Brendan Crabb

Impact of Victoria's Stage 3 lockdown on COVID-19 case numbers

Allan Saul, Nick Scott, Brendan S Crabb, Suman S Majumdar, Benjamin Coghlan, Margaret E Hellard

Journal article  |  2020  |  MEDICAL JOURNAL OF AUSTRALIA

Building momentum for malaria vaccine research and development: key considerations

Chetan E Chitnis, David Schellenberg, Johan Vekemans, Edwin J Asturias, Philip Bejon, Katharine A Collins, Brendan S Crabb, Socrates Herrera, Miriam Laufer, N Regina Rabinovich, Meta Roestenberg, Adelaide Shearley, Halidou Tinto, Marian Wentworth, Kate O'Brien, Pedro Alonso

Journal article  |  2020  |  MALARIA JOURNAL

To maintain momentum towards improved malaria control and elimination, a vaccine would be a key addition to the intervention toolk..

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha, et al.

Journal article  |  2020  |  PLOS MEDICINE

BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

Madeline G Dans, Greta E Weiss, Danny W Wilson, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson

Journal article  |  2020  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

With emerging resistance to frontline treatments, it is vital that new drugs are identified to target Plasmodium falciparum. One o..

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott

Journal article  |  2019  |  SCIENTIFIC REPORTS

We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved mod..

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

Daniel GW Alanine, Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R Donnellan, Nana K Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E Silk, Abhishek Jamwal, Jennifer M Marshall, Kazutoyo Miura, Lander Foquet, Sean C Elias, Genevieve M Labbe, Alexander D Douglas, Jing Jin, Ruth O Payne, Joseph J Illingworth, et al.

Journal article  |  2019  |  CELL

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines agains..

UNINTENDED PREGNANCY AND FAMILY PLANNING USE AMONG ANTENATAL ATTENDEES IN EAST NEW BRITAIN, PAPUA NEW GUINEA

Elizabeth Peach, Chris Morgan, Michelle Scoullar, Freya Fowkes, Elissa Kennedy, Stanley Luchters, Andrew Vallely, Lisa Vallely, Angela Kelly, Leanne Robinson, Brendan Crabb, Peter Siba, William Pomat, JG Beeson

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

The N-terminus of EXP2 forms the membrane-associated pore of the protein exporting translocon PTEX in Plasmodium falciparum

Paul R Sanders, Benjamin K Dickerman, Sarah C Charnaud, Paul A Ramsland, Brendan S Crabb, Paul R Gilson

Journal article  |  2019  |  JOURNAL OF BIOCHEMISTRY

In order to facilitate a number of processes including nutrient acquisition and immune evasion, malaria parasites extensively remo..

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2R gamma(null) Mouse Model of Malaria

Paul R Gilson, William Nguyen, William A Poole, Jose E Teixeira, Jennifer K Thompson, Kaiyuan Guo, Rebecca J Stewart, Trent D Ashton, Karen L White, Laura M Sanz, Francisco-Javier Gamo, Susan A Charman, Sergio Wittlin, James Duffy, Christopher J Tonkin, Wai-Hong Tham, Brendan S Crabb, Brian M Cooke, Christopher D Huston, Alan F Cowman, et al.

Journal article  |  2019  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, Plasmodium fa..

THE EFFECTIVENESS OF REPELLENT DELIVERED THROUGH VILLAGE HEALTH VOLUNTEERS ON MALARIA INCIDENCE IN SOUTHEAST MYANMAR: A STEPPED-WEDGE CLUSTER-RANDOMIZED CONTROLLED TRIAL

Paul Agius, Win Han Oo, Naanki Pasricha, Katherine O'Flaherty, Kyaw Zayar Aung, Aung Thi, Myat Mon Thein, Nyi Nyi Zaw, Htin Kyaw Thu, Wai Yan Min Htay, Aung Paing Soe, Nicole Romero, Zahra Razook, Alyssa Barry, Angela Devine, Julie Simpson, Brendan S Crabb, James G Beeson, Julia Cutts, Freya J Fowkes

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE