Brendan Crabb

Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines

Damien R Drew, Danny W Wilson, Gretchen E Weiss, Lee M Yeoh, Isabelle G Henshall, Brendan S Crabb, Sheetij Dutta, Paul R Gilson, James G Beeson

Journal article  |  2023  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Plasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE A..

Low knowledge of newborn danger signs among pregnant women in Papua New Guinea and implications for health seeking behaviour in early infancy - findings from a longitudinal study.

Donya Eghrari, Michelle JL Scoullar, Alyce N Wilson, Elizabeth Peach, Arthur Elijah, Pele Melepia, Hadlee SupSup, Lisa M Vallely, Peter M Siba, Elissa C Kennedy, Joshua P Vogel, Caroline SE Homer, Leanne J Robinson, Freya JI Fowkes, William Pomat, Brendan S Crabb, James G Beeson, Christopher J Morgan

Journal article  |  2023  |  BMC Pregnancy Childbirth

BACKGROUND: Globally, 2.5 million babies die in the first 28 days of life each year with most of these deaths occurring in low- an..

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

Oliver Looker, Madeline G Dans, Hayley E Bullen, Brad E Sleebs, Brendan S Crabb, Paul R Gilson

Journal article  |  2022  |  TRAFFIC

Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. The..

The impact of three progressively introduced interventions on second wave daily COVID-19 case numbers in Melbourne, Australia.

Allan Saul, Nick Scott, Tim Spelman, Brendan S Crabb, Margaret Hellard

Journal article  |  2022  |  BMC Infect Dis

BACKGROUND: The city of Melbourne, Australia experienced two waves of the COVID-19 epidemic peaking, the first in March and a more..

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture

Hayley E Bullen, Paul R Sanders, Madeline G Dans, Thorey K Jonsdottir, David T Riglar, Oliver Looker, Catherine S Palmer, Betty Kouskousis, Sarah C Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo-Anne Chan, Tania F de Koning-Ward, Jake Baum, James W Kazura, James G Beeson, Alan F Cowman, Paul R Gilson, Brendan S Crabb

Journal article  |  2022  |  MOLECULAR MICROBIOLOGY

Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite'..

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell

Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson

Journal article  |  2022  |  PLOS PATHOGENS

Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium ..

PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion.

Claudia BG Barnes, Madeline G Dans, Thorey K Jonsdottir, Brendan S Crabb, Paul R Gilson

Journal article  |  2022  |  Front Cell Infect Microbiol

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implica..

839A novel approach to investigating poor growth in a longitudinal study of infants in PNG

Clarissa Moreira, Michelle Scoullar, Elizabeth Peach, Ruth Fidelis, Pele Melepeia, William Pomat, Peter Siba, Brendan Crabb, Leanne Robinson, Paul Agius, James Beeson

Journal article  |  2021  |  International Journal of Epidemiology

Abstract Background Children in Papua New Guinea (PNG) experience high rates o..

The introduction of a mandatory mask policy was associated with significantly reduced COVID-19 cases in a major metropolitan city

Nick Scott, Allan Saul, Tim Spelman, Mark Stoove, Alisa Pedrana, Alexander Saeri, Emily Grundy, Liam Smith, Michael Toole, Chandini Raina McIntyre, Brendan S Crabb, Margaret Hellard

Journal article  |  2021  |  PLOS ONE

BACKGROUND: Whilst evidence of use of face masks in reducing COVID-19 cases is increasing, the impact of mandatory use across a la..

O16.1 High burden of reproductive tract infections and poor sexual and reproductive health in pregnancy and postpartum in Papua New Guinea

M Scoullar, P Boeuf, E Peach, E Kearney, R Fidelis, K Tokmun, P Melepia, C Bradshaw, A Elijah, G Fehler, P Siba, S Erskine, E Mokany, E Kennedy, A Umbers, S Luchters, L Robinson, N Wong, A Vallely, S Badman, et al.

Conference Proceedings  |  2021  |  Female reproductive health for STIs and HIV