Kylie Gorringe

Pattern of invasion in stage I mucinous ovarian cancer is prognostic within 2-years of diagnosis

Nicola Meagher, Martin Koebel, Lyndal Anderson, Adeline Tan, Adelyn Bolithon, Michael Anglesio, Paul Cohen, Philip Crowe, Jennifer Doherty, Peter Fasching, Holly Harris, Estrid Hogdall, David Huntsman, Paul James, Beth Karlan, Linda Kelemen, Stefan Kommoss, Gottfried Konecny, Kylie Gorringe, Francesmary Modugno, et al.

Conference Proceedings  |  2021  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Investigation of monogenic causes of familial breast cancer: data from the BEACCON case-control study

Na Li, Belle WX Lim, Ella R Thompson, Simone McInerny, Magnus Zethoven, Dane Cheasley, Simone M Rowley, Michelle W Wong-Brown, Lisa Devereux, Kylie L Gorringe, Erica K Sloan, Alison Trainer, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2021  |  NPJ BREAST CANCER

Breast cancer (BC) has a significant heritable component but the genetic contribution remains unresolved in the majority of high-r..

Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects

Na Li, Magnus Zethoven, Simone McInerny, Lisa Devereux, Yu-Kuan Huang, Niko Thio, Dane Cheasley, Sara Gutierrez-Enriquez, Alejandro Moles-Fernandez, Orland Diez, Tu Nguyen-Dumont, Melissa C Southey, John L Hopper, Jacques Simard, Martine Dumont, Penny Soucy, Alfons Meindl, Rita Schmutzler, Marjanka K Schmidt, Muriel A Adank, et al.

Journal article  |  2021  |  NPJ BREAST CANCER

Bi-allelic loss-of-function (LoF) variants in the base excision repair (BER) gene NTHL1 cause a high-risk hereditary multi-tumor s..

Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus

Jovana R Gotovac, Tanjina Kader, Julia Milne, Kenji M Fujihara, Luis E Lara-Gonzalez, Kylie L Gorringe, Sangeetha N Kalimuthu, Madawa W Jayawardana, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2021  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) develops from its precursor Barrett's esophagus through intermediate stages of ..

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang, Dane Cheasley, Cecile LePage, Matthew J Wakefield, Michelle da Cunha Torres, Simone Rowley, Carolina Salazar, Zhongyue Xing, Prue Allan, David DL Bowtell, Anne-Marie Mes-Masson, Diane M Provencher, Kurosh Rahimi, Linda E Kelemen, Peter A Fasching, Jennifer A Doherty, Marc T Goodman, Ellen L Goode, Suha Deen, Paul DP Pharoah, et al.

Journal article  |  2021  |  MODERN PATHOLOGY

TP53 mutations are implicated in the progression of mucinous borderline tumors (MBOT) to mucinous ovarian carcinomas (MOC). Optimi..

Primary mucinous ovarian neoplasms rarely show germ cell histogenesis

Felix KF Kommoss, Dane Cheasley, Matthew J Wakefield, Clare L Scott, Ian G Campbell, C Blake Gilks, Kylie Gorringe

Journal article  |  2020  |  HISTOPATHOLOGY

Recently, genetic analyses of primary mucinous ovarian tumours (MOT) have considerably enhanced our understanding of the biology o..

Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities

Dane Cheasley, Abhimanyu Nigam, Magnus Zethoven, Sally Hunter, Dariush Etemadmoghadam, Timothy Semple, Prue Allan, Mark S Carey, Marta L Fernandez, Amy Dawson, Martin Kobel, David G Huntsman, Cecile Le Page, Anne-Marie Mes-Masson, Diane Provencher, Neville Hacker, Yunkai Gao, David Bowtell, Anna deFazio, Kylie L Gorringe, et al.

Journal article  |  2020  |  JOURNAL OF PATHOLOGY

Low-grade serous ovarian carcinoma (LGSOC) is associated with a poor response to existing chemotherapy, highlighting the need to p..

The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density

Dane Cheasley, Lisa Devereux, Siobhan Hughes, Carolyn Nickson, Pietro Procopio, Grant Lee, Na Li, Vicki Pridmore, Kenneth Elder, G Bruce Mann, Tanjina Kader, Simone M Rowley, Stephen B Fox, David Byrne, Hugo Saunders, Kenji M Fujihara, Belle Lim, Kylie L Gorringe, Ian G Campbell

Journal article  |  2020  |  NPJ BREAST CANCER

Mammographic density (MD) influences breast cancer risk, but how this is mediated is unknown. Molecular differences between breast..

Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

Sally M Hunter, Genevieve V Dall, Maria A Doyle, Richard Lupat, Jason Li, Prue Allan, Simone M Rowley, David Bowtell, Ian G Campbell, Kylie L Gorringe

Journal article  |  2020  |  BMC RESEARCH NOTES

OBJECTIVE: Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal c..

CDK4/6 and MEK inhibitor combination in low-grade serous ovarian cancer cell lines.

Joshua Hoenisch, Hannah Kim, Amy Dawson, Nicole Lam, Dane A Cheasley, Kylie Gorringe, Ian Campbell, David G Huntsman, Gabriel DiMattia, Martin Kobel, Marta Llaurado Fernandez, Mark S Carey

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH