Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: Immunodetection of alpha-, beta-, and gamma-secretase products
D Le Brocque, A Henry, R Cappai, QX Li, JE Tanner, D Galatis, C Gray, S Holmes, JR Underwood, K Beyreuther, CL Masters, G Evin
Journal article | 1998 | Biochemistry
Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system
JG Culvenor, A Henry, T Hartmann, G Evin, D Galatis, A Friedhuber, ULHR Jayasena, JR Underwood, K Beyreuther, CL Masters, R Cappai
Journal article | 1998 | Amyloid
Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum Golgi intermediate compartment
JG Culvenor, F Maher, G Evin, F MalchiodiAlbedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters
Journal article | 1997 | Journal of Neuroscience Research
Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.
JG Culvenor, F Maher, G Evin, F Malchiodi-Albedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters
Journal article | 1997 | Journal of Neuroscience Research
The recently identified Alzheimer's disease-associated presenilin 1 and 2 (PS1 and PS2) genes encode two homologous multi membrane..
Studies on inhibition of beta-amyloid formation in APP751-transfected IMR-32 cells, and SPA4CT-transfected SHSY5Y cells
D Allsop, G Christie, C Gray, S Holmes, R Markwell, D Owen, L Smith, H Wadsworth, RV Ward, T Hartmann, SF Lichtenthaler, G Evin, S Fuller, J Tanner, CL Masters, K Beyreuther, GW Roberts
Conference Proceedings | 1997 | ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS
A synthetic substrate assay for the gamma-secretase of the beta-A4 amyloid of Alzheimer's disease.
G Evin, K Beyreuther, CL Masters
Journal article | 1995 | Journal of Peptide Science
gamma-secretase, the endoprotease which releases the C-terminus of beta A4 amyloid peptide, cleaves within the hydrophobic transme..
Production and characterization of human renin antibodies prepared with synthetic immunogens.
FX Galen, G Evin, C Carelli, J Bouhnik, JB Michel, JA Ferhentz, D Le N'Guyen, R Seyer, WD Carlson, E Haber
Journal article | 1987 | Journal of Hypertension
Renin is an aspartyl protease that plays a key role in regulating blood pressure. The aim of this study was to use synthetic pepti..
CHEMICAL APPROACH OF SYNTHETIC IMMUNOGENS FROM HUMAN RENIN
FX GALEN, G EVIN, C CARELLI, J BOUHNIK, JB MICHEL, JA FERHENTZ, D LENGUYEN, R SEYER, WD CARLSON, B CASTRO, P CORVOL
Journal article | 1987 | International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
Study of the antigenic determinants of human renin.
G Evin, WD Carlson, M Handschumacher, J Novotný, GR Matsueda, E Haber, J Bouhnik, FX Galen, J Ménard, P Corvol
Journal article | 1986 | Hypertension
The primary structure of human renin, recently established from the complementary DNA sequence of its messenger RNA, shows a stron..
In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor: SR 42128.
M De Claviere, C Cazaubon, C Lacour, D Nisato, JP Gagnol, G Evin, P Corvol
Journal article | 1985 | Journal of Cardiovascular Pharmacology
A new potent renin inhibitor, Iva-Phe-Nle-Sta-Ala-Sta-OH (SR 42128), and its arginine salt (SR 42128A) have been synthesized. This..
Renin inhibition by synthetic peptides related to mouse and human renin prosegments.
G Evin, F Cumin, J Ménard, P Corvol, JA Fehrentz, R Seyer, B Castro
Journal article | 1984 | Journal of Hypertension
Recently the nucleotide sequences of the genes coding for mouse and human renins have been elucidated and the primary structures o..
Themis Dept Access
Florey Department Of Neuroscience And Mental Health
Doctor of Science
University of Nancy I
Master of Science
University of Nancy I